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Cited by 1,239

The DOI matches its Crossref record; 501 of the 501 references it cites were found in a registry or an index.

Store-Operated Calcium Channels

Open access
Prakriya, Murali, Lewis, Richard S.·2015·Physiological Reviews
DOI 10.1152/physrev.00020.2014
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Abstract

Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in virtually all metozoan cells and serve a wide variety of functions ranging from gene expression, motility, and secretion to tissue and organ development and the immune response. SOCs are activated by the depletion of Ca 2+from the endoplasmic reticulum (ER), triggered physiologically through stimulation of a diverse set of surface receptors. Over 15 years after the first characterization of SOCs through electrophysiology, the identification of the STIM proteins as ER Ca 2+sensors and the Orai proteins as store-operated channels has enabled rapid progress in understanding the unique mechanism of store-operate calcium entry (SOCE). Depletion of Ca 2+from the ER causes STIM to accumulate at ER-plasma membrane (PM) junctions where it traps and activates Orai channels diffusing in the closely apposed PM. Mutagenesis studies combined with recent structural insights about STIM and Orai proteins are now beginning to reveal the molecular underpinnings of these choreographic events. This review describes the major experimental advances underlying our current understanding of how ER Ca 2+depletion is coupled to the activation of SOCs. Particular emphasis is placed on the molecular mechanisms of STIM and Orai activation, Orai channel properties, modulation of STIM and Orai function, pharmacological inhibitors of SOCE, and the functions of STIM and Orai in physiology and disease.

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Metadata

Authors
Prakriya, M., & Lewis, R. S.
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
2015-10
Volume
95
Issue
4
Pages
1383-1436
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.00020.2014
OpenAlex
W1934528477
Cited by
1,239
References
501
FWCI
10.78
Type
journal article
Language
en
Open access
green

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