Prebiotic Effects of Wheat Arabinoxylan Related to the Increase in Bifidobacteria, Roseburia and Bacteroides/Prevotella in Diet-Induced Obese Mice
Open accessAbstract
BACKGROUND: Alterations in the composition of gut microbiota--known as dysbiosis--has been proposed to contribute to the development of obesity, thereby supporting the potential interest of nutrients targeting the gut with beneficial effect for host adiposity. We test the ability of a specific concentrate of water-extractable high molecular weight arabinoxylans (AX) from wheat to modulate both the gut microbiota and lipid metabolism in high-fat (HF) diet-induced obese mice. METHODOLOGY/PRINCIPAL FINDINGS: Mice were fed either a control diet (CT) or a HF diet, or a HF diet supplemented with AX (10% w/w) during 4 weeks. AX supplementation restored the number of bacteria that were decreased upon HF feeding, i.e. Bacteroides-Prevotella spp. and Roseburia spp. Importantly, AX treatment markedly increased caecal bifidobacteria content, in particular Bifidobacterium animalis lactis. This effect was accompanied by improvement of gut barrier function and by a lower circulating inflammatory marker. Interestingly, rumenic acid (C18:2 c9,t11) was increased in white adipose tissue due to AX treatment, suggesting the influence of gut bacterial metabolism on host tissue. In parallel, AX treatment decreased adipocyte size and HF diet-induced expression of genes mediating differentiation, fatty acid uptake, fatty acid oxidation and inflammation, and decreased a key lipogenic enzyme activity in the subcutaneous adipose tissue. Furthermore, AX treatment significantly decreased HF-induced adiposity, body weight gain, serum and hepatic cholesterol accumulation and insulin resistance. Correlation analysis reveals that Roseburia spp. and Bacteroides/Prevotella levels inversely correlate with these host metabolic parameters. CONCLUSIONS/SIGNIFICANCE: Supplementation of a concentrate of water-extractable high molecular weight AX in the diet counteracted HF-induced gut dysbiosis together with an improvement of obesity and lipid-lowering effects. We postulate that hypocholesterolemic, anti-inflammatory and anti-obesity effects are related to changes in gut microbiota. These data support a role for wheat AX as interesting nutrients with prebiotic properties related to obesity prevention.
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Numerous studies have demonstrated the capability of prebiotics to promote bifidobacterial presence within the microbiota, correlating with other changes in the overall microbiota composition and metabolism.
“On the other hand, numerous studies have demonstrated the capability of prebiotics to promote bifidobacterial presence within the microbiota, correlating with other changes in the overall microbiota composition and metabolism.”
From Bifidobacteria and Their Health-Promoting Effects (2017) · cites this paper as [62]
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Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423 · see citing works
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works
Self-citationThe gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819 · see citing works
Self-citationGut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults
Larsen, N., Vogensen, F. K., van den Berg, F. W. J., Nielsen, D. S., Andreasen, A. S., Pedersen, B. K., Al-Soud, W. A., Sørensen, S. J., Hansen, L. H., & Jakobsen, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009085 · Cited by 2,952 · see citing works
Turnbaugh, P. J., Bäckhed, F., Fulton, L., & Gordon, J. I. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.02.015 · Cited by 2,915 · see citing works
Bile salt biotransformations by human intestinal bacteria
Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829 · see citing works
Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518 · see citing works
Self-citationPrebiotic effects: metabolic and health benefits
Roberfroid, M. B., Gibson, G. R., Hoyles, L., McCartney, A. L., Rastall, R. A., Rowland, I. R., Wolvers, D. A. W., Watzl, B., Szajewska, H., Stahl, B., et al. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003363 · Cited by 2,098 · see citing works
Self-citationCani, P. D., Neyrinck, A. M., Fava, F., Knauf, C., Burcelin, R., Tuohy, K. M., Gibson, G. R., & Delzenne, N. M. (2007) · Diabetologia · doi:10.1007/s00125-007-0791-0 · Cited by 1,776 · see citing works
Self-citationHigh-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity
Hildebrandt, M. A., Hoffmann, C., Sherrill–Mix, S. A., Keilbaugh, S. A., Hamady, M., Chen, Y., Knight, R., Ahima, R. S., Bushman, F., & Wu, G. D. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.08.042 · Cited by 1,576 · cited 1× · see citing works
“A shift in the composition the murine gut microbiota, such as a decrease in Bacteroidetes or an increase in Firmicutes, was reported to be induced by dietary interventions in favour of a HF diet [3,28,38].”
BackgroundRinttilä, T., Kassinen, A., Malinen, E., Krogius-Kurikka, L., & Palva, A. (2004) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2004.02409.x · Cited by 1,018 · see citing works
The role of the gut microbiota in energy metabolism and metabolic disease
Cani, P., & Delzenne, N. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168164 · Cited by 974 · see citing works
Self-citationArmougom, F., Henry, M., Vialettes, B., Raccah, D., & Raoult, D. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007125 · Cited by 905 · see citing works
Ramirez-Farias, C., Slezak, K., Fuller, Z., Duncan, A., Holtrop, G., & Louis, P. (2008) · British Journal of Nutrition · doi:10.1017/s0007114508019880 · Cited by 822 · see citing works
Muscle and Liver Insulin Resistance Indexes Derived From the Oral Glucose Tolerance Test
Abdul-Ghani, M. A., Matsuda, M., Balas, B., & DeFronzo, R. A. (2006) · Diabetes Care · doi:10.2337/dc06-1519 · Cited by 555 · see citing works
Absence of intestinal microbiota does not protect mice from diet-induced obesity
Fleissner, C. K., Huebel, N., Abd El-Bary, M. M., Loh, G., Klaus, S., & Blaut, M. (2010) · British Journal of Nutrition · doi:10.1017/s0007114510001303 · Cited by 436 · see citing works
Mandard, S., Zandbergen, F., van Straten, E., Wahli, W., Kuipers, F., Müller, M., & Kersten, S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m506519200 · Cited by 433 · see citing works
Martínez, I., Wallace, G., Zhang, C., Legge, R. M., Benson, A. K., Carr, T. P., Moriyama, E. N., & Walter, J. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.00380-09 · Cited by 355 · see citing works
Aronsson, L., Huang, Y., Parini, P., Korach-André, M., Håkansson, J., Gustafsson, J.-Å., Pettersson, S., Arulampalam, V., & Rafter, J. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013087 · Cited by 298 · see citing works
PPARs, Obesity, and Inflammation
Stienstra, R., Duval, C., Müller, M., & Kersten, S. (2007) · PPAR Research · doi:10.1155/2007/95974 · Cited by 287 · see citing works
Devillard, E., McIntosh, F. M., Duncan, S. H., & Wallace, R. J. (2007) · Journal of Bacteriology · doi:10.1128/jb.01359-06 · Cited by 285 · see citing works
Lu, Z. X., Walker, K., Muir, J. G., Mascara, T., & O’Dea, K. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.5.1123 · Cited by 278 · see citing works
In Vitro Fermentation by Human Fecal Microflora of Wheat Arabinoxylans
Hughes, S. A., Shewry, P. R., Li, L., Gibson, G. R., Sanz, M. L., & Rastall, R. A. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf070293g · Cited by 274 · see citing works
Conjugated linoleic acids as functional food: an insight into their health benefits
Benjamin, S., & Spener, F. (2009) · Nutrition & Metabolism · doi:10.1186/1743-7075-6-36 · Cited by 274 · see citing works
Dewulf, E. M., Cani, P. D., Neyrinck, A. M., Possemiers, S., Holle, A. V., Muccioli, G. G., Deldicque, L., Bindels, L. B., Pachikian, B. D., Sohet, F. M., et al. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.05.009 · Cited by 269 · see citing works
Self-citationPossemiers, S., Verthé, K., Uyttendaele, S., & Verstraete, W. (2004) · FEMS Microbiology Ecology · doi:10.1016/j.femsec.2004.05.002 · Cited by 259 · see citing works
Self-citationPossemiers, S., Bolca, S., Grootaert, C., Heyerick, A., Decroos, K., Dhooge, W., Keukeleire, D. D., Rabot, S., Verstraete, W., & de Wiele, T. V. (2006) · Journal of Nutrition · doi:10.1093/jn/136.7.1862 · Cited by 258 · see citing works
Self-citationArabinoxylan fibre improves metabolic control in people with Type II diabetes
Lu, Z. X., Walker, K., Muir, J., & O’Dea, K. (2004) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601857 · Cited by 248 · see citing works
Neyrinck, A. M., Possemiers, S., Verstraete, W., Backer, F. D., Cani, P. D., & Delzenne, N. M. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.10.008 · Cited by 245 · see citing works
Self-citationStructural Characterisation of Water-extractable and Water-unextractable Arabinoxylans in Wheat Bran
Maes, C., & Delcour, J. A. (2002) · Journal of Cereal Science · doi:10.1006/jcrs.2001.0439 · Cited by 244 · see citing works
Microbial metabolism and prebiotic potency of arabinoxylan oligosaccharides in the human intestine
Grootaert, C., Delcour, J. A., Courtin, C. M., Broekaert, W. F., Verstraete, W., & de Wiele, T. V. (2006) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2006.08.004 · Cited by 240 · see citing works
Effects of fructans-type prebiotics on lipid metabolism
Delzenne, N. M., & Kok, N. N. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.456s · Cited by 225 · see citing works
Self-citationPrebiotics and lipid metabolism
Delzenne, N. M., & Williams, C. M. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200202000-00009 · Cited by 220 · see citing works
Self-citationPrebiotic effects of chicory inulin in the simulator of the human intestinal microbial ecosystem
de Wiele, T. V., Boon, N., Possemiers, S., Jacobs, H., & Verstraete, W. (2004) · FEMS Microbiology Ecology · doi:10.1016/j.femsec.2004.07.014 · Cited by 214 · see citing works
Self-citationChitosan as a Lipid Binder: A Langmuir Monolayer Study of Chitosan−Lipid Interactions
Wydro, P., Krajewska, B., & Hąc-Wydro, K. (2007) · Biomacromolecules · doi:10.1021/bm700453x · Cited by 207 · see citing works
Garcia, A. L., Otto, B., Reich, S.-C., Weickert, M. O., Steiniger, J., Machowetz, A., Rudovich, N. N., Möhlig, M., Katz, N., Speth, M., et al. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602525 · Cited by 203 · see citing works
Wall, R., Ross, R. P., Shanahan, F., O’Mahony, L., O’Mahony, C., Coakley, M., Hart, O. M., Lawlor, P. G., Quigley, E. M. M., Kiely, B., et al. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27023 · Cited by 198 · see citing works
Delzenne, N. M., Daubioul, C., Neyrinck, A. M., Lasa, M., & Taper, H. (2002) · British Journal Of Nutrition · doi:10.1079/bjn/2002545 · Cited by 180 · see citing works
Self-citationN.M.*, D., Daubioul, C., Neyrinck, A. M., Lasa, M., & Taper, H. (2002) · British Journal Of Nutrition · doi:10.1079/bjnbjn/2002545 · Cited by 159 · see citing works
Self-citationVentura, M., Reniero, R., & Zink, R. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.6.2760-2765.2001 · Cited by 148 · see citing works
Dietary oligofructose modifies the impact of fructose on hepatic triacylglycerol metabolism
Kok, N. N., Roberfroid, M., & Delzenne, N. M. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90186-9 · Cited by 128 · see citing works
Self-citationPurification and crystallization of rat liver fatty acid synthetase
Linn, T. C. (1981) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(81)90320-9 · Cited by 112 · see citing works
Vardakou, M., Palop, C. N., Christakopoulos, P., et al. (2007) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2007.11.007 · Cited by 108 · see citing works
Lopez, H. W., Levrat, M.-A., Guy, C., Messager, A., Demigné, C., & Rémésy, C. (1999) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(99)00036-4 · Cited by 98 · see citing works
Dietary fibre: new frontiers for food and health.
van der Kamp, J. W., Jones, J. M., McCleary, B. V., & Topping, D. L. (2010) · Wageningen Academic Publishers eBooks · Cited by 98 · see citing works
Neyrinck, A. M., Bindels, L. B., Backer, F. D., Pachikian, B. D., Cani, P. D., & Delzenne, N. M. (2009) · International Immunopharmacology · doi:10.1016/j.intimp.2009.02.015 · Cited by 96 · see citing works
Self-citationCoordinated regulation of the metabolome and lipidome at the host-microbial interface
Bäckhed, F., & Crawford, P. A. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.09.009 · Cited by 89 · see citing works
McIntosh, F. M., Shingfield, K. J., Devillard, E., Russell, W. R., & Wallace, R. J. (2008) · Microbiology · doi:10.1099/mic.0.022921-0 · Cited by 85 · see citing works
Effects of dietary fibers and cholestyramine on the activity of pancreatic lipase in vitro
Lairon, D., Lafont, H., Vigne, J.-L., et al. (1985) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/42.4.629 · Cited by 77 · see citing works
Nakano, R., Kurosaki, E., Yoshida, S., Yokono, M., Shimaya, A., Maruyama, T., & Shibasaki, M. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.03.023 · Cited by 69 · see citing works
Effect of Dietary Lipids on Composition and Glucose Utilization by Rat Adipose Tissue
Awad, A. B. (1981) · Journal of Nutrition · doi:10.1093/jn/111.1.34 · Cited by 69 · see citing works
Devillard, E., McIntosh, F. M., Paillard, D., Thomas, N. A., Shingfield, K. J., & Wallace, R. J. (2009) · Microbiology · doi:10.1099/mic.0.023416-0 · Cited by 65 · see citing works
Neyrinck, A. M., & Delzenne, N. M. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32833ec3fb · Cited by 58 · see citing works
Self-citationDelzenne, N. M., & Cani, P. D. (2009) · International Dairy Journal · doi:10.1016/j.idairyj.2009.11.006 · Cited by 47 · see citing works
Self-citationDietary fibre: new frontiers for food and health
van den Abbeele, P., de Wiele, T. V., Grootaert, C., Verstraete, W., Gérard, P., Bruneau, A., Rabot, S., & Possemiers, S. (2010) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-692-2 · Cited by 32 · see citing works
Self-citationMonobe, M., Maeda‐Yamamoto, M., Matsuoka, Y., et al. (2008) · NIPPON SHOKUHIN KOGYO GAKKAISHI · doi:10.3136/nskkk.55.245 · Cited by 24 · see citing works
Suzuki, S., Ishikawa, S.-I., Arihara, K., et al. (2008) · Nutrition Research · doi:10.1016/j.nutres.2008.02.007 · Cited by 6 · see citing works
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Koropatkin, N. M., Cameron, E. A., & Martens, E. C. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2746 · Cited by 1,419 · see citing works
How informative is the mouse for human gut microbiota research?
Nguyen, T. L. A., Vieira-Silva, S., Liston, A., & Raes, J. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.017400 · Cited by 1,334 · see citing works
“This shift is driven by more complex alterations at lower taxonomic levels within the phylum Bacteroidetes: most genera, including Prevotella and Roseburia, decreased in abundance (Neyrinck et al., 2011), whereas other genera of this phylum, such as Barnesiella, Bacteroides and Alistipes, significantly increased (Zhan…”
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Scott, K. P., Gratz, S. W., Sheridan, P. O., Flint, H. J., & Duncan, S. H. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.020 · Cited by 1,052 · see citing works
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Park, D.-Y., Ahn, Y.-T., Park, S.-H., Huh, C.-S., Yoo, S.-R., Yu, R., Sung, M.-K., McGregor, R. A., & Choi, M.-S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059470 · Cited by 317 · see citing works
Lordan, C., Thapa, D., Ross, R. P., & Cotter, P. D. (2020) · Gut Microbes · doi:10.1080/19490976.2019.1613124 · Cited by 289 · see citing works
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Ganesan, K., Chung, S. K., Vanamala, J., & Xu, B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123720 · Cited by 221 · see citing works
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Hald, S., Schioldan, A. G., Moore, M. E., Dige, A., Lærke, H. N., Agnholt, J., Bach Knudsen, K. E., Hermansen, K., Marco, M. L., Gregersen, S., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159223 · Cited by 180 · see citing works
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Song, M.-Y., Wang, J.-H., Eom, T., & Kim, H. (2015) · Nutrition Research · doi:10.1016/j.nutres.2015.05.001 · Cited by 74 · see citing works
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- Authors
- Neyrinck, A. M., Possemiers, S., Druart, C., Van de Wiele, T., De Backer, F., Cani, P. D., Larondelle, Y., & Delzenne, N. M.
- Affiliations
- UCLouvain (BE)
- Ghent University (BE)
- Corresponding author
- Delzenne, Nathalie M.
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-06-09
- Volume
- 6
- Issue
- 6
- Pages
- e20944
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3111466
- OpenAlex
- W2000920418
- Cited by
- 465
- References
- 58
- Citations by year
- 2026: 8 · 2025: 19 · 2024: 23 · 2023: 26 · 2022: 35 · 2021: 38 · 2020: 39 · 2019: 38 · 2018: 46 · 2017: 42 · 2016: 27 · 2015: 37 · 2014: 27 · 2013: 38 · 2012: 18
- FWCI
- 11.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
- Digital Access to Libraries (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Danone
- Waalse Gewest
- Fonds De La Recherche Scientifique - FNRS
- Fonds Wetenschappelijk Onderzoek
- Instituto Danone
- Vlaamse regering
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Keywords
- arabinoxylan, wheat, prebiotics, diet-induced obesity, gut microbiota, dysbiosis, Roseburia, Bacteroides-Prevotella, high-fat diet, rumenic acid, adipose tissue, lipid metabolism, intestinal barrier, insulin resistance, cholesterol, anti-inflammatory activity, obesity prevention
- MeSH terms
- Animals, Bacteroides, Bifidobacterium, Body Weight, Cholesterol, Diet, Dietary Fats, Gene Expression Regulation, Insulin Resistance, Intestines, Male, Mice, Inbred C57BL, Molecular Weight, Obesity, Triticum, Xylans, Biomarkers, Prevotella, Linoleic Acids, Conjugated, Subcutaneous Fat, Mice, Metagenome, Prebiotics, Bacterial Load
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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