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Store-Operated Calcium Channels

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Prakriya, Murali, Lewis, Richard S.·2015·Physiological Reviews

DOI 10.1152/physrev.00020.2014

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Abstract

Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in virtually all metozoan cells and serve a wide variety of functions ranging from gene expression, motility, and secretion to tissue and organ development and the immune response. SOCs are activated by the depletion of Ca 2+from the endoplasmic reticulum (ER), triggered physiologically through stimulation of a diverse set of surface receptors. Over 15 years after the first characterization of SOCs through electrophysiology, the identification of the STIM proteins as ER Ca 2+sensors and the Orai proteins as store-operated channels has enabled rapid progress in understanding the unique mechanism of store-operate calcium entry (SOCE). Depletion of Ca 2+from the ER causes STIM to accumulate at ER-plasma membrane (PM) junctions where it traps and activates Orai channels diffusing in the closely apposed PM. Mutagenesis studies combined with recent structural insights about STIM and Orai proteins are now beginning to reveal the molecular underpinnings of these choreographic events. This review describes the major experimental advances underlying our current understanding of how ER Ca 2+depletion is coupled to the activation of SOCs. Particular emphasis is placed on the molecular mechanisms of STIM and Orai activation, Orai channel properties, modulation of STIM and Orai function, pharmacological inhibitors of SOCE, and the functions of STIM and Orai in physiology and disease.

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Calreticulin inhibits repetitive intracellular Ca2+ waves
Camacho, P., & Lechleiter, J. D. (1995) · Cell · doi:10.1016/0092-8674(95)90473-5 · Cited by 234
The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction
Varga-Szabo, D., Braun, A., Kleinschnitz, C., Bender, M., Pleines, I., Pham, M., Renné, T., Stoll, G., & Nieswandt, B. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080302 · Cited by 234
TRPC channels function independently of STIM1 and Orai1
DeHaven, W. I., Jones, B. F., Petranka, J. G., Smyth, J. T., Tomita, T., Bird, G. S., & Putney, J. W. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.170431 · Cited by 233
A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells
Srikanth, S., Jung, H.-J., Kim, K.-D., Souda, P., Whitelegge, J., & Gwack, Y. (2010) · Nature Cell Biology · doi:10.1038/ncb2045 · Cited by 233
STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation: Conformational switch upon STIM1-ORAI1 coupling
Muik, M., Fahrner, M., Schindl, R., Stathopulos, P., Frischauf, I., Derler, I., Plenk, P., Lackner, B., Groschner, K., Ikura, M., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.79 · Cited by 232
STIM1: a novel phosphoprotein located at the cell surface
Manji, S. S. M., Parker, N. J., Williams, R. T., van Stekelenburg, L., Pearson, R. B., Dziadek, M., & Smith, P. J. (2000) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(00)00105-9 · Cited by 232
TRPC1: The link between functionally distinct store-operated calcium channels
Ambudkar, I. S., Ong, H. L., Liu, X., Bandyopadhyay, B., & Cheng, K. T. (2007) · Cell Calcium · doi:10.1016/j.ceca.2007.01.013 · Cited by 232
Respiring mitochondria determine the pattern of activation and inactivation of the store-operated Ca2+ current ICRAC
Gilabert, J. A. (2000) · The EMBO Journal · doi:10.1093/emboj/19.23.6401 · Cited by 231
S-glutathionylation activates STIM1 and alters mitochondrial homeostasis
Hawkins, B. J., Irrinki, K. M., Mallilankaraman, K., Lien, Y.-C., Wang, Y., Bhanumathy, C. D., Subbiah, R., Ritchie, M. F., Soboloff, J., Baba, Y., et al. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201004152 · Cited by 226
Experimental pKa Values of Buried Residues: Analysis with Continuum Methods and Role of Water Penetration
Fitch, C. A., Karp, D. A., Lee, K. K., Stites, W. E., Lattman, E. E., & García-Moreno, E. B. (2002) · Biophysical Journal · doi:10.1016/s0006-3495(02)75670-1 · Cited by 226
Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1
Xu, P., Lu, J., Li, Z., Yu, X., Chen, L., & Xu, T. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.09.134 · Cited by 226
An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry
Sharma, S., Quintana, A., Findlay, G. M., Mettlen, M., Baust, B., Jain, M., Nilsson, R., Rao, A., & Hogan, P. G. (2013) · Nature · doi:10.1038/nature12229 · Cited by 225
STIM1 and calmodulin interact with Orai1 to induce Ca 2+ -dependent inactivation of CRAC channels
Mullins, F. M., Park, C. Y., Dolmetsch, R. E., & Lewis, R. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906781106 · Cited by 225
Self-citation
STIM Proteins and the Endoplasmic Reticulum-Plasma Membrane Junctions
Carrasco, S., & Meyer, T. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061609-165311 · Cited by 225
Attenuation of store-operated Ca 2+ current impairs salivary gland fluid secretion in TRPC1(−/−) mice
Liu, X., Cheng, K. T., Bandyopadhyay, B. C., Pani, B., Dietrich, A., Paria, B. C., Swaim, W. D., Beech, D. J., Yildrim, E., Singh, B. B., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701254104 · Cited by 224
STIM1–Orai1 interactions and Orai1 conformational changes revealed by live‐cell FRET microscopy
Navarro‐Borelly, L., Somasundaram, A., Yamashita, M., Ren, D., Miller, R. J., & Prakriya, M. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.162503 · Cited by 222
Self-citation

The machineries, regulation and cellular functions of mitochondrial calcium
Giorgi, C., Marchi, S., & Pinton, P. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0052-8 · Cited by 941
Calcium signalling in T cells
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STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death
Wu, J., Chen, Y.-J., Dobbs, N., Sakai, T., Liou, J., Miner, J. J., & Yan, N. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20182192 · Cited by 323
Mitochondrial calcium cycling in neuronal function and neurodegeneration
Walters, G. C., & Usachev, Y. M. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1094356 · Cited by 105
A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction
Zhang, X., Pathak, T., Yoast, R., Emrich, S., Xin, P., Nwokonko, R. M., Johnson, M., Wu, S., Delierneux, C., Gueguinou, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09593-0 · Cited by 96

See all 1,239

Authors: Prakriya, M., & Lewis, R. S.
Venue: Physiological Reviews
Publisher: American Physiological Society
Published: 2015-10
Volume: 95
Issue: 4
Pages: 1383-1436
ISSN: 0031-9333 (ISSN-L)
1522-1210
DOI: 10.1152/physrev.00020.2014
OpenAlex: W1934528477
Cited by: 1,239
References: 501
FWCI: 10.78
Type: journal article
Language: en
Open access: green

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Store-Operated Calcium Channels

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