The DOI matches its Crossref record; 45 of the 47 references it cites were found in a registry or an index.
Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects
Abstract
Maintenance of reduced or elevated body weight results in respective decreases or increases in energy expended in physical activity, defined as 24-h energy expenditure excluding resting energy expenditure and the thermic effect of feeding, beyond those attributable to weight change. We examined skeletal muscle work efficiency by graded cycle ergometry and, in some subjects, rates of gastrocnemius muscle ATP flux during exercise by magnetic resonance spectroscopy (MRS), in 30 subjects (15 males, 15 females) at initial weight and 10% below initial weight and in 8 subjects (7 males, 1 female) at initial weight and 10% above initial weight to determine whether changes in skeletal muscle work efficiency at altered body weight were correlated with changes in the energy expended in physical activity. At reduced weight, muscle work efficiency was increased in both cycle ergometry [mean (SD) change = +26.5 (26.7)%, P < 0.001] and MRS [ATP flux change = -15.2 (23.2)%, P = 0.044] studies. Weight gain resulted in decreased muscle work efficiency by ergometry [mean (SD) change = -17.8 (20.5)%, P = 0.043]. Changes in muscle efficiency at altered body weight accounted for 35% of the change in daily energy expended in physical activity.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“reductions in skeletal muscle mass and increased work efficiency are reported to contribute directly to this phenomenon [12].”
From Antibody blockade of activin type II receptors preserves skeletal muscle mass and enhances fat loss during GLP-1 receptor agonism (2024) · cites this paper as [12]
Citations
Cites
The Metabolic and Molecular Bases of Inherited Disease
Scriver, R. C. (1995) · Medical Entomology and Zoology · Cited by 12,101
Principles of Exercise Testing and Interpretation.
(1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-106-4-646 · Cited by 2,366
Changes in Energy Expenditure Resulting from Altered Body Weight
Leibel, R. L., Rosenbaum, M., & Hirsch, J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321001 · Cited by 2,012
Self-citationThe theoretical bases of indirect calorimetry: A review
Ferrannini, E. (1988) · Metabolism · doi:10.1016/0026-0495(88)90110-2 · Cited by 1,604
S UCCESSFUL W EIGHT L OSS M AINTENANCE
Wing, R. R., & Hill, J. O. (2001) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.21.1.323 · Cited by 1,382
Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber.
Ravussin, E., Lillioja, S., Anderson, T. E., Christin, L., & Bogardus, C. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112749 · Cited by 1,166
A descriptive study of individuals successful at long-term maintenance of substantial weight loss
Klem, M., Wing, R., McGuire, M., Seagle, H., & Hill, J. (1997) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.2.239 · Cited by 1,060
Role of Nonexercise Activity Thermogenesis in Resistance to Fat Gain in Humans
Levine, J. A., Eberhardt, N. L., & Jensen, M. D. (1999) · Science · doi:10.1126/science.283.5399.212 · Cited by 997
American Physiological Society
Greene, C. W. (1922) · Science · doi:10.1126/science.55.1435.708 · Cited by 791
Dual-energy X-ray absorptiometry body composition model: review of physical concepts
Pietrobelli, A., Formica, C., Wang, Z., & Heymsfield, S. B. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.6.e941 · Cited by 594
Self-citation
Research works printed but not linked: 1
- 10.1210/jcem.87.5.8628 · DOI · Paper page
Cited by
Sorted by citations
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Self-citationSpeakman, J. R., & Mitchell, S. E. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.07.001 · Cited by 797
“…that energy savings in humans might come about by increases in the metabolic efficiency of locomotion rather than decreases in gross movement (Rosenbaum et al., 2003), or the changes may reflect more minor patterns of movement such as fidgeting which would not be apparent when assessed by…”
BackgroundLeptin in Human Physiology and Pathophysiology
Mantzoros, C. S., Magkos, F., Brinkoetter, M., Sienkiewicz, E., Dardeno, T. A., Kim, S.-Y., Hamnvik, O.-P. R., & Koniaris, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00315.2011 · Cited by 593
Rosenbaum, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25977 · Cited by 575
Self-citationRedman, L. M., Smith, S. R., Burton, J. H., Martin, C. K., Il'yasova, D., & Ravussin, E. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.019 · Cited by 472
“Indeed, an increase in skeletal muscle work efficiency has been observed in obese individuals with a metabolic adaptation following weight loss (Rosenbaum et al., 2003).”
Background
Metadata
- Authors
- Rosenbaum, M., Vandenborne, K., Goldsmith, R., Simoneau, J.-A., Heymsfield, S., Joanisse, D. R., Hirsch, J., Murphy, E., Matthews, D., Segal, K. R., & Leibel, R. L.
- Affiliations
- Columbia University (US)
- ORCID
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2003-07
- Volume
- 285
- Issue
- 1
- Pages
- R183-R192
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2169216660
- Cited by
- 255
- References
- 47
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 8 · 2023: 15 · 2022: 9 · 2021: 14 · 2020: 13 · 2019: 8 · 2018: 12 · 2017: 16 · 2016: 8 · 2015: 12 · 2014: 11 · 2013: 10 · 2012: 16
- FWCI
- 19.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2m01rr000102-41, 5r01dk030583-18)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK37948, DK-30583, R01DK037948, DK 26687, P30DK026687)
- National Center for Research Resources (RR00102, RR 00645, M01RR000645)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Keywords
- weight change, weight loss, weight gain, energy expenditure, physical activity energy expenditure, gastrocnemius, physical activity, cycle ergometry, magnetic resonance spectroscopy
- MeSH terms
- Body Composition, Energy Metabolism, Exercise Test, Female, Humans, Male, Muscle Contraction, Magnetic Resonance Spectroscopy, Obesity, Reproducibility of Results, Weight Gain, Weight Loss, Exercise, Muscle, Skeletal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
