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Cited by 76

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Effects of creatine supplementation and exercise training on fitness in men 55–75 yr old

Eijnde, Bert O., Van Leemputte, Marc, Goris, Marina, Labarque, Valery, Taes, Youri, Verbessem, Patricia, Vanhees, Luc, Ramaekers, Monique, Vanden Eynde, Bart, Van Schuylenbergh, Reinout, Dom, René, Richter, Erik A., Hespel, Peter·2003·Journal of Applied Physiology
DOI 10.1152/japplphysiol.00891.2002
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Abstract

effect of oral creatine supplementation (CR; 5 g/day) in conjunction with exercise training on physical fitness was investigated in men between 55 and 75 yr of age ( n = 46). A double-blind randomized placebo-controlled (PL) trial was performed over a 6-mo period. Furthermore, a subgroup ( n = 20) completed a 1-yr follow-up. The training program consisted of cardiorespiratory endurance training as well as moderate resistance training (2–3 sessions/wk). Endurance capacity was evaluated during a maximal incremental bicycle ergometer test, maximal isometric strength of the knee-extensor muscles was assessed by an isokinetic dynamometer, and body composition was assessed by hydrostatic weighing. Furthermore, in a subgroup (PL: n = 13; CR: n = 12) biopsies were taken from m. vastus lateralis to determine total creatine (TCr) content. In PL, 6 mo of training increased peak oxygen uptake rate (+16%; P < 0.05). Fat-free mass slightly increased (+0.3 kg; P < 0.05), whereas percent body fat slightly decreased (-1.2%; P < 0.05). The training intervention did not significantly change either maximal isometric strength or body weight. The responses were independent of CR. Still, compared with PL, TCr was increased by ∼5% in CR, and this increase was closely correlated with initial muscle creatine content ( r = -0.78; P < 0.05). After a 1-yr follow-up, muscle TCr was not higher in CR than in PL. Furthermore, the other measurements were not affected by CR. It is concluded that long-term creatine intake (5 g/day) in conjunction with exercise training does not beneficially impact physical fitness in men between 55 and 75 yr of age.

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Metadata

Authors
Eijnde, B. O., Van Leemputte, M., Goris, M., Labarque, V., Taes, Y., Verbessem, P., Vanhees, L., Ramaekers, M., Vanden Eynde, B., Van Schuylenbergh, R., Dom, R., Richter, E. A., & Hespel, P.
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2003-08
Volume
95
Issue
2
Pages
818-828
ISSN
  • 8750-7587
  • 1522-1601
DOI
10.1152/japplphysiol.00891.2002
Cited by
76
References
18
Language
en

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