Cited by 1,122Iron Metabolism and DisordersFerroptosis and cancer prognosisNeurological diseases and metabolism

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Systemic Iron Homeostasis

Ganz, Tomas·2013·Physiological Reviews

DOI 10.1152/physrev.00008.2013

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Abstract

The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron from macrophages, and the release of stored iron from hepatocytes. Because iron losses are comparatively very small, iron absorption and its regulation by hepcidin and ferroportin determine total body iron content. Hepcidin is in turn feedback-regulated by plasma iron concentration and iron stores, and negatively regulated by the activity of erythrocyte precursors, the dominant consumers of iron. Hepcidin and ferroportin also play a role in host defense and inflammation, and hepcidin synthesis is induced by inflammatory signals including interleukin-6 and activin B. This review summarizes and discusses recent progress in molecular characterization of systemic iron homeostasis and its disorders, and identifies areas for further investigation.

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Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803
Self-citation
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., & Hediger, M. A. (1997) · Nature · doi:10.1038/41343 · Cited by 3,166
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650 · cited 2×
“Subsequently, microbial molecules, the plant-derived inflammatory agent turpentine, and cytokines were shown to be potent inducers of hepcidin synthesis (162, 165, 168, 186).”
BackgroundSelf-citation
Hepcidin, a urinary antimicrobial peptide synthesized in the liver
Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168
Self-citation
Two to tango: Regulation of Mammalian iron metabolism
Hentze, M. W., Muckenthaler, M. U., Galy, B., & Camaschella, C. (2010) · Cell · doi:10.1016/j.cell.2010.06.028 · Cited by 2,120
Identification of the haemoglobin scavenger receptor
Kristiansen, M., Graversen, J. H., Jacobsen, C., Sonne, O., Hoffman, H.-J., Law, S. K. A., & Moestrup, S. K. (2001) · Nature · doi:10.1038/35051594 · Cited by 1,712
A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload
Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P., & Loréal, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008923200 · Cited by 1,697
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S. J., Moynihan, J., Paw, B. H., Drejer, A., Barut, B., Zapata, A., et al. (2000) · Nature · doi:10.1038/35001596 · Cited by 1,667
A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation
McKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80425-6 · Cited by 1,422
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
Nemeth, E., Valore, E. V., Territo, M., Schiller, G., Lichtenstein, A., & Ganz, T. (2003) · Blood · doi:10.1182/blood-2002-10-3235 · Cited by 1,417
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4 of the 282 references couldn’t be matched to a known paper.

Research works printed but not linked: 15

Akinc A, 2011, 53rd ASH Annu Meet Abstr, 688
Aoki CA, 2005, J Clin Gastroenterol, 39, 71
Beutler E, 2007, ASH Annu Meet Abstr, 110, 3
Booten S, 2011, 53rd ASH Annu Meet Abstr, 1047
Cazzola M, 1989, Prog Clin Biol Res, 309, 93
Centers for Disease Control and Prevention, 2011, Morb Mortal Wkly Rep, 60, 201
10.3324/haematol.2010.033449 · DOI
Hohlbaum AM, 2011, 53rd ASH Annu Meet Abstr, 687
Kwiatkowski JL, 2011, ASH Education Program Book, 2011, 451
Mackenzie Bryan, 2011, FASEB J, 25
Mitchell CJ, 2010, FASEB J, 24
Nemeth E, 2006, Haematologica, 91, 727
Riecke K, 2012, 54rd ASH Annu Meet Abstr, 2342
Van Eijk L, 2012, 54rd ASH Ann Meet Abstr, 3452
Wyllie JC, 1982, Lab Invest, 47, 471

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Authors: Ganz, T.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Ganz, Tomas
ORCID: Ganz, Tomas
Venue: Physiological Reviews
Publisher: American Physiological Society
Published: 2013-10
Volume: 93
Issue: 4
Pages: 1721-1741
ISSN: 0031-9333 (ISSN-L)
1522-1210
DOI: 10.1152/physrev.00008.2013
OpenAlex: W2170885365
Cited by: 1,122
References: 282
Citations by year: 2026: 77 · 2025: 91 · 2024: 89 · 2023: 107 · 2022: 91 · 2021: 95 · 2020: 90 · 2019: 67 · 2018: 78 · 2017: 91 · 2016: 97 · 2015: 83 · 2014: 63 · 2013: 1
FWCI: 12.42
Type: journal article
Language: en
Open access: closed
Locations: Physiological Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Keywords: iron homeostasis, hepcidin, ferroportin, intestinal iron absorption, erythroid precursors, inflammation, interleukin-6, activin B, iron deficiency, iron overload
MeSH terms: Ferroportin, Amino Acid Sequence, Hemostasis, Humans, Iron, Macrophages, Molecular Sequence Data, Hepatocytes, Cation Transport Proteins, Hepcidins

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