The DOI matches its Crossref record; 46 of the 47 references it cites were found in a registry or an index.
Resistance training induces qualitative changes in muscle morphology, muscle architecture, and muscle function in elderly postoperative patients
Abstract
Although the negative effects of bed rest on muscle strength and muscle mass are well established, it still remains a challenge to identify effective methods to restore physical capacity of elderly patients recovering from hospitalization. The present study compared different training regimes with respect to muscle strength, muscle fiber size, muscle architecture, and stair walking power in elderly postoperative patients. Thirty-six patients (60–86 yr) scheduled for unilateral hip replacement surgery due to hip osteoarthritis were randomized to either 1) resistance training (RT: 3/wk × 12 wk), 2) electrical stimulation (ES: 1 h/day × 12 wk), or 3) standard rehabilitation (SR: 1 h/day × 12 wk). All measurements were performed at baseline, at 5 wk and 12 wk postsurgery. After 12 wk of resistance training, maximal dynamic muscle strength increased by 30% at 60°/s ( P < 0.05) and by 29% at 180°/s ( P < 0.05); muscle fiber area increased for type I (+17%, P < 0.05), type IIa (+37%, P < 0.05), and type IIx muscle fibers (+51%, P < 0.05); and muscle fiber pennation angle increased by 22% and muscle thickness increased by 15% ( P < 0.05). Furthermore, stair walking power increased by 35% ( P < 0.05) and was related to the increase in type II fiber area ( r = 0.729, P < 0.05). In contrast, there was no increase in any measurement outcomes with electrical stimulation and standard rehabilitation. The present study is the first to demonstrate the effectiveness of resistance training to induce beneficial qualitative changes in muscle fiber morphology and muscle architecture in elderly postoperative patients. In contrast, rehabilitation regimes based on functional exercises and neuromuscular electrical stimulation had no effect. The present data emphasize the importance of resistance training in future rehabilitation programs for elderly individuals.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Although not specifically evaluated in older adults during bed rest, there is clear evidence that resistance exercise is an effective means of combating the loss of muscle mass and function in a variety of populations [25-34].”
From Protecting muscle mass and function in older adults during bed rest (2010) · cites this paper as [33]
Citations
Cites
Muscle Fiber Types: How Many and What Kind?
Brooke, M. H., & Kaiser, K. K. (1970) · Archives of Neurology · doi:10.1001/archneur.1970.00480280083010 · Cited by 2,179
What is the cause of the ageing atrophy?
Lexell, J. E., Taylor, C. C., & Sjöstróm, M. (1988) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(88)90132-3 · Cited by 2,142
Multimodal strategies to improve surgical outcome
Kehlet, H., & Wilmore, D. W. (2002) · The American Journal of Surgery · doi:10.1016/s0002-9610(02)00866-8 · Cited by 1,867
High-Intensity Strength Training in Nonagenarians: Effects on Skeletal Muscle
Fiatarone, M. A. (1990) · JAMA · doi:10.1001/jama.1990.03440220053029 · Cited by 1,593
Aging of skeletal muscle: a 12-yr longitudinal study
Frontera, W. R., Hughes, V. A., Fielding, R. A., Fiatarone, M. A., Evans, W. J., & Roubenoff, R. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.4.1321 · Cited by 1,443
Strength conditioning in older men: skeletal muscle hypertrophy and improved function
Frontera, W. R., Meredith, C. N., O'Reilly, K. P., Knuttgen, H. G., & Evans, W. J. (1988) · Journal of Applied Physiology · doi:10.1152/jappl.1988.64.3.1038 · Cited by 1,386
Human aging, muscle mass, and fiber type composition.
Evans, W. J., & Lexell, J. (1995) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/50a.special_issue.11 · Cited by 1,308
Strength, power and related functional ability of healthy people aged 65-89 years.
SKELTON, D. A., GREIG, C. A., DAVIES, J. M., & YOUNG, A. (1994) · Age and Ageing · doi:10.1093/ageing/23.5.371 · Cited by 934
Häkkinen, K., Kallinen, M., Izquierdo, M., Jokelainen, K., Lassila, H., Mälkiä, E., Kraemer, W. J., Newton, R. U., & Alen, M. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.4.1341 · Cited by 776
High-intensity resistance training improves glycemic control in older patients with type 2 diabetes
Dunstan, D. W., Daly, R. M., Owen, N., Jolley, D., de Courten, M., Shaw, J., & Zimmet, P. (2002) · Diabetes Care · doi:10.2337/diacare.25.10.1729 · Cited by 771
Cited by
Sorted by citations
Cruz-Jentoft, A. J., Landi, F., Schneider, S. M., Zuniga, C., Arai, H., Boirie, Y., Chen, L.-K., Fielding, R. A., Martin, F. C., Michel, J.-P., et al. (2014) · Age and Ageing · doi:10.1093/ageing/afu115 · Cited by 1,963
Rate of force development: physiological and methodological considerations
Maffiuletti, N. A., Aagaard, P., Blazevich, A. J., Folland, J., Tillin, N., & Duchateau, J. (2016) · European Journal of Applied Physiology · doi:10.1007/s00421-016-3346-6 · Cited by 1,424
Self-citationFragala, M. S., Cadore, E. L., Dorgo, S., Izquierdo, M., Kraemer, W. J., Peterson, M. D., & Ryan, E. D. (2019) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000003230 · Cited by 1,290
Aagaard, P., Suetta, C., Caserotti, P., Magnusson, S. P., & Kjær, M. (2010) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/j.1600-0838.2009.01084.x · Cited by 709
Self-citationProtecting muscle mass and function in older adults during bed rest
English, K. L., & Paddon-Jones, D. (2010) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e328333aa66 · Cited by 477
Metadata
- Authors
- Suetta, C., Andersen, J. L., Dalgas, U., Berget, J., Koskinen, S., Aagaard, P., Magnusson, S. P., & Kjaer, M.
- Affiliations
- University of Copenhagen (DK)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2008-07
- Volume
- 105
- Issue
- 1
- Pages
- 180-186
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W1966146867
- Cited by
- 184
- References
- 47
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 11 · 2023: 13 · 2022: 8 · 2021: 11 · 2020: 14 · 2019: 12 · 2018: 10 · 2017: 6 · 2016: 6 · 2015: 11 · 2014: 13 · 2013: 11 · 2012: 10
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Keywords
- resistance training, older adults, postoperative rehabilitation, total hip arthroplasty, hip osteoarthritis, muscle strength, muscle fiber size, muscle architecture, pennation angle, neuromuscular electrical stimulation, muscle fiber type, bed rest
- MeSH terms
- Aged, Aged, 80 and over, Body Weight, Electric Stimulation, Female, Humans, Male, Middle Aged, Osteoarthritis, Physical Fitness, Weight Lifting, Body Mass Index, Walking, Muscle, Skeletal, Muscle Fibers, Skeletal, Arthroplasty, Replacement, Hip, Muscle Strength
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
