Magnocellular contributions to impaired motion processing in schizophrenia
Open accessAbstract
Patients with schizophrenia show impairments in motion processing, along with deficits in lower level processing primarily involving the magnocellular visual pathway. The present study investigates potential magnocellular contributions to impaired motion processing in schizophrenia using a combined neurophysiological and behavioral approach. As compared to prior motion studies in schizophrenia, thresholds were determined for both incoherent and coherent visual motion. In this study, velocity discrimination thresholds were measured for schizophrenia patients (n=14) and age-matched normal control subjects (n=16) using a staircase procedure. Early visual processing was evaluated using steady-state visual evoked potentials (ssVEP), with stimuli biased toward activation of either the magnocellular or parvocellular visual pathways through luminance contrast manipulation. Patients with schizophrenia showed poor velocity discrimination for both incoherent and coherent motion, with no significant group x task interaction. Further, when coherent motion performance was measured at individually determined incoherent motion thresholds, accuracy levels for patients were similar to controls, also indicating similarity of deficit for incoherent vs. coherent motion discrimination. Impairments in velocity discrimination correlated significantly with reduced amplitude of ssVEP elicited by magnocellular -- but not parvocellular -- selective stimuli. This study demonstrates that deficits in motion processing in schizophrenia are significantly related to reduced activation of the magnocellular visual system. Further, this study supports and extends prior reports of impaired motion processing in schizophrenia, and indicates significant bottom-up contributions to higher-order cognitive impairments.
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Significant correlations between impaired motion perception and M-pathway dysfunction point to motion processing deficits in schizophrenia resulting from impaired gain control.
“Significant correlations between impaired motion perception and M-pathway dysfunction also point to motion processing deficits in schizophrenia resulting from impaired gain control (28).”
From Visual perception and its impairment in schizophrenia (2008) · cites this paper as [28]
Patients with schizophrenia show preferential M-pathway dysfunction, although deficits have also been observed in parvocellular processing.
“Patients with schizophrenia show preferential M-pathway dysfunction (21,22,28,35–38), although deficits have also been observed in parvocellular processing (19,20).”
From Visual perception and its impairment in schizophrenia (2008) · cites this paper as [28]
A large number of studies have reported motion processing deficits in schizophrenia.
“A large number of studies have reported motion processing deficits in schizophrenia (28–32).”
From Visual perception and its impairment in schizophrenia (2008) · cites this paper as [28]
Gain control deficits are related to higher-level problems in perceptual organization.
“There is also evidence that gain control deficits, seen in contrast detection and M-pathway deficits, are important in predicting outcome (22,45), and are related to higher-level problems in perceptual organization (28,46) and to symptomatology (20,47–51).”
From Visual perception and its impairment in schizophrenia (2008) · cites this paper as [28]
Numerous studies have shown motion processing deficits in schizophrenia.
“As discussed in the preceding text, numerous studies have shown motion processing deficits in schizophrenia (28,30–32,81).”
From Visual perception and its impairment in schizophrenia (2008) · cites this paper as [28]
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- Authors
- Kim, D., Wylie, G., Pasternak, R., Butler, P. D., & Javitt, D. C.
- Affiliations
- Nathan Kline Institute for Psychiatric Research (US)
- Corresponding author
- Javitt, Daniel C.
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 82
- Issue
- 1
- Pages
- 1-8
- ISSN
- 0920-9964 (ISSN-L)
- PMC
- PMC2045640
- OpenAlex
- W2128944881
- Cited by
- 146
- References
- 44
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 5 · 2019: 9 · 2018: 8 · 2017: 4 · 2016: 7 · 2015: 7 · 2014: 4 · 2013: 10 · 2012: 9
- FWCI
- 5.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust
- National Institute of Mental Health (R37MH049334, R01MH066374, K02-MH-01439, R01 MH49334, R01MH049334, K02MH001439)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Keywords
- schizophrenia, motion processing
- MeSH terms
- Adult, Evoked Potentials, Visual, Female, Humans, Male, Motion Perception, Perceptual Disorders, Schizophrenia, Visual Fields, Visual Pathways, Visual Perception, Vision, Binocular, Diagnostic and Statistical Manual of Mental Disorders
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