Cited by 288Peroxisome Proliferator-Activated ReceptorsAdipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity

The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.

PPARs, Obesity, and Inflammation

Open access

Stienstra, Rinke, Duval, Caroline, Müller, Michael, Kersten, Sander·2007·PPAR Research

DOI 10.1155/2007/95974PMC PMC1783744

Open this paper in CoChat — free account Open PDF

Abstract

The worldwide prevalence of obesity and related metabolic disorders is rising rapidly, increasing the burden on our healthcare system. Obesity is often accompanied by excess fat storage in tissues other than adipose tissue, including liver and skeletal muscle, which may lead to local insulin resistance and may stimulate inflammation, as in steatohepatitis. In addition, obesity changes the morphology and composition of adipose tissue, leading to changes in protein production and secretion. Some of these secreted proteins, including several proinflammatory mediators, may be produced by macrophages resident in the adipose tissue. The changes in inflammatory status of adipose tissue and liver with obesity feed a growing recognition that obesity represents a state of chronic low-level inflammation. Various molecular mechanisms have been implicated in obesity-induced inflammation, some of which are modulated by the peroxisome proliferator-activated receptors (PPARs). PPARs are ligand-activated transcription factors involved in the regulation of numerous biological processes, including lipid and glucose metabolism, and overall energy homeostasis. Importantly, PPARs also modulate the inflammatory response, which makes them an interesting therapeutic target to mitigate obesity-induced inflammation and its consequences. This review will address the role of PPARs in obesity-induced inflammation specifically in adipose tissue, liver, and the vascular wall.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1155/2007/95974

Cites

99 of 99 references verified0 citation errors · 0 not checkable

Statistics

Figure 1 Central role of PPARs in obesity-induced inflammation. (Visceral) obesity and associated fatty liver stimulate inflammation in adipose tissue and liver via increased recruitment and infiltration of macrophages, resulting in increased production of proinflammatory cytokines. By downregulating proinflammatory genes in liver, adipose tissue and the vascular wall, PPARs have a major influence on the progression of obesity-related inflammation and its complications.CC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Nonalcoholic Fatty Liver Disease
Angulo, P. (2002) · New England Journal of Medicine · doi:10.1056/nejmra011775 · Cited by 5,228
Atherosclerosis
Lusis, A. J. (2000) · Nature · doi:10.1038/35025203 · Cited by 4,880
Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial
Dormandy, J. A., Charbonnel, B., Eckland, D. J., Erdmann, E., Massi-Benedetti, M., Moules, I. K., Skene, A. M., Tan, M. H., Lefèbvre, P. J., Murray, G. D., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67528-9 · Cited by 4,129
Banting lecture 1988. Role of insulin resistance in human disease.
Reaven, G. (1988) · Diabetes · doi:10.2337/diabetes.37.12.1595 · Cited by 3,801
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
Tontonoz, P., Hu, E., & Spiegelman, B. M. (1994) · Cell · doi:10.1016/0092-8674(94)90006-x · Cited by 3,564
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature · doi:10.1038/34178 · Cited by 3,525

Show all 98 references

Research works printed but not linked: 4

10.1172/JCI200420468 · DOI
10.1016/S0140-6736(05)17912-4 · DOI · Paper page
10.1210/jc.83.5.1818 · DOI
10.1210/jc.86.7.3452 · DOI

Sorted by citations

Beta Cell Dysfunction and Insulin Resistance
Cerf, M. E. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00037 · Cited by 964
Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review
Miguel, M. G. (2010) · Molecules · doi:10.3390/molecules15129252 · Cited by 933
Obesity, Hypertension, and Cardiac Dysfunction
Mouton, A. J., Li, X., Hall, M. E., & Hall, J. E. (2020) · Circulation Research · doi:10.1161/circresaha.119.312321 · Cited by 561
Mechanisms of Obesity-Induced Inflammation and Insulin Resistance: Insights into the Emerging Role of Nutritional Strategies
McArdle, M. A., Finucane, O. M., Connaughton, R. M., McMorrow, A. M., & Roche, H. M. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00052 · Cited by 552
Cannabinoids go nuclear: evidence for activation of peroxisome proliferator‐activated receptors
O’Sullivan, S. E. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707423 · Cited by 509
Prebiotic Effects of Wheat Arabinoxylan Related to the Increase in Bifidobacteria, Roseburia and Bacteroides/Prevotella in Diet-Induced Obese Mice
Neyrinck, A. M., Possemiers, S., Druart, C., Van de Wiele, T., De Backer, F., Cani, P. D., Larondelle, Y., & Delzenne, N. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020944 · Cited by 465
PPAR-γ signaling in nonalcoholic fatty liver disease: Pathogenesis and therapeutic targets
Chen, H., Tan, H., Wan, J., Zeng, Y., Wang, J., Wang, H., & Lu, X. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108391 · Cited by 342
Dietary Capsaicin Reduces Obesity‐induced Insulin Resistance and Hepatic Steatosis in Obese Mice Fed a High‐fat Diet
Kang, J., Goto, T., Han, I., Kawada, T., Kim, Y. M., & Yu, R. (2009) · Obesity · doi:10.1038/oby.2009.301 · Cited by 318
Nuclear receptors and nonalcoholic fatty liver disease
Cave, M. C., Clair, H. B., Hardesty, J., Falkner, K. C., Feng, W., Clark, B. J., Sidey, J., Shi, H., Aqel, B. A., McClain, C. J., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2016.03.002 · Cited by 292
The Pathogenesis of Pterygium: Current Concepts and Their Therapeutic Implications
Chui, J. J. Y., Girolamo, N. D., Wakefield, D., & Coroneo, M. T. (2008) · The Ocular Surface · doi:10.1016/s1542-0124(12)70103-9 · Cited by 279
PPARs and nonalcoholic fatty liver disease
Liss, K. H. H., & Finck, B. N. (2016) · Biochimie · doi:10.1016/j.biochi.2016.11.009 · Cited by 282
Quercetin Ameliorates Cardiovascular, Hepatic, and Metabolic Changes in Diet-Induced Metabolic Syndrome in Rats
Panchal, S. K., Poudyal, H., & Brown, L. (2012) · Journal of Nutrition · doi:10.3945/jn.111.157263 · Cited by 275
Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice
Dewulf, E. M., Cani, P. D., Neyrinck, A. M., Possemiers, S., Holle, A. V., Muccioli, G. G., Deldicque, L., Bindels, L. B., Pachikian, B. D., Sohet, F. M., et al. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.05.009 · Cited by 276
Akkermansia muciniphila-Derived Extracellular Vesicles as a Mucosal Delivery Vector for Amelioration of Obesity in Mice
Ashrafian, F., Shahryari, A., Behrouzi, A., Moradi, H. R., Raftar, S. K. A., Lari, A., Hadifar, S., Yaghoubfar, R., Badi, S. A., Khatami, S., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02155 · Cited by 268
The Anti-Inflammatory Properties of Phytochemicals and Their Effects on Epigenetic Mechanisms Involved in TLR4/NF-κB-Mediated Inflammation
Saleh, H. A., Yousef, M. H., & Abdelnaser, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.606069 · Cited by 269
Cannabinoid activation of peroxisome proliferator-activated receptors: potential for modulation of inflammatory disease.
O'Sullivan, S., & Kendall, D. (2010) · Immunobiology · doi:10.1016/j.imbio.2009.09.007 · Cited by 249
Probiotics Reduce the Inflammatory Response Induced by a High-Fat Diet in the Liver of Young Rats
Esposito, E., Iacono, A., Bianco, G., Autore, G., Cuzzocrea, S., Vajro, P., Canani, R. B., Calignano, A., Raso, G. M., & Meli, R. (2009) · Journal of Nutrition · doi:10.3945/jn.108.101808 · Cited by 238
The Effects of Soy Isoflavones on Obesity
Ørgaard, A., & Jensen, L. (2008) · Experimental Biology and Medicine · doi:10.3181/0712-mr-347 · Cited by 225
Common and Novel Markers for Measuring Inflammation and Oxidative Stress Ex Vivo in Research and Clinical Practice—Which to Use Regarding Disease Outcomes?
Menzel, A., Samouda, H., Dohet, F., Loap, S., Ellulu, M. S., & Bohn, T. (2021) · Antioxidants · doi:10.3390/antiox10030414 · Cited by 255
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
Smith, J. J., Kenney, R. D., Gagne, D. J., Frushour, B. P., Ladd, W., Galonek, H. L., Israelian, K., Song, J., Razvadauskaite, G., Lynch, A. V., et al. (2009) · BMC Systems Biology · doi:10.1186/1752-0509-3-31 · Cited by 186
Molecular Pathogenesis of NASH
Caligiuri, A., Gentilini, A., & Marra, F. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091575 · Cited by 219
Beyond insulin resistance
Maher, J. J., León, P., & Ryan, J. C. (2008) · Hepatology · doi:10.1002/hep.22399 · Cited by 208
Peroxisome Proliferator-activated Receptor γ Activation Promotes Infiltration of Alternatively Activated Macrophages into Adipose Tissue
Stienstra, R., Duval, C., Keshtkar, S., van der Laak, J. A. W. M., Kersten, S., & Müller, M. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710314200 · Cited by 194
Self-citation
PPARγ inhibits NF-κB-dependent transcriptional activation in skeletal muscle
Remels, A. H. V., LANGEN, R. C. J., Gosker, H. R., Russell, A. P., Spaapen, F., Voncken, J. W., Schrauwen, P., & Schols, A. M. W. J. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90632.2008 · Cited by 194
Short Chain Fatty Acid Metabolism in Relation to Gut Microbiota and Genetic Variability
Meyers, G. R., Samouda, H., & Bohn, T. (2022) · Nutrients · doi:10.3390/nu14245361 · Cited by 208
DNA Methylation in Oocytes and Liver of Female Mice and Their Offspring: Effects of High-Fat-Diet–Induced Obesity
Ge, Z., Luo, S., Lin, F., Liang, Q., Huang, L., Wei, Y., Hou, Y., Han, Z., Schatten, H., & Sun, Q. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1307047 · Cited by 170
Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity
Mayoral, R., Osborn, O., McNelis, J., Johnson, A. M., Oh, D. Y., Llorente, C., Chung, H., Li, P., Través, P. G., Bandyopadhyay, G. K., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.02.007 · Cited by 171
Cocoa and Dark Chocolate Polyphenols: From Biology to Clinical Applications
Magrone, T., Russo, M. A., & Jirillo, E. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00677 · Cited by 164
Isoflavonoids — an overview of their biological activities and potential health benefits
Miadoková, E. (2009) · Interdisciplinary Toxicology · doi:10.2478/v10102-009-0021-3 · Cited by 154
What is the role of lifestyle behaviour change associated with non-communicable disease risk in managing musculoskeletal health conditions with special reference to chronic pain?
Dean, E., & Söderlund, A. (2015) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-015-0545-y · Cited by 163
A phase II trial of a multi‐agent oral antiangiogenic (metronomic) regimen in children with recurrent or progressive cancer
Robison, N. J., Campigotto, F., Chi, S. N., Manley, P. E., Turner, C. D., Zimmerman, M. A., Chordas, C. A., Werger, A. M., Allen, J. C., Goldman, S., et al. (2013) · Pediatric Blood & Cancer · doi:10.1002/pbc.24794 · Cited by 151
Transcriptional profiling reveals divergent roles of PPARα and PPARβ/δ in regulation of gene expression in mouse liver
Sanderson, L. M., Boekschoten, M. V., Desvergne, B., Müller, M. M., & Kersten, S. (2009) · Physiological Genomics · doi:10.1152/physiolgenomics.00127.2009 · Cited by 147
Self-citation
Hibiscus sabdariffa extract inhibits obesity and fat accumulation, and improves liver steatosis in humans
Chang, H.-C., Peng, C., Yeh, D., Kao, E., & Wang, C. (2014) · Food & Function · doi:10.1039/c3fo60495k · Cited by 138
Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity
Pedro, J. M. B., Sica, V., Martins, I., Pol, J. G., Loos, F., Maiuri, M. C., Durand, S., Bossut, N., Aprahamian, F., Anagnostopoulos, G., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.010 · Cited by 127
Phytoestrogens and the metabolic syndrome
Jungbauer, A., & Medjakovic, S. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.12.009 · Cited by 128
Epigenetics: The missing link to understanding β-cell dysfunction in the pathogenesis of type 2 diabetes
Gilbert, E. R., & Liu, D. (2012) · Epigenetics · doi:10.4161/epi.21238 · Cited by 124
Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) controls adipogenesis in obesity in mice and in humans
Meißburger, B., Stachorski, L., Roeder, E., Rudofsky, G., & Wolfrum, C. (2011) · Diabetologia · doi:10.1007/s00125-011-2093-9 · Cited by 119
Mechanisms linking obesity, inflammation and altered metabolism to colon carcinogenesis
Yehuda‐Shnaidman, E., & Schwartz, B. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01024.x · Cited by 112
Identification of co-expression gene networks, regulatory genes and pathways for obesity based on adipose tissue RNA sequencing in a porcine model
Kogelman, L. J. A., Cirera, S., Zhernakova, D. V., Fredholm, M., Franke, L., & Kadarmideen, H. N. (2014) · BMC Medical Genomics · doi:10.1186/1755-8794-7-57 · Cited by 106
Interferon regulatory factor 7 deficiency prevents diet-induced obesity and insulin resistance
Wang, X., Zhang, R., Zhang, S., Deng, S., Jiang, D., Zhong, J., Yang, L. C., Wang, T., Hong, S., Guo, S., et al. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00505.2012 · Cited by 110
The Dietary Isoflavone Daidzein Reduces Expression of Pro-Inflammatory Genes through PPARα/γ and JNK Pathways in Adipocyte and Macrophage Co-Cultures
Sakamoto, Y. S., Kanatsu, J., Toh, M., Naka, A., Kondo, K., & Iida, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149676 · Cited by 98
Epoxyeicosatrienoic acids and soluble epoxide hydrolase: potential therapeutic targets for inflammation and its induced carcinogenesis.
Norwood, S. D., Liao, J., Hammock, B. D., & Yang, G. Y. (2010) · PubMed Central · Cited by 97
Bisphenol A (BPA) Leading to Obesity and Cardiovascular Complications: A Compilation of Current In Vivo Study
Naomi, R., Yazid, M. D., Bahari, H., Yong, Y. K., Rajandram, R., Embong, H., Teoh, S. H., Halim, S., & Othman, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23062969 · Cited by 105
Molecular mechanisms underlying the potential antiobesity‐related diseases effect of cocoa polyphenols
Ali, F., Ismail, A., & Kersten, S. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300277 · Cited by 95
Self-citation
Adipose-derived mesenchymal stem cells improve glucose homeostasis in high-fat diet-induced obese mice
Cao, M., Pan, Q., Dong, H., Yuan, X., Li, Y., Sun, Z., Dong, X., & Wang, H. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0201-3 · Cited by 91
The role of the endocannabinoid system in lipogenesis and fatty acid metabolism
Vettor, R., & Pagano, C. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.10.002 · Cited by 90
Body Mass Index and Obesity- and Diabetes-Associated Genotypes and Risk for Pancreatic Cancer
Tang, H., Dong, X., Hassan, M. M., Abbruzzese, J. L., & Li, D. (2011) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-10-0845 · Cited by 89
Role of peroxisome proliferator-activated receptors in non-alcoholic fatty liver disease inflammation
Silva, A. K. S., & Peixoto, C. A. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2838-4 · Cited by 89
Baicalin inhibits autophagy induced by influenza A virus H3N2
Zhu, H., Han, L., Shi, X., Wang, B., Huang, H. Y., Wang, X., Chen, D., Ju, D., & Feng, M. (2014) · Antiviral Research · doi:10.1016/j.antiviral.2014.11.003 · Cited by 90
Comparative hepatotoxicity of 6:2 fluorotelomer carboxylic acid and 6:2 fluorotelomer sulfonic acid, two fluorinated alternatives to long-chain perfluoroalkyl acids, on adult male mice
Sheng, N., Zhou, X., Zheng, F. Y., Pan, Y., Guo, X., Guo, Y., Sun, Y., & Dai, J. (2016) · Archives of Toxicology · doi:10.1007/s00204-016-1917-2 · Cited by 87
Distinctive modulation of inflammatory and metabolic parameters in relation to zinc nutritional status in adult overweight/obese subjects
Costarelli, L., Muti, E., Malavolta, M., Cipriano, C., Giacconi, R., Tesei, S., Piacenza, F., Pierpaoli, S., Gasparini, N., Faloia, E., et al. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.02.001 · Cited by 85
Relations of C-Reactive Protein and Obesity to the Prevalence and the Odds of Reporting Low Back Pain
Briggs, M. S., Givens, D. L., Schmitt, L. C., & Taylor, C. A. (2012) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2012.11.026 · Cited by 87
The Role of Tocotrienol in Protecting Against Metabolic Diseases
Pang, K.-L., & Chin, K. (2019) · Molecules · doi:10.3390/molecules24050923 · Cited by 82
Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on Cannabidiol
Bielawiec, P., Harasim‐Symbor, E., & Chabowski, A. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00114 · Cited by 82
Lipids dysregulation in diseases: core concepts, targets and treatment strategies
Dakal, T. C., Xiao, F., Bhusal, C. K., Sabapathy, P. C., Segal, R., Chen, J., & Bai, X. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-024-02425-1 · Cited by 89
Adenovirus 36 as an Obesity Agent Maintains the Obesity State by Increasing MCP-1 and Inducing Inflammation
Na, H.-N., & Nam, J. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir864 · Cited by 80
Misregulation of PPAR Functioning and Its Pathogenic Consequences Associated with Nonalcoholic Fatty Liver Disease in Human Obesity
Videla, L. A., & Pettinelli, P. (2012) · PPAR Research · doi:10.1155/2012/107434 · Cited by 79
Calorie Restriction with a High-Fat Diet Effectively Attenuated Inflammatory Response and Oxidative Stress-Related Markers in Obese Tissues of the High Diet Fed Rats
Park, S., Park, N.-Y., Valacchi, G., & Lim, Y. (2012) · Mediators of Inflammation · doi:10.1155/2012/984643 · Cited by 77
Insights into the role of macrophage migration inhibitory factor in obesity and insulin resistance
Finucane, O. M., Reynolds, C. M., McGillicuddy, F. C., & Roche, H. M. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112000730 · Cited by 81
Targeting n-3 Polyunsaturated Fatty Acids in Non-Alcoholic Fatty Liver Disease
Valenzuela, R., Ortíz, M., Hernández‐Rodas, M. C., Echeverría, F., & Videla, L. A. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867326666190410121716 · Cited by 75
Diet-induced obesity alters the maternal metabolome and early placenta transcriptome and decreases placenta vascularity in the mouse†
Stuart, T., O’Neill, K. E., Condon, D. E., Sasson, I., Sen, P., Xia, Y., & Simmons, R. A. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy010 · Cited by 74
Chicoric acid prevents obesity by attenuating hepatic steatosis, inflammation and oxidative stress in high-fat diet-fed mice
Xiao, H., Xie, G. Y., Wang, J., Hou, X., Wang, X., Wu, W., & Liu, X. (2013) · Food Research International · doi:10.1016/j.foodres.2013.07.033 · Cited by 74
Effects of Tetramethylpyrazine from Chinese Black Vinegar on Antioxidant and Hypolipidemia Activities in HepG2 Cells
Chen, J., Tian, J., Ge, H., Liu, R., & Xiao, J. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.12.017 · Cited by 69
Dietary natural products as epigenetic modifiers in aging-associated inflammation and disease
Evans, L. W., Stratton, M. S., & Ferguson, B. S. (2020) · Natural Product Reports · doi:10.1039/c9np00057g · Cited by 71
Adiponectin and PPAR: a setup for intricate crosstalk between obesity and non-alcoholic fatty liver disease
Ishtiaq, S. M., Rashid, H., Hussain, Z., Arshad, M. I., & Khan, J. A. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09510-2 · Cited by 66
Antiobesity potential of Piperonal: promising modulation of body composition, lipid profiles and obesogenic marker expression in HFD-induced obese rats
Meriga, B., Parim, B., Chunduri, V. R., Naik, R. R., Nemani, H., Suresh, P., Ganapathy, S., & Uddandrao, V. V. S. (2017) · Nutrition & Metabolism · doi:10.1186/s12986-017-0228-9 · Cited by 64
Adenovirus 36 and Obesity: An Overview
Ponterio, E., & Gnessi, L. (2015) · Viruses · doi:10.3390/v7072787 · Cited by 69
Oleoylethanolamide: A novel pharmaceutical agent in the management of obesity‐an updated review
Payahoo, L., Khajebishak, Y., & Ostadrahimi, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27913 · Cited by 64
PPARγ2 C1431T Polymorphism Interacts with the Antiobesogenic Effects of Kochujang, a Korean Fermented, Soybean-Based Red Pepper Paste, in Overweight/Obese Subjects: A 12-Week, Double-Blind Randomized Clinical Trial
Lee, Y., Cha, Y., Park, Y., & Lee, M. (2017) · Journal of Medicinal Food · doi:10.1089/jmf.2016.3911 · Cited by 58
Human Placental Transcriptome Reveals Critical Alterations in Inflammation and Energy Metabolism with Fetal Sex Differences in Spontaneous Preterm Birth
Lien, Y., Zhang, Z., Cheng, Y., Polyák, E., Sillers, L., Falk, M. J., Ischiropoulos, H., Parry, S. I., & Simmons, R. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157899 · Cited by 56
Dual-specificity phosphatase 6 deficiency regulates gut microbiome and transcriptome response against diet-induced obesity in mice
Ruan, J., Statt, S. N., Huang, C.-T., Tsai, Y.-T., Kuo, C.-C., Chan, H., Liao, Y.-C., Tan, T., & Kao, C. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.220 · Cited by 56
Maternal and Neonatal Levels of Perfluoroalkyl Substances in Relation to Gestational Weight Gain
Ashley‐Martin, J., Dodds, L. A., Arbuckle, T. E., Morisset, A., Fisher, M. M., Bouchard, M. F., Shapiro, G. D., Ettinger, A. S., Monnier, P., Dallaire, R., et al. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13010146 · Cited by 57
Endocannabinoids, Adipose Tissue and Lipid Metabolism
Pagano, C., Rossato, M., & Vettor, R. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01690.x · Cited by 56
The Functions of PPARs in Aging and Longevity
Erol, A. (2007) · PPAR Research · doi:10.1155/2007/39654 · Cited by 54
Experimental animal models of chronic inflammation
Rafiyan, M., Sadeghmousavi, S., Akbarzadehmoallemkolaei, M., & Rezaei, N. (2023) · Current Research in Immunology · doi:10.1016/j.crimmu.2023.100063 · Cited by 54
Rearing system causes changes of behavior, microbiome, and gene expression of chickens
Chen, S., Xiang, H., Zhang, H., Zhu, X., Wang, D., Wang, J., Yin, T., Liu, L., Kong, M., Li, H., et al. (2019) · Poultry Science · doi:10.3382/ps/pez140 · Cited by 53
Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation
Khan, S. A., Ali, A., Khan, S. A., Zahran, S. A., Damanhouri, G. A., Azhar, E. I., & Qadri, I. (2014) · Mediators of Inflammation · doi:10.1155/2014/502749 · Cited by 55
Prebiotic and Synbiotic Modifications of Beta Oxidation and Lipogenic Gene Expression after Experimental Hypercholesterolemia in Rat Liver
Alves, C. C., Waitzberg, D. L., de Andrade, L. S., Aguiar, L. D. S., Reis, M. B., Guanabara, C. C., Aguiar, O., Ribeiro, D. A., & Sala, P. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02010 · Cited by 52
Crosstalk between PPARs and gut microbiota in NAFLD
Wu, L., Li, J., Feng, J., Ji, J., Yu, Q., Li, Y., Zheng, Y., Dai, W., Wu, J., & Guo, C. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111255 · Cited by 52
A fish protein hydrolysate alters fatty acid composition in liver and adipose tissue and increases plasma carnitine levels in a mouse model of chronic inflammation
Bjørndal, B., Berge, C., Ramsvik, M. S., Svardal, A. M., Bohov, P., Skorve, J., & Berge, R. K. (2013) · Lipids in Health and Disease · doi:10.1186/1476-511x-12-143 · Cited by 51
Glycinergic Signaling in Macrophages and Its Application in Macrophage-Associated Diseases
Gan, Z., Zhang, M., Xie, D., Wu, X., Hong, C., Fu, J., Fan, L., Wang, S., & Han, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.762564 · Cited by 53
Hepatic monocyte chemoattractant protein-1 is upregulated by dietary cholesterol and contributes to liver steatosis
Rull, A., Rodríguez, F., Aragonès, G., Marsillach, J., Beltrán‐Debón, R., Alonso‐Villaverde, C., Camps, J., & Joven, J. (2009) · Cytokine · doi:10.1016/j.cyto.2009.08.006 · Cited by 50
The effects of canola and olive oils consumption compared to sunflower oil, on lipid profile and hepatic steatosis in women with polycystic ovarian syndrome: a randomized controlled trial
Yahay, M., Heidari, Z., Allameh, Z. S., & Amani, R. (2021) · Lipids in Health and Disease · doi:10.1186/s12944-021-01433-9 · Cited by 56
Retinal Microglia and Uveal Tract Dendritic Cells and Macrophages Are Not CX3CR1 Dependent in Their Recruitment and Distribution in the Young Mouse Eye
Kezic, J. M., Xu, H., Chinnery, H. R., Murphy, C. C., & McMenamin, P. G. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-0953 · Cited by 48
A novel soluble β-1,3- d -glucan Salecan reduces adiposity and improves glucose tolerance in high-fat diet-fed mice
Zhang, Y., Xia, L., Pang, W., Wang, T., Chen, P., Zhu, B., & Zhang, J. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512000980 · Cited by 47
Crosstalk between Peroxisome Proliferator-Activated Receptors and Toll-Like Receptors: A Systematic Review
Dana, N., Vaseghi, G., & Javanmard, S. H. (2019) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2019.003 · Cited by 45
Relevance of Peroxisome Proliferator Activated Receptors in Multitarget Paradigm Associated with the Endocannabinoid System
Lago-Fernandez, A., Zarzo-Arias, S., Jagerovic, N., & Morales, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031001 · Cited by 50
Integrative analysis of microRNAs and mRNAs revealed regulation of composition and metabolism in Nelore cattle
de Oliveira, G. B., Regitano, L. C. D. A., César, A. S. M., Reecy, J. M., Degaki, K., Poleti, M., Felício, A., Koltes, J. E., & Coutinho, L. L. (2018) · BMC Genomics · doi:10.1186/s12864-018-4514-3 · Cited by 45
Prostate cancer cell proliferation and angiogenesis in different obese mice models
Ribeiro, A. M., Andrade, S., Pinho, F., Monteiro, J. D., Costa, M. M., Lopes, C., Águas, A. P., & Monteiro, M. P. (2010) · International Journal of Experimental Pathology · doi:10.1111/j.1365-2613.2010.00726.x · Cited by 47
Diminished diet-induced hyperglycemia and dyslipidemia and enhanced expression of PPARα and FGF21 in mice with hepatic ablation of brain-derived neurotropic factor
Teillon, S., Calderon, G. A., & Rios, M. (2010) · Journal of Endocrinology · doi:10.1677/joe-09-0405 · Cited by 44
Cumulative exposure to environmental pollutants during early pregnancy and reduced fetal growth: the Project Viva cohort
Rokoff, L. B., Rifas‐Shiman, S. L., Coull, B. A., Cárdenas, A., Calafat, A. M., Ye, X., Gryparis, A., Schwartz, J. D., Sagiv, S. K., Gold, D. R., et al. (2018) · Environmental Health · doi:10.1186/s12940-018-0363-4 · Cited by 42
Altered levels of sirtuin genes (SIRT1, SIRT2, SIRT3 and SIRT6) and their target genes in adipose tissue from individual with obesity
Martínez-Jiménez, V., Cortez-Espinosa, N., Rodríguez-Varela, E., Vega‐Cárdenas, M., Briones-Espinoza, M., Ruiz-Rodríguez, V. M., López‐López, N., Briseño-Medina, A., Turiján-Espinoza, E., & Portales‐Pérez, D. P. (2018) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2018.11.011 · Cited by 43
Dietary açai attenuates hepatic steatosis via adiponectin-mediated effects on lipid metabolism in high-fat diet mice
Guerra, J. F. D. C., Maciel, P. S., de Abreu, I. C. M. E., Pereira, R. R., Silva, M., Cardoso, L. D. M., Pinheiro-Sant’Ana, H. M., de Lima, W. G., Silva, M. E., & Pedrosa, M. L. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.01.025 · Cited by 43
Intrauterine Inflammation Alters the Transcriptome and Metabolome in Placenta
Lien, Y., Zhang, Z., Barila, G., Brown, A. G., Elovitz, M. A., & Simmons, R. A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.592689 · Cited by 44
Fucosterol Protects against Concanavalin A-Induced Acute Liver Injury: Focus on P38 MAPK/NF-κB Pathway Activity
Mo, W., Wang, C., Li, J., Chen, K., Xia, Y., Li, S., Xu, L., Lu, X., Wang, W., & Guo, C. (2018) · Gastroenterology Research and Practice · doi:10.1155/2018/2824139 · Cited by 40
Comparative Study of the Antioxidant and Anti-Inflammatory Effects of Leaf Extracts from Four Different Morus alba Genotypes in High Fat Diet-Induced Obesity in Mice
Leyva‐Jiménez, F. J., Ruiz‐Malagón, A. J., Molina‐Tijeras, J. A., Diez‐Echave, P., Vezza, T., Hidalgo‐Garcia, L., Lozano‐Sánchez, J., Arraéz-Román, D., Cenís, J. L., Pérez, A. A. L., et al. (2020) · Antioxidants · doi:10.3390/antiox9080733 · Cited by 47
Activation of peroxisome proliferator-activated receptor alpha in human peripheral blood mononuclear cells reveals an individual gene expression profile response
Bouwens, M., Afman, L. A., & Müller, M. M. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-262 · Cited by 39
Self-citation
Epoxy-Oxylipins and Soluble Epoxide Hydrolase Metabolic Pathway as Targets for NSAID-Induced Gastroenteropathy and Inflammation-Associated Carcinogenesis
Jones, R., Liao, J., Tong, X., Xu, D., Sun, L., Li, H., & Yang, G. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00731 · Cited by 39
Prescribing Optimal Nutrition and Physical Activity as “First-Line” Interventions for Best Practice Management of Chronic Low-Grade Inflammation Associated with Osteoarthritis: Evidence Synthesis
Dean, E., & Hansen, R. G. (2012) · Arthritis · doi:10.1155/2012/560634 · Cited by 39
Obesity‐associated biochemical markers of inflammation and the role of grain phytochemicals
Soujanya, K. V., & Jayadeep, A. P. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14257 · Cited by 38

Authors: Stienstra, R., Duval, C., Müller, M., & Kersten, S.
Affiliations: Wageningen University & Research (NL)
Corresponding author: Kersten, Sander
ORCID: Stienstra, Rinke
Müller, Michael
Kersten, Sander
Venue: PPAR Research
Publisher: Hindawi Limited
Published: 2007
Volume: 2007
Pages: 1-10
ISSN: 1687-4757 (ISSN-L)
1687-4765
DOI: 10.1155/2007/95974
PMC: PMC1783744
OpenAlex: W1963979793
Cited by: 287
References: 98
Citations by year: 2026: 5 · 2025: 9 · 2024: 14 · 2023: 24 · 2022: 14 · 2021: 23 · 2020: 23 · 2019: 12 · 2018: 13 · 2017: 12 · 2016: 16 · 2015: 10 · 2014: 14 · 2013: 22 · 2012: 23
FWCI: 5.30
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (unspecified)
Locations: PPAR Research (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion)
UEA Digital Repository (University of East Anglia) (acceptedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Radboud Repository (Radboud University) (submittedVersion)
Radboud Repository (Radboud University) (submittedVersion, other-oa)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: peroxisome proliferator-activated receptors, obesity, inflammation, adipose tissue, liver, steatohepatitis, insulin resistance, macrophages, pro-inflammatory mediators, vascular inflammation, energy homeostasis, metabolic disorders, therapeutic target

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

PPARs, Obesity, and Inflammation

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks