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Cited by 425

The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.

Targeted Liposomal Drug Delivery to Monocytes and Macrophages

Open access
Kelly, Ciara, Jefferies, Caroline, Cryan, Sally-Ann·2011·Journal of Drug Delivery
DOI 10.1155/2011/727241
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Abstract

As the role of monocytes and macrophages in a range of diseases is better understood, strategies to target these cell types are of growing importance both scientifically and therapeutically. As particulate carriers, liposomes naturally target cells of the mononuclear phagocytic system (MPS), particularly macrophages. Loading drugs into liposomes can therefore offer an efficient means of drug targeting to MPS cells. Physicochemical properties including size, charge and lipid composition can have a very significant effect on the efficiency with which liposomes target MPS cells. MPS cells express a range of receptors including scavenger receptors, integrins, mannose receptors and Fc-receptors that can be targeted by the addition of ligands to liposome surfaces. These ligands include peptides, antibodies and lectins and have the advantages of increasing target specificity and avoiding the need for cationic lipids to trigger intracellular delivery. The goal for targeting monocytes/macrophages using liposomes includes not only drug delivery but also potentially a role in cell ablation and cell activation for the treatment of conditions including cancer, atherosclerosis, HIV, and chronic inflammation.

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Metadata

Authors
Kelly, C., Jefferies, C., & Cryan, S.-A.
Venue
Journal of Drug Delivery
Publisher
Wiley
Published
2011-10-26
Volume
2011
Pages
1-11
ISSN
  • 2090-3014 (ISSN-L)
  • 2090-3022
DOI
10.1155/2011/727241
OpenAlex
W2000590130
Cited by
425
References
103
FWCI
6.23
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Targeted Liposomal Drug Delivery to Monocytes and Macrophages. https://app.cochat.ai/papers/10.1155/2011/727241
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Kelly, C., Jefferies, C., & Cryan, S.-A. (2011). Targeted Liposomal Drug Delivery to Monocytes and Macrophages. Journal of Drug Delivery. https://doi.org/10.1155/2011/727241

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.