The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Baroreflex control of heart rate by oxytocin in the solitary-vagal complex
Abstract
Previous work demonstrated that oxytocinergic projections to the solitary vagal complex are involved in the restraint of exercise-induced tachycardia (2). In the present study, we tested the idea that oxytocin (OT) terminals in the solitary vagal complex [nucleus of the solitary tract (NTS)/dorsal motor nucleus of the vagus (DMV)] are involved in baroreceptor reflex control of heart rate (HR). Studies were conducted in male rats instrumented for chronic cardiovascular monitoring with a cannula in the NTS/DMV for brain injections. Basal mean arterial pressure and HR and reflex HR responses during loading and unloading of the baroreceptors (phenylephrine/sodium nitroprusside intravenously) were recorded after administration of a selective OT antagonist (OT ant) or OT into the NTS/DMV. The NTS/DMV was selected for study because this region contains such a specific and dense concentration of OT-immunoreactive terminals. Vehicle injections served as a control. OT and OT ant changed baroreflex control of HR in opposite directions. OT (20 pmol) increased the maximal bradycardic response (from −56 ± 9 to −75 ± 11 beats/min), whereas receptor blockade decreased the bradycardia (from −61 ± 13 to −35 ± 2 beats/min). OT ant also reduced the operating range of the reflex, thus decreasing baroreflex gain (from −5.68 ± 1.62 to −2.83 ± 1.05 beats · min−1· mmHg−1). OT injected into the NTS/DMV of atenolol-treated rats still potentiated the bradycardic responses to pressor challenges, whereas OT injections had no effect in atropine-treated rats. The brain stem effect was specific because neither vehicle administration nor injection of OT or OT ant into the fourth cerebral ventricle had any effect. Our data suggest that OT terminals in the solitary vagal complex modulate reflex control of the heart, acting to facilitate vagal outflow and the slowdown of the heart.
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“The vagus is densely populated with oxytocin receptors in rodents19,21–26”
From Voluntary upregulation of heart rate variability through biofeedback is improved by mental contemplative training (2019) · cites this paper as [23]
In the citing paper
“The vagus nerve is densely populated by oxytocin receptors19,21–26”
From Voluntary upregulation of heart rate variability through biofeedback is improved by mental contemplative training (2019) · cites this paper as [23]
Citations
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“The involvement of OT in the autonomic control of the circulation has been previously demonstrated (6, 8, 16, 22, 29, 32).”
A Mathematical Model to Assess Changes in the Baroreceptor Reflex
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Magnocellular Hypothalamic Projections to the Lower Brain Stem and Spinal Cord of the Rat
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Research works printed but not linked: 1
- Michelini LC, 1999, Soc Neurosci Abstr, 25, 12
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Koenig, J., & Thayer, J. F. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.007 · Cited by 860
Brown, R. P., & Gerbarg, P. L. (2005) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2005.11.189 · Cited by 655
Vagus Nerve and Vagus Nerve Stimulation, a Comprehensive Review: Part I
Yuan, H., & Silberstein, S. D. (2015) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12647 · Cited by 402
Grippo, A. J., Trahanas, D. M., Zimmerman, R. R., Porges, S. W., & Carter, C. S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.017 · Cited by 240
Oxytocin increases autonomic cardiac control: Moderation by loneliness
Norman, G. J., Cacioppo, J. T., Morris, J. S., Malarkey, W. B., Berntson, G. G., & DeVries, A. C. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2010.11.006 · Cited by 211
Metadata
- Authors
- Higa, K. T., Mori, E., Viana, F. F., Morris, M., & Michelini, L. C.
- Affiliations
- Department of Physiology and Biophysics, Biomedical Sciences Institute, University of Sao Paulo, 05508-900 Sao Paulo, Brazil; and
- Universidade de São Paulo (BR)
- Wright State University (US)
- ORCID
- Michelini, Lisete C.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2002-02-01
- Volume
- 282
- Issue
- 2
- Pages
- R537-R545
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2064531921
- Cited by
- 157
- References
- 41
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 8 · 2017: 8 · 2016: 13 · 2015: 11 · 2014: 9 · 2013: 10 · 2012: 10
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- NSUWorks (Nova Southeastern University) (submittedVersion)
- Funders
- National Institutes of Health (5r01hl043178-09)
- National Heart, Lung, and Blood Institute (HL-43178)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- oxytocin, baroreflex, heart rate, nucleus tractus solitarius, dorsal motor nucleus of the vagus, vagal outflow, bradycardia, baroreflex gain, atenolol, atropine, oxytocin antagonist, brainstem
- MeSH terms
- Animals, Blood Pressure, Bradycardia, Heart Rate, Immunohistochemistry, Male, Motor Neurons, Nitroprusside, Oxytocin, Phenylephrine, Rats, Inbred WKY, Sympathomimetics, Tachycardia, Vagus Nerve, Vasodilator Agents, Solitary Nucleus, Baroreflex, Receptors, Oxytocin, Fourth Ventricle, Rats
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