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Cited by 77Neuroscience and Neuropharmacology ResearchVisual perception and processing mechanismsNeurotransmitter Receptor Influence on Behavior

Effect of stimulus contrast and size on NMDA receptor activity in cat lateral geniculate nucleus

Kwon, Y. H., Nelson, S. B., Toth, L. J., Sur, M.·1992·Journal of Neurophysiology
DOI 10.1152/jn.1992.68.1.182
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Abstract

1. We studied the effect of varying excitatory and inhibitory drive on the N-methyl-D-aspartate (NMDA) receptor-mediated component of the visual responses of neurons in the cat dorsal lateral geniculate nucleus (dLGN) by varying the contrast and size of stimuli presented to the receptive fields of these cells. 2. Cells were classified as either on- or off-center, X or Y, and lagged or nonlagged. Stimulus contrast, and hence the amount of excitatory drive, was varied by changing the brightness of a spot, whose size and location matched the cell's receptive field center, relative to a fixed background luminance. Responses to varying contrast were collected from each cell before, during, and after iontophoretic application of D-2-amino-5-phosphonovaleric acid (D-APV), a specific NMDA receptor antagonist. From each contrast-response plot, a sigmoidal curve fit yielded five parameters on which we examined the effect of D-APV: the threshold contrast, saturation contrast, contrast at half saturation (C50), slope (gain) at C50, and saturation response. 3. In most cells, application of D-APV reduced both the saturation response and the gain of the contrast-response curve, but did not reduce or change significantly the threshold contrast, saturation contrast, or C50. 4. Cells varied in their sensitivity to D-APV, but for any given cell, the D-APV-sensitive component was nearly always a linear function of the control visual response level. Thus, for a spot of optimal size, there was a constant proportion of the visual response attributable to NMDA receptors, regardless of the amplitude of the response. 5. When the effect of D-APV on the visual responses to an optimal spot at varying contrasts was compared among different classes of dLGN cells, the visual responses of lagged X cells were reduced to a greater extent than those of either nonlagged X cells or the combined population of nonlagged X and Y cells. 6. Stimulus size (spot diameter) was also varied systematically at a fixed contrast to vary the inhibitory drive to dLGN cells. As stimulus size was increased, the response first increased because of increased stimulation of the receptive field center and then decreased because of increasing amounts of surround inhibition. 7. The D-APV-sensitive component of individual cell responses was greater when the stimulus spot was less than or equal to optimal size than when the spot was larger. Thus the contribution of NMDA receptors to the visual response decreased with increasing surround inhibition.(ABSTRACT TRUNCATED AT 400 WORDS)

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Crossref · 10.1152/jn.1992.68.1.182

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  • The decreased slope at low contrast and decreased plateau in patients closely resembles results seen after microinfusion of an NMDA antagonist into cat LGN and visual cortex.

    “The decreased slope at low contrast and decreased plateau in patients closely resembles results seen after microinfusion of an NDMA antagonist into cat LGN and visual cortex (16,17) (Figure 3A and 3B), consistent with glutamatergic theories of schizophrenia (23–25).”

    From Visual perception and its impairment in schizophrenia (2008) · cites this paper as [16]

  • NMDA antagonists produce shallower gain at low contrast and a much lower plateau indicating decreased signal amplification.

    “Indeed, NMDA antagonists produce shallower gain at low contrast and a much lower plateau indicating decreased signal amplification (16,17) (Figure 3A).”

    From Visual perception and its impairment in schizophrenia (2008) · cites this paper as [16]

  • The resemblance between patient contrast response curves and NMDA antagonist effects is consistent with glutamatergic theories of schizophrenia.

    “The decreased slope at low contrast and decreased plateau in patients closely resembles results seen after microinfusion of an NDMA antagonist into cat LGN and visual cortex (16,17) (Figure 3A and 3B), consistent with glutamatergic theories of schizophrenia (23–25).”

    From Visual perception and its impairment in schizophrenia (2008) · cites this paper as [16]

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Authors
Kwon, Y. H., Nelson, S. B., Toth, L. J., & Sur, M.
Affiliations
Massachusetts Institute of Technology (US)
ORCID
Venue
Journal of Neurophysiology
Publisher
American Physiological Society
Published
1992-07-01
Volume
68
Issue
1
Pages
182-196
ISSN
  • 0022-3077 (ISSN-L)
  • 1522-1598
DOI
10.1152/jn.1992.68.1.182
OpenAlex
W152063503
Cited by
77
References
43
Citations by year
2026: 1 · 2024: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 2 · 2013: 3 · 2012: 1
FWCI
0.67
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurophysiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Eye Institute (EY07023)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
NMDA receptor, lateral geniculate nucleus, D-APV, stimulus contrast, stimulus size, excitatory drive, surround inhibition, receptive fields, cat visual system, synaptic transmission, iontophoresis, contrast threshold, nonlinearity
MeSH terms
Animals, Cats, Geniculate Bodies, Iontophoresis, Photic Stimulation, Quinoxalines, Contrast Sensitivity, 2-Amino-5-phosphonovalerate, Receptors, N-Methyl-D-Aspartate, 6-Cyano-7-nitroquinoxaline-2,3-dione

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