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Role of calcium ions in regulation of mammalian intramitochondrial metabolism
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“One candidate is the known effect of matrix Ca2+ in stimulating the matrix dehydrogenases including pyruvate dehydrogenase and the TCA dehydrogenases (McCormack et al., 1990).”
From Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism (2018) · cites this paper as McCormack et al., 1990
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“With low intensity stress, limited MPT leads to mitoptosis, which is followed by the elimination of degraded mitochondria.”
BackgroundInfluentialThe mitochondrial calcium uniporter is a highly selective ion channel
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“Several TCA-cycle enzymes, including pyruvate dehydrogenase and a-ketoglutarate dehydrogenase, are regulated by calcium (McCor- mack et al., 1990).”
InfluentialMitochondria and calcium: from cell signalling to cell death
Duchen, M. R. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00057.x · Cited by 1,261
“…major targets of the mitochondrial Ca¥ import pathway are the dehydrogenases of the TCA cycle, as the ratelimiting enzymes are all upregulated by Ca¥-dependent processes, as discussed by Maechler & Wollheim (2000) and Rizzuto et al. (2000) (this issue, and see McCormack et al. 1990 for review).”
BackgroundMitochondria and neuronal survival
Nicholls, D. G., & Budd, S. L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.315 · Cited by 1,243
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“78 Increased mitochondrial Ca 2 + is bene fi cial up to a point; however, chronic mitochondrial Ca 2 + overload triggered Bcl-2-mediated regulated cell death, which is primarily mediated through the induction of the mitochondrial permeability transition pore (mPTP).”
BackgroundDecoding of cytosolic calcium oscillations in the mitochondria
Hajnóczky, G., Gaspers, L. D., Seitz, M. B., & Thomas, A. P. (1995) · Cell · doi:10.1016/0092-8674(95)90430-1 · Cited by 1,110
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“We speculated that constitutive low-level InsP3R Ca 2+ release promotes oxidative phosphorylation by activation of the ATP synthase (Balaban, 2009; Territo et al., 2000) and/or dehydrogenases to provide reducing equivalents (McCormack et al., 1990).”
InfluentialRapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin
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“Sustained Ca can stimulate mitochondrial dehydrogenases, impairing the cell’s ability to suppress electron flux through the electron transport chain during hypoxia (McCormack et al. 1990).”
BackgroundRegulation of mitochondrial dehydrogenases by calcium ions
Denton, R. M. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.01.005 · Cited by 885
“Early approaches before 1990 are reviewed in [6].”
Self-citationMitochondria and neuronal activity
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“Repetitive electrical stimulation of motor neurons (10–60 s, 50–100 Hz) resulted in an plateau elevation of [Ca(2) ]m in mitochondria in axon terminals to about 1 M (45), which is in the appropriate range for activation of mitochondrial dehydrogenases (145), but well below the value necessary for opening of the MPTP (…”
BackgroundInfluentialDistinct fission signatures predict mitochondrial degradation or biogenesis.
Kleele, T., Rey, T., Winter, J., Zaganelli, S., Mahecic, D., Perreten Lambert, H., Ruberto, F. P., Nemir, M., Wai, T., Pedrazzini, T., et al. (2021) · Nature · doi:10.1038/s41586-021-03510-6 · Cited by 794
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“activity mediated by cyclic AMP and intramitochondrial [Ca(2) ] accumulation (38, 112, 113).”
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“An increase in [Ca(2) ]M can also activate several TCA cycle enzymes, leading to increased NADH production, secondary enhancement of electron transport, and repolarization of M (440, 1224).”
BackgroundMitochondria in health and disease: perspectives on a new mitochondrial biology
Duchen, M. R. (2004) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.03.001 · Cited by 747
“In the early 1990s it became clear that the three major rate limiting enzymes of the citric acid cycle are all upregulated by Ca2þ (McCormack et al., 1990).”
BackgroundThe permeability transition pore complex: another view
Halestrap, A. P., McStay, G. P., & Clarke, S. J. (2002) · Biochimie · doi:10.1016/s0300-9084(02)01375-5 · Cited by 709
“The resulting increase in matrix NADH/NAD stimulates respiration leading to an increase in proton motive force (pmf) and ATP production [14].”
Self-citationMitochondrial Dysfunction in Cardiac Disease: Ischemia–Reperfusion, Aging, and Heart Failure
Lesnefsky, E. J., Moghaddas, S., Tandler, B., Kerner, J., & Hoppel, C. L. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1378 · Cited by 719
Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death
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“Ca2+ flux across the inner mitochondrial membrane (IMM) regulates cell bioenergetics, cytoplasmic Ca2+ ([Ca]i) signals and activation of cell death pathways (Balaban, 2009; Denton and McCormack, 1980; Duchen et al., 2008; Gunter and Gunter, 1994; Hajnoczky et al., 1995; Hansford, 1994; Herrington et al., 1996; Lemaste…”
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“Intramitochondrial Ca(2) is recognized as an allosteric activator of matrix dehydrogenases, such as NAD -isocitrate dehydrogenase, pyruvate dehydrogenase and -ketoglutarate dehydrogenase (104) and as co-factor of mitochondrial nitric oxide (NO) synthase (mtNOS) (59).”
BackgroundRole of Mitochondrial Ca2+ in the Regulation of Cellular Energetics
Glancy, B. C., & Balaban, R. S. (2012) · Biochemistry · doi:10.1021/bi2018909 · Cited by 649
“With many cellular systems the addition of Ca2+, via a wide variety of methods, has convincingly demonstrated an activation of NAD(P)H generation by the entry of Ca2+ into the mitochondrial matrix (12).”
BackgroundInfluentialBonora, M., Patergnani, S., Rimessi, A., De Marchi, E., Suski, J. M., Bononi, A., Giorgi, C., Marchi, S., Missiroli, S., Poletti, F., et al. (2012) · Purinergic Signalling · doi:10.1007/s11302-012-9305-8 · Cited by 644
“NADH and thus ATP production [55, 56].”
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“A substantial impetus was given to attempts to address these issues by the discovery that the key rate-limiting enzymes of the citric acid cycle are upregulated by Ca¥, either directly or through the regulation of phosphorylation reactions (for review, see McCormack et al. 1990).”
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Control of respiration and ATP synthesis in mammalian mitochondria and cells
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Mitochondria as all‐round players of the calcium game
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Mitochondrial Participation in the Intracellular Ca2+ Network
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“The rapid rise of Cam to even modest physiological Cac loads presumably also means that mitochondrial energy metabolism adjusts itself to cellular activities from moment to moment (McCormack et al., 1990; Gunter et al., 1994; Hajnóczky et al., 1995; Rutter et al., 1996).”
BackgroundEndoplasmic Reticulum and the Unfolded Protein Response
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“Additionally, also many other mitochondrial processes, such as fatty acid oxidation, amino acid catabolism, F1-ATPase manganese superoxide dismutase activity, aspartate and glutamate carrier, as well as the adenine-nucleotide translocase activity, are regulated by mitochondrial calcium (McCormack et al., 1990; Hayashi…”
BackgroundQuasi‐synaptic calcium signal transmission between endoplasmic reticulum and mitochondria
Csordás, G., Thomas, A. P., & Hajnóczky, G. (1999) · The EMBO Journal · doi:10.1093/emboj/18.1.96 · Cited by 550
“Calcium is a well-known activator of mitochondrial dehydrogenases (for review see McCormack et al., 1990) and so Ca2 could be an ideal signal to synchronize cell function and mitochondrial metabolism during stimulation by Ca2 -mobilizing stimuli.”
BackgroundCellular magnesium homeostasis
Romani, A. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.05.010 · Cited by 542
Mitochondrial function in normal and diabetic β-cells
Maechler, P., & Wollheim, C. B. (2001) · Nature · doi:10.1038/414807a · Cited by 519
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“At the same time, whereas pulsatile, transient increases in matrix [Ca] ([Ca]mt), which occur in stimulated cells, are essential for stimulating Casensitive dehydrogenases and upregulating ATP production (Jouaville et al., 1999; McCormack et al., 1990), continuous Ca accumulation in resting conditions would on the one…”
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Apoptosis driven by IP3‐linked mitochondrial calcium signals
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Control of aldosterone secretion: a model for convergence in cellular signaling pathways
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Mitochondria buffer physiological calcium loads in cultured rat dorsal root ganglion neurons
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“Indeed, it has been suggested that intramitochondrial CaZ+ serves as a means to couple energy demands to ATP production (McCormack et al., 1990).”
BackgroundRaffaello, A., Stefani, D. D., Sabbadin, D., Teardo, E., Merli, G., Picard, A., Checchetto, V., Moro, S., Szabó, I., & Rizzuto, R. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.157 · Cited by 489
“…it became soon clear that the [Ca 2 þ ] mt changes modulate key cellular processes, such as aerobic metabolism (through Ca 2 þ -sensitive dehydrogenases; McCormack et al , 1990; Denton, 2009) and the release of pro-apoptotic factors (Szalai et al , 1999 Pinton et al , 2001; Scorrano et al , 2003).”
Mitochondrial Dysfunction in Cancer
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“Key ETC proteins (subunits of ND and cytochrome b, for example) are encoded by the mitochondrial genome and since these proteins are translated in the mitochondrial matrix, coordinated induction of mitochondrial encoded tRNAs and rRNA expression is also required (104).”
BackgroundInfluentialMCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism
Mallilankaraman, K. B., Cárdenas, C., Doonan, P. J., Chandramoorthy, H. C. K., Irrinki, K. M., Golenár, T., Csordás, G., Madireddi, P., Yang, J., Müller, M., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2622 · Cited by 487
Regulation of energy substrate metabolism in the diabetic heart
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Ca2+ transfer from the ER to mitochondria: When, how and why
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“localized in the matrix, the pyruvate-, α-ketoglutarate- and isocitrate-dehydrogenases (collectively called the Ca2+-sensitive mitochondrial dehydrogenases, CSMDHs) are activated by Ca2+, with different mechanisms: the first through a Ca2+-dependent dephosphorylation step, the others via direct binding to a regulatory…”
BackgroundSzabadkai, G., Simoni, A. M., Chami, M., Wieckowski, M. R., Youle, R. J., & Rizzuto, R. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.09.026 · Cited by 468
“Conversely, the sensitivity to staurosporinecreased cellular needs (McCormack et al., 1990).”
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“Moreover, when taken up by the mitochondria, Ca(2) can physiologically increase ATP generation by activating matrix dehydrogenases (6).”
BackgroundMitochondria-Immobilized pH-Sensitive Off–On Fluorescent Probe
Lee, M. H., Park, N., Yi, C., Han, J. H., Hong, J. H., Kim, K. P., Kang, D. H., Sessler, J. L., Kang, C., & Kim, J. S. (2014) · Journal of the American Chemical Society · doi:10.1021/ja506301n · Cited by 473
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“Activation of the TCA cycle dehydrogenases by increasing mitochondrial calcium (McCormack et al., 1990) with the calcium ionophore A23187 (0.”
BackgroundInfluentialRapizzi, E., Pinton, P., Szabadkai, G., Wieckowski, M. R., Vandecasteele, G., Baird, G., Tuft, R. A., Fogarty, K. E., & Rizzuto, R. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200205091 · Cited by 453
“On one hand, an increase in [Ca 2 ] m can increase the production of ATP by activating matrix dehydrogenases in agonist-stimulated cells (McCormack et al., 1990; Robb-Gaspers et al., 1998; Jouaville et al., 1999).”
BackgroundCheung, K., Shineman, D. W., Müller, M., Cárdenas, C., Mei, L., Yang, J., Tomita, T., Iwatsubo, T., Lee, V. M. ‐., & Foskett, J. K. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.015 · Cited by 460
Direct Inhibition of Mitochondrial Respiratory Chain Complex III by Cell-permeable Ceramide
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Ca 2+ activation of heart mitochondrial oxidative phosphorylation: role of the F 0 /F 1 -ATPase
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“The activation of the PDC observed in working hearts submitted to increased workload or perfused with epinephrine appears to be the result of increased mitochondrial Ca 21 entry.(52)”
BackgroundEnjoy the Trip: Calcium in Mitochondria Back and Forth
Stefani, D. D., Rizzuto, R., & Pozzan, T. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034216 · Cited by 424
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“The overall rate of the Krebs cycle is considered to be determined by the activities of citrate synthase, isocitrate dehydrogenase, and a-KGDH (Cooney et al., 1981; McCormack et al., 1990; Moreno-Sanchez et al., 1990).”
BackgroundHeart mitochondria: gates of life and death
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“For instance, uptake of Ca2þ results in the activation of three dehydrogenases in the mitochondrial matrix.(35) This causes an increase in mitochondrial NADH/NADþ ratio which may result in increased energy available for mitochondrial functions.”
BackgroundMallilankaraman, K. B., Cárdenas, C., Doonan, P. J., Chandramoorthy, H. C. K., Irrinki, K. M., Golenár, T., Csordás, G., Madireddi, P., Yang, J., Müller, M., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3202 · Cited by 418
Mitochondria: The Hub of Cellular Ca2+Signaling
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“ply of reducing equivalents [NAD(P)H+] (67, 84, 86).”
BackgroundReactive oxygen species and yeast apoptosis
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“Mild increases in matrix Ca can stimulate activity of the tricarboxylic acid cycle enzymes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and NAD-isocitrate dehydrogenase [127] leading to increased respiratory energy production.”
BackgroundEnergy metabolism of the heart: From basic concepts to clinical applications applications
Taegtmeyer, H. (1994) · Current Problems in Cardiology · doi:10.1016/0146-2806(94)90008-6 · Cited by 392
Mitochondrial dysfunction in neurodegenerative disorders
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“This ultimately increases ATP production [91,92].”
Reactive oxygen species and oxidative stress in osteoclastogenesis, skeletal aging and bone diseases
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“The increase in intermitochondrial Ca2+ is then able to escalate the rate of oxidative phosphorylation by activating isocitrate dehydrogenase, α-ketoglutarate dehydrogenase, and pyruvate dehydrogenase [44], which will also increase the amount of superoxide produced.”
BackgroundGunter, T. E., Yule, D. I., Gunter, K. K., Eliseev, R. A., & Salter, J. D. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.03.071 · Cited by 419
An Integrated Model of Cardiac Mitochondrial Energy Metabolism and Calcium Dynamics
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“In isolated mitochondria, Ca (21)stimulation can increase NADH (McCormack et al., 1990; Hansford and Zorov, 1998; Territo et al., 2000), but the magnitude of this increase will also depend on any downstream effects on NADH oxidation.”
BackgroundInfluentialMitochondrial calcium transport: mechanisms and functions
Gunter, T. E., Buntinas, L., Sparagna, G. C., Eliseev, R. A., & Gunter, K. K. (2000) · Cell Calcium · doi:10.1054/ceca.2000.0168 · Cited by 378
Mitochondrial calcium as a key regulator of mitochondrial ATP production in mammalian cells
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“[10], and see chapter by Denton in this volume).”
BackgroundInfluentialEndothelial Mitochondria: Contributing to Vascular Function and Disease
Davidson, S. M., & Duchen, M. R. (2007) · Circulation Research · doi:10.1161/01.res.0000261970.18328.1d · Cited by 381
Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism
Yellen, G. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201803152 · Cited by 371
“, 2014) If both components of the NAD(P)H signal are substantially mitochondrial in origin, then what accounts for the overshoot? One candidate is the known effect of matrix Ca2+ in stimulating the matrix dehydrogenases including pyruvate dehydrogenase and the TCA dehydrogenases (McCormack et al., 1990).”
BackgroundIntegrating cytosolic calcium signals into mitochondrial metabolic responses
Gaspers, L. D., Burnett, P., Rutter, G. A., Denton, R. M., Rizzuto, R., & Thomas, A. P. (1998) · The EMBO Journal · doi:10.1093/emboj/17.17.4987 · Cited by 370
“…in the concentration of Ca2 in mitochondria ([Ca2 ]m), and that this is important for the stimulation of mitochondrial oxidative metabolism (McCormack et al., 1990; Duchen, © Oxford University Press 4987 1992; Loew et al., 1994; Rizzuto et al., 1994; Hajnóczky et al., 1995; Rutter et al.,…”
BackgroundSelf-citationLogan, C. V., Szabadkai, G., Sharpe, J. A., Parry, D. A., Torelli, S., Childs, A., Kriek, M., Phadke, R., Johnson, C. A., Roberts, N. Y., et al. (2013) · Nature Genetics · doi:10.1038/ng.2851 · Cited by 372
The role of the mitochondrial permeability transition pore in heart disease
Halestrap, A. P., & Pasdois, P. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.12.017 · Cited by 362
Self-citationTinel, H., Cancela, J., Mogami, H., Gerasimenko, J. V., Gerasimenko, O. V., Tepikin, A. V., & Petersen, O. H. (1999) · The EMBO Journal · doi:10.1093/emboj/18.18.4999 · Cited by 365
Mechanisms of Altered Ca 2+ Handling in Heart Failure
Luo, M., & Anderson, M. E. (2013) · Circulation Research · doi:10.1161/circresaha.113.301651 · Cited by 392
“reducing equivalents (NADH/NADPH) for electron transport.(116) Metabolic regulation by mitochondrial Ca uptake,”
A mitochondrial bioenergetic etiology of disease
Wallace, D. C. (2013) · Journal of Clinical Investigation · doi:10.1172/jci61398 · Cited by 342
Control of mitochondrial ATP synthesis in the heart
Harris, D. A., & Das, A. M. (1991) · Biochemical Journal · doi:10.1042/bj2800561 · Cited by 352
Cardiac Energy Metabolism Homeostasis: Role of Cytosolic Calcium
Balaban, R. S. (2002) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2002.2082 · Cited by 357
Plant organellar calcium signalling: an emerging field
Stael, S., Wurzinger, B., Mair, A., Mehlmer, N., Vothknecht, U. C., & Teige, M. (2011) · Journal of Experimental Botany · doi:10.1093/jxb/err394 · Cited by 357
“On the other hand, the elevation of Ca inside the mitochondria positively affects ATP production by up-regulating the major limiting enzymes of the citric acid cycle (similar to the up-regulation of the Calvin cycle in chloroplasts) (McCormack et al., 1990).”
BackgroundMitochondrial metabolism of reactive oxygen species
Venditti, P., Stefano, L. D., & Meo, S. D. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.01.008 · Cited by 359
“Conversely, under oxidative stress, mitochondrial Ca overload depresses mitochondrial function (McCormack et al., 1990) and primes different processes, which might lead to irreversible cell damage.”
BackgroundCa2+-dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons
Duchen, M. R. (1992) · Biochemical Journal · doi:10.1042/bj2830041 · Cited by 335
Bound and determined: A computer program for making buffers of defined ion concentrations
Brooks, S. P. J., & Storey, K. B. (1992) · Analytical Biochemistry · doi:10.1016/0003-2697(92)90183-8 · Cited by 335
Manganese neurotoxicity and the role of reactive oxygen species
Martinez‐Finley, E. J., Gavin, C. E., Aschner, M., & Gunter, T. E. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.01.032 · Cited by 345
Garlid, K., Santos, P. D. D., Xie, Z., Costa, A. D. T., & Pauček, P. (2003) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(03)00109-9 · Cited by 333
“Volume-activation appears to play an important role in hormone-stimulated gluconeogenesis and FA oxidation, and stimulation of FA oxidation can be mimicked in hepatocytes by increasing matrix volume with low doses of valinomycin [167,168].”
BackgroundMitochondrial Ca2+ homeostasis in intact cells.
Rizzuto, R., Bastianutto, C., Brini, M., Murgia, M., & Pozzan, T. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.5.1183 · Cited by 323
Park, M. K., Ashby, M. C., Erdemli, G., Petersen, O. H., & Tepikin, A. V. (2001) · The EMBO Journal · doi:10.1093/emboj/20.8.1863 · Cited by 323
Metadata
- Authors
- McCormack, J. G., Halestrap, A. P., & Denton, R. M.
- Affiliations
- University of Leeds (GB)
- ORCID
- Halestrap, A. P.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 1990-04-01
- Volume
- 70
- Issue
- 2
- Pages
- 391-425
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W1935060748
- Cited by
- 1,398
- References
- 0
- Citations by year
- 2026: 18 · 2025: 21 · 2024: 16 · 2023: 33 · 2022: 26 · 2021: 44 · 2020: 40 · 2019: 39 · 2018: 36 · 2017: 40 · 2016: 47 · 2015: 37 · 2014: 53 · 2013: 63 · 2012: 68
- FWCI
- 10.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Keywords
- calcium ions, mitochondrial calcium, calcium signaling, mammalian mitochondria
- MeSH terms
- Animals, Calcium, Humans, Ions, Mammals, Mitochondria, Osmolar Concentration, Oxidoreductases, Oxygen Consumption, Pyrophosphatases
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