Suppression of food intake by intravenous nutrients and insulin in the baboon
Abstract
Intravenous nutrients were infused at 25 and 50% of total base-line daily caloric intake to determine the role of circulating factors on spontaneous food ingestion in young adult male baboons (Papio cynocephalus). Glucose infusion suppressed food intake (15.1%) when 25% of total calories was infused (P less than 0.05) and 41.8% when 50% of total calories was infused (P less than 0.05) for 14-21 days. Both infusions produced basal hyperglycemia (82-172 mg/dl during 25% glucose and 120-239 mg/dl during 50% glucose). Both infusions also caused an increase in circulating insulin (48.1-63.1 microU/ml during 25% glucose and 68.5-77.2 microU/ml during 50% glucose). The simultaneous infusion of exogenous insulin (0.33 mU X kg-1 X min-1) prevented hyperglycemia (85.8-87.9 mg/dl during 25% glucose) but maintained raised basal peripheral insulin levels (52.4-84.4 microU/ml). The 13% suppression of food intake (P less than 0.05) was similar to glucose infusion alone. Comparable infusions of Intralipid as 25 and 50% of total daily calories also suppressed spontaneous food intake but did not produce hyperglycemia or elevated insulin levels. The magnitude of suppression was similar to that of glucose: 16% when 25% of basal calories was infused (P less than 0.05) and 31.3% when 50% of basal calories was infused (P less than 0.05). However, the pattern was different with a more rapid effect, which tended to diminish in time, rather than the slow effect found with glucose, which was maintained…
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Insulin released in response to a meal enters the brain via the blood-brain barrier to decrease food intake by stimulating hypothalamic pro-opiomelanocortin neurons and initiating PI3K signaling in these neurons.
“Conversely, insulin released in response to a meal enters the brain via the blood–brain–barrier138 to decrease food intake139, 140 by stimulating hypothalamic pro-opiomelanocortin neurons141 and initiating the PI3K signaling pathway142 in these pro-opiomelanocortin neurons.143”
From Pancreatic regulation of glucose homeostasis. (2016) · cites this paper as [140]
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- Authors
- Woods, S. C., Stein, L. J., McKay, L. D., & Porte, D.
- ORCID
- Woods, S. C.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1984-08-01
- Volume
- 247
- Issue
- 2
- Pages
- R393-R401
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2284220714
- Cited by
- 130
- References
- 2
- Citations by year
- 2026: 1 · 2025: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 1
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- feeding inhibition, glucose infusion, insulin, hyperglycemia, Intralipid, baboons, basal metabolic rate, primate feeding behavior
- MeSH terms
- Animals, Blood Glucose, Body Weight, Energy Intake, Eating, Fat Emulsions, Intravenous, Glucose, Insulin, Male, Papio, Time Factors
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