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Cited by 147Thermoregulation and physiological responsesMuscle metabolism and nutritionCardiovascular and exercise physiology

Heat stress increases muscle glycogen use but reduces the oxidation of ingested carbohydrates during exercise

Jentjens, Roy L. P. G., Wagenmakers, Anton J. M., Jeukendrup, Asker E.·2002·Journal of Applied Physiology
DOI 10.1152/japplphysiol.00482.2001
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Abstract

The aim of the present study was to test the hypothesis that the oxidation rate of ingested carbohydrate (CHO) is impaired during exercise in the heat compared with a cool environment. Nine trained cyclists (maximal oxygen consumption 65 +/- 1 ml x kg body wt(-1) x min(-1)) exercised on two different occasions for 90 min at 55% maximum power ouptput at an ambient temperature of either 16.4 +/- 0.2 degrees C (cool trial) or 35.4 +/- 0.1 degrees C (heat trial). Subjects received 8% glucose solutions that were enriched with [U-13C]glucose for measurements of exogenous glucose, plasma glucose, liver-derived glucose and muscle glycogen oxidation. Exogenous glucose oxidation during the final 30 min of exercise was significantly (P < 0.05) lower in the heat compared with the cool trial (0.76 +/- 0.06 vs. 0.84 +/- 0.05 g/min). Muscle glycogen oxidation during the final 30 min of exercise was increased by 25% in the heat (2.07 +/- 0.16 vs. 1.66 +/- 0.09 g/min; P < 0.05), and liver-derived glucose oxidation was not different. There was a trend toward a higher total CHO oxidation and a lower plasma glucose oxidation in the heat although this did not reach statistical significance (P = 0.087 and P = 0.082, respectively). These results demonstrate that the oxidation rate of ingested CHO is reduced and muscle glycogen utilization is increased during exercise in the heat compared with a cool environment.

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Authors
Jentjens, R. L. P. G., Wagenmakers, A. J. M., & Jeukendrup, A. E.
Affiliations
  • University of Birmingham (GB)
  • Maastricht University (NL)
ORCID
Wagenmakers, Anton J. M.
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2002-04-01
Volume
92
Issue
4
Pages
1562-1572
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/japplphysiol.00482.2001
OpenAlex
W2102907141
Cited by
146
References
53
Citations by year
2026: 8 · 2025: 10 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 11 · 2019: 9 · 2018: 7 · 2017: 3 · 2016: 7 · 2015: 6 · 2014: 6 · 2013: 8 · 2012: 4
FWCI
3.00
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (submittedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
heat stress, carbohydrate oxidation, exercise in the heat, exogenous glucose, plasma glucose, trained cyclists, 13C-glucose tracer, endurance exercise
MeSH terms
Adult, Bicycling, Blood Glucose, Carbon Isotopes, Dietary Carbohydrates, Digestive System, Physical Exertion, Glucose, Glycogen, Heart Rate, Humans, Male, Oxidation-Reduction, Perception, Plasma Volume, Body Mass Index, Muscle, Skeletal, Heat Stress Disorders, Lactic Acid

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