Cited by 131Muscle metabolism and nutritionMuscle Physiology and DisordersPI3K/AKT/mTOR signaling in cancer

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Signals mediating skeletal muscle remodeling by resistance exercise: PI3-kinase independent activation of mTORC1

Philp, Andrew, Hamilton, D. Lee, Baar, Keith·2011·Journal of Applied Physiology

DOI 10.1152/japplphysiol.00941.2010

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Abstract

For over 10 years, we have known that the activation of the mammalian target of rapamycin complex 1 (mTORC1) has correlated with the increase in skeletal muscle size and strength that occurs following resistance exercise. Initial cell culture and rodent models of muscle growth demonstrated that the activation of mTORC1 is common to hypertrophy induced by growth factors and increased loading. The further observation that high loads increased the local production of growth factors led to the paradigm that resistance exercise stimulates the autocrine production of factors that act on membrane receptors to activate mTORC1, and this results in skeletal muscle hypertrophy. Over the last few years, there has been a paradigm shift. From both human and rodent studies, it has become clear that the phenotypic and molecular responses to resistance exercise occur in a growth factor-independent manner. Although the mechanism of load-induced mTORC1 activation remains to be determined, it is clear that it does not require classical growth factor signaling.

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Authors: Philp, A., Hamilton, D. L., & Baar, K.
Affiliations: University of California, Davis (US)
University of Dundee (GB)
Corresponding author: Baar, Keith
ORCID: Philp, Andrew
Hamilton, D. Lee
Baar, Keith
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 2011-02
Volume: 110
Issue: 2
Pages: 561-568
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/japplphysiol.00941.2010
OpenAlex: W1993994764
Cited by: 131
References: 86
Citations by year: 2026: 3 · 2025: 10 · 2024: 1 · 2023: 9 · 2022: 8 · 2021: 3 · 2020: 5 · 2019: 4 · 2018: 6 · 2017: 11 · 2016: 11 · 2015: 10 · 2014: 14 · 2013: 21 · 2012: 13
FWCI: 5.03
Type: journal article
Language: en
Open access: closed
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
Stirling Online Research Repository (University of Stirling) (submittedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: resistance training, skeletal muscle remodeling, mTORC1, muscle hypertrophy, mechanical loading, autocrine growth factor, muscle growth
MeSH terms: Mechanistic Target of Rapamycin Complex 1, Animals, Humans, Models, Biological, Proteins, Signal Transduction, Muscle, Skeletal, Phosphatidylinositol 3-Kinases, Multiprotein Complexes, TOR Serine-Threonine Kinases

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Signals mediating skeletal muscle remodeling by resistance exercise: PI3-kinase independent activation of mTORC1

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