The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Oxidative Stress, Mitochondrial Dysfunction, and Aging
Open accessAbstract
Aging is an intricate phenomenon characterized by progressive decline in physiological functions and increase in mortality that is often accompanied by many pathological diseases. Although aging is almost universally conserved among all organisms, the underlying molecular mechanisms of aging remain largely elusive. Many theories of aging have been proposed, including the free-radical and mitochondrial theories of aging. Both theories speculate that cumulative damage to mitochondria and mitochondrial DNA (mtDNA) caused by reactive oxygen species (ROS) is one of the causes of aging. Oxidative damage affects replication and transcription of mtDNA and results in a decline in mitochondrial function which in turn leads to enhanced ROS production and further damage to mtDNA. In this paper, we will present the current understanding of the interplay between ROS and mitochondria and will discuss their potential impact on aging and age-related diseases.
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“Many theories on aging have been proposed, and the free-radical theory suggests that cumulative damage to mitochondria and mitochondrial DNA caused by ROS is one of the important causes of aging and aging-related diseases [33].”
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“reported to increase with age, in part due to the accumulation of reactive oxygen species (ROS) (Keating, 2008; Prigione et al., 2010; Suhr et al., 2010; Cui et al., 2012).”
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Metadata
- Authors
- Cui, H., Kong, Y., & Zhang, H.
- Venue
- Journal of Signal Transduction
- Publisher
- Wiley
- Published
- 2012-10-02
- Volume
- 2012
- Pages
- 1-13
- ISSN
- 2090-1739 (ISSN-L)
- 2090-1747
- OpenAlex
- W2021460489
- Cited by
- 1,022
- References
- 52
- FWCI
- 10.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
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