Cellular Senescence: Aging, Cancer, and Injury
Calcinotto, Arianna, Kohli, Jaskaren, Zagato, Elena, Pellegrini, Laura, Demaria, Marco, Alimonti, Andrea·2019·Physiological Reviews
Cites (374)
Items 201–374 of 374
- Recurrent turnover of senescent cells during regeneration of a complex structureYun, Maximina H, Davaapil, Hongorzul, Brockes, Jeremy P · 2015 · eLife
- Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent MannerMin Sup Song, Arkaitz Carracedo, Leonardo Salmena, Su Jung Song, Ainara Egia, Marcos Malumbres, Pier Paolo Pandolfi · 2011 · Cell
- A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesisAlimonti, Andrea, Nardella, Caterina, Chen, Zhenbang, Clohessy, John G., Carracedo, Arkaitz, Trotman, Lloyd C., Cheng, Ke, Varmeh, Shohreh, Kozma, Sara C., Thomas, George et al. · 2010 · Journal of Clinical Investigation
- Cellular senescence in osteoarthritis pathologyMcCulloch, Kendal, Litherland, Gary J., Rai, Taranjit Singh · 2017 · Aging Cell
- Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2.O. Le Bacquer, E. Petroulakis, S. Paglialunga, F. Poulin, D. Richard, K. Cianflone, N. Sonenberg · 2007 · Journal of Clinical Investigation
- Skp2-Mediated Degradation of p27 Regulates Progression into MitosisKeiko Nakayama, Hiroyasu Nagahama, Yoji Andrew Minamishima, Satoshi Miyake, Noriko Ishida, Shigetsugu Hatakeyama, Masatoshi Kitagawa, Shun-ichiro Iemura, Tohru Natsume, Keiko Nakayama · 2004 · Developmental Cell
- Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidneyMelk, Anette, Schmidt, Bernhard M.W., Takeuchi, Oki, Sawitzki, Birgit, Rayner, David C., Halloran, Philip F. · 2004 · Kidney International
- Historical claims and current interpretations of replicative agingWoodring Erik Wright, Jerry W. Shay · 2002 · Nature Biotechnology
- Results of the Phase I trial of RG7112, a small-molecule MDM2 antagonist in leukemiaAndreeff, Michael, Kelly, Kevin R., Yee, Karen, Assouline, Sarit, Strair, Roger, Popplewell, Leslie, Bowen, David, Martinelli, Giovanni, Drummond, Mark W., Vyas, Paresh et al. · 2016 · Clinical Cancer Research
- p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretionHelman, Aharon, Klochendler, Agnes, Azazmeh, Narmen, Gabai, Yael, Horwitz, Elad, Anzi, Shira, Swisa, Avital, Condiotti, Reba, Granit, Roy Z, Nevo, Yuval et al. · 2016 · Nature Medicine
- Vascular Smooth Muscle Cell Senescence Promotes Atherosclerosis and Features of Plaque VulnerabilityWang, Julie, Uryga, Anna K., Reinhold, Johannes, Figg, Nichola, Baker, Lauren, Finigan, Alison, Gray, Kelly, Kumar, Sheetal, Clarke, Murray, Bennett, Martin · 2015 · Circulation
- NKG2D ligands mediate immunosurveillance of senescent cellsSagiv, Adi, Burton, Dominick G. A., Moshayev, Zhana, Vadai, Ezra, Wensveen, Felix, Ben-Dor, Shifra, Golani, Ofra, Polic, Bojan, Krizhanovsky, Valery · 2016 · Aging
- p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescenceFujita, Kaori, Mondal, Abdul M., Horikawa, Izumi, Nguyen, Giang H., Kumamoto, Kensuke, Sohn, Jane J., Bowman, Elise D., Mathe, Ewy A., Schetter, Aaron J., Pine, Sharon R. et al. · 2009 · Nature Cell Biology
- p53-Mediated Senescence Impairs the Apoptotic Response to Chemotherapy and Clinical Outcome in Breast CancerJackson, James G., Pant, Vinod, Li, Qin, Chang, Leslie L., Quintás-Cardama, Alfonso, Garza, Daniel, Tavana, Omid, Yang, Peirong, Manshouri, Taghi, Li, Yi et al. · 2012 · Cancer Cell
- Mechanism of Human Telomerase Inhibition by BIBR1532, a Synthetic, Non-nucleosidic Drug CandidateEmanuelle Pascolo, Christian Wenz, Joachim Lingner, Norbert H. Hauel, Henning W. M. Priepke, Iris Kauffmann, Pilar Garin‐Chesa, Wolfgang J. Rettig, Klaus Damm, Andreas Schnapp · 2002 · Journal of Biological Chemistry
- SAR405838: An Optimized Inhibitor of MDM2–p53 Interaction That Induces Complete and Durable Tumor RegressionWang, Shaomeng, Sun, Wei, Zhao, Yujun, McEachern, Donna, Meaux, Isabelle, Barrière, Cédric, Stuckey, Jeanne A., Meagher, Jennifer L., Bai, Longchuan, Liu, Liu et al. · 2014 · Cancer Research
- A continuous correlation between oxidative stress and telomere shortening in fibroblastsRichter, Torsten, Zglinicki, Thomas von · 2007 · Experimental Gerontology
- Impact of senescence-associated secretory phenotype and its potential as a therapeutic target for senescence-associated diseasesWatanabe, Sugiko, Kawamoto, Shimpei, Ohtani, Naoko, Hara, Eiji · 2017 · Cancer Science
- Finding the Missing Links among Metabolites, Microbes, and the HostDorrestein, Pieter C., Mazmanian, Sarkis K., Knight, Rob · 2014 · Immunity
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor SuppressorCoppé, Jean-Philippe, Patil, Christopher K, Rodier, Francis, Sun, Yu, Muñoz, Denise P, Goldstein, Joshua, Nelson, Peter S, Desprez, Pierre-Yves, Campisi, Judith · 2008 · PLoS Biology
- Injury-Induced Senescence Enables In Vivo Reprogramming in Skeletal MuscleChiche, Aurélie, Le Roux, Isabelle, von Joest, Mathieu, Sakai, Hiroshi, Aguín, Sabela Búa, Cazin, Coralie, Salam, Rana, Fiette, Laurence, Alegria, Olinda, Flamant, Patricia et al. · 2017 · Cell Stem Cell
- The Pathophysiology and Treatment of OsteoporosisMatthew T. Drake, Bart Lyman Clarke, Edward Michael Lewiecki · 2015 · Clinical Therapeutics
- A Potent Small-Molecule Inhibitor of the MDM2–p53 Interaction (MI-888) Achieved Complete and Durable Tumor Regression in MiceYujun Zhao, Shanghai Yu, Wei Sun, Liu Liu, Jianfeng Lü, Donna McEachern, Sanjeev Shargary, Denzil Bernard, Xiaoqin Li, Ting Zhao et al. · 2013 · Journal of Medicinal Chemistry
- Myeloid derived suppressor cells – a new therapeutic target in the treatment of cancerRobert Wesolowski, Joseph Markowitz, William Edgar Carson · 2013 · Journal for ImmunoTherapy of Cancer
- Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical DevelopmentSun, Daqing, Li, Zhihong, Rew, Yosup, Gribble, Michael, Bartberger, Michael D., Beck, Hilary P., Canon, Jude, Chen, Ada, Chen, Xiaoqi, Chow, David et al. · 2014 · Journal of Medicinal Chemistry
- The physiology of wound healingM. Flanagan · 2000 · Journal of Wound Care
- Pancreatic beta cell senescence contributes to the pathogenesis of type 2 diabetes in high-fat diet-induced diabetic miceSone, H., Kagawa, Y. · 2005 · Diabetologia
- Senescent vascular smooth muscle cells drive inflammation through an interleukin-1α-dependent senescence-associated secretory phenotypeGardner, Sarah E., Humphry, Melanie, Bennett, Martin R., Clarke, Murray C.H. · 2015 · Arteriosclerosis, Thrombosis, and Vascular Biology
- Cellular senescence and the aging brainChinta, Shankar J., Woods, Georgia, Rane, Anand, Demaria, Marco, Campisi, Judith, Andersen, Julie K. · 2015 · Experimental Gerontology
- Targeting the p27 E3 ligase SCFSkp2 results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagyQing Chen, Weilin Xie, Deborah J. Kuhn, Peter Michael Voorhees, Antonia Lopez‐Girona, Derek Mendy, Laura G. Corral, Véronique Plantevin Krenitsky, Weiming Xu, Laure Moutouh–de Parseval et al. · 2008 · Blood
- Immunosuppressive CD14 + HLA‐DR low/− monocytes in prostate cancerStanimir Vuk‐Pavlović, Peggy A. Bulur, Yi Lin, Rui Qin, Carol L. Szumlanski, Xinghua Zhao, Allan B. Dietz · 2009 · The Prostate
- A role for the p38 mitogen-acitvated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents.Ricardo Sánchez‐Prieto, José M. Rojas, Yoichi Taya, Jorge Silvio Gutkind · 2000 · PubMed
- Structural Basis of Inhibition of the Human NAD+-Dependent Deacetylase SIRT5 by SuraminAnja Schuetz, Jinrong Min, Tatiana Antoshenko, Chia-Lin Wang, Abdellah Allali‐Hassani, Aiping Dong, P. Loppnau, Masoud Vedadi, Alexey V. Bochkarev, Rolf Sternglanz et al. · 2007 · Structure
- A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemiaMing-Jer Huang, Yuan-chih Cheng, Chien-Ru Liu, Shufan Lin, H. Eugene Liu · 2006 · Experimental Hematology
- Matricellular Protein CCN1 Promotes Regression of Liver Fibrosis through Induction of Cellular Senescence in Hepatic MyofibroblastsKim, Ki-Hyun, Chen, Chih-Chiun, Monzon, Ricardo I., Lau, Lester F. · 2013 · Molecular and Cellular Biology
- Robust, universal biomarker assay to detect senescent cells in biological specimensEvangelou, Konstantinos, Lougiakis, Nikolaos, Rizou, Sophia V., Kotsinas, Athanassios, Kletsas, Dimitris, Muñoz‐Espín, Daniel, Kastrinakis, Nikolaos G, Pouli, Nicole, Marakos, Panagiotis, Townsend, Paul et al. · 2017 · Aging Cell
- Journal of Cell Biology2019
- Cellular senescence controls fibrosis in wound healingJun, Joon-Il, Lau, Lester F. · 2010 · Aging
- Cdk2 suppresses cellular senescence induced by the c-myc oncogeneStefano Campaner, Mirko Doni, Per Hydbring, Alessandro Verrecchia, Lucia Bianchi, Domenico Sardella, Thomas Schleker, Daniele Perna, Susanna Tronnersjö, Matilde Murga et al. · 2009 · Nature Cell Biology
- Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescenceSwanson, Eric C., Manning, Benjamin, Zhang, Hong, Lawrence, Jeanne B. · 2013 · Journal of Cell Biology
- INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosisLiu, Yan, Sanoff, Hanna K., Cho, Hyunsoon, Burd, Christin E., Torrice, Chad, Mohlke, Karen L., Ibrahim, Joseph G., Thomas, Nancy E., Sharpless, Norman E. · 2009 · PLoS ONE
- Reactivation of Mutant p53 and Induction of Apoptosis in Human Tumor Cells by Maleimide AnalogsVladimir J.N. Bykov, Natalia Issaeva, Nicole Zache, Alexandre Shilov, Monica Hultcrantz, Jan Bergman, Galina Selivanova, Klas G. Wiman · 2005 · Journal of Biological Chemistry
- Essential role for premature senescence of myofibroblasts in myocardial fibrosisMeyer, Kathleen, Hodwin, Bettina, Ramanujam, Deepak, Engelhardt, Stefan, Sarikas, Antonio · 2016 · Journal of the American College of Cardiology
- Granule exocytosis mediates immune surveillance of senescent cellsSagiv, A, Biran, A, Yon, M, Simon, J, Lowe, S W, Krizhanovsky, V · 2013 · Oncogene
- VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400Young, Arthur P., Schlisio, Susanne, Minamishima, Yoji Andrew, Zhang, Qing, Li, Lianjie, Grisanzio, Chiara, Signoretti, Sabina, Kaelin, William G. · 2008 · Nature Cell Biology
- Activation of the PI3K Pathway in Cancer Through Inhibition of PTEN by Exchange Factor P-REX2aBarry M. Fine, Cindy Hodakoski, Susan Koujak, Tao Su, Lao H. Saal, Matthew Maurer, Benjamin David Hopkins, Megan E. Keniry, Maria Luisa Sulis, Sarah M. Mense et al. · 2009 · Science
- Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis, via glycolysis and ketone productionClaudia Capparelli, Carmela Guido, Diana Whitaker‐Menezes, Gloria Bonuccelli, Renee M. Balliet, Timothy G. Pestell, Allison F. Goldberg, Richard G. Pestell, Anthony Howell, Sharon Sneddon et al. · 2012 · Cell Cycle
- Reversible Senescence in Human CD4+CD45RA+CD27− Memory T CellsDi Mitri, Diletta, Azevedo, Rita I, Henson, Sian M, Libri, Valentina, Riddell, Natalie E, Macaulay, Richard, Kipling, David, Soares, Maria V D, Battistini, Luca, Akbar, Arne N · 2011 · The Journal of Immunology
- Lack of Replicative Senescence in Cultured Rat Oligodendrocyte Precursor CellsDean G. Tang, Yasuhito M. Tokumoto, James A. Apperly, Alison C. Lloyd, MARTIN C. RAFF · 2001 · Science
- High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in CancerWang, Liqin, Leite de Oliveira, Rodrigo, Wang, Cun, Fernandes Neto, João M., Mainardi, Sara, Evers, Bastiaan, Lieftink, Cor, Morris, Ben, Jochems, Fleur, Willemsen, Lisa et al. · 2017 · Cell Reports
- Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competitionLiu, Xia, Mo, Wei, Ye, Jian, Li, Lingyun, Zhang, Yanping, Hsueh, Eddy C., Hoft, Daniel F., Peng, Guangyong · 2018 · Nature Communications
- A new vision of immunity: homeostasis of the superorganismGérard Eberl · 2010 · Mucosal Immunology
- The Telomerase Antagonist, Imetelstat, Efficiently Targets Glioblastoma Tumor-Initiating Cells Leading to Decreased Proliferation and Tumor GrowthCalin O. Marian, Steve K. Cho, Brian M. Mcellin, Elizabeth Anne Maher, Kimmo J. Hatanpaa, Christopher J. Madden, Bruce Mickey, Woodring Erik Wright, Jerry W. Shay, Robert M. Bachoo · 2010 · Clinical Cancer Research
- NKG2D ligands as therapeutic targets.2013 · Europe PMC (PubMed Central)
- Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineagesSchönland, Stefan O., Lopez, Consuelo, Widmann, Thomas, Zimmer, Julia, Bryl, Ewa, Goronzy, Jörg J., Weyand, Cornelia M. · 2003 · Proceedings of the National Academy of Sciences
- Excessive caloric intake acutely causes oxidative stress, GLUT4 carbonylation, and insulin resistance in healthy menBoden, Guenther, Homko, Carol, Barrero, Carlos A., Stein, T. Peter, Chen, Xinhua, Cheung, Peter, Fecchio, Chiara, Koller, Sarah, Merali, Salim · 2015 · Science Translational Medicine
- Hallmarks of telomeres in ageing researchJW Shay, Woodring Erik Wright · 2007 · The Journal of Pathology
- Tumor-Derived γδ Regulatory T Cells Suppress Innate and Adaptive Immunity through the Induction of ImmunosenescenceYe, Jian, Ma, Chunling, Hsueh, Eddy C, Eickhoff, Christopher S, Zhang, Yanping, Varvares, Mark A, Hoft, Daniel F, Peng, Guangyong · 2013 · The Journal of Immunology
- Senescent Cardiac Fibroblast Is Critical for Cardiac Fibrosis after Myocardial InfarctionZhu, Fuli, Li, Yulin, Zhang, Junmeng, Piao, Chunmei, Liu, Tingting, Li, Hui-Hua, Du, Jie · 2013 · PLoS ONE
- Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancerJingjing Chen, Ilaria Guccini, Diletta Di Mitri, Daniela Brina, Ajinkya Revandkar, Manuela Sarti, Emiliano Pasquini, Abdullah Alajati, Sandra Pinton, Marco Losa et al. · 2018 · Nature Genetics
- Reversing the Life Cycle: Medusae Transforming into Polyps and Cell Transdifferentiation in Turritopsis nutricula (Cnidaria, Hydrozoa)Stefano Piraino, Ferdinando Boero, B. Aeschbach, Volker Johann Schmid · 1996 · Biological Bulletin
- Human regulatory T cells induce T-lymphocyte senescenceYe, Jian, Huang, Xingxu, Hsueh, Eddy C., Zhang, Qunyuan, Ma, Chunling, Zhang, Yanping, Varvares, Mark A., Hoft, Daniel F., Peng, Guangyong · 2012 · Blood
- Bleomycin induces cellular senescence in alveolar epithelial cellsAoshiba, K., Tsuji, T., Nagai, A. · 2003 · European Respiratory Journal
- Cellular senescence in the glaucomatous outflow pathwayPaloma B. Liton, Pratap Challa, Sandra S. Stinnett, Coralia Luna, David Lee Epstein, Pedro González · 2005 · Experimental Gerontology
- Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence?Clara Correia‐Melo, Graeme Hewitt, João F. Passos · 2014 · Longevity & Healthspan
- Lin28 modulates cell growth and associates with a subset of cell cycle regulator mRNAs in mouse embryonic stem cellsBingsen Xu, Kexiong Zhang, Yingqun Huang · 2009 · RNA
- Therapeutic interventions for aging: the case of cellular senescenceSoto-Gamez, Abel, Demaria, Marco · 2017 · Drug Discovery Today
- Frailty in childhood cancer survivorsNess, Kirsten K., Armstrong, Gregory T., Kundu, Mondira, Wilson, Carmen L., Tchkonia, Tamara, Kirkland, James L. · 2015 · Cancer
- Tumor Stroma-Derived TGF-β Limits Myc-Driven Lymphomagenesis via Suv39h1-Dependent SenescenceReimann, Maurice, Lee, Soyoung, Loddenkemper, Christoph, Dörr, Jan R., Tabor, Vedrana, Aichele, Peter, Stein, Harald, Dörken, Bernd, Jenuwein, Thomas, Schmitt, Clemens A. · 2010 · Cancer Cell
- APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cellsMohell, N, Alfredsson, J, Fransson, Å, Uustalu, M, Byström, S, Gullbo, J, Hallberg, A, Bykov, V J N, Björklund, U, Wiman, K G · 2015 · Cell Death & Disease
- Telomere Length and Human Telomerase Reverse Transcriptase Expression As Markers for Progression and Prognosis of Colorectal CarcinomaRalf Gertler, Robert Rosenberg, Dominik Stricker, Jan Friederichs, Axel Hoos, Martin Werner, Kurt Ulm, Bernhard Holzmann, H. Nekarda, Joerg-Ruediger Siewert · 2004 · Journal of Clinical Oncology
- Anti-senescence compounds: A potential nutraceutical approach to healthy agingGurău, Felicia, Baldoni, Simone, Prattichizzo, Francesco, Espinosa, Emma, Amenta, Francesco, Procopio, Antonio Domenico, Albertini, Maria Cristina, Bonafè, Massimiliano, Olivieri, Fabiola · 2018 · Ageing Research Reviews
- COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesisJun Qin, San‐Pin Wu, Chad J. Creighton, Fangyan Dai, Xin Xie, Chiang-Min Cheng, Anna Frolov, Gustavo Ayala, Xia Lin, Xin-Hua Feng et al. · 2012 · Nature
- HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene lociAird, Katherine M., Iwasaki, Osamu, Kossenkov, Andrew V., Tanizawa, Hideki, Fatkhutdinov, Nail, Bitler, Benjamin G., Le, Linh, Alicea, Gretchen, Yang, Ting-Lin, Johnson, F. Brad et al. · 2016 · Journal of Cell Biology
- Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytesMyung, Na-Hye, Zhu, Xiongwei, Kruman, Inna I., Castellani, Rudy J., Petersen, Robert B., Siedlak, Sandra L., Perry, George, Smith, Mark A., Lee, Hyoung-gon · 2008 · AGE
- Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodelingRajagopalan, Sumati, Long, Eric O. · 2012 · Proceedings of the National Academy of Sciences
- p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytesMondal, Abdul M., Horikawa, Izumi, Pine, Sharon R., Fujita, Kaori, Morgan, Katherine M., Vera, Elsa, Mazur, Sharlyn J., Appella, Ettore, Vojtesek, Borivoj, Blasco, Maria A. et al. · 2013 · Journal of Clinical Investigation
- IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent mannerNishizawa, Hitoshi, Iguchi, Genzo, Fukuoka, Hidenori, Takahashi, Michiko, Suda, Kentaro, Bando, Hironori, Matsumoto, Ryusaku, Yoshida, Kenichi, Odake, Yukiko, Ogawa, Wataru et al. · 2016 · Scientific Reports
- Telomerase, senescence and ageingMay Shawi, Chantal Autexier · 2008 · Mechanisms of Ageing and Development
- MLL1 is essential for the senescence-associated secretory phenotypeCapell, Brian C., Drake, Adam M., Zhu, Jiajun, Shah, Parisha P., Dou, Zhixun, Dorsey, Jean, Simola, Daniel F., Donahue, Greg, Sammons, Morgan, Rai, Taranjit Singh et al. · 2016 · Genes & Development
- HMGA2, MicroRNAs, and Stem Cell AgingScott M. Hammond, Norman E. Sharpless · 2008 · Cell
- Telomerase Antagonists GRN163 and GRN163L Inhibit Tumor Growth and Increase Chemosensitivity of Human Hepatoma *Djojosubroto, Meta W., Chin, Allison C., Go, Ning, Schaetzlein, Sonja, Manns, Michael P., Gryaznov, Sergei, Harley, Calvin B., Rudolph, Lenhard K. · 2005 · Hepatology
- Cellular senescence impact on immune cell fate and functionVicente, Rita, Mausset-Bonnefont, Anne-Laure, Jorgensen, Christian, Louis-Plence, Pascale, Brondello, Jean-Marc · 2016 · Aging Cell
- C/EBPβ cooperates with RB:E2F to implement RasV12‐induced cellular senescenceThomas B. Sebastian, Radek Malı́k, Sara Thomas, Julien Sage, Peter F. Johnson · 2005 · The EMBO Journal
- Telomerase Template Antagonist GRN163L Disrupts Telomere Maintenance, Tumor Growth, and Metastasis of Breast CancerHochreiter, Amelia E., Xiao, Hongling, Goldblatt, Erin M., Gryaznov, Sergei M., Miller, Kathy D., Badve, Sunil, Sledge, George W., Herbert, Brittney-Shea · 2006 · Clinical Cancer Research
- CD8 T Cells and AgingRita B. Effros, Zeling Cai, Phyllis‐Jean Linton · 2003 · Critical Reviews in Immunology
- Ink4a/Arf links senescence and agingSharpless, Norman E. · 2004 · Experimental Gerontology
- Rb Regulates DNA Damage Response and Cellular Senescence through E2F-Dependent Suppression of N-Ras IsoprenylationShamma, Awad, Takegami, Yujiro, Miki, Takao, Kitajima, Shunsuke, Noda, Makoto, Obara, Takao, Okamoto, Takahiro, Takahashi, Chiaki · 2009 · Cancer Cell
- Senescent cells expose and secrete an oxidized form of membrane-bound vimentin as revealed by a natural polyreactive antibodyFrescas, David, Roux, Christelle M., Aygun-Sunar, Semra, Gleiberman, Anatoli S., Krasnov, Peter, Kurnasov, Oleg V., Strom, Evguenia, Virtuoso, Lauren P., Wrobel, Michelle, Osterman, Andrei L. et al. · 2017 · Proceedings of the National Academy of Sciences
- Telomere/telomerase dynamics within the human immune system: Effect of chronic infection and stressEffros, Rita B. · 2011 · Experimental Gerontology
- Telomerase inhibition by peptide nucleic acids reverses `immortality' of transformed human cellsShammas, Masood A, Simmons, Carla G, Corey, David R, Shmookler Reis, Robert J · 1999 · Oncogene
- Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiotaJunyue Xing, Yongquan Ying, Chenxi Mao, Yiwei Liu, Tingting Wang, Qian Zhao, Xiaoling Zhang, Fuxia Yan, Hao Zhang · 2018 · Nature Communications
- Anti‐ IL ‐6 receptor m A b eliminates myeloid‐derived suppressor cells and inhibits tumor growth by enhancing T ‐cell responsesKentaro Sumida, Daiko Wakita, Yoshinori Narita, Kazutaka Masuko, Satoshi Terada, Kazue Watanabe, Takayuki Satoh, Hidemitsu Kitamura, Takashi Nishimura · 2012 · European Journal of Immunology
- Effects of a novel telomerase inhibitor, GRN163L, in human breast cancerGinelle C. Gellert, Z. Günnur Dikmen, Woodring Erik Wright, Sergei M Gryaznov, Jerry W. Shay · 2005 · Breast Cancer Research and Treatment
- Simvastatin suppresses breast cancer cell proliferation induced by senescent cellsLiu, Su, Uppal, Harpreet, Demaria, Marco, Desprez, Pierre-Yves, Campisi, Judith, Kapahi, Pankaj · 2015 · Scientific Reports
- Conserved and novel functions of programmed cellular senescence during vertebrate developmentDavaapil, Hongorzul, Brockes, Jeremy P., Yun, Maximina H. · 2016 · Development
- Novel Small Molecule Cyclin-Dependent Kinases Modulators in Human Clinical TrialsAdrian Mario Senderowicz · 2003 · Cancer Biology & Therapy
- Increased expression of p16(INK4a) and p27(Kip1) cyclin-dependent kinase inhibitor genes in aging human kidney and chronic allograft nephropathyChkhotua, Archil B, Gabusi, Elena, Altimari, Annalisa, D’Errico, Antonia, Yakubovich, Michaela, Vienken, Joerg, Stefoni, Sergio, Chieco, Pasquale, Yussim, Alexander, Grigioni, Walter F · 2003 · American Journal of Kidney Diseases
- CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: Duration of cell cycle arrest and MTOR activity determine geroconversionOlga V. Leontieva, Mikhail V. Blagosklonny · 2013 · Cell Cycle
- Risk factors associated with increased bovine leukemia virus proviral load in infected cattle in Japan from 2012 to 2014Ayumu Ohno, Shin‐nosuke Takeshima, Yuki Matsumoto · 2015 · Virus Research
- A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescenceDaniel S. Peeper, Avi Shvarts, Thijn R. Brummelkamp, Sirith Douma, Eugene Y. Koh, George Q. Daley, René Bernards · 2002 · Nature Cell Biology
- Recovery of function in osteoarthritic chondrocytes induced by p16INK4a-specific siRNA in vitroZhou, H. W. · 2004 · Rheumatology
- Combinatorial approach to cancer immunotherapy: strength in numbersAnna E. Vilgelm, Douglas Buckner Johnson, Ann J. Richmond · 2016 · Journal of Leukocyte Biology
- The Expanding Role of Cell Cycle RegulatorsTyler Jacks, Robert A. Weinberg · 1998 · Science
- Telomerase is up-regulated in human germinal center B cells in vivo and can be re-expressed in memory B cells activated in vitroB T Hu, S C Lee, Elides Marin, Daniel H. Ryan, Richard A. Insel · 1997 · The Journal of Immunology
- Early role for IL-6 signalling during generation of induced pluripotent stem cells revealed by heterokaryon RNA-SeqBrady Jennifer J, Mavis Li, Silpa Suthram, Hui Jiang, Wing Hung Wong, Helen M. Blau · 2013 · Nature Cell Biology
- P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in GlaucomaDorota Skowronska‐Krawczyk, Ling Zhao, Jie Zhu, Robert Neal Weinreb, Guiqun Cao, Jing Luo, Ken Flagg, Sherrina H. Patel, Cindy H. Wen, Martin Krupa et al. · 2015 · Molecular Cell
- Constitutive HER2 Signaling Promotes Breast Cancer Metastasis through Cellular SenescencePier Davide Angelini, Mariano F. Zacarías Fluck, Kim Pedersen, Josep Lluís Parra-Palau, Marc Guiu, Cristina Bernadó Morales, Rocío Vicario, Antonio Luque-García, Nerea Peiró Navalpotro, J. Giralt et al. · 2013 · Cancer Research
- The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agentsCédric Dos Santos, Tinisha McDonald, YinWei Ho, Hongjun Liu, Allen Lin, Stephen J. Forman, Ya‐Huei Kuo, Ravi Bhatia · 2013 · Blood
- Radiation-inducible Immunotherapy for Cancer: Senescent Tumor Cells as a Cancer VaccineYuru Meng, Elena V. Efimova, Khaled Hamzeh, Thomas E. Darga, Helena J. Mauceri, Yang‐Xin Fu, Stephen J. Kron, Ralph R. Weichselbaum · 2012 · Molecular Therapy
- Molecular and Cell Biology of Replicative SenescenceGoberdhan P. Dimri, Judith Campisi · 1994 · Cold Spring Harbor Symposia on Quantitative Biology
- RNAi-Mediated Silencing of Myc Transcription Inhibits Stem-like Cell Maintenance and Tumorigenicity in Prostate CancerGianluca Civenni, Anastasia V. Malek, Domenico Albino, Ramón García‐Escudero, Sara Napoli, Stefano Di Marco, Sandra Pinton, Manuela Sarti, Giuseppina Maria Carbone, Carlo Vittorio Catapano · 2013 · Cancer Research
- A Role for CXCR2 in Senescence, but What about in Cancer?Juan Carlos Acosta, Jesús Gil · 2009 · Cancer Research
- Non-Cell-Autonomous Regulation of Cellular Senescence in CancerDiletta Di Mitri, Andrea Alimonti · 2015 · Trends in Cell Biology
- p16INK4a inactivation is not required to immortalize human mammary epithelial cellsBrittney‐Shea Herbert, Woodring Erik Wright, Jerry W. Shay · 2002 · Oncogene
- Reactivating TP53 signaling by the novel MDM2 inhibitor DS-3032b as a therapeutic option for high-risk neuroblastomaArnhold, Viktor, Schmelz, Karin, Proba, Jutta, Winkler, Annika, Wünschel, Jasmin, Toedling, Joern, Deubzer, Hedwig E., Künkele, Annette, Eggert, Angelika, Schulte, Johannes H. et al. · 2018 · Oncotarget
- Telomerase Inhibitor Imetelstat (GRN163L) Limits the Lifespan of Human Pancreatic Cancer CellsKatrina M. Burchett, Ying Yan, Michel M. Ouellette · 2014 · PLoS ONE
- Tumor Suppressor p53 Inhibits Systemic Autoimmune Diseases by Inducing Regulatory T CellsHirotoshi Kawashima, Hiroaki Takatori, Kotaro Suzuki, Arifumi Iwata, Masaya Yokota, Akira Suto, Tohru Minamino, Koichi Hirose, Hiroshi Nakajima · 2013 · The Journal of Immunology
- Replicative Senescence, Aging and Growth-Regulatory Transcription FactorsGoberdhan P. Dimri, Alessandro Testori, Meileen Acosta, Judith Campisi · 1996 · Neurosignals
- Estrogen Receptor Ligands Ameliorate Fatty Liver Through a Nonclassical Estrogen Receptor/Liver X Receptor Pathway in MiceSong‐iee Han, Yoko Komatsu, Akiko Murayama, Knut Rune Steffensen, Yoshimi Nakagawa, Yuka Nakajima, Michiko Suzuki, Shohei Oie, Paolo Parini, Lise‐Lotte Vedin et al. · 2013 · Hepatology
- New aspects of IFN‐α/β signalling in immunity, oncogenesis and bone metabolismAkinori Takaoka, Tadatsugu Taniguchi · 2003 · Cancer Science
- Chapter 5 Sirtuins and p53Ingeborg van Leeuwen, Sonia Laı́n · 2009 · Advances in cancer research
- The effects of graded caloric restriction:
<scp>XII</scp>
. Comparison of mouse to human impact on cellular senescence in the colonFontana, Luigi, Mitchell, Sharon E., Wang, Boshi, Tosti, Valeria, van Vliet, Thijmen, Veronese, Nicola, Bertozzi, Beatrice, Early, Dayna S., Maissan, Parcival, Speakman, John R. et al. · 2018 · Aging Cell
- Aging-Associated Vascular Phenotype in Mutant Mice With Low Levels of BubR1Matsumoto, Takuya, Baker, Darren J., d’Uscio, Livius V., Mozammel, Gazi, Katusic, Zvonimir S., van Deursen, Jan M. · 2007 · Stroke
- Clinical utility of recombinant adenoviral human p53 gene therapy: current perspectivesGuangxia Chen, Shu Jie Zhang, Xiaohua He, Shiyu Liu, Chao Ma, Xiaoping Zou · 2014 · OncoTargets and Therapy
- Telomerase as a Cancer Target. Development of New MoleculesDiego Luis Mengual Gómez, Romina Gabriela Armando, Carolina Susana Cerrudo, Pablo Daniel Ghiringhelli, Daniel Eduardo Gomez · 2016 · Current Topics in Medicinal Chemistry
- p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cellsPuyu Li, Ming Zhao, Amanda B. Parris, Xiaoshan Feng, Xiaohe Yang · 2015 · Biochemical and Biophysical Research Communications
- <i>Cdkn2a</i>
Is an Atherosclerosis Modifier Locus That Regulates Monocyte/Macrophage ProliferationKuo, Chao-Ling, Murphy, Andrew J., Sayers, Scott, Li, Rong, Yvan-Charvet, Laurent, Davis, Jaeger Z., Krishnamurthy, Janakiraman, Liu, Yan, Puig, Oscar, Sharpless, Norman E. et al. · 2011 · Arteriosclerosis, Thrombosis, and Vascular Biology
- D-Type Cyclins and Their Cyclin-dependent Kinases: G1 Phase Integrators of the Mitogenic ResponseCharles J. Sherr, Jun‐ya Kato, Dawn E. Quelle, Masao Matsuoka, Martine F. Roussel · 1994 · Cold Spring Harbor Symposia on Quantitative Biology
- Disposition and metabolism of topically administered α‐tocopherol acetate: A common ingredient of commercially available sunscreens and cosmeticsAlberts, David S., Goldman, Rayna, Xu, Min‐Jian, Dorr, Robert T., Quinn, Jaime, Welch, Kevin, Guillen‐Rodriguez, Jose, Aickin, Mikel, Peng, Yei‐Mei, Loescher, Lois et al. · 1996 · Nutrition and Cancer
- RAS in cellular transformation and senescenceGina M. DeNicola, David Arthur Tuveson · 2009 · European Journal of Cancer
- Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR)Christoph Garbers, Fabian Kuck, Samadhi Aparicio-Siegmund, Kirstin Konzak, Mareike Kessenbrock, Annika Sommerfeld, Dieter Häussinger, Philipp Alexander Lang, Dirk Brenner, Tak W. Mak et al. · 2013 · Cell Cycle
- IFN-α Inhibits Telomerase in Human CD8+ T Cells by Both hTERT Downregulation and Induction of p38 MAPK SignalingLanna, Alessio, Coutavas, Elias, Levati, Lauretta, Seidel, Judith, Rustin, Malcolm H A, Henson, Sian M, Akbar, Arne N, Franzese, Ornella · 2013 · The Journal of Immunology
- HER2 overcomes PTEN (loss)-induced senescence to cause aggressive prostate cancerImran Ahmad, Rachana Patel, Lukram Babloo Singh, Colin Nixon, Morag M. Seywright, Robert J. Barnetson, Valerie G. Brunton, William J. Muller, Joanne Edwards, Owen James Sansom et al. · 2011 · Proceedings of the National Academy of Sciences
- p16INK4a Exerts an Anti-Inflammatory Effect through Accelerated IRAK1 Degradation in MacrophagesYousuke Murakami, Fumitaka Mizoguchi, Tetsuya Saito, Nobuyuki Miyasaka, Hitoshi Kohsaka · 2012 · The Journal of Immunology
- Mutant mice with small amounts of BubR1 display accelerated age-related gliosisHartman, Tyler K., Wengenack, Thomas M., Poduslo, Joseph F., van Deursen, Jan M. · 2007 · Neurobiology of Aging
- NF1 loss induces senescence during human melanocyte differentiation in an iPSC‐based modelL. Larribère, Hui-Zi Wu, Daniel Novák, Marta Gałach, Mathias Bernhardt, Elias Orouji, Kasia Weina, Nathalie Knappe, C. Sachpekidis, L. Umansky et al. · 2015 · Pigment Cell & Melanoma Research
- Inhibition of telomerase by BIBR 1532 and related analoguesDeb K. Barma, Anissa N. Elayadi, John Russell Falck, David R. Corey · 2003 · Bioorganic & Medicinal Chemistry Letters
- Raman and Infrared Spectroscopy Distinguishing Replicative Senescent from Proliferating Primary Human Fibroblast Cells by Detecting Spectral Differences Mainly Due to Biomolecular AlterationsKatharina Eberhardt, Claudia Beleites, Shiva Marthandan, Christian Matthäus, Stephan Diekmann, Jürgen Popp · 2017 · Analytical Chemistry
- Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescenceAjinkya Revandkar, Maria Luna Perciato, Alberto Toso, Abdullah Alajati, Jingjing Chen, Hermeto Gerber, Mitko I. Dimitrov, Andrea Rinaldi, Nicolas Delaleu, Emiliano Pasquini et al. · 2016 · Nature Communications
- Expression of the senescence marker p16INK4a in skin biopsies of acute lymphoblastic leukemia survivors: a pilot studySophie Marcoux, Oanh Lê, Chloé Langlois-Pelletier, Caroline Laverdière, Afshin Hatami, Philippe Robaey, Christian M. Beausejour · 2013 · Radiation Oncology
- Oncogene-Expressing Senescent Melanocytes Up-Regulate MHC Class II, a Candidate Melanoma Suppressor FunctionJohn van Tuyn, Farah Jaber‐Hijazi, Douglas J. MacKenzie, John J Cole, Elizabeth R. Mann, Jeff S. Pawlikowski, Taranjit Singh, David M. Nelson, Tony McBryan, Andre Ivanov et al. · 2017 · Journal of Investigative Dermatology
- A Novel Chalcone Polyphenol Inhibits the Deacetylase Activity of SIRT1 and Cell Growth in HEK293T CellsTomoaki Kahyo, Shuji Ichikawa, Takahiro Hatanaka, Maki K. Yamada, Mitsutoshi Setou · 2008 · Journal of Pharmacological Sciences
- Skp2 Inhibitors: Novel Anticancer StrategiesYeongju Lee, Hyun-Suk Lim · 2016 · Current Medicinal Chemistry
- The Peripheral Myeloid Expansion Driven by Murine Cancer Progression Is Reversed by Radiation Therapy of the TumorMarka R. Crittenden, Talicia Savage, Benjamin Cottam, Keith S. Bahjat, William L. Redmond, Shelly Bambina, Melissa J. Kasiewicz, Pippa Newell, Andrew Mark Jackson, Michael J. Gough · 2013 · PLoS ONE
- A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumoursMadhuri Kalathur, Alberto Toso, Jingjing Chen, Ajinkya Revandkar, Claudia Danzer-Baltzer, Ilaria Guccini, Abdullah Alajati, Manuela Sarti, Sandra Pinton, Lara Brambilla et al. · 2015 · Nature Communications
- Skp2: A dream target in the coming age of cancer therapyChia‐Hsin Chan, John Kenneth Morrow, Shuxing Zhang · 2014 · Cell Cycle
- Downregulation of the tumour suppressor p16INK4A contributes to the polarisation of human macrophages toward an adipose tissue macrophage (ATM)-like phenotypeLucı́a Fuentes, Kristiaan Wouters, Sarah Anissa Hannou, Céline Cudejko, Elena Rigamonti, Thérèse Hervèe Mayi, Bruno Derudas, François N. Pattou, Giulia Chinetti, Bart Staels et al. · 2011 · Diabetologia
- An update on gene therapy in China.Juan Shi, Dexian Zheng · 2009 · PubMed
- Aging tumour cells to cure cancer: “pro-senescence” therapy for cancerArianna Calcinotto, Andrea Alimonti · 2017 · Swiss Medical Weekly
- Molecular mechanism of G1 arrest and cellular senescence induced by LEE011, a novel CDK4/CDK6 inhibitor, in leukemia cellsYanfang Tao, Nana Wang, Lixiao Xu, Zhiheng Li, Xiaolu Li, Yunyun Xu, Fang Fang, Mei Li, Guanghui Qian, Yanhong Li et al. · 2017 · Cancer Cell International
- Tumor Dormancy, Oncogene Addiction, Cellular Senescence, and Self-Renewal ProgramsDavid I. Bellovin, Bikul Das, Dean W. Felsher · 2012 · Advances in experimental medicine and biology
- Premature Cell Senescence and T Cell Receptor–Independent Activation of CD8+ T Cells in Juvenile Idiopathic ArthritisJeffrey Dvergsten, Robert G. Mueller, Patricia C. Griffin, Sameem M. Abedin, Allyson M. Pishko, Joshua J. Michel, Margalit E. Rosenkranz, Ann M. Reed, DANIEL A. KIETZ, Abbe N. Vallejo · 2013 · Arthritis & Rheumatism
- Friend or foe? Telomerase as a pharmacological target in cancer and cardiovascular diseaseKarima Ait‐Aissa, Johnathan D. Ebben, Andrew O. Kadlec, Andreas Beyer · 2016 · Pharmacological Research
- P16INK4a upregulation mediated by TBK1 induces retinal ganglion cell senescence in ischemic injuryL u Li, Yin Zhao, Hong Zhang · 2017 · Cell Death and Disease
- Idiopathic pulmonary fibrosisPeter Timothy Saunders, Richard Toshner, Toby M. Maher · 2018
- Cellular and molecular mechanisms of negligible senescence: insight from the sea urchinAndrea G. Bodnar · 2014 · Invertebrate Reproduction & Development
- Efficient inhibition of human telomerase activity by antisense oligonucleotides sensitizes cancer cells to radiotherapyXuemei Ji, Conghua Xie, Minghao Fang, Fuxiang Zhou, Wenjie Zhang, Mingsheng Zhang, Yunfeng Zhou · 2006 · Acta Pharmacologica Sinica
- Inhibition of human telomerase by diphosphates of acyclic nucleoside phosphonatesMiroslav Hájek, Naděžda Matulová, Ivan Votruba, Antonı́n Holý, Eva Tloušťová · 2005 · Biochemical Pharmacology
- Enhancing chemotherapy efficacy by reprogramming the senescence-associated secretory phenotype of prostate tumorsAlberto Toso, Diletta Di Mitri, Andrea Alimonti · 2015 · OncoImmunology
- Raman and infrared spectroscopy differentiate senescent from proliferating cells in a human dermal fibroblast 3D skin modelKatharina Eberhardt, Christian Matthäus, Doreen Winter, Cornelia Wiegand, Uta‐Christina Hipler, Stephan Diekmann, Jürgen Popp · 2017 · The Analyst
- p19ARF is a critical mediator of both cellular senescence and an innate immune response associated with MYC inactivation in mouse model of acute leukemiaAlper Yetil, Benedict Anchang, Arvin M. Gouw, Stacey J. Adam, Tahera Zabuawala, Ramya Parameswaran, Jan van Riggelen, Sylvia K. Plevritis, Dean W. Felsher · 2015 · Oncotarget
- CDK4/6 inhibitor: from quiescence to senescenceAkihiro Yoshida, John Alan Diehl · 2015 · Oncoscience
- Phase 1 summary of plasma concentration–QTc analysis for idasanutlin, an MDM2 antagonist, in patients with advanced solid tumors and AMLSteven D. Blotner, Lin-Chi Chen, Cristiano Ferlini, Jianguo Zhi · 2018 · Cancer Chemotherapy and Pharmacology
- CD34+ cells from patients with myelodysplastic syndrome present different p21 dependent premature senescenceYin Xiao, Jie Wang, Hui Kyoung Song, Ping Zou, Daohong Zhou, Lingbo Liu · 2012 · Leukemia Research
- Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogsVladimir J.N. Bykov, Natalia Issaeva, Nicole Zache, Alexandre Shilov, Monica Hultcrantz, Jan Bergman, Galina Selivanova, Klas G. Wiman · 2017 · Journal of Biological Chemistry
- PRIMA-1 Selectively Induces Global DNA Demethylation in p53 Mutant-Type Thyroid Cancer CellsWei Qiang, Tianbo Jin, Qi Yang, Wei Liu, Shu Liu, Meiju Ji, Nongyue He, Chao Chen, Bingyin Shi, Peng Hou · 2014 · Journal of Biomedical Nanotechnology
- Targeted Delivery of Oncogene‐Selective Antisense Oligonucleotides in Neuroectodermal Tumors: Therapeutic ImplicationsFabio Pastorino, Chiara Brignole, Danilo Marimpietri · 2004 · Annals of the New York Academy of Sciences
- Telomerase RNA Inhibition Using Antisense Oligonucleotide Against Human Telomerase RNA Linked to a 2′,5′-OligoadenylateYasuko Kondo, Seiji Kondo · 2007 · Methods in molecular biology
- Stress Response Pathways in CancerG. Wondrak · 2015 · Springer Netherlands
- Different roads to inactivationSarah E. Seton-Rogers · 2009 · Nature reviews. Cancer
- [Mesenchymal stem cells inhibit the expression of CD25 on phytohaemagglutinin-activated lymphocytes].Yingbin Liu, Haoran Qian, Defei Hong et al. · 2007 · PubMed
- THE ESSENCE OF SENESCENCE1967 · JAMA
- Untitled workBarbero · 2014 · 10.1016/j