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Cited by 1,147

The DOI matches its Crossref record; 175 of the 175 references it cites were found in a registry or an index.

Mammalian Hibernation: Cellular and Molecular Responses to Depressed Metabolism and Low Temperature

CAREY, HANNAH V., ANDREWS, MATTHEW T., MARTIN, SANDRA L.·2003·Physiological Reviews
DOI 10.1152/physrev.00008.2003
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Abstract

Carey, Hannah V., Matthew T. Andrews, and Sandra L. Martin. Mammalian Hibernation: Cellular and Molecular Responses to Depressed Metabolism and Low Temperature. Physiol Rev 83: 1153-1181, 2003; 10.1152/physrev. 00008.2003.—Mammalian hibernators undergo a remarkable phenotypic switch that involves profound changes in physiology, morphology, and behavior in response to periods of unfavorable environmental conditions. The ability to hibernate is found throughout the class Mammalia and appears to involve differential expression of genes common to all mammals, rather than the induction of novel gene products unique to the hibernating state. The hibernation season is characterized by extended bouts of torpor, during which minimal body temperature (T b) can fall as low as −2.9°C and metabolism can be reduced to 1% of euthermic rates. Many global biochemical and physiological processes exploit low temperatures to lower reaction rates but retain the ability to resume full activity upon rewarming. Other critical functions must continue at physiologically relevant levels during torpor and be precisely regulated even at T b values near 0°C. Research using new tools of molecular and cellular biology is beginning to reveal how hibernators survive repeated cycles of torpor and arousal during the hibernation season. Comprehensive approaches that exploit advances in genomic and proteomic technologies are needed to further define the differentially expressed genes that distinguish the summer euthermic from winter hibernating states. Detailed understanding of hibernation from the molecular to organismal levels should enable the translation of this information to the development of a variety of hypothermic and hypometabolic strategies to improve outcomes for human and animal health.

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Metadata

Authors
CAREY, H. V., ANDREWS, M. T., & MARTIN, S. L.
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
2003-10
Volume
83
Issue
4
Pages
1153-1181
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.00008.2003
OpenAlex
W1973175580
Cited by
1,147
References
175
FWCI
2.82
Type
journal article
Language
en
Open access
closed

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