The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Regulation of Nutrient Transport across the Placenta
Open accessAbstract
Abnormal fetal growth, both growth restriction and overgrowth, is associated with perinatal complications and an increased risk of metabolic and cardiovascular disease later in life. Fetal growth is dependent on nutrient availability, which in turn is related to the capacity of the placenta to transport these nutrients. The activity of a range of nutrient transporters has been reported to be decreased in placentas of growth restricted fetuses, whereas at least some studies indicate that placental nutrient transport is upregulated in fetal overgrowth. These findings suggest that changes in placental nutrient transport may directly contribute to the development of abnormal fetal growth. Detailed information on the mechanisms by which placental nutrient transporters are regulated will therefore help us to better understand how important pregnancy complications develop and may provide a foundation for designing novel intervention strategies. In this paper we will focus on recent studies of regulatory mechanisms that modulate placental transport of amino acids, fatty acids, and glucose.
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Cites
Placental-specific IGF-II is a major modulator of placental and fetal growth
Constância, M., Hemberger, M., Hughes, J., Dean, W., Ferguson-Smith, A., Fundele, R., Stewart, F., Kelsey, G., Fowden, A., Sibley, C., et al. (2002) · Nature · doi:10.1038/nature00819 · Cited by 1,054
Obesity in Pregnancy Stimulates Macrophage Accumulation and Inflammation in the Placenta
Challier, J. C., Basu, S., Bintein, T., Minium, J., Hotmire, K., Catalano, P. M., & Hauguel-de Mouzon, S. (2008) · Placenta · doi:10.1016/j.placenta.2007.12.010 · Cited by 712
Jansson, T., & Powell, T. L. (2007) · Clinical Science · doi:10.1042/cs20060339 · Cited by 542
Self-citationWadhwa, P. D., Garite, T. J., Porto, M., Glynn, L., Chicz-DeMet, A., Dunkel-Schetter, C., & Sandman, C. A. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.06.070 · Cited by 402
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Constância, M., Angiolini, E., Sandovici, I., Smith, P., Smith, R., Kelsey, G., Dean, W., Ferguson-Smith, A., Sibley, C. P., Reik, W., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504468103 · Cited by 323 · cited 1×
“The increased nutrient transport maintains fetal growth within the normal range until late pregnancy when compensatory mechanisms fail and IUGR develops [18, 19].”
BackgroundRoos, S., Jansson, N., Palmberg, I., Säljö, K., Powell, T. L., & Jansson, T. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.129676 · Cited by 283
Self-citationJones, H. N., Jansson, T., & Powell, T. L. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00195.2009 · Cited by 168 · cited 10×
“Uptake of taurine in villous tissue from human placenta is not affected by cytokines or hormones, such as IGF-I and II, IL-1β, IL-6, GH, leptin, or TNF-α [65].”
BackgroundInfluentialSelf-citationPlacental mTOR links maternal nutrient availability to fetal growth
Roos, S., Powell, T. L., & Jansson, T. (2009) · Biochemical Society Transactions · doi:10.1042/bst0370295 · Cited by 156
Self-citationRegulation of placental amino acid transporter activity by mammalian target of rapamycin
Roos, S., Kanai, Y., Prasad, P. D., Powell, T. L., & Jansson, T. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00330.2008 · Cited by 150
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Cited by
The placenta in fetal growth restriction: What is going wrong?
Sun, C., Groom, K. M., Oyston, C., Chamley, L. W., Clark, A. R., & James, J. L. (2020) · Placenta · doi:10.1016/j.placenta.2020.05.003 · Cited by 253
Romero, R., Erez, O., Hüttemann, M., Maymon, E., Panaitescu, B., Conde-Agudelo, A., Pacora, P., Yoon, B. H., & Grossman, L. I. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.06.003 · Cited by 253
The omniscient placenta: Metabolic and epigenetic regulation of fetal programming
Nugent, B. M., & Bale, T. L. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.09.001 · Cited by 222
The Programming Power of the Placenta
Sferruzzi-Perri, A. N., & Camm, E. J. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00033 · Cited by 223
Role of placental nutrient sensing in developmental programming
JANSSON, T., & POWELL, T. L. (2013) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0b013e3182993a2e · Cited by 172
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Metadata
- Authors
- Lager, S., & Powell, T. L.
- Venue
- Journal of Pregnancy
- Publisher
- Wiley
- Published
- 2012
- Volume
- 2012
- Pages
- 1-14
- ISSN
- 2090-2727 (ISSN-L)
- 2090-2735
- OpenAlex
- W2115042312
- Cited by
- 455
- References
- 12
- FWCI
- 24.83
- Type
- journal article
- Language
- en
- Open access
- gold
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