The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Histamine in the Nervous System
Abstract
Histamine is a transmitter in the nervous system and a signaling molecule in the gut, the skin, and the immune system. Histaminergic neurons in mammalian brain are located exclusively in the tuberomamillary nucleus of the posterior hypothalamus and send their axons all over the central nervous system. Active solely during waking, they maintain wakefulness and attention. Three of the four known histamine receptors and binding to glutamate NMDA receptors serve multiple functions in the brain, particularly control of excitability and plasticity. H1 and H2 receptor-mediated actions are mostly excitatory; H3 receptors act as inhibitory auto- and heteroreceptors. Mutual interactions with other transmitter systems form a network that links basic homeostatic and higher brain functions, including sleep-wake regulation, circadian and feeding rhythms, immunity, learning, and memory in health and disease.
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Citations
Cites
Neuronal Oscillations in Cortical Networks
Buzsáki, G., & Draguhn, A. (2004) · Science · doi:10.1126/science.1099745 · Cited by 6,576
Hypothalamic regulation of sleep and circadian rhythms
Saper, C. B., Scammell, T. E., & Lu, J. (2005) · Nature · doi:10.1038/nature04284 · Cited by 2,804
Stressor specificity of central neuroendocrine responses: implications for stress-related disorders
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Association of depression with medical illness: Does cortisol play a role?
Brown, E. S., Varghese, F. P., & McEwen, B. S. (2004) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00473-6 · Cited by 578 · cited 1×
“Modulation of somatotrope and brain-bone axis communication by the hypothalamic histamine system may impact bone physiology but also adult stem cell plasticity (700), immunity, and cancer, providing an intriguing link between brain function and tissue homeostasis (79, 730).”
BackgroundCritical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms
Chou, T. C., Scammell, T. E., Gooley, J. J., Gaus, S. E., Saper, C. B., & Lu, J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-33-10691.2003 · Cited by 576
The sedative component of anesthesia is mediated by GABAA receptors in an endogenous sleep pathway
Nelson, L. E., Guo, T. Z., Lu, J., Saper, C. B., Franks, N. P., & Maze, M. (2002) · Nature Neuroscience · doi:10.1038/nn913 · Cited by 568
Elaborate interactions between the immune and nervous systems
Steinman, L. (2004) · Nature Immunology · doi:10.1038/ni1078 · Cited by 556
Identification of sleep-promoting neurons in vitro
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Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors
Dai, H., Kaneko, K., Kato, H., Fujii, S., Jing, Y., Xu, A., Sakurai, E., Kato, M., Okamura, N., Kuramasu, A., et al. (2007) · Neuroscience Research · doi:10.1016/j.neures.2006.10.020 · Cited by 136 · cited 6×
“Likewise, H1R-KO mice are less anxious than wild-type mice (834), but both H1R-KO and H2R-KO mice show improved amygdala-dependent auditory and hippocampus-dependent contextual fear acquisition (127).”
BackgroundInfluential
Cited by
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477
Histamine and H1-antihistamines: Celebrating a century of progress
Simons, F. E. R., & Simons, K. J. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.09.005 · Cited by 541
The circadian regulation of food intake
Challet, E. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0210-x · Cited by 428
Histidine Metabolism and Function
Brosnan, M. E., & Brosnan, J. T. (2020) · The Journal of Nutrition · doi:10.1093/jn/nxaa079 · Cited by 326
Regulation of the immune response and inflammation by histamine and histamine receptors
O’Mahony, L., Akdis, M., & Akdis, C. A. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.06.051 · Cited by 313
Metadata
- Authors
- Haas, H. L., Sergeeva, O. A., & Selbach, O.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2008-07
- Volume
- 88
- Issue
- 3
- Pages
- 1183-1241
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2123035658
- Cited by
- 1,228
- References
- 11
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
