Adipo-myokines: two sides of the same coin–mediators of inflammation and mediators of exercise

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419

Adipose Tissue as an Endocrine Organ

Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810

Adipokines in inflammation and metabolic disease

Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243

A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238

Muscles, exercise and obesity: skeletal muscle as a secretory organ

Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909

Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6

Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388

AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity

Hu, E., Liang, P., & Spiegelman, B. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10697 · Cited by 2,261

Muscle–Organ Crosstalk: The Emerging Roles of Myokines

Severinsen, M. C. K., & Pedersen, B. K. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa016 · Cited by 1,226

Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis

Kalinkovich, A., & Livshits, G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.008 · Cited by 882

Sedentary Behavior and Cardiovascular Morbidity and Mortality: A Science Advisory From the American Heart Association

Young, D. R., Hivert, M.-F., Alhassan, S., Camhi, S. M., Ferguson, J. F., Katzmarzyk, P. T., Lewis, C. E., Owen, N., Perry, C. K., Siddique, J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000440 · Cited by 791

Physical activity and muscle-brain crosstalk

Pedersen, B. K. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0174-x · Cited by 772

Skeletal muscle: A review of molecular structure and function, in health and disease

Mukund, K., & Subramaniam, S. (2019) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1462 · Cited by 805

Role of Skeletal Muscle in Insulin Resistance and Glucose Uptake

Merz, K. E., & Thurmond, D. C. (2020) · Comprehensive Physiology · doi:10.1002/cphy.c190029 · Cited by 494

Exercise as an anti-inflammatory therapy for rheumatic diseases—Myokine regulation

Benatti, F. B., & Pedersen, B. K. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.193 · Cited by 474

Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases

Leal, L. G., Lopes, M. A., & Batista, M. L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01307 · Cited by 382

Muscle as a paracrine and endocrine organ

Giudice, J., & Taylor, J. M. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.05.005 · Cited by 331

Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans

Huh, J. Y., Dincer, F., Mesfum, E., & Mantzoros, C. S. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.42 · Cited by 309

Interrelationship among muscle, fat, and bone: Connecting the dots on cellular, hormonal, and whole body levels

Ilich, J. Z., Kelly, O. J., Inglis, J. E., Panton, L. B., Duque, G., & Ormsbee, M. J. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.02.007 · Cited by 282

Adipose tissue and its role in organ crosstalk

Romacho, T., Elsen, M., Röhrborn, D., & Eckel, J. (2014) · Acta Physiologica · doi:10.1111/apha.12246 · Cited by 292

Inflammation induced loss of skeletal muscle

Londhe, P., & Guttridge, D. C. (2015) · Bone · doi:10.1016/j.bone.2015.03.015 · Cited by 276

Three new players in energy regulation: Preptin, adropin and irisin

Aydın, S. (2014) · Peptides · doi:10.1016/j.peptides.2014.03.021 · Cited by 261

Multifactorial Mechanism of Sarcopenia and Sarcopenic Obesity. Role of Physical Exercise, Microbiota and Myokines

Bilski, J., Pierzchalski, P., Szczepanik, M., Bonior, J., & Zoladz, J. A. (2022) · Cells · doi:10.3390/cells11010160 · Cited by 271

The role of exercise-induced myokines in regulating metabolism

Huh, J. Y. (2018) · Archives of Pharmacal Research · doi:10.1007/s12272-017-0994-y · Cited by 242

Biomarkers in sarcopenia: A multifactorial approach

Curcio, F., Ferro, G., Basile, C., Liguori, I., Parrella, P., Pirozzi, F., Della‐Morte, D., Gargiulo, G., Testa, G., Tocchetti, C. G., et al. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.09.007 · Cited by 236

Myokines in insulin resistance and type 2 diabetes

Eckardt, K., Görgens, S. W., Raschke, S., & Eckel, J. (2014) · Diabetologia · doi:10.1007/s00125-014-3224-x · Cited by 234

Serum Irisin Levels Are Regulated by Acute Strenuous Exercise

Löffler, D., Müller, U., Scheuermann, K., Friebe, D., Gesing, J. K., Bielitz, J., Erbs, S., Landgraf, K., Wagner, I. V., Kieß, W., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2932 · Cited by 222

Irisin and FNDC5 in retrospect

Erickson, H. (2013) · Adipocyte · doi:10.4161/adip.26082 · Cited by 211

Metabolic adaptation in obesity and type ii diabetes: myokines, adipokines and hepatokines

Oh, K.-J., Lee, D., Kim, W., Han, B., Lee, S., & Bae, K.-H. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms18010008 · Cited by 210

Biomarkers of insulin sensitivity and insulin resistance: Past, present and future

Park, S. E., Park, C., & Sweeney, G. (2015) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2015.1023429 · Cited by 212

Crosstalk between adipokines and myokines in fat browning

Rodríguez, A., Becerril, S., Ezquerro, S., Méndez-Giménez, L., & Frühbeck, G. (2016) · Acta Physiologica · doi:10.1111/apha.12686 · Cited by 196

Sarcopenia – The search for emerging biomarkers

Kalinkovich, A., & Livshits, G. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.05.001 · Cited by 191

Circulating Irisin in Healthy, Young Individuals: Day-Night Rhythm, Effects of Food Intake and Exercise, and Associations With Gender, Physical Activity, Diet, and Body Composition

Anastasilakis, A. D., Pοlyzos, S. A., Saridakis, Z. G., Kynigopoulos, G., Skouvaklidou, E. C., Molyvas, D., Vasiloglou, M. F., Apostolou, A., Karagiozoglou‐Lampoudi, Τ., Siopi, A., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1367 · Cited by 190

High-intensity exercise causes greater irisin response compared with low-intensity exercise under similar energy consumption

Tsuchiya, Y., Ando, D., Goto, K., Kiuchi, M., Yamakita, M., & Koyama, K. (2014) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.233.135 · Cited by 176

Pathophysiology of Non Alcoholic Fatty Liver Disease

Petta, S., Gastaldelli, A., Rebelos, E., Bugianesi, E., Messa, P., Miele, L., Svegliati‐Baroni, G., Valenti, L. V. C., & Bonino, F. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122082 · Cited by 182

Exercise and regulation of adipokine and myokine production

(2015) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2015.07.002 · Cited by 168

Adipose Organ Development and Remodeling

Cinti, S. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170042 · Cited by 197

Free radicals and male reproduction.

Agarwal, A. K., & Allamaneni, S. S. R. (2011) · PubMed · Cited by 154

Myokines mediate the cross talk between skeletal muscle and other organs

Chen, W., Wang, L., You, W., & Shan, T. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30033 · Cited by 162

Role of Interleukin-6 in Vascular Health and Disease

Villar-Fincheira, P., Sanhueza-Olivares, F., Norambuena-Soto, I., Cancino-Arenas, N., Hernandez-Vargas, F., Troncoso, R., Gabrielli, L., & Chiong, M. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.641734 · Cited by 154

Sarcopenia and Cognitive Function: Role of Myokines in Muscle Brain Cross-Talk

Scisciola, L., Fontanella, R. A., Surina, S., Cataldo, V., Paolisso, G., & Barbieri, M. (2021) · Life · doi:10.3390/life11020173 · Cited by 153

The search for exercise factors in humans

Catoire, M., & Kersten, S. (2015) · The FASEB Journal · doi:10.1096/fj.14-263699 · Cited by 137

Myokines and Resistance Training: A Narrative Review

Zunner, B. E. M., Wachsmuth, N. B., Eckstein, M. L., Scherl, L., Schierbauer, J., Haupt, S., Stumpf, C., Reusch, L., & Moser, O. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073501 · Cited by 146

Regulation of myokine expression: Role of exercise and cellular stress

Ost, M., Coleman, V., Kasch, J., & Klaus, S. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.02.018 · Cited by 135

Effectiveness of nutritional supplementation on sarcopenia and recovery in hip fracture patients. A multi-centre randomized trial

Malafarina, V., Uriz-Otano, F., Malafarina, C., Martinez, J. A., & Zulet, M. A. (2017) · Maturitas · doi:10.1016/j.maturitas.2017.04.010 · Cited by 131

Myokines in skeletal muscle physiology and metabolism: Recent advances and future perspectives

Das, D. K., Graham, Z. A., & Cardozo, C. P. (2020) · Acta Physiologica · doi:10.1111/apha.13367 · Cited by 129

Impact of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA expression in human skeletal muscle

Eaton, M., Granata, C., Barry, J., Safdar, A., Bishop, D., & Little, J. P. (2018) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2017.01.003 · Cited by 126

Chronic inflammation and sarcopenia: A regenerative cell therapy perspective

Chhetri, J. K., Barreto, P. D. S., Fougère, B., Rolland, Y., Vellas, B. J., & Cesari, M. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2017.12.023 · Cited by 129

Mechanisms by Which Skeletal Muscle Myokines Ameliorate Insulin Resistance

Balakrishnan, R., & Thurmond, D. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094636 · Cited by 143

Functional impact of sarcopenia in respiratory muscles

Elliott, J. E., Greising, S. M., Mantilla, C. B., & Sieck, G. C. (2015) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2015.10.001 · Cited by 124

Irisin, Two Years Later

Novelle, M. G., Contreras, C., Romero, A., López, M., & Diéguez, C. (2013) · International Journal of Endocrinology · doi:10.1155/2013/746281 · Cited by 122

Interleukin-15 facilitates muscle regeneration through modulation of fibro/adipogenic progenitors

Kang, X., Yang, M., Shi, Y., Xie, M., Zhu, M. P., Zheng, X., Zhang, C., Ge, Z., Bian, X., Lv, J.-T., et al. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0251-0 · Cited by 121

Muscle-Organ Crosstalk: Focus on Immunometabolism

Bay, M. L., & Pedersen, B. K. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.567881 · Cited by 117

Irisin and Its Relation to Insulin Resistance and Puberty in Obese Children: A Longitudinal Analysis

Reinehr, T., Elfers, C., Lass, N., & Roth, C. L. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1208 · Cited by 107

Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age

Lisco, G., Disoteo, O., Tullio, A. D., Geronimo, V. D., Giagulli, V. A., Monzani, F., Jirillo, E., Cozzi, R. C., Guastamacchia, E., Pergola, G. D., et al. (2023) · Nutrients · doi:10.3390/nu16010063 · Cited by 111

IL-15 activates the Jak3/STAT3 signaling pathway to mediate glucose uptake in skeletal muscle cells

Krolopp, J. E., Thornton, S. M., & Abbott, M. J. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00626 · Cited by 104

Global mRNA sequencing of human skeletal muscle: Search for novel exercise-regulated myokines

Pourteymour, S., Eckardt, K., Holen, T., Langleite, T. M., Lee-Ødegård, S., Jensen, J., Birkeland, K. I., Drevon, C. A., & Hjorth, M. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.01.007 · Cited by 98

Inflammatory Markers in Anorexia Nervosa: An Exploratory Study

Dalton, B., Campbell, I. C., Chung, R., Breen, G. D., Schmidt, U. H., & Himmerich, H. (2018) · Nutrients · doi:10.3390/nu10111573 · Cited by 97

Effects of sprint interval or combined aerobic and resistance training on myokines in overweight women with type 2 diabetes: A randomized controlled trial

Banitalebi, E., Kazemi, A., Faramarzi, M., Nasiri, S., & Haghighi, M. M. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.11.062 · Cited by 100

Exercise Inhibits NLRP3 Inflammasome Activation in Obese Mice via the Anti-Inflammatory Effect of Meteorin-like

Javaid, H. M. A., Sahar, N.-E., Zhuge, D., & Huh, J. Y. (2021) · Cells · doi:10.3390/cells10123480 · Cited by 96

Fat deposition and accumulation in the damaged and inflamed skeletal muscle: cellular and molecular players

Sciorati, C., Clementi, E., Manfredi, A. A., & Rovere, P. Q. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1857-7 · Cited by 99

Searching for the link between inflammaging and sarcopenia

Wang, T. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101611 · Cited by 90

Hepatokines and non-alcoholic fatty liver disease

Lebensztejn, D. M., Flisiak-Jackiewicz, M., Białokoz-Kalinowska, I., Bobrus-Chociej, A., & Kowalska, I. (2016) · Acta Biochimica Polonica · doi:10.18388/abp.2016_1252 · Cited by 90

Exercise-induced hypoalgesia: potential mechanisms in animal models of neuropathic pain

Kami, K., Tajima, F., & Senba, E. (2016) · Anatomical Science International · doi:10.1007/s12565-016-0360-z · Cited by 85

Myokines, physical activity, insulin resistance and autoimmune diseases

Díaz, B. B., González, D. A., Gannar, F., Pérez, M. C. R., & de León, A. C. (2018) · Immunology Letters · doi:10.1016/j.imlet.2018.09.002 · Cited by 82

Myostatin in relation to physical activity and dysglycaemia and its effect on energy metabolism in human skeletal muscle cells

Hjorth, M., Pourteymour, S., Görgens, S. W., Langleite, T. M., Lee, S., Holen, T., Gulseth, H. L., Birkeland, K. I., Jensen, J., Drevon, C. A., et al. (2016) · Acta Physiologica · doi:10.1111/apha.12631 · Cited by 83

Fatty Acids, Antioxidants and Physical Activity in Brain Aging

Freitas, H. R., Ferreira, G. C., Trevenzoli, I. H., Oliveira, K. J., & Reis, R. A. D. M. (2017) · Nutrients · doi:10.3390/nu9111263 · Cited by 85

Intramuscular fat and physical performance at the Framingham Heart Study

Therkelsen, K. E., Pedley, A., Hoffmann, U., Fox, C. S., & Murabito, J. M. (2016) · AGE · doi:10.1007/s11357-016-9893-2 · Cited by 77

The relationship between brain-derived neurotrophic factor, irisin and cognitive skills of endurance athletes

Belviranlı, M., Okudan, N., Kabak, B., Erdoğan, M., & Karanfılcı, M. (2016) · The Physician and Sportsmedicine · doi:10.1080/00913847.2016.1196125 · Cited by 77

Prevention of cardiovascular disease in rheumatoid arthritis

Hollan, I., Dessein, P. H., Ronda, N., Wasko, M. C., Svenungsson, E., Agewall, S., Tervaert, J.-W. C., Maki-Petaja, K. M., Grundtvig, M., Karpouzas, G. A., et al. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2015.06.004 · Cited by 72

Effects of Aerobic Exercises on Serum Levels of Myonectin and Insulin Resistance in Obese and Overweight Women

Pourranjbar, M., Arabnejad, N., Naderipour, K., & Rafie, F. (2018) · Journal of Medicine and Life · doi:10.25122/jml-2018-0033 · Cited by 73

Strength training reduces circulating interleukin-6 but not brain-derived neurotrophic factor in community-dwelling elderly individuals

Forti, L. N., Njemini, R., Beyer, I., Eelbode, E., Meeusen, R., Mets, T., & Bautmans, I. (2014) · AGE · doi:10.1007/s11357-014-9704-6 · Cited by 67

Metabolic Health—The Role of Adipo-Myokines

Gräf, C., & Ferrari, N. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246159 · Cited by 70

The secretome of skeletal muscle cells: A systematic review

Florin, A., Lambert, C., Sanchez, C., Zappia, J., Durieux, N., Tieppo, A. M., Mobasheri, A., & Henrotin, Y. E. (2020) · Osteoarthritis and Cartilage Open · doi:10.1016/j.ocarto.2019.100019 · Cited by 73

Altered Myokine Secretion Is an Intrinsic Property of Skeletal Muscle in Type 2 Diabetes

Ciaraldi, T. P., Ryan, A. J., Mudaliar, S. R., & Henry, R. R. (2016) · PLOS ONE · doi:10.1371/journal.pone.0158209 · Cited by 66

State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions

Lavin, K. M., Coen, P. M., Baptista, L. C. P., Bell, M. B., Drummer, D. J., Harper, S. A., Lixandrão, M. E., McAdam, J. S., O’Bryan, S. M., Ramos, S. V., et al. (2022) · Comprehensive physiology · doi:10.1002/cphy.c200033 · Cited by 78

Early body composition, but not body mass, is associated with future accelerated decline in muscle quality

Fabbri, E., Shaffer, N. C., Gonzalez-Freire, M., Shardell, M., Zoli, M., Studenski, S., & Ferrucci, L. (2017) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12183 · Cited by 52

Lack of Adipocyte-Fndc5/Irisin Expression and Secretion Reduces Thermogenesis and Enhances Adipogenesis

Pérez-Sotelo, D., Roca-Rivada, A., de la Torre, I. B., Baltar, J., Castro, A. I., Domínguez, E., Collado, M., Casanueva, F. F., & Pardo, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-16602-z · Cited by 59

Follistatin-like 1 as a Novel Adipomyokine Related to Insulin Resistance and Physical Activity

Xu, X., Zhang, T., Mokou, M., Li, L., Li, P., Song, J., Liu, H., Zhu, Z., Liu, D., Yang, M., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa629 · Cited by 57

IL-6, Antioxidant Capacity and Muscle Damage Markers Following High-Intensity Interval Training Protocols

Cipryan, L. (2017) · Journal of Human Kinetics · doi:10.1515/hukin-2017-0031 · Cited by 61

Exercise, skeletal muscle and inflammation: ARE-binding proteins as key regulators in inflammatory and adaptive networks

Beiter, T., Hoene, M., Prenzler, F., Mooren, F. C., Steinacker, J. M., Weigert, C., Niess, A. M., & Munz, B. (2026) · PubMed · doi:10.22029/eir.2015.1695 · Cited by 56

Sedentary time, metabolic abnormalities, and all-cause mortality after myocardial infarction: A mediation analysis

Wu, Z., Huang, Z., Wu, Y., Huang, S., Wang, Y., Zhao, H., Chen, S., Wu, S., & Gao, X. (2018) · European Journal of Preventive Cardiology · doi:10.1177/2047487318804611 · Cited by 55

Voluntary running exercise protects against sepsis-induced early inflammatory and pro-coagulant responses in aged mice

Tyml, K., Swarbreck, S. B., Pape, C., Secor, D., Koropatnick, J. D., Feng, Q., Veldhuizen, R. A. W., & Gill, S. E. (2017) · Critical Care · doi:10.1186/s13054-017-1783-1 · Cited by 53

Skeletal muscle glucose metabolism and inflammation in the development of the metabolic syndrome

Marette, A., Liu, Y., & Sweeney, G. (2014) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-014-9296-6 · Cited by 55

Muscle damage and inflammation after eccentric exercise: can the repeated bout effect be removed?

Margaritelis, N. V., Theodorou, A. A., Baltzopoulos, V., Maganaris, C. N., Paschalis, V., Kyparos, A., & Nikolaidis, M. G. (2015) · Physiological Reports · doi:10.14814/phy2.12648 · Cited by 55

Current Evidence of the Role of the Myokine Irisin in Cancer

Tsiani, E., Tsakiridis, N., Kouvelioti, R., Jaglanian, A., & Klentrou, P. (2021) · Cancers · doi:10.3390/cancers13112628 · Cited by 52

Novel insights into regulators and functional modulators of adipogenesis

Kim, H., Jang, H., Muthamil, S., Shin, U. C., Lyu, J., Kim, S.-W., Go, Y., Park, S., Lee, H. G., & Park, J. H. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117073 · Cited by 54

Serum irisin levels and thyroid function—Newly discovered association

Ruchała, M., Zybek, A., & Szczepanek‐Parulska, E. (2014) · Peptides · doi:10.1016/j.peptides.2014.07.021 · Cited by 51

Chronic Stress Contributes to Osteosarcopenic Adiposity via Inflammation and Immune Modulation: The Case for More Precise Nutritional Investigation

Ilich, J. Z., Gilman, J. C., Cvijetić, S., & Boschiero, D. (2020) · Nutrients · doi:10.3390/nu12040989 · Cited by 51

Gut microbiota and regulation of myokine-adipokine function

Suriano, F., Hul, M. V., & Cani, P. D. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.03.006 · Cited by 50

The effect of fitness level on cardiac autonomic regulation, IL-6, total antioxidant capacity, and muscle damage responses to a single bout of high-intensity interval training

Cipryan, L. (2016) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2016.11.001 · Cited by 47

Evidence for acute contraction-induced myokine secretion by C2C12 myotubes

Furuichi, Y., Manabe, Y., Takagi, M., Aoki, M., & FUJII, N. L. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206146 · Cited by 47

Exercise in pregnancy does not alter gestational weight gain, MCP ‐1 or leptin in obese women

Nitert, M. D., Barrett, H. L., Denny, K. J., McIntyre, D. H., Callaway, L. K., & the BAMBINO group (2015) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/ajo.12300 · Cited by 50

Metabolic and inflammatory genes in schizophrenia

Chase, K. A., Rosen, C., Gin, H., Bjorkquist, O., Feiner, B., Marvin, R., Conrin, S., & Sharma, R. P. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2014.11.007 · Cited by 41

Locus Characterization and Gene Expression of Bovine FNDC5: Is the Myokine Irisin Relevant in Cattle?

Komolka, K., Albrecht, E., Schering, L., Brenmoehl, J., Hoeflich, A., & Maak, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088060 · Cited by 44

Compensatory anabolic signaling in the sarcopenia of experimental chronic arthritis

Little, R. D., Prieto‐Potín, I., Pérez-Baos, S., Villalvilla, A., Gratal, P., Cicuttini, F., Largo, R., & Herrero‐Beaumont, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-06581-6 · Cited by 44

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Intensity Dependent Effects of Interval Resistance Training on Myokines and Cardiovascular Risk Factors in Males With Obesity

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Inflammatory and Oxidative Stress Markers in Skeletal Muscle of Obese Subjects

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