The DOI matches its Crossref record; 180 of the 180 references it cites were found in a registry or an index.
Adipo-myokines: two sides of the same coin–mediators of inflammation and mediators of exercise
Open accessAbstract
This review summarizes the current literature regarding the most discussed contraction-regulated moykines like IL-6, IL-15, irisin, BDNF, ANGPTL4, FGF21, myonectin and MCP-1. It is suggested that the term myokine is restricted to proteins secreted from skeletal muscle cells, excluding proteins that are secreted by other cell types in skeletal muscle tissue and excluding proteins which are only described on the mRNA level. Interestingly, many of the contraction-regulated myokines described in the literature are additionally known to be secreted by adipocytes. We termed these proteins adipo-myokines. Within this review, we try to elaborate on the question why pro-inflammatory adipokines on the one hand are upregulated in the obese state, and have beneficial effects after exercise on the other hand. Both, adipokines and myokines do have autocrine effects within their corresponding tissues. In addition, they are involved in an endocrine crosstalk with other tissues. Depending on the extent and the kinetics of adipo-myokines in serum, these molecules seem to have a beneficial or an adverse effect on the target tissue.
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“Specifically, plasma ANGPTL4 acts on myotubes, and is well-established as a myokine derived from physical exercise (exercise factor; Raschke and Eckel, 2013; Ingerslev et al., 2017).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Raschke and Eckel, 2013
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“The performance of this protein is related to several physiological processes, among them are insulin sensitivity, lipid metabolism, adipogenesis (Cinkajzlova et al., 2018), and the increase of circulating fatty acids, which are generated mainly by chronic caloric restrictions, fasting, and aerobic physical training (Raschke and Eckel, 2013).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Raschke and Eckel, 2013
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Cited by
Sorted by citations
Muscle–Organ Crosstalk: The Emerging Roles of Myokines
Severinsen, M. C. K., & Pedersen, B. K. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa016 · Cited by 1,226
“The role of myokines has previously been reviewed (7, 11-37), identifying more than 650 myokines (38).”
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Metadata
- Authors
- Raschke, S., & Eckel, J.
- Affiliations
- Deutsches Diabetes-Zentrum e.V. (DE)
- Corresponding author
- Eckel, Jürgen
- Venue
- Mediators of Inflammation
- Publisher
- Wiley
- Published
- 2013
- Volume
- 2013
- Pages
- 1-16
- ISSN
- 0962-9351 (ISSN-L)
- 1466-1861
- PMC
- PMC3686148
- OpenAlex
- W2116932335
- Cited by
- 296
- References
- 179
- Citations by year
- 2026: 12 · 2025: 11 · 2024: 16 · 2023: 17 · 2022: 26 · 2021: 21 · 2020: 24 · 2019: 18 · 2018: 30 · 2017: 30 · 2016: 37 · 2015: 28 · 2014: 22 · 2013: 3
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Mediators of Inflammation (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Bundesministerium für Bildung und Forschung
- Bundesministerium für Gesundheit
- Ministerium für Wissenschaft und Forschung des Landes Nordrhein-Westfalen
- Topics
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- myokines, adipokines, skeletal muscle contraction, interleukin-6, irisin, brain-derived neurotrophic factor, ANGPTL4, FGF21, myonectin, MCP-1, IL-15, obesity, inflammation, physical activity, autocrine signaling, adipocytes
- MeSH terms
- Angiopoietin-Like Protein 4, Adipose Tissue, Animals, Endocrine System, Fibroblast Growth Factors, Gene Expression Regulation, Humans, Inflammation, RNA, Messenger, Exercise, Interleukin-6, Muscle, Skeletal, Chemokine CCL2, Brain-Derived Neurotrophic Factor, Interleukin-15, Leptin, Follistatin-Related Proteins, Angiopoietins, Adipokines
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