The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Development of the corticosteroid stress axis and receptor expression in zebrafish
Abstract
Using zebrafish embryos and larvae, we examined the temporal patterns of cortisol and expression of genes involved in corticosteroid synthesis and signaling. Embryonic cortisol levels decreased ∼70% from 1.5 h postfertilization (hpf) to hatch (∼42 hpf) and then increased 27-fold by 146 hpf. The mRNA abundances of steroidogenic acute regulatory protein, 11β-hydroxylase and 11β-hydroxysteroid dehydrogenase type 2, increased severalfold after hatch and preceded the rise of cortisol levels. In contrast to other teleosts that possess two glucocorticoid receptors (GRs) and one mineralocorticoid receptor (MR), only one GR and MR were identified in zebrafish, which were cloned and sequenced. GR mRNA abundance decreased from 1.5 to 25 hpf, rebounded, and then was stable from 49 to 146 hpf. MR transcripts increased continuously from 1.5 hpf and were 52-fold higher by 97 hpf. An acute cortisol response to a stressor was not detected until 97 hpf, whereas melanocortin type 2 receptor mRNA increased between 25 and 49 hpf. Collectively, the patterns of cortisol and the expression of cortisol biosynthetic genes and melanocortin type 2 receptor suggest that the corticoid stress axis in zebrafish is fully developed only after hatch. The temporal differences in GR, MR, and 11β-hydroxysteroid dehydrogenase type 2 gene expression lead us to propose a key role for MR signaling by maternal cortisol during embryogenesis, whereas cortisol secretion after hatch may be regulating GR expression and signaling in zebrafish.
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Cites
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Cortisol in teleosts: dynamics, mechanisms of action, and metabolic regulation
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Self-citationAnimal models of human disease: zebrafish swim into view
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Endocrinology of the stress response
Charmandari, E., Tsigos, C., & Chrousos, G. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.040403.120816 · Cited by 1,799
Zebrafish hox Clusters and Vertebrate Genome Evolution
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Advances in Male Contraception
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From 2R to 3R: evidence for a fish-specific genome duplication (FSGD)
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Zebrafish Comparative Genomics and the Origins of Vertebrate Chromosomes
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Brun, N. R., van Hage, P., Hunting, E. R., Haramis, A.-P. G., Vink, S. C., Vijver, M. G., Schaaf, M. J. M., & Tudorache, C. (2019) · Communications Biology · doi:10.1038/s42003-019-0629-6 · Cited by 246
A Zebrafish Genetic Screen Identifies Neuromedin U as a Regulator of Sleep/Wake States
Chiu, C. N., Rihel, J., Lee, D. A., Singh, C., Mosser, E. A., Chen, S., Sapin, V., Pham, U., Engle, J., Niles, B. J., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.007 · Cited by 101
Tokarz, J., Mindnich, R., Norton, W., Möller, G., Hrabé de Angelis, M., & Adamski, J. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.10.022 · Cited by 48
Anxiolytic drug discovery: What are the novel approaches and how can we improve them?
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Metadata
- Authors
- Alsop, D., & Vijayan, M. M.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2008-03
- Volume
- 294
- Issue
- 3
- Pages
- R711-R719
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2145334570
- Cited by
- 429
- References
- 42
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- closed
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