The DOI matches its Crossref record; 85 of the 86 references it cites were found in a registry or an index.
Signals mediating skeletal muscle remodeling by resistance exercise: PI3-kinase independent activation of mTORC1
Abstract
For over 10 years, we have known that the activation of the mammalian target of rapamycin complex 1 (mTORC1) has correlated with the increase in skeletal muscle size and strength that occurs following resistance exercise. Initial cell culture and rodent models of muscle growth demonstrated that the activation of mTORC1 is common to hypertrophy induced by growth factors and increased loading. The further observation that high loads increased the local production of growth factors led to the paradigm that resistance exercise stimulates the autocrine production of factors that act on membrane receptors to activate mTORC1, and this results in skeletal muscle hypertrophy. Over the last few years, there has been a paradigm shift. From both human and rodent studies, it has become clear that the phenotypic and molecular responses to resistance exercise occur in a growth factor-independent manner. Although the mechanism of load-induced mTORC1 activation remains to be determined, it is clear that it does not require classical growth factor signaling.
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In the citing paper
“However, resistance exercise activates mTOR in a growth factor-independent manner [12].”
From Using Molecular Biology to Maximize Concurrent Training (2014) · cites this paper as [12]
In the citing paper
“linked kinases have each been proposed as mechanosensors that initiate the signal that generates greater subsequent activity of the mechanistic target of rapamycin complex 1 (mTORC1).”
From Concurrent exercise training: do opposites distract? (2017) · cites this paper as Philp et al., 2011
In the citing paper
“The downstream effectors of mTORC1 are the 70KDa ribosomal S6 protein kinase (S6K) and eukaryotic initiation factor 4E binding protein (4E-BP) that have been shown to have key roles in promoting translation initiation and ribosome biogenesis (Philp et al., 2011).”
From Concurrent exercise training: do opposites distract? (2017) · cites this paper as Philp et al., 2011
Citations
Cites
The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., & Sabatini, D. M. (2008) · Science · doi:10.1126/science.1157535 · Cited by 2,773
Bodine, S. C., Stitt, T. N., Gonzalez, M., Kline, W. O., Stover, G. L., Bauerlein, R., Zlotchenko, E., Scrimgeour, A., Lawrence, J. C., Glass, D. J., et al. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1014 · Cited by 2,752
Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., & Sabatini, D. M. (2010) · Cell · doi:10.1016/j.cell.2010.02.024 · Cited by 2,464
Rommel, C., Bodine, S. C., Clarke, B. A., Rossman, R., Nunez, L., Stitt, T. N., Yancopoulos, G. D., & Glass, D. J. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1009 · Cited by 1,583
TENSEGRITY: THE ARCHITECTURAL BASIS OF CELLULAR MECHANOTRANSDUCTION
Ingber, D. E. (1997) · Annual Review of Physiology · doi:10.1146/annurev.physiol.59.1.575 · Cited by 1,565
Regulation of TORC1 by Rag GTPases in nutrient response
Kim, E., Goraksha-Hicks, P., Li, L., Neufeld, T. P., & Guan, K.-L. (2008) · Nature Cell Biology · doi:10.1038/ncb1753 · Cited by 1,349
Mixed muscle protein synthesis and breakdown after resistance exercise in humans
Phillips, S. M., Tipton, K. D., Aarsland, A., Wolf, S. E., & Wolfe, R. R. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.1.e99 · Cited by 1,132
Notch-Mediated Restoration of Regenerative Potential to Aged Muscle
Conboy, I. M., Conboy, M. J., Smythe, G. M., & Rando, T. A. (2003) · Science · doi:10.1126/science.1087573 · Cited by 1,121
Stretch‐activated single ion channel currents in tissue‐cultured embryonic chick skeletal muscle.
Guharay, F., & Sachs, F. (1984) · The Journal of Physiology · doi:10.1113/jphysiol.1984.sp015317 · Cited by 1,002
Signaling in Muscle Atrophy and Hypertrophy
Sandri, M. (2008) · Physiology · doi:10.1152/physiol.00041.2007 · Cited by 866
Research works printed but not linked: 3
- Hamilton DL, 2009, PI3K/mTORC1 Signalling During Skeletal Muscle Differentiation and Growth
- Laurent GJ, 1980, Fed Proc, 39, 42
- Shai SY, 2002, Genet Eng NY, 24, 87
Cited by
Sorted by citations
mTOR Signaling in Growth Control and Disease
Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509
Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation
Egan, B., & Zierath, J. R. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.012 · Cited by 2,084
Integrative Biology of Exercise
Hawley, J. A., Hargreaves, M., Joyner, M. J., & Zierath, J. R. (2014) · Cell · doi:10.1016/j.cell.2014.10.029 · Cited by 1,152
Exercise Attenuates the Major Hallmarks of Aging
Garatachea, N., Pareja-Galeano, H., Sanchis-Gomar, F., Santos-Lozano, A., Fiuza-Luces, C., Morán, M., Emanuele, E., Joyner, M. J., & Lucia, A. (2015) · Rejuvenation Research · doi:10.1089/rej.2014.1623 · Cited by 413
Concurrent exercise training: do opposites distract?
Coffey, V. G., & Hawley, J. A. (2017) · The Journal of Physiology · doi:10.1113/jp272270 · Cited by 351
Metadata
- Authors
- Philp, A., Hamilton, D. L., & Baar, K.
- Affiliations
- University of California, Davis (US)
- University of Dundee (GB)
- Corresponding author
- Baar, Keith
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2011-02
- Volume
- 110
- Issue
- 2
- Pages
- 561-568
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W1993994764
- Cited by
- 131
- References
- 86
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 1 · 2023: 9 · 2022: 8 · 2021: 3 · 2020: 5 · 2019: 4 · 2018: 6 · 2017: 11 · 2016: 11 · 2015: 10 · 2014: 14 · 2013: 21 · 2012: 13
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Stirling Online Research Repository (University of Stirling) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- resistance training, skeletal muscle remodeling, mTORC1, muscle hypertrophy, mechanical loading, autocrine growth factor, muscle growth
- MeSH terms
- Mechanistic Target of Rapamycin Complex 1, Animals, Humans, Models, Biological, Proteins, Signal Transduction, Muscle, Skeletal, Phosphatidylinositol 3-Kinases, Multiprotein Complexes, TOR Serine-Threonine Kinases
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