The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Aging, muscle fiber type, and contractile function in sprint-trained athletes
Abstract
Biopsy samples were taken from the vastus lateralis of 18- to 84-yr-old male sprinters ( n = 91). Fiber-type distribution, cross-sectional area, and myosin heavy chain (MHC) isoform content were identified using ATPase histochemistry and SDS-PAGE. Specific tension and maximum shortening velocity ( V o) were determined in 144 single skinned fibers from younger (18–33 yr, n = 8) and older (53–77 yr, n = 9) runners. Force-time characteristics of the knee extensors were determined by using isometric contraction. The cross-sectional area of type I fibers was unchanged with age, whereas that of type II fibers was reduced ( P < 0.001). With age there was an increased MHC I ( P < 0.01) and reduced MHC IIx isoform content ( P < 0.05) but no differences in MHC IIa. Specific tension of type I and IIa MHC fibers did not differ between younger and older subjects. V o of fibers expressing type I MHC was lower ( P < 0.05) in older than in younger subjects, but there was no difference in V o of type IIa MHC fibers. An aging-related decline of maximal isometric force ( P < 0.001) and normalized rate of force development ( P < 0.05) of knee extensors was observed. Normalized rate of force development was positively associated with MHC II ( P < 0.05). The sprint-trained athletes experienced the typical aging-related reduction in the size of fast fibers, a shift toward a slower MHC isoform profile, and a lower V o of type I MHC fibers, which played a role in the decline in explosive force production. However, the muscle characteristics were preserved at a high level in the oldest runners, underlining the favorable impact of sprint exercise on aging muscle.
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Citations
Cites
Skeletal muscle adaptations during early phase of heavy-resistance training in men and women.
Staron, R. S., Karapondo, D. L., Kraemer, W. J., Fry, A. C., Gordon, S. E., Falkel, J. E., Hagerman, F. C., & Hikida, R. S. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.76.3.1247 · Cited by 796 · cited 1×
“Training studies have also indicated that a decrease in MHC IIx can occur rapidly, within a period of 1–2 wk of intense training (19, 65).”
BackgroundFiber Type Composition of the Vastus Lateralis Muscle of Young Men and Women
Staron, R. S., Hagerman, F. C., Hikida, R. S., Murray, T. F., Hostler, D. P., Crill, M. T., Ragg, K. E., & Toma, K. (2000) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540004800506 · Cited by 730
Hakkinen, K., Newton, R. U., Gordon, S. E., McCormick, M., Volek, J. S., Nindl, B. C., Gotshalk, L. A., Campbell, W. W., Evans, W. J., Hakkinen, A., et al. (1998) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/53a.6.b415 · Cited by 423
Oxidative capacity of human muscle fiber types: effects of age and training status
Proctor, D. N., Sinning, W. E., Walro, J. M., Sieck, G. C., & Lemon, P. W. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.78.6.2033 · Cited by 283
Calcium-Sensitive Cross-Bridge Transitions in Mammalian Fast and Slow Skeletal Muscle Fibers
Metzger, J. M., & Moss, R. L. (1990) · Science · doi:10.1126/science.2309121 · Cited by 148
Häkkinen, K., Kraemer, W. J., Pakarinen, A., Tripleltt-Mcbride, T., Mcbride, J. M., Häkkinen, A., Alen, M., Mcguigan, M. R., Bronks, R., & Newton, R. U. (2002) · Canadian Journal of Applied Physiology · doi:10.1139/h02-013 · Cited by 125
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Sarcopenia: Aging-Related Loss of Muscle Mass and Function
Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L., & Sandri, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00061.2017 · Cited by 1,797
Self-citationRate of force development: physiological and methodological considerations
Maffiuletti, N. A., Aagaard, P., Blazevich, A. J., Folland, J., Tillin, N., & Duchateau, J. (2016) · European Journal of Applied Physiology · doi:10.1007/s00421-016-3346-6 · Cited by 1,424
Sarcopenia: characteristics, mechanisms and functional significance
Narici, M. V., & Maffulli, N. (2010) · British Medical Bulletin · doi:10.1093/bmb/ldq008 · Cited by 827
Aagaard, P., Suetta, C., Caserotti, P., Magnusson, S. P., & Kjær, M. (2010) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/j.1600-0838.2009.01084.x · Cited by 709
Fish oil–derived n−3 PUFA therapy increases muscle mass and function in healthy older adults
Smith, G. I., Julliand, S., Reeds, D. N., Sinacore, D. R., Klein, S., & Mittendorfer, B. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.105833 · Cited by 507
Metadata
- Authors
- Korhonen, M. T., Cristea, A., Alén, M., Häkkinen, K., Sipilä, S., Mero, A., Viitasalo, J. T., Larsson, L., & Suominen, H.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2006-09
- Volume
- 101
- Issue
- 3
- Pages
- 906-917
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2145069786
- Cited by
- 302
- References
- 6
- FWCI
- 27.02
- Type
- journal article
- Language
- en
- Open access
- closed
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