Extracellular vesicles: pathogenetic, diagnostic and therapeutic value in traumatic brain injury
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INTRODUCTION: Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Accurate classification according to injury-specific and patient-specific characteristics is critical to help informed clinical decision-making and to the pursuit of precision medicine in TBI. Reliable biomarker signatures for improved TBI diagnostics are required but still an unmet need. Areas covered: Extracellular vesicles (EVs) represent a new class of biomarker candidates in TBI. These nano-sized vesicles have key roles in cell signaling profoundly impacting pathogenic pathways, progression and long-term sequelae of TBI. As such EVs might provide novel neurobiological insights, enhance our understanding of the molecular mechanisms underlying TBI pathophysiology and recovery, and serve as biomarker signatures and therapeutic targets and delivery systems. Expert commentary: EVs are fast gaining momentum in TBI research, paving the way for new transformative diagnostic and treatment approaches. Their potential to sort out TBI variability and active involvement in the mechanisms underpinning different clinical phenotypes point out unique opportunities for improved classification, risk-stratification ad intervention, harboring promise of predictive, personalized, and even preemptive therapeutic strategies. Although a great deal of progress has been made, substantial efforts are still required to ensure the needed rigorous validation and reproducibility for clinical implementation of EVs.
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Insights from EV components provide valuable information about the intrinsic repair mechanisms of the CNS.
“Moreover, these insights provide valuable information about the intrinsic repair mechanisms of the CNS [178].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [178]
Cites
Extracellular vesicles: Exosomes, microvesicles, and friends
Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099 · see citing works
Biological properties of extracellular vesicles and their physiological functions
Yáñez‐Mó, M., Siljander, P. R. ‐., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27066 · Cited by 5,926 · see citing works
Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766 · see citing works
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930 · see citing works
Membrane vesicles as conveyors of immune responses
Théry, C., Ostrowski, M., & Segura, É. (2009) · Nature reviews. Immunology · doi:10.1038/nri2567 · Cited by 3,869 · see citing works
Communication by Extracellular Vesicles: Where We Are and Where We Need to Go
Tkach, M., & Théry, C. (2016) · Cell · doi:10.1016/j.cell.2016.01.043 · Cited by 3,444 · see citing works
Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research
Maas, A. I. R., Menon, D. K., Adelson, P. D., Andelic, N., Bell, M. J., Belli, A., Bragge, P., Brazinova, A., Büki, A., Chesnut, R. M., et al. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30371-x · Cited by 2,609 · see citing works
Self-citationSun, D., Zhuang, X., Xiang, X., Liu, Y., Zhang, S., Liu, C., Barnes, S., Grizzle, W. E., Miller, D., & Zhang, H. (2010) · Molecular Therapy · doi:10.1038/mt.2010.105 · Cited by 1,579 · see citing works
Théry, C., Boussac, M., Véron, P., Ricciardi‐Castagnoli, P., Raposo, G., Garin, J., & Amigorena, S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7309 · Cited by 1,564 · see citing works
Exosomes: proteomic insights and diagnostic potential
Simpson, R. J., Lim, J. W., Moritz, R. L., & Mathivanan, S. (2009) · Expert Review of Proteomics · doi:10.1586/epr.09.17 · Cited by 1,113 · see citing works
Saman, S., Kim, W., Raya, M., Visnick, Y., Miro, S., Saman, S., Jackson, B., McKee, A. C., Alvarez, V. E., Lee, N. C. Y., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.277061 · Cited by 985 · see citing works
Traumatic Brain Injury: A Disease Process, Not an Event
Masel, B. E., & DeWitt, D. S. (2010) · Journal of Neurotrauma · doi:10.1089/neu.2010.1358 · Cited by 957 · see citing works
Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury
Shlosberg, D., Benifla, M., Kaufer, D., & Friedman, A. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.74 · Cited by 897 · see citing works
Unterberg, A. W., Stover, J., Kress, B., & Kiening, K. L. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.06.046 · Cited by 881 · see citing works
Rapid Secretion of Interleukin-1β by Microvesicle Shedding
Mackenzie, A. B., Wilson, H. L., Kiss‐Toth, E., Dower, S., North, R. A., & Surprenant, A. (2001) · Immunity · doi:10.1016/s1074-7613(01)00229-1 · Cited by 862 · see citing works
Microparticles in Hemostasis and Thrombosis
Owens, A. P., & Mackman, N. (2011) · Circulation Research · doi:10.1161/circresaha.110.233056 · Cited by 836 · see citing works
Body fluid derived exosomes as a novel template for clinical diagnostics
Keller, S., Ridinger, J., Rupp, A.-K., Janssen, J. W. G., & Altevogt, P. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-86 · Cited by 752 · see citing works
Zhang, Y., Chopp, M., Meng, Y., Katakowski, M., Xin, H., Mahmood, A., & Xiong, Y. (2015) · Journal of neurosurgery · doi:10.3171/2014.11.jns14770 · Cited by 737 · see citing works
Membrane Microparticles: Two Sides of the Coin
Hugel, B., Martínez, M. C., Kunzelmann, C., & Freyssinet, J.-M. (2005) · Physiology · doi:10.1152/physiol.00029.2004 · Cited by 698 · see citing works
The Neuropathology and Neurobiology of Traumatic Brain Injury
Blennow, K., Hardy, J., & Zetterberg, H. (2012) · Neuron · doi:10.1016/j.neuron.2012.11.021 · Cited by 669 · see citing works
Astrocytes and Glioblastoma cells release exosomes carrying mtDNA
Guescini, M., Genedani, S., Stocchi, V., & Agnati, L. F. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0288-8 · Cited by 662 · see citing works
Current methods for the isolation of extracellular vesicles
Momen-Heravi, F., Balaj, L., Alian, S., Mantel, P., Halleck, A., Trachtenberg, A., Soria, C. E., Oquin, S., Bonebreak, C. M., Saraçoğlu, E., et al. (2013) · Biological chemistry · doi:10.1515/hsz-2013-0141 · Cited by 568 · see citing works
Undén, J., Ingebrigtsen, T., & Romner, B. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-50 · Cited by 437 · see citing works
Kim, D.-K., Nishida, H., An, S. Y., Shetty, A. K., Bartosh, T. J., & Prockop, D. J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522297113 · Cited by 434 · see citing works
HUANG, S. H., Ge, X., Yu, J., Han, Z., Yin, Z., Li, Y., Chen, F., Wang, H., Zhang, J., & Lei, P. (2017) · The FASEB Journal · doi:10.1096/fj.201700673r · Cited by 422 · see citing works
Zhang, Y., Chopp, M., Zhang, Z. G., Katakowski, M., Xin, H., Qu, C., Ali, M. M., Mahmood, A., & Xiong, Y. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.08.003 · Cited by 394 · see citing works
Maegele, M., Schöchl, H., Menovsky, T., Maréchal, H., Marklund, N., Büki, A., & Stanworth, S. J. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30197-7 · Cited by 359 · see citing works
Exosomes: Mediators of Neurodegeneration, Neuroprotection and Therapeutics
Kalani, A., Tyagi, A. A., & Tyagi, N. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8544-1 · Cited by 333 · see citing works
Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury
Kumar, A., Stoica, B. A., Loane, D. J., Yang, M., Abulwerdi, G. A., Khan, N., Kumar, A., Thom, S. R., & Faden, A. I. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0819-4 · Cited by 318 · see citing works
Biró, É., Sturk-Maquelin, K. N., Vogel, G. M. T., Meuleman, D. G., Smit, M. J., Hack, C. E., Sturk, A., & Nieuwland, R. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2003.00456.x · Cited by 314 · see citing works
Myeloid microvesicles are a marker and therapeutic target for neuroinflammation
Verderio, C., Muzio, L., Turola, E., Bergami, A., Novellino, L., Ruffini, F., Riganti, L., Corradini, I., Francolini, M., Garzetti, L., et al. (2012) · Annals of Neurology · doi:10.1002/ana.23627 · Cited by 299 · see citing works
MicroRNA-9 Regulates Neurogenesis in Mouse Telencephalon by Targeting Multiple Transcription Factors
Shibata, M., Nakao, H., Kiyonari, H., Abe, T., & Aizawa, S. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5085-10.2011 · Cited by 294 · see citing works
Wang, S., Cesca, F., Loers, G., Schweizer, M., Buck, F., Benfenati, F., Schachner, M., & Kleene, R. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6476-10.2011 · Cited by 288 · see citing works
Emerging roles of exosomes in neuron-glia communication
Frühbeis, C., Fröhlich, D., & Krämer-Albers, E.-M. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00119 · Cited by 275 · see citing works
Pre-analytical and analytical issues in the analysis of blood microparticles
Yuana, Y., Bertina, R. M., & Osanto, S. (2010) · Thrombosis and Haemostasis · doi:10.1160/th10-09-0595 · Cited by 268 · see citing works
Maumus, M., Jørgensen, C., & Noël, D. (2013) · Biochimie · doi:10.1016/j.biochi.2013.04.017 · Cited by 266 · see citing works
Thelin, E. P., Zeiler, F. A., Ercole, A., Mondello, S., Büki, A., Bellander, B., Helmy, A. E., Menon, D. K., & Nelson, D. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00300 · Cited by 263 · see citing works
Self-citationExosome‐mediated inflammasome signaling after central nervous system injury
de Rivero Vaccari, J. P., Brand, F., Adamczak, S., Lee, S. W., Perez‐Barcena, J., Wang, M. Y., Bullock, M. R., Dietrich, W. D., & Keane, R. W. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13036 · Cited by 240 · see citing works
MSCs-Derived Exosomes and Neuroinflammation, Neurogenesis and Therapy of Traumatic Brain Injury
Yang, Y., Ye, Y., Su, X., He, J., Bai, W., & He, X. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00055 · Cited by 236 · see citing works
Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia
Bahrini, I., Song, J., Díez, D., & Hanayama, R. (2015) · Scientific Reports · doi:10.1038/srep07989 · Cited by 196 · see citing works
Neuroprotective Strategies for Traumatic Brain Injury: Improving Clinical Translation
Kabadi, S. V., & Faden, A. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15011216 · Cited by 183 · see citing works
Blood-based diagnostics of traumatic brain injuries
Mondello, S., Muller, U., Jeromin, A., Streeter, J., Hayes, R., & Wang, K. K. W. (2011) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.10.104 · Cited by 181 · see citing works
Self-citationMaas, A. I. R., Murray, G. D., Roozenbeek, B., Lingsma, H. F., Butcher, I., McHugh, G. S., Weir, J., Lü, J., & Steyerberg, E. W. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70234-5 · Cited by 172 · see citing works
Brain-derived microparticles induce systemic coagulation in a murine model of traumatic brain injury
Tian, Y., Salsbery, B., Wang, M., Yuan, H., Yang, J., Zhao, Z., Wu, X., Zhang, Y., Konkle, B. A., Thiagarajan, P., et al. (2015) · Blood · doi:10.1182/blood-2014-09-598805 · Cited by 171 · see citing works
Mondello, S., Sorinola, A., Czeiter, E., Vámos, Z., Amrein, K., Synnot, A., Donoghue, E., Sándor, J., Wang, K., Diaz-Arrastia, R. R., et al. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2017.5182 · Cited by 168 · see citing works
Self-citationHarrison, E. B., Hochfelder, C. G., Lamberty, B. G., Meays, B. M., Morsey, B. M., Kelso, M. L., Fox, H. S., & Yelamanchili, S. V. (2016) · FEBS Open Bio · doi:10.1002/2211-5463.12092 · Cited by 151 · see citing works
Microglia-derived extracellular vesicles in Alzheimer’s Disease: A double-edged sword
Trotta, T., Antonietta Panaro, M., Cianciulli, A., Mori, G., Di Benedetto, A., & Porro, C. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.12.020 · Cited by 126 · see citing works
Bragge, P., Synnot, A., Maas, A. I. R., Menon, D. K., Cooper, D. J., Rosenfeld, J. V., & Gruen, R. L. (2015) · Journal of Neurotrauma · doi:10.1089/neu.2015.4233 · Cited by 123 · see citing works
Sparvero, L. J., Amoscato, A. A., Kochanek, P. M., Pitt, B. R., Kagan, V. E., & Bayır, H. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07055.x · Cited by 121 · see citing works
Morel, N., Morel, O., Petit, L., Hugel, B., Cochard, J.-F., Freyssinet, J., Sztark, F., & Dabadie, P. (2008) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e31816493ad · Cited by 115 · see citing works
Żmigrodzka, M., Guzera, M., Miśkiewicz, A., Jagielski, D., & Winnicka, A. (2016) · Tumor Biology · doi:10.1007/s13277-016-5358-6 · Cited by 111 · see citing works
Microvesicles: Novel Biomarkers for Neurological Disorders
Colombo, E., Borgiani, B., Verderio, C., & Furlan, R. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00063 · Cited by 107 · see citing works
Mondello, S., Schmid, K. E., Berger, R. P., Kobeissy, F. H., Italiano, D., Jeromin, A., Hayes, R. L., Tortella, F. C., & Büki, A. (2013) · Medicinal Research Reviews · doi:10.1002/med.21295 · Cited by 103 · see citing works
Self-citationZhou, Y., Cai, W., Zhao, Z., Hilton, T., Wang, M., Yeon, J., Liu, W., Zhang, F., Shi, F., Wu, X., et al. (2017) · Blood · doi:10.1182/blood-2017-08-801738 · Cited by 101 · see citing works
Circulating Microparticles Reflect Treatment Effects and Clinical Status in Multiple Sclerosis
Sáenz-Cuesta, M., Irizar, H., Castillo‐Triviño, T., Muñoz‐Culla, M., Osorio-Querejeta, I., Prada, A. J., Sepúlveda, L., Lopez-Mato, M. P., de Munaín, A. L., Comabella, M., et al. (2014) · Biomarkers in Medicine · doi:10.2217/bmm.14.9 · Cited by 98 · see citing works
Live Cell Imaging of Outward and Inward Vesiculation Induced by the Complement C5b-9 Complex
Moskovich, O., & Fishelson, Z. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703742200 · Cited by 97 · see citing works
Andrews, A. M., Lutton, E. M., Merkel, S. F., Razmpour, R., & Ramirez, S. H. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00043 · Cited by 96 · see citing works
Exosome platform for diagnosis and monitoring of traumatic brain injury
Taylor, D. D., & Gerçel-Taylor, Ç. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0503 · Cited by 85 · see citing works
Patz, S., Trattnig, C., Grünbacher, G., Ebner, B., Gülly, C., Novak, A., Rinner, B., Leitinger, G., Absenger, M., Tomescu, O. A., et al. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2012.2596 · Cited by 83 · see citing works
Nekludov, M., Mobarrez, F., Gryth, D., Bellander, B., & Wallén, H. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2013.3168 · Cited by 75 · see citing works
Microvesicles in the brain: Biomarker, messenger or mediator?
Porro, C., Trotta, T., & Panaro, M. A. (2015) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2015.09.006 · Cited by 73 · see citing works
Mondello, S., Gabrielli, A., Catani, S., D’Ippolito, M., Jeromin, A., Ciaramella, A., Bossù, P., Schmid, K. E., Tortella, F. C., Wang, K., et al. (2012) · Brain Injury · doi:10.3109/02699052.2012.700083 · Cited by 62 · see citing works
Self-citationWerner, J. K., & Stevens, R. D. (2015) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000265 · Cited by 55 · see citing works
Cellular microparticles and pathophysiology of traumatic brain injury
Zhao, Z., Zhou, Y., Tian, Y., Li, M., Dong, J., & Zhang, J. (2017) · Protein & Cell · doi:10.1007/s13238-017-0414-6 · Cited by 52 · see citing works
Microparticles impact coagulation after traumatic brain injury
Midura, E. F., Jernigan, P. L., Kuethe, J. W., Friend, L. A., Veile, R., Makley, A. T., Caldwell, C. C., & Goodman, M. D. (2015) · Journal of Surgical Research · doi:10.1016/j.jss.2015.02.064 · Cited by 49 · see citing works
Brain-Derived Microparticles in Patients with Severe Isolated TBI
Nekludov, M., Bellander, B., Gryth, D., Wallén, H., & Mobarrez, F. (2017) · Brain Injury · doi:10.1080/02699052.2017.1358395 · Cited by 43 · see citing works
Kondo, K., Maruishi, M., Ueno, H., Sawada, K., Hashimoto, Y., Ohshita, T., Takahashi, T., Ohtsuki, T., & Matsumoto, M. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-147 · Cited by 25 · see citing works
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Bidirectional Microglia–Neuron Communication in Health and Disease
Szepesi, Z., Manouchehrian, O., Bachiller, S., & Deierborg, T. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00323 · Cited by 459 · see citing works
A Literature Review of Traumatic Brain Injury Biomarkers
Ghaith, H. S., Nawar, A. A., Gabra, M. D., Essam, M., Nafady, M. H., Bahbah, E. I., Ebada, M. A., Ashraf, G. M., Negida, A., & Barreto, G. E. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02822-6 · Cited by 190 · see citing works
Emerging Roles of miRNAs in Brain Development and Perinatal Brain Injury
Cho, K. H. T., Xu, B., Blenkiron, C., & Fraser, M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00227 · Cited by 114 · see citing works
Diagnostic and Therapeutic Potential of Extracellular Vesicles
Kodam, S. P., & Ullah, M. (2021) · Technology in Cancer Research & Treatment · doi:10.1177/15330338211041203 · Cited by 82 · see citing works
Mondello, S., Guedes, V. A., Lai, C., Czeiter, E., Amrein, K., Kobeissy, F. H., Mechref, Y. S., Jeromin, A., Mithani, S., Martin, C. A., et al. (2020) · Cells · doi:10.3390/cells9040977 · Cited by 71 · see citing works
Self-citationExtracellular Vesicles miRNA Cargo for Microglia Polarization in Traumatic Brain Injury
Panaro, M. A., Benameur, T., & Porro, C. (2020) · Biomolecules · doi:10.3390/biom10060901 · Cited by 54 · see citing works
Making sense of gut feelings in the traumatic brain injury pathogenesis
Royes, L. F. F., & Gómez‐Pinilla, F. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.012 · Cited by 52 · see citing works
ENIGMA brain injury: Framework, challenges, and opportunities
Dennis, E. L., Baron, D. A., Bartnik‐Olson, B., Caeyenberghs, K., Esopenko, C., Hillary, F. G., Kenney, K., Koerte, I. K., Lin, A. P., Mayer, A. R., et al. (2020) · Human Brain Mapping · doi:10.1002/hbm.25046 · Cited by 49 · see citing works
Self-citationCrosstalk between Microglia and Neurons in Neurotrauma: An Overview of the Underlying Mechanisms
Shaito, A. A., Kobeissy, F. H., Haidar, M. A., Ibeh, S., Shakkour, Z., Reslan, M. A., Nwaiwu, J. I., Moqidem, Y. A., Sader, G., Nickles, R. G., et al. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666211202123322 · Cited by 50 · see citing works
Self-citationLedreux, A., Pryhoda, M. K., Gorgens, K. A., Shelburne, K. B., Gilmore, A., Linseman, D. A., Fleming, H., Koza, L. A., Campbell, J., Wolff, A., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00761 · Cited by 49 · see citing works
Beard, K., Meaney, D. F., & Issadore, D. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2020.6990 · Cited by 44 · see citing works
Wang, K., Pareja, J. C. M., Mondello, S., Diaz-Arrastia, R. R., Wellington, C. L., Kenney, K., Puccio, A. M., Hutchison, J. S., McKinnon, N. K., Okonkwo, D. O., et al. (2021) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2021.2005583 · Cited by 47 · see citing works
Self-citationUnraveling the Emerging Niche Role of Extracellular Vesicles (EVs) in Traumatic Brain Injury (TBI)
Ashique, S., Pal, R., Sharma, H., Mishra, N., & Garg, A. (2024) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273288155240201065041 · Cited by 36 · see citing works
Olsen, A., Babikian, T., Bigler, E. D., Caeyenberghs, K., Conde, V., Dams-O’Connor, K., Dobryakova, E., Genova, H. M., Grafman, J. H., Haberg, A. K., et al. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00313-7 · Cited by 37 · see citing works
Self-citationExploiting blood-based biomarkers to align preclinical models with human traumatic brain injury
Lisi, I., Moro, F., Mazzone, E., Marklund, N., Pischiutta, F., Kobeissy, F. H., Mao, X., Corrigan, F., Helmy, A. E., Nasrallah, F. A., et al. (2024) · Brain · doi:10.1093/brain/awae350 · Cited by 33 · see citing works
Self-citationFunctionalized hydrogels in neural injury repairing
Zhao, W., Tu, H., Chen, J., Wang, J., Liu, H. C., Zhang, F.-S., & Li, J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1199299 · Cited by 31 · see citing works
Mondello, S., Guedes, V. A., Lai, C., Jeromin, A., Bazarian, J. J., & Gill, J. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00651 · Cited by 27 · see citing works
Self-citationExtracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions
Choi, H. K., Chen, M., Goldston, L. L., & Lee, K.-B. (2024) · Nano Convergence · doi:10.1186/s40580-024-00426-5 · Cited by 26 · see citing works
Rammal, G., Fahs, A., Kobeissy, F. H., Mechref, Y. S., Zhao, J., Zhu, R., Diab‐Assaf, M., Saab, R. H., & Ghayad, S. E. (2019) · Journal of Proteome Research · doi:10.1021/acs.jproteome.9b00157 · Cited by 26 · see citing works
Self-citationDong, X., Dong, J., & Zhang, J. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01165-6 · Cited by 24 · see citing works
TMT-based proteomics analysis to screen potential biomarkers of acute-phase TBI in rats
Wang, H., Chen, J., Gao, C., Chen, W., Chen, G., Zhang, M., Luo, C., Wang, T., Chen, X., & Tao, L. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118631 · Cited by 25 · see citing works
The role of microglia in neurodegenerative diseases: from the perspective of ferroptosis
Liu, Y.-J., Jia, G.-R., Zhang, S.-H., Guo, Y., Ma, X.-Z., Xu, H.-M., & Xie, J.-X. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01560-4 · Cited by 29 · see citing works
Yarahmadi, A., Dorri Giv, M., Hosseininejad, R., Rezaie, A., Mohammadi, N., Afkhami, H., & Farokhi, A. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1472679 · Cited by 21 · see citing works
Role of exosomal ncRNAs in traumatic brain injury
Beylerli, O., Тамразов, Р. И., Фанилевич, Г. И., Ilyasova, T., Shumadalova, A. V., Bai, Y., & Yang, B. (2023) · Non-coding RNA Research · doi:10.1016/j.ncrna.2023.10.004 · Cited by 21 · see citing works
Gamage, T., & Fraser, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.744840 · Cited by 15 · see citing works
Clinical Theragnostic Signature of Extracellular Vesicles in Traumatic Brain Injury (TBI)
Dey, A., Ghosh, S., Bhuniya, T., Koley, M., Bera, A., Guha, S., Chakraborty, K., Muthu, S., Gorai, S., Vorn, R., et al. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00386 · Cited by 16 · see citing works
Chi, W., He, Y., Chen, S., Guo, L., Yuan, Y., Li, R., Liu, R., Zhou, D., Du, J., Xu, T., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.05.010 · Cited by 16 · see citing works
Lafrenaye, A. D., Mondello, S., Povlishock, J. T., Gorse, K. M., Walker, S., Hayes, R. L., Wang, K., & Kochanek, P. M. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2020.586958 · Cited by 14 · see citing works
Self-citation(−)‐Phenserine tartrate (PhenT) as a treatment for traumatic brain injury
Greig, N. H., Lecca, D., Hsueh, S., Nogueras‐Ortiz, C. J., Kapogiannis, D., Tweedie, D., Glotfelty, E. J., Becker, R. E., Chiang, Y. H., & Hoffer, B. J. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13274 · Cited by 14 · see citing works
Gao, Y., Zhang, H., Li, X., Li, L., Li, F., Li, T., Peng, R., Wang, C., Wang, J., Liu, X., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2257427 · Cited by 11 · see citing works
Chen, Y., Zhang, H., Hu, X., Cai, W., Jiang, L., Wang, Y., Wu, Y., Wang, X., Ni, W., & Zhou, K. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03501-w · Cited by 11 · see citing works
Spatial and temporal mapping of neuron-microglia interaction modes in acute ischemic stroke
Dou, X., Ji, W., Dai, M., Sun, S., Chen, R., Yang, J., Long, J., Ge, Y., & Lin, Y. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115772 · Cited by 10 · see citing works
Beard, K., Gauff, A. K., Pennington, A. M., Marion, D. W., Smith, J. M., & Sloley, S. S. (2024) · Journal of Neurotrauma · doi:10.1089/neu.2024.0136 · Cited by 9 · see citing works
Zhi, K., Kumar, A., Raji, B., Kochat, H., & Kumar, S. (2020) · Expert Review of Precision Medicine and Drug Development · doi:10.1080/23808993.2020.1812382 · Cited by 9 · see citing works
Olsen, A., Babikian, T., Bigler, E. D., Caeyenberghs, K., Conde, V., Dams-O’Connor, K., Dobryakova, E., Genova, H. M., Grafman, J. H., Haberg, A. K., et al. (2019) · doi:10.31234/osf.io/jnsb2 · Cited by 9 · see citing works
Self-citationRao, D. B., Pardo, I. D. R., Chang, J., Bolon, B. N., & Garman, R. H. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-821046-8.00007-4 · Cited by 7 · see citing works
Editorial: Biomarkers in Neurology
Mondello, S., Salama, M. M., Mohamed, W. M. Y., & Kobeissy, F. H. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00190 · Cited by 7 · see citing works
Self-citationThe role of autophagy in brain health and disease: Insights into exosome and autophagy interactions
Wang, H., Lv, C., Feng, L., Guo, J., Zhao, S., & Jiang, P. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e38959 · Cited by 6 · see citing works
Recent Advances in Fluorescence Imaging of Traumatic Brain Injury in Animal Models
Lu, F., Cao, J., Su, Q., Zhao, Q., Wang, H., Guan, W., & Zhou, W. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.660993 · Cited by 6 · see citing works
Extracellular vesicles in disorders of hemostasis following traumatic brain injury
McMahon, A., Weiß, L., Bennett, K., Curley, G., Áinle, F. N., & Maguire, P. B. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1373266 · Cited by 5 · see citing works
Neurosurgical Breakthroughs of the Last 50 Years: A Historical Journey Through the Past and Present
Jesús, O. D. (2025) · World Neurosurgery · doi:10.1016/j.wneu.2025.123816 · Cited by 5 · see citing works
Detection of disease-associated microRNAs — application for autism spectrum disorders
Konečná, B., Radošinská, J., Keményová, P., & Repiská, G. (2020) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0015 · Cited by 4 · see citing works
Exploration of cerebral vasospasm from the perspective of microparticles
Gao, Y., Li, K., Li, X., Li, Q., Wang, J., Zhang, S., & Zhang, J. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1013437 · Cited by 3 · see citing works
Kiel, M. D., Pawlak, S. A., van Dijk, S., Kirkpatrick, K., Stelzer, I. A., & Gumusoglu, S. B. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.08.015 · Cited by 2 · see citing works
Gao, Y., Zhang, H., Li, X., Li, L., Li, F., Tuo, L., Peng, R., Wang, C., Wang, J., Zhang, S., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1939529/v1 · Cited by 2 · see citing works
Biomarkers of Acute Brain Injury
Barmpagiannos, K., Lazaridis, N., Apostolopoulou, A., & Fyntanidou, B. (2024) · Neuroglia · doi:10.3390/neuroglia5040024 · Cited by 1 · see citing works
Research progress on biomarkers of traumatic brain injury
Shen, X., Cheng, S., Chen, S., Wang, M., Li, T., Xu, W., Zhang, Y., Yuan, P., & Shi, L. (2026) · Animal Models and Experimental Medicine · doi:10.1002/ame2.70173 · Cited by 1 · see citing works
Wang, Z., Yuan, W.-L., Li, J., & Qin, M. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18040477 · Cited by 1 · see citing works
Effect of exosome-derived non-coding RNA on traumatic brain injury.
Wu, Y., & Liu, J. (2021) · PubMed Central · doi:10.11817/j.issn.1672-7347.2021.190702
Effect of Vitamin E on Serum MDA and Antioxidant Enzymes in Traumatic Brain Injury-Induced Rats
Usman, B., Sajo, M. U., Adam, M. K., Mshelia, P. A., Bulama, I., & Sanda, K. A. (2023) · Journal of Complementary and Alternative Medical Research · doi:10.9734/jocamr/2023/v24i1492
Liang, S., & Hu, Z. (2024) · Biomedical Papers · doi:10.5507/bp.2024.038
Kurbanaliev, I. S., Jalilov, M. V., Genzheeva, A. A., & Магарамов, А. М. (2025) · Yakut Medical Journal · doi:10.25789/ymj.2025.91.26
Sun, M., Li, S., He, Z., Xie, J., Luo, Y., Fan, X., Zhang, J., Qin, L., Peng, L., Qiu, T., et al. (2026) · Advanced Science · doi:10.1002/advs.78308
- Authors
- Mondello, S., Thelin, E. P., Shaw, G., Salzet, M., Visalli, C., Cizkova, D., Kobeissy, F., & Buki, A.
- Affiliations
- University of Messina (IT)
- University of Cambridge (GB)
- EnCor Biotechnology Inc., Gainesville, FL, USA
- Université de Lille (FR)
- Slovak Academy of Sciences (SK)
- University of Florida (US)
- Department of Neurosurgery, Pecs University, Pecs, Hungary
- Corresponding author
- Mondello, Stefania
- ORCID
- Venue
- Expert Review of Proteomics
- Publisher
- Informa UK Limited
- Published
- 2018-04-25
- Volume
- 15
- Issue
- 5
- Pages
- 451-461
- ISSN
- 1478-9450 (ISSN-L)
- 1744-8387
- OpenAlex
- W2801217405
- Cited by
- 53
- References
- 67
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 7 · 2022: 4 · 2021: 7 · 2020: 11 · 2019: 5 · 2018: 1
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Expert Review of Proteomics (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion)
- Apollo
- Funders
- Italian Ministry of Health (GR-2013-02354960)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Keywords
- extracellular vesicles, traumatic brain injury, biomarkers, risk stratification, TBI pathophysiology, therapeutic target, drug delivery systems, precision medicine, clinical implementation
- MeSH terms
- Extracellular Vesicles, Brain Injuries, Traumatic, Animals, Body Fluids, Humans, Inflammation, Biomarkers, Exosomes
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