The DOI matches its Crossref record.
Eccentric exercise-induced injury to rat skeletal muscle
Abstract
These experiments were designed to study skeletal muscle pathology resulting from eccentric-biased exercise in rats. The effects on the muscles of running on a treadmill on a 0 degrees incline (similar amounts of concentric and eccentric contractions), down a 16 degrees incline (primarily eccentric contractions), and up a 16 degrees incline (primarily concentric contractions) at 16 m . min-1 for 90 min were assessed by following postexercise changes in 1) plasma creatine kinase and lactate dehydrogenase activities, 2) glucose-6-phosphate dehydrogenase (G-6-PDase) activity (bio- and histochemically) in the physiological extensor muscles, and 3) histological appearance of the muscles. The data indicate the following. 1) Whereas all exercise protocols resulted in elevations of plasma enzymes immediately after running, only eccentric exercise caused late phase elevations 1.5–2 days postexercise. 2) Significant increases in muscle G-6-PDase activity, which were always associated with accumulations of mononuclear cells, always occurred within some muscles of each extensor group 1–3 days following downhill and uphill running and did not occur following level running; the increases in activity were usually of lower magnitude in the muscles of uphill runners than in those of downhill runners; the deeply located, predominantly slow-twitch muscles were most affected by both down- and uphill running. 3) Muscle histology demonstrated localized disruption of normal banding patterns of some fibers immediately after exercise and accumulations of macrophages in the interstitium and in some (less than 5%) muscle fibers by 24 h postexercise in the deep slow muscles of the antigravity groups. Although the data generally indicated that eccentric exercise causes greater injury to the muscles, questions remain.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Sarcopenia: Aging-Related Loss of Muscle Mass and Function
Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L., & Sandri, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00061.2017 · Cited by 1,797
Moderate exercise is an antioxidant: Upregulation of antioxidant genes by training
Gomez-Cabrera, M.-C., Domenech, E., & Viña, J. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.02.001 · Cited by 1,020
Baar, K., & Esser, K. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.276.1.c120 · Cited by 726
Time-course of changes in inflammatory and performance responses following a soccer game
Ispirlidis, I., Fatouros, I. G., Jamurtas, A. Z., Nikolaidis, M. G., Michailidis, I., Douroudos, I., Margonis, K., Chatzinikolaou, A., Kalistratos, E., Katrabasas, I., et al. (2008) · Clinical Journal of Sport Medicine · doi:10.1097/jsm.0b013e3181818e0b · Cited by 467
Exercise acts as a drug; the pharmacological benefits of exercise
Vina, J., Sanchis‐Gomar, F., Martinez‐Bello, V, & Gomez‐Cabrera, M. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01970.x · Cited by 443
Contraction-induced injury: recovery of skeletal muscles in young and old mice
Brooks, S. V., & Faulkner, J. A. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.258.3.c436 · Cited by 238
Excitation failure in eccentric contraction-induced injury of mouse soleus muscle
Warren, G. L., Lowe, D. A., Hayes, D. A., Karwoski, C. J., Prior, B. M., & Armstrong, R. B. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019783 · Cited by 189
Self-citationTime course of changes in performance and inflammatory responses after acute plyometric exercise
Chatzinikolaou, A., Fatouros, I. G., Gourgoulis, V., Avloniti, A., Jamurtas, A. Z., Nikolaidis, M. G., Douroudos, I., Michailidis, Y., Beneka, A., Malliou, P., et al. (2010) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181d1d318 · Cited by 177
Muscle function and protein metabolism after initiation of eccentric contraction-induced injury
Lowe, D. A., Warren, G. L., Ingalls, C. P., Boorstein, D. B., & Armstrong, R. B. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.79.4.1260 · Cited by 170
Self-citationEston, R. G., Mickleborough, J., & Baltzopoulos, V (1995) · British Journal of Sports Medicine · doi:10.1136/bjsm.29.2.89 · Cited by 161
Muscle Damage, Endocrine, and Immune Marker Response to a Soccer Match
Thorpe, R., & Sunderland, C. (2012) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e318241e174 · Cited by 158
Warren, G. L., Ingalls, C. P., Lowe, D. A., & Armstrong, R. B. (2002) · Journal of Orthopaedic & Sports Physical Therapy · doi:10.2519/jospt.2002.32.2.58 · Cited by 128
Self-citationMalaguti, M., Angeloni, C., Garatachea, N., Baldini, M., Leoncini, E., Collado, P. S., Teti, G., Falconi, M., Gonzalez-Gallego, J., & Hrelia, S. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00293.2009 · Cited by 103
Ingalls, C. P., Warren, G. L., & Armstrong, R. B. (1998) · Journal of Muscle Research & Cell Motility · doi:10.1023/a:1005368831198 · Cited by 91
Self-citationSalivary cortisol and α‐amylase responses to repeated bouts of downhill running
Mckune, A. J., Bach, C. W., Semple, S. J., & Dyer, B. J. (2014) · American Journal of Human Biology · doi:10.1002/ajhb.22605 · Cited by 22
Hong, K.-B., Lee, H.-S., Kim, D. H., Moon, J. M., & Park, Y. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/4319398 · Cited by 10
Metadata
- Authors
- Armstrong, R. B., Ogilvie, R. W., & Schwane, J. A.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1983-01-01
- Volume
- 54
- Issue
- 1
- Pages
- 80-93
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2141399230
- Cited by
- 772
- References
- 0
- FWCI
- 18.54
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
