Cited by 157Heart Rate Variability and Autonomic ControlNeuroendocrine regulation and behaviorNeuroscience of respiration and sleep

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Baroreflex control of heart rate by oxytocin in the solitary-vagal complex

Higa, Keila T., Mori, Eliana, Viana, Fabiano F., Morris, Mariana, Michelini, Lisete C.·2002·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI 10.1152/ajpregu.00806.2000

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Abstract

Previous work demonstrated that oxytocinergic projections to the solitary vagal complex are involved in the restraint of exercise-induced tachycardia (2). In the present study, we tested the idea that oxytocin (OT) terminals in the solitary vagal complex [nucleus of the solitary tract (NTS)/dorsal motor nucleus of the vagus (DMV)] are involved in baroreceptor reflex control of heart rate (HR). Studies were conducted in male rats instrumented for chronic cardiovascular monitoring with a cannula in the NTS/DMV for brain injections. Basal mean arterial pressure and HR and reflex HR responses during loading and unloading of the baroreceptors (phenylephrine/sodium nitroprusside intravenously) were recorded after administration of a selective OT antagonist (OT ant) or OT into the NTS/DMV. The NTS/DMV was selected for study because this region contains such a specific and dense concentration of OT-immunoreactive terminals. Vehicle injections served as a control. OT and OT ant changed baroreflex control of HR in opposite directions. OT (20 pmol) increased the maximal bradycardic response (from −56 ± 9 to −75 ± 11 beats/min), whereas receptor blockade decreased the bradycardia (from −61 ± 13 to −35 ± 2 beats/min). OT ant also reduced the operating range of the reflex, thus decreasing baroreflex gain (from −5.68 ± 1.62 to −2.83 ± 1.05 beats · min−1· mmHg−1). OT injected into the NTS/DMV of atenolol-treated rats still potentiated the bradycardic responses to pressor challenges, whereas OT injections had no effect in atropine-treated rats. The brain stem effect was specific because neither vehicle administration nor injection of OT or OT ant into the fourth cerebral ventricle had any effect. Our data suggest that OT terminals in the solitary vagal complex modulate reflex control of the heart, acting to facilitate vagal outflow and the slowdown of the heart.

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Authors: Higa, K. T., Mori, E., Viana, F. F., Morris, M., & Michelini, L. C.
Affiliations: Department of Physiology and Biophysics, Biomedical Sciences Institute, University of Sao Paulo, 05508-900 Sao Paulo, Brazil; and
Universidade de São Paulo (BR)
Wright State University (US)
ORCID: Michelini, Lisete C.
Venue: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher: American Physiological Society
Published: 2002-02-01
Volume: 282
Issue: 2
Pages: R537-R545
ISSN: 0363-6119 (ISSN-L)
1522-1490
DOI: 10.1152/ajpregu.00806.2000
OpenAlex: W2064531921
Cited by: 157
References: 41
Citations by year: 2026: 3 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 8 · 2017: 8 · 2016: 13 · 2015: 11 · 2014: 9 · 2013: 10 · 2012: 10
FWCI: 2.41
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
PubMed (publishedVersion)
NSUWorks (Nova Southeastern University) (submittedVersion)
Funders: National Institutes of Health (5r01hl043178-09)
National Heart, Lung, and Blood Institute (HL-43178)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords: oxytocin, baroreflex, heart rate, nucleus tractus solitarius, dorsal motor nucleus of the vagus, vagal outflow, bradycardia, baroreflex gain, atenolol, atropine, oxytocin antagonist, brainstem
MeSH terms: Animals, Blood Pressure, Bradycardia, Heart Rate, Immunohistochemistry, Male, Motor Neurons, Nitroprusside, Oxytocin, Phenylephrine, Rats, Inbred WKY, Sympathomimetics, Tachycardia, Vagus Nerve, Vasodilator Agents, Solitary Nucleus, Baroreflex, Receptors, Oxytocin, Fourth Ventricle, Rats

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Baroreflex control of heart rate by oxytocin in the solitary-vagal complex

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