Excessive caloric intake acutely causes oxidative stress, GLUT4 carbonylation, and insulin resistance in healthy men
Open accessAbstract
Acute overnutrition in healthy men caused rapid weight gain and insulin resistance, as well as oxidative stress.
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Men fed a high-calorie diet for one week gained significant weight and developed insulin resistance, with oxidative damage detected in adipose tissue biopsies without an increase in inflammatory cell markers.
“Men fed a high-calorie diet for one week gained significant weight accompanied with insulin resistance (77).Oxidative damage was detected in AT biopsies without an increase in inflammatory cell markers.”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [77]
Healthy men can become insulin insensitive during acute excessive caloric intake without showing inflammatory changes in adipose tissue.
“Boden et al. showed that healthy men can become insulin insensitive during acute excessive caloric intake but do not display inflammatory changes in AT (77).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [77]
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- Authors
- Boden, G., Homko, C., Barrero, C. A., Stein, T. P., Chen, X., Cheung, P., Fecchio, C., Koller, S., & Merali, S.
- Affiliations
- Temple University (US)
- Rowan University (US)
- Corresponding author
- Boden, Guenther
- Merali, Salim
- Venue
- Science Translational Medicine
- Published
- 2015-09-09
- Volume
- 7
- Issue
- 304
- Pages
- 304re7-304re7
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC5600191
- OpenAlex
- W2175551147
- Cited by
- 214
- References
- 45
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 16 · 2023: 20 · 2022: 26 · 2021: 20 · 2020: 24 · 2019: 17 · 2018: 32 · 2017: 17 · 2016: 14
- FWCI
- 16.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R01-DK090588)
- American Diabetes Association (1-10-CT-06)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- insulin resistance, oxidative stress, GLUT4, protein carbonylation, overnutrition, caloric excess, adipose tissue, weight gain, obesity, type 2 diabetes, glucose transport, metabolic syndrome
- MeSH terms
- Adipose Tissue, Energy Intake, Health, Humans, Insulin Resistance, Male, Middle Aged, Models, Molecular, Oxidation-Reduction, Protein Processing, Post-Translational, Reactive Oxygen Species, Oxidative Stress, Overnutrition, Protein Carbonylation, Glucose Transporter Type 4
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