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Role and Therapeutic Potential of VEGF in the Nervous System

Ruiz de Almodovar, Carmen, Lambrechts, Diether, Mazzone, Massimiliano, Carmeliet, Peter·2009·Physiological Reviews

DOI 10.1152/physrev.00031.2008

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Abstract

The development of the nervous and vascular systems constitutes primary events in the evolution of the animal kingdom; the former provides electrical stimuli and coordination, while the latter supplies oxygen and nutrients. Both systems have more in common than originally anticipated. Perhaps the most striking observation is that angiogenic factors, when deregulated, contribute to various neurological disorders, such as neurodegeneration, and might be useful for the treatment of some of these pathologies. The prototypic example of this cross-talk between nerves and vessels is the vascular endothelial growth factor or VEGF. Although originally described as a key angiogenic factor, it is now well established that VEGF also plays a crucial role in the nervous system. We describe the molecular properties of VEGF and its receptors and review the current knowledge of its different functions and therapeutic potential in the nervous system during development, health, disease and in medicine.

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Items 201–400 of 443

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Pan, Q., Chathery, Y., Wu, Y., Rathore, N., Tong, R. K., Peale, F., Bagri, A., Tessier-Lavigne, M., Koch, A. W., & Watts, R. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703554200 · Cited by 204
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Li, Q., Ford, M. C., Lavik, E. B., & Madri, J. A. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.21087 · Cited by 202
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Raab, S., Beck, H., Gaumann, A., Yüce, A., Gerber, H.-P., Plate, K., Hammes, H.-P., Ferrara, N., & Breier, G. (2004) · Thrombosis and Haemostasis · doi:10.1160/th03-09-0582 · Cited by 202
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Zhang, H., Vutskits, L., Pepper, M. S., & Kiss, J. Z. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200308040 · Cited by 200
Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells
ABU-GHAZALEH, R., Kabir, J., Jia, H., Mel, L. O. B. O., & Zachary, I. C. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3600255 · Cited by 197
Plasmin Activates the Lymphangiogenic Growth Factors VEGF-C and VEGF-D
McColl, B. K., Baldwin, M. E., Roufail, S., Freeman, C., Moritz, R. L., Simpson, R. J., Alitalo, K., Stacker, S. A., & Achen, M. G. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030361 · Cited by 197
Vascular Endothelial Growth Factor-B–Deficient Mice Display an Atrial Conduction Defect
Aase, K., von Euler, G., Li, X., Pontén, A., Thorén, P., Cao, R., Cao, Y., Olofsson, B., Gebre-Medhin, S., Pekny, M., et al. (2001) · Circulation · doi:10.1161/01.cir.104.3.358 · Cited by 197
Hypoxia regulatory elements of the human vascular endothelial growth factor gene.
Minchenko, О. H., Salceda, S., Bauer, T., & Caro, J. (1994) · PubMed · Cited by 196
VEGF-B inhibits apoptosis via VEGFR-1–mediated suppression of the expression of BH3-only protein genes in mice and rats
Li, Y., Zhang, F., Nagai, N., Tang, Z., Zhang, S., Scotney, P., Lennartsson, J., Zhu, C., Qu, Y., Fang, C., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33673 · Cited by 194
Vascular endothelial growth factor in Alzheimer's disease and experimental cerebral ischemia
Kalaria, R. N., Cohen, D. L., Premkumar, D. R. D., Nag, S., LaManna, J. C., & Lust, W. D. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00190-9 · Cited by 192
Androgen Receptor YAC Transgenic Mice Recapitulate SBMA Motor Neuronopathy and Implicate VEGF164 in the Motor Neuron Degeneration
Sopher, B. L., Thomas, P. S., LaFevre-Bernt, M. A., Holm, I. E., Wilke, S. A., Ware, C. B., Jin, L.-W., Libby, R. T., Ellerby, L. M., & La Spada, A. R. (2004) · Neuron · doi:10.1016/s0896-6273(04)00082-0 · Cited by 191
VEGF‐overexpressing transgenic mice show enhanced post‐ischemic neurogenesis and neuromigration
Wang, Y., Jin, K., Mao, X. O., Xie, L., Banwait, S., Marti, H. H., & Greenberg, D. A. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21169 · Cited by 190
Ranibizumab Combined With Verteporfin Photodynamic Therapy in Neovascular Age-related Macular Degeneration (FOCUS): Year 2 Results
Antoszyk, A. N., Tuomi, L., Chung, C. Y., & Singh, A. (2008) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2007.12.029 · Cited by 190
Vascular Endothelial Growth Factor-B Promotes In Vivo Angiogenesis
Silvestre, J.-S., Tamarat, R., Ebrahimian, T. G., Le-Roux, A., Clergue, M., Emmanuel, F., Duriez, M., Schwartz, B., Branellec, D., & Lévy, B. I. (2003) · Circulation Research · doi:10.1161/01.res.0000081594.21764.44 · Cited by 188
Guidance of vascular and neural network formation
Eichmann, A., Noble, F. L., Autiero, M., & Carmeliet, P. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.01.008 · Cited by 186
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Zonta, M., Sebelin, A., Gobbo, S., Fellin, T., Pozzan, T., & Carmignoto, G. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.046706 · Cited by 186
Angiogenic and astroglial responses to vascular endothelial growth factor administration in adult rat brain
Krum, J. M., Mani, N., & Rosenstein, J. M. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00615-7 · Cited by 185
Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons
Makita, T., Sucov, H. M., Gariepy, C. E., Yanagisawa, M., & Ginty, D. D. (2008) · Nature · doi:10.1038/nature06859 · Cited by 184
VEGF-mediated inflammation precedes angiogenesis in adult brain
CROLL, S. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.02.010 · Cited by 184
Neuropilin structure governs VEGF and semaphorin binding and regulates angiogenesis
Geretti, E., Shimizu, A., & Klagsbrun, M. (2008) · Angiogenesis · doi:10.1007/s10456-008-9097-1 · Cited by 184
Intrinsic Tyrosine Kinase Activity is Required for Vascular Endothelial Growth Factor Receptor 2 Ubiquitination, Sorting and Degradation in Endothelial Cells
Ewan, L. C., Jopling, H. M., Jia, H., Mittar, S., Bagherzadeh, A., Howell, G. J., Walker, J. H., Zachary, I. C., & Ponnambalam, S. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00462.x · Cited by 183
Vascular Endothelial Growth Factor Is Expressed in Multiple Sclerosis Plaques and Can Induce Inflammatory Lesions in Experimental Allergic Encephalomyelitis Rats
Proescholdt, M. A., Jacobson, S., Tresser, N., Oldfield, E. H., & Merrill, M. J. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.10.914 · Cited by 182
Increased blood–brain barrier permeability and endothelial abnormalities induced by vascular endothelial growth factor
Dobrogowska, D. H., Lossinsky, A. S., Tarnawski, M., & Vorbrodt, A. W. (1998) · Journal of Neurocytology · doi:10.1023/a:1006907608230 · Cited by 180
Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression
Yonghua, Z., Kunlin, J., Ou Mao, X., & Greenberg, D. A. (2003) · The FASEB Journal · doi:10.1096/fj.02-0515com · Cited by 180
Human Vascular Endothelial Growth Factor Protects Axotomized Retinal Ganglion Cells In Vivo by Activating ERK-1/2 and Akt Pathways
Kilic, Ü., Kilic, E., Järve, A., Guo, Z., Spudich, A., Bieber, K., Barzena, U., Bassetti, C. L., Marti, H. H., & Hermann, D. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0434-06.2006 · Cited by 179
Vascular endothelial growth factor-B (VEGFB) stimulates neurogenesis: Evidence from knockout mice and growth factor administration
Sun, Y., Jin, K., Childs, J. T., Xie, L., Mao, X. O., & Greenberg, D. A. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2005.10.016 · Cited by 178
VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain
Le Bras, B., Barallobre, M.-J., Homman-Ludiye, J., Ny, A., Wyns, S., Tammela, T., Haiko, P., Karkkainen, M. J., Yuan, L., Muriel, M.-P., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1646 · Cited by 178
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Schwarz, Q., Gu, C., Fujisawa, H., Sabelko, K., Gertsenstein, M., Nagy, A., Taniguchi, M., Kolodkin, A. L., Ginty, D. D., Shima, D. T., et al. (2004) · Genes & Development · doi:10.1101/gad.322904 · Cited by 178
Vascular endothelial growth factor induces chemotaxis and proliferation of microglial cells
Forstreuter, F., Lucius, R., & Mentlein, R. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00315-6 · Cited by 177
Phosphorylation of Tyr1214 within VEGFR-2 Triggers the Recruitment of Nck and Activation of Fyn Leading to SAPK2/p38 Activation and Endothelial Cell Migration in Response to VEGF
Lamalice, L., Houle, F., & Huot, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603928200 · Cited by 177
Stabilization of the retinal vascular network by reciprocal feedback between blood vessels and astrocytes
West, H., Richardson, W. D., & Fruttiger, M. (2005) · Development · doi:10.1242/dev.01732 · Cited by 176
The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching
Kappas, N. C., Zeng, G., Chappell, J. C., Kearney, J. B., Hazarika, S., Kallianos, K. G., Patterson, C., Annex, B. H., & Bautch, V. L. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200709114 · Cited by 175
VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes
Halin, C., Tobler, N. E., Vigl, B., Brown, L. F., & Detmar, M. (2007) · Blood · doi:10.1182/blood-2007-01-066811 · Cited by 174
Co-accumulation of vascular endothelial growth factor with β-amyloid in the brain of patients with Alzheimer’s disease
Yang, S.-P., Bae, D.-G., Kang, H. J., Gwag, B. J., Gho, Y. S., & Chae, C.-B. (2004) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00111-8 · Cited by 169
Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-γ and migration of endothelial cells expressing Flt 1
Landgren, E., Schiller, P., Cao, Y., & Claesson-Welsh, L. (1998) · Oncogene · doi:10.1038/sj.onc.1201545 · Cited by 168
Vascular Endothelial Growth Factor Overexpression Delays Neurodegeneration and Prolongs Survival in Amyotrophic Lateral Sclerosis Mice
Wang, Y., Ou Mao, X., Xie, L., Banwait, S., Marti, H. H., Greenberg, D. A., & Jin, K. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4433-06.2007 · Cited by 168
Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes/macrophages
Murakami, M., Iwai, S., Hiratsuka, S., Yamauchi, M., Nakamura, K., Iwakura, Y., & Shibuya, M. (2006) · Blood · doi:10.1182/blood-2006-04-016030 · Cited by 166
The neural tube patterns vessels developmentally using the VEGF signaling pathway
Hogan, K. A., Ambler, C. A., Chapman, D. L., & Bautch, V. L. (2004) · Development · doi:10.1242/dev.01039 · Cited by 166
VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2
Garrett, T. A., Van Buul, J. D., & Burridge, K. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.05.027 · Cited by 164
Vascular endothelial growth factor receptor Flt-1 negatively regulates developmental blood vessel formation by modulating endothelial cell division
Kearney, J. B., Ambler, C. A., Monaco, K.-A., Johnson, N., Rapoport, R. G., & Bautch, V. L. (2002) · Blood · doi:10.1182/blood.v99.7.2397 · Cited by 163
Vascular Endothelial Growth Factor (VEGF) in Seizures:
Croll, S. D., Goodman, J. H., & Scharfman, H. E. (2004) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4757-6376-8_4 · Cited by 160
VEGF Protects Brain against Focal Ischemia without Increasing Blood–Brain Permeability When Administered Intracerebroventricularly
Kaya, D., Gürsoy-Özdemir, Y., Yemisci, M., Tuncer, N., Aktan, S., & Dalkara, T. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600109 · Cited by 160
Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS
Zheng, C., Nennesmo, I., Fadeel, B., & Henter, J. (2004) · Annals of Neurology · doi:10.1002/ana.20223 · Cited by 157
Caspase-3 and the regulation of hypoxic neuronal death by vascular endothelial growth factor
Jin, K., Mao, X., Parmentier‐Batteur, S., McEachron, E., Leahy, A. A., & Greenberg, D. A. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00154-3 · Cited by 155
Expression of vascular endothelial growth factor and its receptors in rat neural stem cells
Maurer, M. H., Tripps, W. K. C., Feldmann, R., & Kuschinsky, W. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00407-5 · Cited by 154
Erythropoietin and VEGF promote neural outgrowth from retinal explants in postnatal rats.
Böcker-Meffert, S., Rosenstiel, P. C., Röhl, C., Warneke, N., Held‐Feindt, J., Sievers, J., & Lucius, R. (2002) · PubMed · Cited by 153
Tyrosine Residues 951 and 1059 of Vascular Endothelial Growth Factor Receptor-2 (KDR) Are Essential for Vascular Permeability Factor/Vascular Endothelial Growth Factor-induced Endothelium Migration and Proliferation, Respectively
Zeng, H., Sanyal, S., & Mukhopadhyay, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103130200 · Cited by 153
The VHL tumor suppressor and HIF: insights from genetic studies in mice
Kapitsinou, P. P., & Haase, V. H. (2008) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402313 · Cited by 151
New insights into the local regulation of blood flow by perivascular nerves and endothelium
Burnstock, G., & Ralevic, V. (1994) · British Journal of Plastic Surgery · doi:10.1016/0007-1226(94)90136-8 · Cited by 151
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Lemmens, R., Hoecke, A. V., Hersmus, N., Geelen, V., Dhollander, I., Thijs, V., Bosch, L. V. D., Carmeliet, P., & Robberecht, W. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm193 · Cited by 151
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Ding, Y.-H., Luan, X.-D., Li, J., Rafols, J., Guthinkonda, M., Diaz, F., & Ding, Y. (2004) · Current Neurovascular Research · doi:10.2174/1567202043361875 · Cited by 150
Vascular endothelial growth factor stimulates neurite outgrowth from cerebral cortical neurons via Rho kinase signaling
Jin, K., Mao, X. O., & Greenberg, D. A. (2005) · Journal of Neurobiology · doi:10.1002/neu.20215 · Cited by 149
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Grimmond, S. M., Lagercrantz, J., Drinkwater, C. C., Silins, G. U., Townson, S. M., Pollock, P. M., Gotley, D. C., Carson, E., Rakar, S., Nordenskjöld, M., et al. (1996) · Genome Research · doi:10.1101/gr.6.2.124 · Cited by 149
Neuropilin-1-VEGFR-2 Complexing Requires the PDZ-binding Domain of Neuropilin-1*
Prahst, C., Héroult, M., Lanahan, A., Uziel, N., Kessler, O., Shraga-Heled, N., Simons, M., Neufeld, G., & Augustin, H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.c800137200 · Cited by 146
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Carmona, G., Göttig, S., Orlandi, A., Scheele, J. S., Bäuerle, T., Jugold, M., Kiessling, F. M., Henschler, R., Zeiher, A. M., Dimmeler, S., et al. (2008) · Blood · doi:10.1182/blood-2008-02-138438 · Cited by 145
Condensation of the central nervous system in embryonic Drosophila is inhibited by blocking hemocyte migration or neural activity
Olofsson, B., & Page, D. T. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2004.12.020 · Cited by 145
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Tepaß, U. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(02)00342-8 · Cited by 144
Transient Coexpression of Nestin, GFAP, and Vascular Endothelial Growth Factor in Mature Reactive Astroglia Following Neural Grafting or Brain Wounds
Krum, J. M., & Rosenstein, J. M. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7222 · Cited by 143
VEGF-induced activation of the PI3-K/Akt pathway reduces mutant SOD1-mediated motor neuron cell death
Li, B., Xu, W., Luo, C., Gozal, D., & Liu, R. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(03)00025-1 · Cited by 143
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Rancillac, A., Rossier, J., Guille‐Collignon, M., Tong, X., Geoffroy, H., Amatore, C. A., Arbault, S., Hamel, É., & Cauli, B. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5515-05.2006 · Cited by 143
Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice
Tı̂rziu, D., Chorianopoulos, E., Moodie, K. L., Palac, R. T., Zhuang, Z. W., Tjwa, M., Roncal, C., Eriksson, U., Fu, Q., Elfenbein, A., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32024 · Cited by 143
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Soga, N., Namba, N., McAllister, S., Cornelius, L. A., Teitelbaum, S. L., Dowdy, S. F., Kawamura, J., & Hruska, K. A. (2001) · Experimental Cell Research · doi:10.1006/excr.2001.5295 · Cited by 140
Ocular vascular endothelial growth factor levels in diabetic rats are elevated before observable retinal proliferative changes
Sone, H., Kawakami, Y., Okuda, Y., Sekine, Y., Honmura, S., Matsuo, K.-I., Segawa, T., Suzuki, H., & Yamashita, K. (1997) · Diabetologia · doi:10.1007/s001250050740 · Cited by 138
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Chittenden, T. W., Claes, F., Lanahan, A. A., Autiero, M., Palac, R. T., Tkachenko, E., Elfenbein, A., de Almodóvar, C. R., Dedkov, E. I., Tomanek, R. J., et al. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.03.012 · Cited by 137
Self-citation
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Neural Progenitor Cells Treated with EPO Induce Angiogenesis through the Production of Vegf
Wang, L., Chopp, M., Gregg, S. R., Zhang, R. L., Teng, H., Jiang, A., Feng, Y., & Zhang, Z. G. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.32 · Cited by 136
Astrocytes shed extracellular vesicles that contain fibroblast growth factor-2 and vascular endothelial growth factor
Proia, P., Schiera, G., Mineo, M., Ingrassia, A. M. R., Santoro, G., Savettieri, G., & Liegro, I. D. (2008) · International Journal of Molecular Medicine · doi:10.3892/ijmm.21.1.63 · Cited by 136
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Manoonkitiwongsa, P. S., Schultz, R. L., McCreery, D. B., Whitter, E. F., & Lyden, P. D. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000126236.54306.21 · Cited by 132
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Mateo, I., Llorca, J., Infante, J., Rodríguez‐Rodríguez, E., Fernández‐Viadero, C., Peña, N., Berciano, J., & Combarros, O. (2006) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2006.00775.x · Cited by 132
Vascular Endothelial Growth Factor Protects Cultured Rat Hippocampal Neurons Against Hypoxic Injury via an Antiexcitotoxic, Caspase-Independent Mechanism
Svensson, B., Peters, M., König, H., Poppe, M., Levkau, B., Rothermundt, M., Arolt, V., Kögel, D., & Prehn, J. H. M. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000037988.07114.98 · Cited by 131
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Rennel, E. S., Waine, E., Guan, H., Schüler, Y., Leenders, W. P. J., Woolard, J., Sugiono, M., Gillatt, D. A., Kleinerman, E. S., Bates, D. O., et al. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604309 · Cited by 131
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Quattrini, C., Jeziorska, M., Boulton, A. J. M., & Malik, R. A. (2007) · Diabetes Care · doi:10.2337/dc07-1556 · Cited by 131
Selective requirements for NRP1 ligands during neurovascular patterning
Vieira, J. M., Schwarz, Q., & Ruhrberg, C. (2007) · Development · doi:10.1242/dev.002402 · Cited by 131
Assembly of Trunk and Limb Blood Vessels Involves Extensive Migration and Vasculogenesis of Somite-Derived Angioblasts
Ambler, C. A., Nowicki, J. L., Burke, A. C., & Bautch, V. L. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0267 · Cited by 126
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McCloskey, D. P., Croll, S. D., & Scharfman, H. E. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2577-05.2005 · Cited by 125
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Self-citation
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Hypoxia-mediated Selective mRNA Translation by an Internal Ribosome Entry Site-independent Mechanism
Young, R. M., Wang, S.-J., Gordan, J. D., Ji, X., Liebhaber, S. A., & Simon, M. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710079200 · Cited by 123
Promotion of regeneration of corticospinal tract axons in rats with recombinant vascular endothelial growth factor alone and combined with adenovirus coding for this factor
Facchiano, F., Fernandez, E., Mancarella, S., Maira, G., Miscusi, M., D’Arcangelo, D., Cimino-Reale, G., Falchetti, M. L., Capogrossi, M. C., & Pallini, R. (2002) · Journal of neurosurgery · doi:10.3171/jns.2002.97.1.0161 · Cited by 121
Reevaluation of the Role of VEGF-B Suggests a Restricted Role in the Revascularization of the Ischemic Myocardium
Li, X., Tjwa, M., Hove, I. V., Enholm, B., Neven, E., Paavonen, K., Jeltsch, M., Juan, T. D., Sievers, R. E., Chorianopoulos, E., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.158725 · Cited by 119
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Lack of Hypoxia-Inducible Factor-1α Impairs Midbrain Neural Precursor Cells Involving Vascular Endothelial Growth Factor Signaling
Milošević, J., Maisel, M., Wegner, F., Leuchtenberger, J., Wenger, R. H., Gerlach, M., Storch, A., & Schwarz, J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2482-06.2007 · Cited by 118
Improvement in Chronic Ischemic Neuropathy After Intramuscular phVEGF165 Gene Transfer in Patients With Critical Limb Ischemia
Simovic, D., Isner, J. M., Ropper, A. H., Pieczek, A., & Weinberg, D. H. (2001) · Archives of Neurology · doi:10.1001/archneur.58.5.761 · Cited by 118
Vascular Endothelial Growth Factor (VEGF) in Autoimmune Diseases
de Carvalho, J. F., Blank, M., & Shoenfeld, Y. (2007) · Journal of Clinical Immunology · doi:10.1007/s10875-007-9083-1 · Cited by 118
Boundary formation in the hindbrain: Eph only it were simple…
Cooke, J. E., & Moens, C. B. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02134-3 · Cited by 117
Vascular Endothelial Growth Factor Antagonist Reduces Brain Edema Formation and Venous Infarction
Kimura, R., Nakase, H., Tamaki, R., & Sakaki, T. (2005) · Stroke · doi:10.1161/01.str.0000165925.20413.14 · Cited by 117
Vascular Endothelial Growth Factor Rescues HN33 Neural Cells from Death Induced by Serum Withdrawal
Jin, K. L., Mao, X., & Greenberg, D. A. (2000) · Journal of Molecular Neuroscience · doi:10.1385/jmn:14:3:197 · Cited by 116
Vascular endothelial growth factor expression in peripheral nerves and dorsal root ganglia in diabetic neuropathy in rats
Samii, A., Unger, J. W., & Lange, W. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00064-6 · Cited by 116
Cell type specific expression of vascular endothelial growth factor and angiopoietin-1 and -2 suggests an important role of astrocytes in cerebellar vascularization
Acker, T., Beck, H., & Plate, K. H. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00471-3 · Cited by 116
Low levels of the vascular endothelial growth factor in CSF from early ALS patients
Devos, D., Moreau, C., Lassalle, P., Perez, T., Seze, J. D., Danel-Brunaud, V., Destée, A., Tonnel, A., & Just, N. (2004) · Neurology · doi:10.1212/01.wnl.0000129913.44351.a3 · Cited by 115
Vascular Endothelial Growth Factor–Mediated Decrease in Plasma Soluble Vascular Endothelial Growth Factor Receptor-2 Levels as a Surrogate Biomarker for Tumor Growth
Ebos, J. M. L., Lee, C. R., Bogdanovic, E., Alami, J., Slyke, P. V., Francia, G., Xu, P., Mutsaers, A. J., Dumont, D., & Kerbel, R. S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-3217 · Cited by 115
Vascular endothelial growth factor promotes neurite maturation in primary CNS neuronal cultures
Khaibullina, A. A., Rosenstein, J. M., & Krum, J. M. (2004) · Developmental Brain Research · doi:10.1016/j.devbrainres.2003.09.022 · Cited by 114
VEGF mRNA and Its Receptorflt-1Are Expressed in Reactive Astrocytes Following Neural Grafting and Tumor Cell Implantation in the Adult CNS
Krum, J. M., & Rosenstein, J. M. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6930 · Cited by 114
Cell Type-Specific Expression of Neuropilins in an MCA-Occlusion Model in Mice Suggests a Potential Role in Post-Ischemic Brain Remodeling
Beck, H., Acker, T., Püschel, A. W., Fujisawa, H., Carmeliet, P., & Plate, K. H. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.4.339 · Cited by 113
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Induction of VEGF and VEGF receptors in the spinal cord after mechanical spinal injury and prostaglandin administration
Sköld, M. K., Cullheim, S., Hammarberg, H., Piehl, F., Suneson, A., Lake, S., Sjögren, A., Walum, E., & Risling, M. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00263.x · Cited by 111
Vascular endothelial growth factor protects spinal cord motoneurons against glutamate‐induced excitotoxicity via phosphatidylinositol 3‐kinase
Tolosa, L., Mir, M., Asensio, V. J., Olmos, G., & Lladó, J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05206.x · Cited by 110
Expression levels of vascular endothelial growth factor and its receptors in Parkinson's disease
Wada, K., Arai, H., Takanashi, M., Fukae, J., Oizumi, H., Yasuda, T., Mizuno, Y., & Mochizuki, H. (2006) · NeuroReport · doi:10.1097/01.wnr.0000215769.71657.65 · Cited by 109
The effect of vascular endothelial growth factor and brain‐derived neurotrophic factor on cavernosal nerve regeneration in a nerve‐crush rat model
Hsieh, P. ‐., Bochinski, D. J., Lin, G., et al. (2003) · British Journal of Urology · doi:10.1046/j.1464-410x.2003.04373.x · Cited by 109
Vascular endothelial growth factor (VEGF) signaling regulates hippocampal neurons by elevation of intracellular calcium and activation of calcium/calmodulin protein kinase II and mammalian target of rapamycin
Kim, B. W., Choi, M. L., Kim, Y.-S., Park, H., Lee, H., Yun, C., Kim, E. J., Choi, J.-S., Kim, S., Rhim, H., et al. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.12.009 · Cited by 109
Novel Human Vascular Endothelial Growth Factor Genes VEGF-B and VEGF-C Localize to Chromosomes 11q13 and 4q34, Respectively
Paavonen, K., Horelli‐Kuitunen, N., Chilov, D., Kukk, E., Pennanen, S., Kallioniemi, O., Pajusola, K., Olofsson, B., Eriksson, U., Joukov, V., et al. (1996) · Circulation · doi:10.1161/01.cir.93.6.1079 · Cited by 108
The origin and development of retinal astrocytes in the mouse
Huxlin, K. R., Sefton, A. J., & Furby, J. (1992) · Journal of Neurocytology · doi:10.1007/bf01186955 · Cited by 108
Roles of the endogenous VEGF receptors flt-1 and flk-1 in astroglial and vascular remodeling after brain injury
Krum, J. M., Mani, N., & Rosenstein, J. M. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.03.019 · Cited by 106
Localization of VEGF-B in the mouse embryo suggests a paracrine role of the growth factor in the developing vasculature
Aase, K., Lymboussaki, A., Kaipainen, A., Olofsson, B., Alitalo, K. K., & Eriksson, U. (1999) · Developmental Dynamics · Cited by 105
Correlation of spectroscopy and magnetization transfer imaging in the evaluation of demyelinating lesions and normal appearing white matter in multiple sclerosis
Hiehle, J. F., Lenkinski, R. E., Grossman, R. I., Dousset, V., Ramer, K., Schnall, M. D., Cohen, J. A., & González‐Scarano, F. (1994) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910320303 · Cited by 104
Interactions between glial progenitors and blood vessels during early postnatal corticogenesis: Blood vessel contact represents an early stage of astrocyte differentiation
Zerlin, M., & Goldman, J. E. (1997) · The Journal of Comparative Neurology · Cited by 102
Vascular Endothelial Growth Factor Directly Inhibits Primitive Neural Stem Cell Survival But Promotes Definitive Neural Stem Cell Survival
Wada, T., Haigh, J. J., Ema, M., Hitoshi, S., Chaddah, R., Rossant, J., Nagy, A., & van der Kooy, D. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0526-06.2006 · Cited by 102
First Blood Vessels in the Avian Neural Tube Are Formed by a Combination of Dorsal Angioblast Immigration and Ventral Sprouting of Endothelial Cells
Kurz, H., Gärtner, T., Eggli, P. S., et al. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0012 · Cited by 101
TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury
Taoufik, E., Petit, E., Divoux, D., Tseveleki, V., Mengozzi, M., Roberts, M. L., Valable, S., Ghezzi, P., Quackenbush, J. F., Brines, M. L., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801447105 · Cited by 101
Upregulation of Flk-1 by bFGF via the ERK pathway is essential for VEGF-mediated promotion of neural stem cell proliferation
Xiao, Z., Kong, Y., Yang, S., Li, M., Wen, J., & Li, L. (2007) · Cell Research · doi:10.1038/sj.cr.7310126 · Cited by 100
VEGF and vascular changes in chronic neuroinflammation
Kirk, S., & Karlik, S. J. (2003) · Journal of Autoimmunity · doi:10.1016/s0896-8411(03)00139-2 · Cited by 99
Molecular Cloning and Expression of a Functional Snake Venom Vascular Endothelium Growth Factor (VEGF) from theBothrops insularis Pit Viper
Junqueira-de-Azevedo, I. L. M., Farsky, S. H. P., Oliveira, M. L. S., & Ho, P. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106531200 · Cited by 99
Neurons produce FGF2 and VEGF and secrete them at least in part by shedding extracellular vesicles
Schiera, G., Proia, P., Alberti, C., et al. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00100.x · Cited by 98
Upregulation of vascular growth factors in multiple sclerosis: Correlation with MRI findings
Su, J.-J., Osoegawa, M., Matsuoka, T., Minohara, M., Tanaka, M., Ishizu, T., Mihara, F., Taniwaki, T., & Kira, J. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.11.006 · Cited by 98
Expression of Vascular Endothelial Growth Factor and Its Receptors in the Central Nervous System in Amyotrophic Lateral Sclerosis
Brockington, A., Wharton, S. B., Fernando, M. S., Gelsthorpe, C., Baxter, L., Ince, P. G., Lewis, C. E., & Shaw, P. J. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000196134.51217.74 · Cited by 97
Astrocyte-derived VEGF mediates survival and tube stabilization of hypoxic brain microvascular endothelial cells in vitro
Chow, J. Y., Ogunshola, O. O., Fan, S.-Y., Li, Y., Ment, L. R., & Madri, J. A. (2001) · Developmental Brain Research · doi:10.1016/s0165-3806(01)00220-6 · Cited by 97
VEGF Gene and Phenotype Relation with Alzheimer's Disease and Mild Cognitive Impairment
Chiappelli, M., Borroni, B., Archetti, S., Calabrese, E., Romanelli, M. M. C., Franceschi, M., Padovani, A., & Licastro, F. (2006) · Rejuvenation Research · doi:10.1089/rej.2006.9.485 · Cited by 96
Granulocyte colony-stimulating factor stimulates neurogenesis via vascular endothelial growth factor with STAT activation
Jung, K., Chu, K., Lee, S., Kim, S.-J., Sinn, D.-I., Kim, S. U., Kim, M., & Roh, J. (2006) · Brain Research · doi:10.1016/j.brainres.2005.12.037 · Cited by 96
Therapeutic Angiogenesis Inhibits or Rescues Chemotherapy-induced Peripheral Neuropathy: Taxol- and Thalidomide-induced Injury of Vasa Nervorum is Ameliorated by VEGF
Kirchmair, R., Tietz, A. B., Panagiotou, E. M., Walter, D. H., Silver, M., Yoon, Y., Schratzberger, P., Weber, A. C., KUSANO, K. F., Weinberg, D. H., et al. (2006) · Molecular Therapy · doi:10.1038/sj.mt.6300019 · Cited by 92
Macrophage-mediated corpse engulfment is required for normalDrosophilaCNS morphogenesis
Sears, H. C., Kennedy, C. J., & Garrity, P. (2003) · Development · doi:10.1242/dev.00586 · Cited by 92
A comparative study of the expression patterns for vegf, vegf-b/vrf and vegf-c in the developing and adult mouse
Lagercrantz, J., Farnebo, F. A., Larsson, C., Tvrdik, T., Weber, G., & Piehl, F. (1998) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(98)00040-2 · Cited by 92
Effects of intraventricular infusion of vascular endothelial growth factor on cerebral blood flow, edema, and infarct volume
Harrigan, M. R., Ennis, S. R., Sullivan, S. E., & Keep, R. F. (2003) · Acta Neurochirurgica · doi:10.1007/s00701-002-1035-1 · Cited by 91
Activated Ras induces a proangiogenic phenotype in primary endothelial cells
Meadows, K. N., Bryant, P. W., Vincent, P. A., & Pumiglia, K. M. (2004) · Oncogene · doi:10.1038/sj.onc.1206921 · Cited by 90
An upstream open reading frame within an IRES controls expression of a specific VEGF-A isoform
Bastide, A., Karaa, Z. S., Bornes, S., Hiéblot, C., Lacazette, É., Prats, H., & Touriol, C. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn093 · Cited by 90
Newly identified biologically active and proteolysis-resistant VEGF-A isoform VEGF111 is induced by genotoxic agents
Mineur, P., Colige, A., Deroanne, C., Dubail, J., Kesteloot, F., Habraken, Y., Noël, A., Vöö, S. A., Waltenberger, J. L., Lapiere, C. M., et al. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200703052 · Cited by 89
Adeno-Associated Viral Vector-Mediated Hypoxia-Inducible Vascular Endothelial Growth Factor Gene Expression Attenuates Ischemic Brain Injury After Focal Cerebral Ischemia in Mice
Shen, F., Su, H., Fan, Y., Chen, Y., Zhu, Y., Liu, W., Young, W. L., & Yang, G. (2006) · Stroke · doi:10.1161/01.str.0000240407.14765.e8 · Cited by 87
Segmental organization of neural crest migration
Krull, C. E. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00395-1 · Cited by 86
Increased Severity of Cerebral Ischemic Injury in Vascular Endothelial Growth Factor-B–Deficient Mice
Sun, Y., Jin, K., Childs, J., Xie, L., Mao, X. O., & Greenberg, D. A. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000134477.38980.38 · Cited by 86
Ligand-induced internalization selects use of common receptor neuropilin-1 by VEGF165 and semaphorin3A
Narazaki, M., & Tosato, G. (2006) · Blood · doi:10.1182/blood-2005-10-4113 · Cited by 86
Direct transport of VEGF from the nasal cavity to brain
Yang, J., Liu, H., Cheng, S., Wang, Z., Cheng, X., Yu, H.-X., & Liu, X. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.10.090 · Cited by 86
Mutant Cu/Zn-Superoxide Dismutase Associated with Amyotrophic Lateral Sclerosis Destabilizes Vascular Endothelial Growth Factor mRNA and Downregulates Its Expression
Lu, L., Zheng, L., Viera, L., Suswam, E. A., Li, Y., Li, X., Estévez, Á. G., & King, P. H. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1877-07.2007 · Cited by 85
VEGF165 Therapy Exacerbates Secondary Damage Following Spinal Cord Injury
Benton, R. L., & Whittemore, S. R. (2003) · Neurochemical Research · doi:10.1023/a:1026013106016 · Cited by 84
Astrocyte growth effects of vascular endothelial growth factor (VEGF) application to perinatal neocortical explants: receptor mediation and signal transduction pathways
Mani, N., Khaibullina, A., Krum, J. M., & Rosenstein, J. M. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2004.12.022 · Cited by 84
The vascular endothelial growth factor mRNA contains an internal ribosome entry site
Miller, D. L., Dibbens, J. A., Damert, A., Risau, W., Vadas, M. A., & Goodall, G. J. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01025-4 · Cited by 84
Prognostic value of blood vessel density in ischaemic stroke
Krupiński, J., Kałuza, J., Kumar, P., Wang, M., & Kumar, S. (1993) · The Lancet · doi:10.1016/0140-6736(93)91734-4 · Cited by 83
Poly(A)-binding Protein-interacting Protein 2, a Strong Regulator of Vascular Endothelial Growth Factor mRNA
Onesto, C., Berra, E., Grépin, R., & Pagès, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400219200 · Cited by 82
Meta-analysis of vascular endothelial growth factor variations in amyotrophic lateral sclerosis: increased susceptibility in male carriers of the −2578AA genotype
Lambrechts, D., Poesen, K., Fernández‐Santiago, R., Al‐Chalabi, A., Bo, R. D., van Vught, P. W. J., Khan, S. A., Marklund, S. L., Brockington, A., van Marion, I., et al. (2008) · Journal of Medical Genetics · doi:10.1136/jmg.2008.058222 · Cited by 82
Self-citation
Rac Regulates Vascular Endothelial Growth Factor Stimulated Motility
Soga, N., Connolly, J. O., Chellaiah, M. A., Kawamura, J., & Hruska, K. A. (2001) · Cell Communication & Adhesion · doi:10.3109/15419060109080703 · Cited by 80
Electroconvulsive seizure restores neurogenesis and hippocampus‐dependent fear memory after disruption by irradiation
Warner‐Schmidt, J. L., Madsen, T. M., & Duman, R. S. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06118.x · Cited by 79
Regulatory role of dynamin‐2 in VEGFR‐2/KDR‐mediated endothelial signaling
Bhattacharya, R., Kang, N., Hughes, D. A., Mukherjee, P., Shah, V. H., McNiven, M. A., & Mukhopadhyay, D. (2005) · The FASEB Journal · doi:10.1096/fj.05-3889fje · Cited by 78
The differences between high and low-dose administration of VEGF to dopaminergic neurons of in vitro and in vivo Parkinson's disease model
Yasuhara, T., Shingo, T., Muraoka, K., Ji, Y., Kameda, M., Takeuchi, A., Yano, A., Nishio, S., Matsui, T., Miyoshi, Y., et al. (2005) · Brain Research · doi:10.1016/j.brainres.2004.12.055 · Cited by 77
Physiology of Angiogenesis
Kurz, H. (2000) · Journal of Neuro-Oncology · doi:10.1023/a:1006485716743 · Cited by 76
Astrocytic Calcium Signaling: The Information Currency Coupling Neuronal Activity to the Cerebral Microcirculation
Straub, S. V., & Nelson, M. T. (2007) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2007.05.001 · Cited by 76
Antiangiogenesis Mediates Cisplatin-Induced Peripheral Neuropathy: Attenuation or Reversal by Local Vascular Endothelial Growth Factor Gene Therapy Without Augmenting Tumor Growth
Kirchmair, R., Walter, D. H., Ii, M., Rittig, K., Tietz, A. B., Murayama, T., Emanueli, C., Silver, M., Wecker, A., Amant, C., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.470849 · Cited by 75
HSV-mediated gene transfer of vascular endothelial growth factor to dorsal root ganglia prevents diabetic neuropathy
Chattopadhyay, M., Krisky, D. M., Wolfe, D. P., Jc, G., Mata, M. M., & Dj, F. (2005) · Gene Therapy · doi:10.1038/sj.gt.3302533 · Cited by 73
Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development
Schwarz, Q., Waimey, K. E., Golding, M., et al. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.08.020 · Cited by 73
Elevated serum angiogenin levels in ALS
Cronin, S., Greenway, M. J., Ennis, S., Kieran, D., Green, A., Prehn, J. H. M., & Hardiman, O. M. (2006) · Neurology · doi:10.1212/01.wnl.0000244466.46020.47 · Cited by 72
Vascular Endothelial Growth Factor Prevents Paralysis and Motoneuron Death in a Rat Model of Excitotoxic Spinal Cord Neurodegeneration
Tovar‐y‐Romo, L. B., Zepeda, A., & Tapia, R. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181567c16 · Cited by 71
Angiogenesis in multiple sclerosis: is it good, bad or an epiphenomenon?
Kirk, S., Frank, J. A., & Karlik, S. J. (2003) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2003.10.016 · Cited by 71
Control of the Vascular Endothelial Growth Factor Internal Ribosome Entry Site (IRES) Activity and Translation Initiation by Alternatively Spliced Coding Sequences
Bornes, S., Boulard, M., Hiéblot, C., Zanibellato, C., Iacovoni, J. S., Prats, H., & Touriol, C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308410200 · Cited by 70
Cellular distribution of vascular endothelial growth factor A (VEGFA) and B (VEGFB) and VEGF receptors 1 and 2 in focal cortical dysplasia type IIB
Boer, K., Troost, D., Spliet, W. G. M., van Rijen, P. C., Gorter, J. A., & Aronica, E. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0354-6 · Cited by 69
Cerebral angiogenesis after collagenase-induced intracerebral hemorrhage in rats
Tang, T., Liu, X., Zhang, Z., Zhou, H.-J., Luo, J., Huang, J.-F., Yang, Q., & Li, X.-Q. (2007) · Brain Research · doi:10.1016/j.brainres.2007.08.028 · Cited by 67
Generation of transgenic mice with mild and severe retinal neovascularisation
Lai, C.-M. (2005) · British Journal of Ophthalmology · doi:10.1136/bjo.2004.059089 · Cited by 67
Vascular endothelial growth factor improves recovery of sensorimotor and cognitive deficits after focal cerebral ischemia in the rat
Wang, Y., Galván, V., Gorostiza, O. F., Ataie, M., Jin, K., & Greenberg, D. A. (2006) · Brain Research · doi:10.1016/j.brainres.2006.07.060 · Cited by 66
Encapsulated vascular endothelial growth factor—secreting cell grafts have neuroprotective and angiogenic effects on focal cerebral ischemia
Yano, A., Shingo, T., Takeuchi, A., Yasuhara, T., Kobayashi, K., Takahashi, K., Muraoka, K., Matsui, T., Miyoshi, Y., Hamada, H., et al. (2005) · Journal of neurosurgery · doi:10.3171/jns.2005.103.1.0104 · Cited by 66
Paradoxical response of VEGF expression to hypoxia in CSF of patients with ALS
Moreau, C. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.070904 · Cited by 64
Hypoxic Regulation of VEGF mRNA Stability by RNA-binding Proteins
Levy, A. P. (1998) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(98)00020-6 · Cited by 64
Sympathetic Innervation of Human Mesenteric Artery and Vein
Birch, D. J., Turmaine, M., Boulos, P. B., et al. (2008) · Journal of Vascular Research · doi:10.1159/000119095 · Cited by 64
Transgenic Overexpression of Vascular Endothelial Growth Factor-B Isoforms by Endothelial Cells Potentiates Postnatal Vessel Growth In Vivo and In Vitro
Mould, A. W., Greco, S. A., Cahill, M. M., Tonks, I. D., Bellomo, D., Patterson, C., Zournazi, A., Nash, A. D., Scotney, P. D., Hayward, N. K., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000182631.33638.77 · Cited by 64
The role of the Eph-ephrin signalling system in the regulation of developmental patterning
Coulthard, M. G., Duffy, S., Down, M., Evans, B., Power, M.-A., Smith, F., Stylianou, C., Wimmer-Kleikamp, S. H., Oates, A. C., Lackmann, M., et al. (2002) · The International Journal of Developmental Biology · doi:10.1387/ijdb.12141423 · Cited by 63
Overexpression of Vascular Endothelial Growth Factor 189 in Breast Cancer Cells Leads to Delayed Tumor Uptake with Dilated Intratumoral Vessels
Hervé, M.-A., Buteau-Lozano, H., Vassy, R., Bièche, I., Velasco, G., Pla, M., Perret, G. Y., Mourah, S., & Perrot‐Applanat, M. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070181 · Cited by 63
VEGF promotes vascular sympathetic innervation
Marko, S. B., & Damon, D. H. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00291.2008 · Cited by 63
VEGF Protein Associates to Neurons in Remote Regions following Cortical Infarct
Stowe, A. M., Plautz, E. J., Eisner‐Janowicz, I., Frost, S. B., Barbay, S., Zoubina, E. V., Dancause, N., Taylor, M. D., & Nudo, R. J. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600320 · Cited by 62
Schwann cells upregulate vascular endothelial growth factor secondary to chronic nerve compression injury
Gupta, R., Gray, M., Chao, T., Bear, D. G., Modafferi, E. F., & Mozaffar, T. (2005) · Muscle & Nerve · doi:10.1002/mus.20272 · Cited by 62
Neurobarrier coupling in the brain: Adjusting glucose entry with demand
Leybaert, L., Bock, M. D., Moorhem, M. V., Decrock, E., & Vuyst, E. D. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21189 · Cited by 62
Enhancement of ischemia‐induced tyrosine phosphorylation of Kv1.2 by vascular endothelial growth factor via activation of phosphatidylinositol 3‐kinase
Qiu, M., Zhang, R., & Sun, F. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02110.x · Cited by 61
Angiogenic and neurotrophic effects of vascular endothelial growth factor (VEGF165): studies of grafted and cultured embryonic ventral mesencephalic cells
Pitzer, M. R., Sortwell, C. E., Daley, B. F., McGuire, S. O., Marchionini, D. M., Fleming, M. F., & Collier, T. J. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00100-6 · Cited by 61
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Dewil, M., Lambrechts, D., Sciot, R., Shaw, P. J., Ince, P. G., Robberecht, W., & Bosch, L. V. D. (2007) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00850.x · Cited by 60
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Zheng, C., Sköld, M. K., Li, J., Nennesmo, I., Fadeel, B., & Henter, J. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.09.088 · Cited by 60
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Miki, Y., Nonoguchi, N., Ikeda, N., Coffin, R. S., Kuroiwa, T., & Miyatake, S. (2007) · Neurosurgery · doi:10.1227/01.neu.0000290907.30814.42 · Cited by 58
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Yang, S., Zhang, L., Huang, Y., & Sun, F. (2003) · The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology · doi:10.1002/ar.a.10103 · Cited by 57
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Sköld, M. K., Risling, M., & Holmin, S. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04527.x · Cited by 57
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Nishi, J.-I., Minamino, T., Miyauchi, H., Nojima, A., Tateno, K., Okada, S., Orimo, M., Moriya, J., Fong, G., Sunagawa, K., et al. (2008) · Circulation Research · doi:10.1161/circresaha.108.174128 · Cited by 56
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Iłżecka, J. (2004) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2003.12.007 · Cited by 48
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Geretti, E., Shimizu, A., Kurschat, P., & Klagsbrun, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702942200 · Cited by 48
Expression of angiogenic and neurotrophic factors in the progenitor cell niche of adult monkey subventricular zone
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See all 448

Authors: Ruiz de Almodovar, C., Lambrechts, D., Mazzone, M., & Carmeliet, P.
Venue: Physiological Reviews
Publisher: American Physiological Society
Published: 2009-04
Volume: 89
Issue: 2
Pages: 607-648
ISSN: 0031-9333 (ISSN-L)
1522-1210
DOI: 10.1152/physrev.00031.2008
OpenAlex: W2147461659
Cited by: 448
References: 443
FWCI: 1.54
Type: journal article
Language: en
Open access: closed

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Role and Therapeutic Potential of VEGF in the Nervous System

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