Cited by 296Exercise and Physiological ResponsesAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

The DOI matches its Crossref record; 180 of the 180 references it cites were found in a registry or an index.

Adipo-myokines: two sides of the same coin–mediators of inflammation and mediators of exercise

Open access

Raschke, Silja, Eckel, Jürgen·2013·Mediators of Inflammation

DOI 10.1155/2013/320724PMC PMC3686148

Open this paper in CoChat — free account Open PDF

Abstract

This review summarizes the current literature regarding the most discussed contraction-regulated moykines like IL-6, IL-15, irisin, BDNF, ANGPTL4, FGF21, myonectin and MCP-1. It is suggested that the term myokine is restricted to proteins secreted from skeletal muscle cells, excluding proteins that are secreted by other cell types in skeletal muscle tissue and excluding proteins which are only described on the mRNA level. Interestingly, many of the contraction-regulated myokines described in the literature are additionally known to be secreted by adipocytes. We termed these proteins adipo-myokines. Within this review, we try to elaborate on the question why pro-inflammatory adipokines on the one hand are upregulated in the obese state, and have beneficial effects after exercise on the other hand. Both, adipokines and myokines do have autocrine effects within their corresponding tissues. In addition, they are involved in an endocrine crosstalk with other tissues. Depending on the extent and the kinetics of adipo-myokines in serum, these molecules seem to have a beneficial or an adverse effect on the target tissue.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1155/2013/320724

Cites

180 of 180 references verified0 citation errors · 0 not checkable

Statistics

Figure 1 Adipokines, myokines, and adipo-myokines. A search of original articles in pubMed was performed for all myokines described in Table 1 to identify myokines that were also secreted by adipocytes. The search terms used were “adipose tissue,” “adipocyte,” and the indicated cytokine/protein. Reference lists of identified articles were also used to search for further papers. Indicated references published data that the cytokines/proteins are secreted or not secreted by adipocytes or adipose tissue. No data was published on the secretion of LIF and irisin from adipocytes or adipose tissue.CC BY · PubMed Central

Figure 2 Leptin secretion from primary human myotubes and adipocytes. Primary human skeletal muscle cells and preadipocytes were differentiated in vitro for 6 and 14 days, respectively. Supernatants were collected on day 2/6 and day 0/14 of differentiation, respectively. Leptin secretion was measured by ELISA (R&D Systems), n ≥ 8. Samples were measured according to the manufacturer's instructions.CC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Adipose Tissue as an Endocrine Organ
Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810
Adipokines in inflammation and metabolic disease
Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017
Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238
Muscles, exercise and obesity: skeletal muscle as a secretory organ
Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388
AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity
Hu, E., Liang, P., & Spiegelman, B. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10697 · Cited by 2,261
Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.
Baggiolini, M., Dewald, B., & Moser, B. (1994) · PubMed · Cited by 2,232
Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes
DeFronzo, R. A., & Tripathy, D. (2009) · Diabetes Care · doi:10.2337/dc09-s302 · Cited by 2,102 · cited 1×
“The activation of inflammatory pathways leads to insulin resistance in peripheral tissues such as skeletal muscle and adipose tissue itself, constituting an early defect in the pathogenesis of type 2 diabetes [15].”
Background
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
Fisher, F. M., Kleiner, S., Douris, N., Fox, E. C., Mepani, R. J., Verdeguer, F., Wu, J., Kharitonenkov, A., Flier, J. S., Maratos-Flier, E., et al. (2012) · Genes & Development · doi:10.1101/gad.177857.111 · Cited by 1,478
Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ
Trayhurn, P., & Beattie, J. H. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns200194 · Cited by 1,292
Monocyte chemoattractant protein 1 in obesity and insulin resistance
Sartipy, P., & Loskutoff, D. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1133870100 · Cited by 1,229
Interleukin-6-deficient mice develop mature-onset obesity
Wallenius, V., Wallenius, K., Ahrén, B., Rudling, M., Carlsten, H., Dickson, S. L., Ohlsson, C., & Jansson, J.-O. (2002) · Nature Medicine · doi:10.1038/nm0102-75 · Cited by 1,213
Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6
Steensberg, A., van Hall, G., Osada, T., Sacchetti, M., Saltin, B., & Pedersen, B. K. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00237.x · Cited by 1,095
The role of exercise and PGC1α in inflammation and chronic disease
Handschin, C., & Spiegelman, B. M. (2008) · Nature · doi:10.1038/nature07206 · Cited by 1,083
Interleukin-6 (IL-6) Induces Insulin Resistance in 3T3-L1 Adipocytes and Is, Like IL-8 and Tumor Necrosis Factor-α, Overexpressed in Human Fat Cells from Insulin-resistant Subjects
Rotter, V., Nagaev, I., & Smith, U. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301977200 · Cited by 1,062
FNDC5 and Irisin in Humans: I. Predictors of Circulating Concentrations in Serum and Plasma and II. mRNA Expression and Circulating Concentrations in Response to Weight Loss and Exercise
Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.09.002 · Cited by 1,040
Pro‐ and anti‐inflammatory cytokine balance in strenuous exercise in humans
Ostrowski, K., Rohde, T., Asp, S., Schjerling, P., & Pedersen, B. K. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.287ad.x · Cited by 1,014
Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle
Barrès, R., Yan, J., Egan, B., Treebak, J. T., Rasmussen, M., Fritz, T., Caidahl, K., Krook, A., O'Gorman, D. J., & Zierath, J. R. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.001 · Cited by 965 · cited 1×
“Although PPARδ is known to be activated by high-intensity exercise [78], Catoire et al.”
Background
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
Ellingsgaard, H., Hauselmann, I., Schuler, B., Habib, A. M., Baggio, L. L., Meier, D. T., Eppler, E., Bouzakri, K., Wueest, S., Muller, Y. D., et al. (2011) · Nature Medicine · doi:10.1038/nm.2513 · Cited by 922
Evidence for a release of brain-derived neurotrophic factor from the brain during exercise
Rasmussen, P., Brassard, P., Adser, H., Pedersen, M. V., Leick, L., Hart, E., Secher, N. H., Pedersen, B. K., & Pilegaard, H. (2009) · Experimental Physiology · doi:10.1113/expphysiol.2009.048512 · Cited by 914
Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase
Carey, A. L., Steinberg, G. R., Macaulay, S. L., Thomas, W. G., Holmes, A. G., Ramm, G., Prelovsek, O., Hohnen-Behrens, C., Watt, M. J., James, D. E., et al. (2006) · Diabetes · doi:10.2337/db05-1404 · Cited by 898
Interleukin-6 induces cellular insulin resistance in hepatocytes.
Senn, J. J., Klover, P. J., Nowak, I. A., & Mooney, R. A. (2002) · Diabetes · doi:10.2337/diabetes.51.12.3391 · Cited by 883 · cited 3×
“IL-6 promotes insulin resistance [91, 98, 99] ✓”
Background
Muscle‐derived interleukin‐6: mechanisms for activation and possible biological roles
FEBBRAIO, M. A., & PEDERSEN, B. K. (2002) · The FASEB Journal · doi:10.1096/fj.01-0876rev · Cited by 875
The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function.
FERRIS, L. T., WILLIAMS, J. S., & SHEN, C.-L. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31802f04c7 · Cited by 849
A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
Wang, J., Liu, R., Hawkins, M. A., Barzilai, N., & Rossetti, L. (1998) · Nature · doi:10.1038/31474 · Cited by 823
Interleukin-6 in acute exercise and training: what is the biological relevance?
Fischer, C. P. (2026) · PubMed · doi:10.22029/eir.2006.1620 · Cited by 817
Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans
Bruun, J. M., Lihn, A. S., Verdich, C., Pedersen, S. B., Toubro, S., Astrup, A. V., & Richelsen, B. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00110.2003 · Cited by 779
Interleukin-6 stimulates lipolysis and fat oxidation in humans
van Hall, G., Steensberg, A., Sacchetti, M., Fischer, C., Keller, C., Schjerling, P., Hiscock, N., Møller, K., Saltin, B., Febbraio, M. A., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021687 · Cited by 767
Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase
Matthews, V. B., Åström, M.-B., Chan, M. H. S., Bruce, C. R., Krabbe, K. S., Prelovsek, O., Åkerström, T., Yfanti, C., Broholm, C., Mortensen, O. H., et al. (2009) · Diabetologia · doi:10.1007/s00125-009-1364-1 · Cited by 722
A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy
Ruas, J. L., White, J. P., Rao, R. R., Kleiner, S., Brannan, K. T., Harrison, B. C., Greene, N. P., Wu, J., Estall, J. L., Irving, B. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.10.050 · Cited by 677
Muscles and their myokines
Pedersen, B. K. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.048074 · Cited by 668
Circulating Interleukin‐6 in Relation to Adiposity, Insulin Action, and Insulin Secretion
Vozarova, B., Weyer, C., Hanson, K. A., Tataranni, P. A., Bogardus, C., & Pratley, R. E. (2001) · Obesity Research · doi:10.1038/oby.2001.54 · Cited by 637
Adipose Tissue IL-6 Content Correlates with Resistance to Insulin Activation of Glucose Uptake both in Vivo and in Vitro
Bastard, J., Maachi, M., Nhieu, J. T. V., Jardel, C., Bruckert, É., Grimaldi, A., Robert, J., Capeau, J., & Hainque, B. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8450 · Cited by 636
The diseasome of physical inactivity – and the role of myokines in muscle–fat cross talk
Pedersen, B. K. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.179515 · Cited by 631
FNDC5/irisin is not only a myokine but also an adipokine
Roca-Rivada, A., Castelao, C., Senin, L. L., Landrove, M. O., Baltar, J., Crujeiras, A. B., Seoane, L. M., Casanueva, F. F., & Pardo, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060563 · Cited by 612 · cited 2×
“Furthermore, to demonstrate the secretion of irisin from HEK293 cells and to analyze murine and human serum samples, the authors used an antibody, which most likely cannot detect the cleaved irisin, since the antibody used is directed against the C-terminal part of the protein (Abcam 149–178, Cterminal) [58].”
Background
Dipeptidyl Peptidase 4 Is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome
Lamers, D., Famulla, S., Wronkowitz, N., Hartwig, S., Lehr, S., Ouwens, D. M., Eckardt, K., Kaufman, J., Rydén, M., Müller, S., et al. (2011) · Diabetes · doi:10.2337/db10-1707 · Cited by 583
Self-citation
A Cysteine-rich Adipose Tissue-specific Secretory Factor Inhibits Adipocyte Differentiation
Kim, K., Lee, K., Moon, Y. S., & Sul, H. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100028200 · Cited by 582
Monocyte Chemoattractant Protein-1 Release Is Higher in Visceral than Subcutaneous Human Adipose Tissue (AT): Implication of Macrophages Resident in the AT
Bruun, J. M., Lihn, A. S., Pedersen, S. B., & Richelsen, B. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1696 · Cited by 555
Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content
Keller, C., Steensberg, A., Pilegaard, H., Osada, T., Saltin, B., Pedersen, B. K., & Neufer, P. D. (2001) · The FASEB Journal · doi:10.1096/fj.01-0507fje · Cited by 514
Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters
Kim, C.-S., Park, H.-S., Kawada, T., Kim, J.-H., Lim, D., Hubbard, N. E., Kwon, B.-S., Erickson, K. L., & Yu, R. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803259 · Cited by 511
Chronic Exposure to Interleukin-6 Causes Hepatic Insulin Resistance in Mice
Klover, P. J., Zimmers, T. A., Koniaris, L. G., & Mooney, R. A. (2003) · Diabetes · doi:10.2337/diabetes.52.11.2784 · Cited by 488
C1q: Structure, function, and receptors
Kishore, U., & Reid, K. B. M. (2000) · Immunopharmacology · doi:10.1016/s0162-3109(00)80301-x · Cited by 480
Time course of proteolytic, cytokine, and myostatin gene expression after acute exercise in human skeletal muscle
Louis, E., Raue, U., Yang, Y., Jemiolo, B., & Trappe, S. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00679.2007 · Cited by 478
Strength Training with Blood Flow Restriction Diminishes Myostatin Gene Expression
Laurentino, G. C., Ugrinowitsch, C., Roschel, H., Aoki, M. S., Soares, A. G., Neves, M., Aihara, A. Y., Fernandes, A. D. R. C., & Tricoli, V. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318233b4bc · Cited by 466
Interleukin‐6 production in contracting human skeletal muscle is influenced by pre‐exercise muscle glycogen content
Steensberg, A., Febbraio, M. A., Osada, T., Schjerling, P., van Hall, G., Saltin, B., & Pedersen, B. K. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00633.x · Cited by 444
Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects
Christiansen, T., Richelsen, B., & Bruun, J. M. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802839 · Cited by 424
FGF21 is an Akt‐regulated myokine
Izumiya, Y., Bina, H. A., Ouchi, N., Akasaki, Y., Kharitonenkov, A., & Walsh, K. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.10.021 · Cited by 415
Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis
Seldin, M. M., Peterson, J. M., Byerly, M. S., Wei, Z., & Wong, G. W. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.336834 · Cited by 406
Is irisin a human exercise gene?
Timmons, J. A., Baar, K., Davidsen, P. K., & Atherton, P. J. (2012) · Nature · doi:10.1038/nature11364 · Cited by 393
Circulating Fibroblast Growth Factor-21 Is Elevated in Impaired Glucose Tolerance and Type 2 Diabetes and Correlates With Muscle and Hepatic Insulin Resistance
Chavez, A. O., Molina-Carrion, M., Abdul-Ghani, M. A., Folli, F., DeFronzo, R. A., & Tripathy, D. (2009) · Diabetes Care · doi:10.2337/dc09-0684 · Cited by 390
Adipokines: A treasure trove for the discovery of biomarkers for metabolic disorders
Lehr, S., Hartwig, S., & Sell, H. (2011) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201100052 · Cited by 376
Exercise-induced myokines and their role in chronic diseases
Pedersen, B. K. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.02.010 · Cited by 370
Acute BDNF and cortisol response to low intensity exercise and following ramp incremental exercise to exhaustion in humans
Rojas Vega, S., Strüder, H. K., Vera Wahrmann, B., Schmidt, A., Bloch, W., & Hollmann, W. (2006) · Brain Research · doi:10.1016/j.brainres.2006.08.105 · Cited by 357
Carbohydrate ingestion influences skeletal muscle cytokine mRNA and plasma cytokine levels after a 3-h run
Nieman, D. C., Davis, J. M., Henson, D. A., Walberg-Rankin, J., Shute, M., Dumke, C. L., Utter, A. C., Vinci, D. M., Carson, J. A., Brown, A., et al. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01130.2002 · Cited by 353
Follistatin-like 1, a secreted muscle protein, promotes endothelial cell function and revascularization in ischemic tissue through a nitric-oxide synthase-dependent mechanism
Ouchi, N., Oshima, Y., Ohashi, K., Higuchi, A., Ikegami, C., Izumiya, Y., & Walsh, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803440200 · Cited by 338
Adiposity Elevates Plasma MCP-1 Levels Leading to the Increased CD11b-positive Monocytes in Mice
Takahashi, K., Mizuarai, S., Araki, H., Mashiko, S., Ishihara, A., Kanatani, A., Itadani, H., & Kotani, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309895200 · Cited by 327
Increased secretion and expression of myostatin in skeletal muscle from extremely obese women
Hittel, D. S., Berggren, J. R., Shearer, J., Boyle, K., & Houmard, J. A. (2009) · Diabetes · doi:10.2337/db08-0943 · Cited by 324
Dynamics of the skeletal muscle secretome during myoblast differentiation
Henningsen, J., Rigbolt, K. T. G., Blagoev, B., Pedersen, B. K., & Kratchmarova, I. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.002113 · Cited by 303
Association between measures of insulin sensitivity and circulating levels of interleukin-8, interleukin-6 and tumor necrosis factor-alpha. Effect of weight loss in obese men
Bruun, J. M., Verdich, C., Toubro, S., Astrup, A. V., & Richelsen, B. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1480535 · Cited by 301
Subcutaneous and Visceral Adipose Tissue Gene Expression of Serum Adipokines That Predict Type 2 Diabetes
Samaras, K., Botelho, N. K., Chisholm, D. J., & Lord, R. V. (2009) · Obesity · doi:10.1038/oby.2009.443 · Cited by 287
Expression of interleukin-15 in human skeletal muscle effect of exercise and muscle fibre type composition
Nielsen, A. R., Mounier, R., Plomgaard, P., Mortensen, O. H., Penkowa, M., Speerschneider, T., Pilegaard, H., & Pedersen, B. K. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.139618 · Cited by 266
Obesity and Inflammation: Change in Adiponectin, C-Reactive Protein, Tumour Necrosis Factor-Alpha and Interleukin-6 After Bariatric Surgery
Illán-Gómez, F., Gonzálvez-Ortega, M., Orea-Soler, I., Alcaraz-Tafalla, M. S., Aragón-Alonso, A., Pascual-Díaz, M., Pérez-Paredes, M., & Lozano-Almela, M. L. (2012) · Obesity Surgery · doi:10.1007/s11695-012-0643-y · Cited by 265
Chemerin Correlates with Markers for Fatty Liver in Morbidly Obese Patients and Strongly Decreases after Weight Loss Induced by Bariatric Surgery
Sell, H., Divoux, A., Poitou, C., Basdevant, A., Bouillot, J., Bédossa, P., Tordjman, J., Eckel, J., & Clément, K. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2374 · Cited by 262
Self-citation
Release and regulation of leptin, resistin and adiponectin from human placenta, fetal membranes, and maternal adipose tissue and skeletal muscle from normal and gestational diabetes mellitus-complicated pregnancies
Lappas, M., Yee, K., Permezel, M., & Rice, G. E. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.06227 · Cited by 251
Identification and Validation of Novel Adipokines Released from Primary Human Adipocytes
Lehr, S., Hartwig, S., Lamers, D., Famulla, S., Müller, S., Hanisch, F., Cuvelier, C. A., Ruige, J. B., Eckardt, K., Ouwens, D. M., et al. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.010504 · Cited by 249
Self-citation
Contractile C2C12myotube model for studying exercise-inducible responses in skeletal muscle
Nedachi, T., Fujita, H., & Kanzaki, M. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90280.2008 · Cited by 247
The biological roles of exercise-induced cytokines: IL-6, IL-8, and IL-15
Nielsen, A. R., & Pedersen, B. K. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-054 · Cited by 246
Accelerated de novo sarcomere assembly by electric pulse stimulation in C2C12 myotubes
Fujita, H., Nedachi, T., & Kanzaki, M. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.03.002 · Cited by 246
IL-7 is expressed and secreted by human skeletal muscle cells
Haugen, F., Norheim, F., Lian, H., Wensaas, A. J., Dueland, S., Berg, O., Funderud, A., Skålhegg, B. S., Raastad, T., & Drevon, C. A. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00094.2009 · Cited by 237 · cited 1×
“New technological advances, like array studies and proteomic analysis, made the analysis of the qualitative and quantitative analysis of the secretome of skeletalmuscle possible.”
Background
Characterization of the Human Visceral Adipose Tissue Secretome
Álvarez‐Llamas, G., Szalowska, E., de Vries, M. P., Weening, D., Landman, K., Hoek, A., Wolffenbuttel, B. H. R., Roelofsen, H., & Vonk, R. J. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600265-mcp200 · Cited by 236
Influence of mode and carbohydrate on the cytokine response to heavy exertion
NIEMAN, D. C., NEHLSEN-CANNARELLA, S. L., FAGOAGA, O. R., HENSON, D. A., UTTER, A., DAVIS, J. M., WILLIAMS, F., & BUTTERWORTH, D. E. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199805000-00005 · Cited by 233
Association of interleukin-15 protein and interleukin-15 receptor genetic variation with resistance exercise training responses
Riechman, S. E., Balasekaran, G., Roth, S. M., & Ferrell, R. E. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00491.2004 · Cited by 228
Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines
Papanicolaou, D. A., Petrides, J. S., Tsigos, C., Bina, S., Kalogeras, K. T., Wilder, R. L., Gold, P. W., Deuster, P. A., & Chrousos, G. P. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.3.e601 · Cited by 226
Monocyte Chemotactic Protein-1 Is a Potential Player in the Negative Cross-Talk between Adipose Tissue and Skeletal Muscle
Sell, H., Dietze‐Schroeder, D., Kaiser, U., & Eckel, J. (2006) · Endocrinology · doi:10.1210/en.2005-0969 · Cited by 226
Self-citation
IL-6 selectively stimulates fat metabolism in human skeletal muscle
Wolsk, E., Mygind, H., Grøndahl, T. S., Pedersen, B. K., & van Hall, G. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00328.2010 · Cited by 221 · cited 1×
“Furthermore, IL-6 rapidly and markedly increased AMPK and increased fatty acid oxidation [104, 105].”
Background
Adipokines oversecreted by omental adipose tissue in human obesity
Maury, E., Ehala-Aleksejev, K., Guiot, Y., Détry, R., Vandenhooft, A., & Brichard, S. M. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00127.2007 · Cited by 212
Human Primary Adipocytes Exhibit Immune Cell Function: Adipocytes Prime Inflammation Independent of Macrophages
Meijer, K., de Vries, M., Al-Lahham, S., Bruinenberg, M., Weening, D., Dijkstra, M., Kloosterhuis, N., van der Lei, R. J., van der Want, H., Kroesen, B., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017154 · Cited by 211
BDNF is expressed in skeletal muscle satellite cells and inhibits myogenic differentiation
Mousavi, K., & Jasmin, B. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5398-05.2006 · Cited by 210
Secretome of Primary Cultures of Human Adipose-derived Stem Cells
Zvonic, S., LeFevre, M. L., Kilroy, G. E., Floyd, Z. E., DeLany, J. P., Kheterpal, I., Gravois, A., Dow, R., White, A., Wu, X., et al. (2006) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600217-mcp200 · Cited by 208
The Adipose Tissue as an Endocrine Organ
Adamczak, M., & Więcek, A. (2013) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2012.12.008 · Cited by 207
Circulating Brain-Derived Neurotrophic Factor and Indices of Metabolic and Cardiovascular Health: Data from the Baltimore Longitudinal Study of Aging
Golden, E., Emiliano, A. B., Maudsley, S. R., Windham, B. G., Carlson, O. D., Egan, J. M., Driscoll, I. F., Ferrucci, L., Martin, B., & Mattson, M. P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010099 · Cited by 202
Interleukin-15 stimulates adiponectin secretion by 3T3-L1 adipocytes: Evidence for a skeletal muscle-to-fat signaling pathway
QUINN, L., STRAITBODEY, L., ANDERSON, B., ARGILES, J., & HAVEL, P. (2005) · Cell Biology International · doi:10.1016/j.cellbi.2005.02.005 · Cited by 199
Fibroblast Growth Factor-21 Is Induced in Human Skeletal Muscles by Hyperinsulinemia
Hojman, P., Pedersen, M., Nielsen, A. R., Krogh-Madsen, R., Yfanti, C., Åkerstrom, T., Nielsen, S., & Pedersen, B. K. (2009) · Diabetes · doi:10.2337/db09-0713 · Cited by 198
Carbohydrate ingestion attenuates the increase in plasma interleukin-6, but not skeletal muscle interleukin-6 mRNA, during exercise in humans
Starkie, R. L., Arkinstall, M. J., Koukoulas, I., Hawley, J. A., & Febbraio, M. A. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0585a.x · Cited by 197
Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass
Nielsen, A. R., Højman, P., Erikstrup, C., Fischer, C. P., Plomgaard, P., Mounier, R., Mortensen, O. H., Broholm, C., Taudorf, S., Krogh‐Madsen, R., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2561 · Cited by 194
Cross-talk between skeletal muscle and adipose tissue: A link with obesity?
Argilés, J. M. A., López‐Soriano, J., Almendro, V., Busquets, S., & López-Soriano, F. J. (2004) · Medicinal Research Reviews · doi:10.1002/med.20010 · Cited by 194
Mutation in a short-chain collagen gene, CTRP5 , results in extracellular deposit formation in late-onset retinal degeneration: a genetic model for age-related macular degeneration
Hayward, C., Shu, X., Cideciyan, A. V., Lennon, A., Barran, P., Zareparsi, S., Sawyer, L., Hendry, G., Dhillon, B., Milam, A. H., et al. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg289 · Cited by 191
Myostatin Gene Expression is Reduced in Humans with Heavy-Resistance Strength Training: A Brief Communication
Roth, S. M., Martel, G. F., Ferrell, R. E., Metter, E. J., Hurley, B. F., & Rogers, M. A. (2003) · Experimental Biology and Medicine · doi:10.1177/153537020322800609 · Cited by 184
Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via Peroxisome Proliferator–Activated Receptor (PPAR)-δ and Is of Metabolic Relevance in Humans
Staiger, H., Haas, C., Machann, J., Werner, R., Weisser, M., Schick, F., Machicao, F., Stefan, N., Fritsche, A., & Häring, H.-U. (2009) · Diabetes · doi:10.2337/db07-1438 · Cited by 183
Profiling of the secreted proteins during 3T3-L1 adipocyte differentiation leads to the identification of novel adipokines
Wang, P., Mariman, E. C. M., Keijer, J., Bouwman, F. G., Noben, J., Robben, J., & Renes, J. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4256-z · Cited by 182
Elevated Serum Levels of Pigment Epithelium-Derived Factor in the Metabolic Syndrome
Yamagishi, S., Adachi, H., Abe, A., Yashiro, T., Enomoto, M., Furuki, K., Hino, A., Jinnouchi, Y., Takenaka, K., Matsui, T., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2654 · Cited by 181
Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength training
Norheim, F., Raastad, T., Thiede, B., Rustan, A. C., Drevon, C. A., & Haugen, F. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00326.2011 · Cited by 180
Significance of chemokines and activated platelets in patients with diabetes
Nomura, S., Shouzu, A., Omoto, S., Nishikawa, M., & Fukuhara, S. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01324.x · Cited by 180
Caloric Restriction and Exercise Increase Plasma ANGPTL4 Levels in Humans via Elevated Free Fatty Acids
Kersten, S., Lichtenstein, L., Steenbergen, E., Mudde, K., Hendriks, H. F. J., Hesselink, M. K., Schrauwen, P., & Müller, M. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.182147 · Cited by 178
Exercise increases serum fibroblast growth factor 21 (FGF21) levels
Cuevas-Ramos, D., Almeda-Valdés, P., Meza-Arana, C. E., Brito-Córdova, G., Gómez-Pérez, F. J., Mehta, R., Oseguera-Moguel, J., & Aguilar-Salinas, C. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038022 · Cited by 178
Brain-derived Neurotrophic Factor Regulates Satellite Cell Differentiation and Skeltal Muscle Regeneration
Clow, C., & Jasmin, B. J. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-02-0154 · Cited by 175
Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: A potential role in body weight control
Carbó, N., López-Soriano, J., Costelli, P., Alvarez, B., Busquets, S., Baccino, F. M., Quinn, L. S., López-Soriano, F. J., & Argilés, J. M. (2001) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(00)00188-4 · Cited by 174 · cited 1×
“Since IL-15 has been described to have anabolic effects, it may play a role in reducing adipose tissue mass as part of muscle-adipose tissue crosstalk [124].”
Background
Electrical Pulse Stimulation of Cultured Human Skeletal Muscle Cells as an In Vitro Model of Exercise
Nikolić, N., Bakke, S. S., Kase, E. T., Rudberg, I., Halle, I. F., Rustan, A. C., Thoresen, G. H., & Aas, V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033203 · Cited by 173
Inflammation, Obesity, and the Metabolic Syndrome
Yudkin, J. S. (2007) · Hormone and Metabolic Research · doi:10.1055/s-2007-985898 · Cited by 172
Mouse PeP: A novel peroxisomal protein linked to myoblast differentiation and development
Ferrer-Martı́nez, A., Ruiz‐Lozano, P., & Chien, K. R. (2002) · Developmental Dynamics · doi:10.1002/dvdy.10099 · Cited by 169
Interleukin-6 and tumor necrosis factor-? are not increased in patients with Type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness
Carey, A. L., Bruce, C. R., Sacchetti, M., Anderson, M. J., Olsen, D. B., Saltin, B., Hawley, J. A., & Febbraio, M. A. (2004) · Diabetologia · doi:10.1007/s00125-004-1403-x · Cited by 168
Expression of monocyte chemoattractant protein‐1 and interleukin‐8 receptors on subsets of T cells: correlation with transendothelial chemotactic potential
Qin, S., LaRosa, G. J., Campbell, J. J., Smith‐Heath, H., Kassam, N., Shi, X., Zeng, L., Butcher, E. C., & Mackay, C. R. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260320 · Cited by 167
Regulation of Leptin Production in Cultured Mature White Adipocytes
Hardie, L. J., Guilhot, N., & Trayhurn, P. (1996) · Hormone and Metabolic Research · doi:10.1055/s-2007-979878 · Cited by 166
Influence of carbohydrate ingestion on immune changes after 2 h of intensive resistance training
Nieman, D. C., Davis, J. M., Brown, V. A., Henson, D. A., Dumke, C. L., Utter, A. C., Vinci, D. M., Downs, M. F., Smith, J., Carson, J. A., et al. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01064.2003 · Cited by 166
Repeated resistance exercise training induces different changes in mRNA expression of MAFbx and MuRF-1 in human skeletal muscle
Mascher, H., Tannerstedt, J., Brink-Elfegoun, T., Ekblom, B. T., Gustafsson, T. P., & Blomstrand, E. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00504.2007 · Cited by 165
Pigment epithelium-derived factor (PEDF) is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells
Famulla, S., Lamers, D., Hartwig, S., Paßlack, W., Horrighs, A., Cramer, A., Lehr, S., Sell, H., & Eckel, J. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.212 · Cited by 158
Self-citation
Pro‐ and anti‐angiogenic factors in human skeletal muscle in response to acute exercise and training
Høier, B., Nordsborg, N. B., Andersen, S., Jensen, L., Nybo, L., Bangsbo, J., & Hellsten, Y. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.216135 · Cited by 158
LIF is a contraction-induced myokine stimulating human myocyte proliferation
Broholm, C., Laye, M. J., Brandt, C., Vadalasetty, R., Pilegaard, H., Pedersen, B. K., & Scheele, C. C. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01399.2010 · Cited by 155
In-depth analysis of the secretome identifies three major independent secretory pathways in differentiating human myoblasts
Le Bihan, M.-C., Bigot, A., Jensen, S. S., Dennis, J. L., Rogowska-Wrzesinska, A., Lainé, J., Gache, V., Furling, D., Jensen, O. N., Voit, T., et al. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.09.008 · Cited by 153
Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans
Steensberg, A., Fischer, C. P., Sacchetti, M., Keller, C., Osada, T., Schjerling, P., van Hall, G., Febbraio, M. A., & Pedersen, B. K. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.032938 · Cited by 152
Regional differences in protein production by human adipose tissue
Arner, P. (2001) · Biochemical Society Transactions · doi:10.1042/bst0290072 · Cited by 151
Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells
Hashemi, M. ‐., Ghaedi, K., Salamian, A., Karbalaie, K., Emadi‐Baygi, M., Tanhaei, S., Nasr‐Esfahani, M. H., & Baharvand, H. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.11.041 · Cited by 149
Effects of a three‐month combined exercise programme on fibroblast growth factor 21 and fetuin‐A levels and arterial stiffness in obese women
Yang, S. J., Hong, H. C., Choi, H. Y., Yoo, H. J., Cho, G. J., Hwang, T. G., Baik, S. H., Choi, D. S., Kim, S. M., & Choi, K. M. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04078.x · Cited by 147
Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans
Steensberg, A., Fischer, C. P., Sacchetti, M., Keller, C., Osada, T., Schjerling, P., van Hall, G., Febbraio, M. A., & Pedersen, B. K. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00631.x · Cited by 146
Direct Cross-talk of Interleukin-6 and Insulin Signal Transduction via Insulin Receptor Substrate-1 in Skeletal Muscle Cells
Weigert, C., Hennige, A. M., Lehmann, R., Brodbeck, K., Baumgärtner, F., Schaüble, M., Häring, H. U., & Schleicher, E. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509782200 · Cited by 142
Temporal Profiling of the Adipocyte Proteome during Differentiation Using a Five-Plex SILAC Based Strategy
Molina, H., Yang, Y., Ruch, T. R., Kim, J. W., Mortensen, P., Otto, T. C., Nalli, A., Tang, Q.-Q., Lane, M. D., Chaerkady, R., et al. (2008) · Journal of Proteome Research · doi:10.1021/pr800650r · Cited by 142
Contractile activity of human skeletal muscle cells prevents insulin resistance by inhibiting pro-inflammatory signalling pathways
Lambernd, S., Taube, A., Schober, A., Platzbecker, B., Görgens, S. W., Schlich, R., Jeruschke, K., Weiss, J., Eckardt, K., & Eckel, J. (2012) · Diabetologia · doi:10.1007/s00125-012-2454-z · Cited by 140
Self-citation
Upregulation of circulating IL-15 by treadmill running in healthy individuals: Is IL-15 an endocrine mediator of the beneficial effects of endurance exercise?
Tamura, Y., Watanabe, K., Kantani, T., Hayashi, J., Ishida, N., & Kaneki, M. (2011) · Endocrine Journal · doi:10.1507/endocrj.k10e-400 · Cited by 137 · cited 1×
“Recently, it has been shown that 30min treadmill running at 70% of maximum heart rate resulted in a significant increase in circulating IL-15 level in untrained healthy youngmen (about 12%), measured 10min after exercise [50].”
Background
Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload
Shimano, M., Ouchi, N., Nakamura, K., van Wijk, B., Ohashi, K., Asaumi, Y., Higuchi, A., Pimentel, D. R., Sam, F., Murohara, T., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108559108 · Cited by 136
Exercise induces expression of leukaemia inhibitory factor in human skeletal muscle
Broholm, C., Mortensen, O. H., Nielsen, S., Akerstrom, T., Zankari, A., Dahl, B., & Pedersen, B. K. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.149781 · Cited by 132
Quantitative Proteomic Analysis of the Secretory Proteins from Rat Adipose Cells Using a 2D Liquid Chromatography−MS/MS Approach
Chen, X., Cushman, S. W., Pannell, L. K., & Hess, S. Y. (2005) · Journal of Proteome Research · doi:10.1021/pr049772a · Cited by 131
Temporal Profiling of the Secretome during Adipogenesis in Humans
Zhong, J., Krawczyk, S. A., Chaerkady, R., Huang, H., Goel, R., Bader, J. S., Wong, G. W., Corkey, B. E., & Pandey, A. (2010) · Journal of Proteome Research · doi:10.1021/pr100521c · Cited by 120
Pronounced Effects of Acute Endurance Exercise on Gene Expression in Resting and Exercising Human Skeletal Muscle
Catoire, M., Mensink, M., Boekschoten, M. V., Hangelbroek, R., Müller, M., Schrauwen, P., & Kersten, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051066 · Cited by 116
Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes
Gray, N. E., Lam, L. N., Yang, K., Zhou, A. Y., Koliwad, S., & Wang, J.-C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.294124 · Cited by 116
Regulation of follistatin-like protein 1 expression and secretion in primary human skeletal muscle cells
Görgens, S. W., Raschke, S., Holven, K. B., Jensen, J., Eckardt, K., & Eckel, J. (2013) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2013.768270 · Cited by 115
Self-citation
Inflammatory gene changes associated with the repeated-bout effect
Hubal, M. J., Chen, T. C., Thompson, P. D., & Clarkson, P. M. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00853.2007 · Cited by 113
Effects of long-term exercise and diet intervention on plasma adipokine concentrations
Rokling-Andersen, M. H., Reseland, J. E., Veierød, M. B., Anderssen, S. A., Jacobs, D. R., Urdal, P., Jansson, J., & Drevon, C. A. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1293 · Cited by 110
Adipose tissue-derived nerve growth factor and brain-derived neurotrophic factor: results from experimental stress and diabetes.
Sornelli, F., Fiore, M., Chaldakov, G. N., & Aloe, L. (2009) · PubMed · Cited by 108
C1q Tumor Necrosis Factor α-related Protein Isoform 5 Is Increased in Mitochondrial DNA-depleted Myocytes and Activates AMP-activated Protein Kinase
Park, S., Choi, J. H., Ryu, H. S., Pak, Y. K., Park, K. S., Lee, H. K., & Lee, W. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.005611 · Cited by 107
Contraction-induced interleukin-6 gene transcription in skeletal muscle is regulated by c-Jun terminal kinase/activator protein-1
Whitham, M., Chan, M. H. S., Pal, M., Matthews, V. B., Prelovsek, O., Lunke, S., El-Osta, A., Broenneke, H., Alber, J., Brüning, J. C., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.310581 · Cited by 107
Circulating Pigment Epithelium-Derived Factor Levels Are Associated with Insulin Resistance and Decrease after Weight Loss
Sabater, M., Moreno‐Navarrete, J. M., Ortega, F. J., Pardo, G., Salvador, J., Ricart, W., Frühbeck, G., & Fernández‐Real, J. M. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0630 · Cited by 104
IL-15 Overexpression Promotes Endurance, Oxidative Energy Metabolism, and Muscle PPARδ, SIRT1, PGC-1α, and PGC-1β Expression in Male Mice
Quinn, L. S., Anderson, B. G., Conner, J. D., & Wolden-Hanson, T. (2013) · Endocrinology · doi:10.1210/en.2012-1773 · Cited by 102
Resistance exercise increases NF-κB activity in human skeletal muscle
Vella, L. D., Caldow, M. K., Larsen, A., Tassoni, D., Gatta, P. A. D., Gran, P., Russell, A. P., & Cameron‐Smith, D. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00336.2011 · Cited by 100
Skeletal Muscle Satellite Cells Are Committed to Myogenesis and Do Not Spontaneously Adopt Nonmyogenic Fates
Starkey, J. D., Yamamoto, M., Yamamoto, S., & Goldhamer, D. J. (2011) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2010.956995 · Cited by 95
Interleukin-6 acts as insulin sensitizer on glycogen synthesis in human skeletal muscle cells by phosphorylation of Ser473 of Akt
Weigert, C., Hennige, A. M., Brodbeck, K., Häring, H. U., & Schleicher, E. D. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00448.2004 · Cited by 94
NF-κB activity in muscle from obese and type 2 diabetic subjects under basal and exercise-stimulated conditions
Tantiwong, P., Shanmugasundaram, K., Monroy, A., Ghosh, S., Li, M., DeFronzo, R. A., Cersósimo, E., Sriwijitkamol, A., Mohan, S., & Musi, N. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00776.2009 · Cited by 93
Effects of oral creatine and resistance training on serum myostatin and GASP-1
Saremi, A., Gharakhanloo, R., Sharghi, S., Gharaati, M. R., Larijani, B., & Omidfar, K. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.12.019 · Cited by 93
Comparative proteomic analysis of the insulin‐induced L6 myotube secretome
Yoon, J. H., Yea, K., Kim, J., Choi, Y. S., Park, S., Lee, H., Lee, C. S., Suh, P., & Ryu, S. H. (2008) · PROTEOMICS · doi:10.1002/pmic.200800187 · Cited by 89
The role of neurotrophins in muscle under physiological and pathological conditions
Chevrel, G., Hohlfeld, R., & Sendtner, M. (2005) · Muscle & Nerve · doi:10.1002/mus.20444 · Cited by 82
Identification of Secreted Proteins during Skeletal Muscle Development
Chan, X., McDermott, J. C., & Siu, K. W. M. (2007) · Journal of Proteome Research · doi:10.1021/pr060448k · Cited by 81
Increased serum pigment epithelium derived factor levels in Type 2 diabetes patients
Jenkins, A. J., Zhang, S. X., Gosmanova, A. K., Aston, C. E., Dashti, A., Baker, M. Z., Lyons, T. J., & Ma, J. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.06.019 · Cited by 80
Comparative analysis of the secretory proteome of human adipose stromal vascular fraction cells during adipogenesis
Kim, J. J., Choi, Y. S., Lim, S., Yea, K., Yoon, J. H., Jun, D., Ha, S. H., Kim, J., Kim, J. H., Suh, P., et al. (2009) · PROTEOMICS · doi:10.1002/pmic.200900218 · Cited by 76
Characterization of the human visceral adipose tissue secretome
Álvarez‐Llamas, G., Szalowska, E., de Vries, M. P., Weening, D., Landman, K., Hoek, A., Wolffenbuttel, B. H. R., Roelofsen, H., & Vonk, R. J. (2007) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 75
Increased IL-15 production of muscle cells in polymyositis and dermatomyositis
Sugiura, T. (2002) · International Immunology · doi:10.1093/intimm/dxf062 · Cited by 73
Acute exercise increases circulating inflammatory markers in overweight and obese compared with lean subjects
Christiansen, T., Bruun, J. M., Paulsen, S. K., Ølholm, J., Overgaard, K., Pedersen, S. B., & Richelsen, B. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-013-2592-0 · Cited by 73
Identification of Novel Human Adipocyte Secreted Proteins by Using SGBS Cells
Rosenow, A., Arrey, T. N., Bouwman, F. G., Noben, J., Wabitsch, M., Mariman, E. C. M., Karas, M., & Renes, J. (2010) · Journal of Proteome Research · doi:10.1021/pr100621g · Cited by 68
Insulin downregulates angiopoietin-like protein 4 mRNA in 3T3-L1 adipocytes
Yamada, T., Ozaki, N., Kato, Y., Miura, Y., & Oiso, Y. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.07.032 · Cited by 64
Link between leptin and interleukin-6 levels in the initial phase of obesity related inflammation
Stelzer, I., Zelzer, S., Raggam, R. B., Prüller, F., Truschnig-Wilders, M., Meinitzer, A., Schnedl, W. J., Horejsi, R., Möller, R., Weghuber, D., et al. (2011) · Translational research · doi:10.1016/j.trsl.2011.10.001 · Cited by 63
Skeletal muscle insulin resistance induced by adipocyte-conditioned medium: underlying mechanisms and reversibility
Sell, H., Eckardt, K., Taube, A., Tews, D., Gurgui, M., van Echten‐Deckert, G., & Eckel, J. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00529.2007 · Cited by 63
Self-citation
Downregulated expression of the secreted glycoprotein follistatin-like 1 (Fstl1) is a robust hallmark of preadipocyte to adipocyte conversion
Wu, Y., Zhou, S., & Smas, C. M. (2010) · Mechanisms of Development · doi:10.1016/j.mod.2009.12.003 · Cited by 61
Pathways leading to muscle insulin resistance – The muscle – fat connection
Sell, H., Eckel, J., & Dietze-Schroeder, D. (2006) · Archives of Physiology and Biochemistry · doi:10.1080/13813450600711540 · Cited by 61
Self-citation
Interleukin‐15 treatment improves glucose homeostasis and insulin sensitivity in obese mice
Barra, N. G., Chew, M. V., Holloway, A. C., & Ashkar, A. A. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01495.x · Cited by 59
Human skeletal muscle releases leptin in vivo
Wolsk, E., Mygind, H. W., Grøndahl, T. S., Pedersen, B. K., & van Hall, G. (2012) · Cytokine · doi:10.1016/j.cyto.2012.08.021 · Cited by 57
Treadmill exercise promotes interleukin 15 expression in skeletal muscle and interleukin 15 receptor alpha expression in adipose tissue of high-fat diet rats
Yang, H., Chang, J.-R., Chen, W.-J., Zhao, L., Qu, B., Tang, C., Qi, Y., & Zhang, J. (2012) · Endocrine · doi:10.1007/s12020-012-9809-6 · Cited by 56
Assessment of Inflammatory and Oxidative Biomarkers in Obesity and Their Associations with Body Mass Index
Piva, S. J., Tatsch, E., de Carvalho, J. A. M., Bochi, G. V., Kober, H., Duarte, T., Duarte, M. M. M. F., da Cruz, I. B. M., Moretto, M. B., & Moresco, R. N. (2012) · Inflammation · doi:10.1007/s10753-012-9538-2 · Cited by 53
Effects of Aerobic Exercise Training on C1q Tumor Necrosis Factor α-Related Protein Isoform 5 (Myonectin): Association with Insulin Resistance and Mitochondrial DNA Density in Women
Lim, S. K., Choi, S. H., Koo, B. K., Kang, S. M., Yoon, J. W., Jang, H. C., Choi, S. M., Lee, M. G., Lee, W., Shin, H., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1743 · Cited by 52
Quantitative analysis of the secretion of the MCP family of chemokines by muscle cells
Henningsen, J., Pedersen, B. K., & Kratchmarova, I. (2010) · Molecular BioSystems · doi:10.1039/c0mb00209g · Cited by 51 · cited 2×
“Chan et al. andHenningsen et al. have investigated altered regulation of secretome components at different time points of muscle differentiation of murine C2C12 cells by a quantitative proteomics approach [25–27], while Yoon et al. have studied the regulation of myokine secretion by rat skeletal…”
BackgroundMethod
The effects of different exercise intensity on myokine and angiogenesis factors.
Yeo, N. H., Woo, J., Shin, K.-O., Park, J. Y., & Kang, S. (2012) · PubMed · Cited by 49
Proteomic Analysis of Tumor Necrosis Factor-Alpha (TNF-α)-Induced L6 Myotube Secretome Reveals Novel TNF-α-Dependent Myokines in Diabetic Skeletal Muscle
Yoon, J. H., Song, P., Jang, J., Kim, D., Choi, S., Kim, J. J., Ghim, J., Kim, D., Park, S., Lee, H., et al. (2011) · Journal of Proteome Research · doi:10.1021/pr200573b · Cited by 47
Inhibitor κB kinase is involved in the paracrine crosstalk between human fat and muscle cells
Dietze‐Schroeder, D., Ramrath, S., Ritzeler, O., Tennagels, N., Hauner, H., & Eckel, J. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802701 · Cited by 45
Self-citation
Low Macrophage Accumulation in Skeletal Muscle of Obese Type 2 Diabetics and Elderly Subjects
Tam, C. S., Sparks, L. M., Johannsen, D. L., Covington, J. D., Church, T. S., & Ravussin, É. (2012) · Obesity · doi:10.1038/oby.2012.24 · Cited by 45
Secretomics for skeletal muscle cells: A discovery of novel regulators?
Yoon, J. H., Kim, J., Song, P., Lee, T. G., Suh, P., & Ryu, S. H. (2012) · Advances in Biological Regulation · doi:10.1016/j.jbior.2012.03.001 · Cited by 44
Effect of angiogenesis inhibitor TNP-470 on the progression of human gastric cancer xenotransplanted into nude mice
Kanai, T., Konno, H., Tanaka, T., Matsumoto, K., Baba, M., Nakamura, S., & Baba, S. (1997) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19970529)71:5 · Cited by 41
Interleukin-7 Regulates Adipose Tissue Mass and Insulin Sensitivity in High-Fat Diet-Fed Mice through Lymphocyte-Dependent and Independent Mechanisms
Lucas, S., Taront, S., Magnan, C., Fauconnier, L., Delacre, M., Macia, L., Delanoye, A., Verwaerde, C., Spriet, C., Saule, P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040351 · Cited by 40
Early inflammatory and myogenic responses to resistance exercise in the elderly
Mathers, J. L., Farnfield, M. M., GARNHAM, A. P., Caldow, M. K., Cameron‐Smith, D., & Peake, J. M. (2012) · Muscle & Nerve · doi:10.1002/mus.23317 · Cited by 39
TNF-α modulates statin effects on secretion and expression of MCP-1, PAI-1 and adiponectin in 3T3-L1 differentiated adipocytes
Lobo, S. M. D. V., Quinto, B. M. R., Oyama, L. M., Nakamichi, R., Ribeiro, A. B., Zanella, M. T., Dalboni, M. A., & Batista, M. C. (2012) · Cytokine · doi:10.1016/j.cyto.2012.04.039 · Cited by 36
Ultrastructural localisation of intramuscular expression of BDNF mRNA by silver-gold intensified non-radioactive in situ hybridisation
Liem, R. I., Brouwer, N., & Copray, J. C. V. M. (2001) · Histochemistry and Cell Biology · doi:10.1007/s00418-001-0349-z · Cited by 36
Similar changes of gene expression in human skeletal muscle after resistance exercise and multiple fine needle biopsies
Friedmann‐Bette, B., Schwartz, F. R., Eckhardt, H., Billeter-Clark, R., Bonaterra, G. A., & Kinscherf, R. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00959.2011 · Cited by 31
Insulin resistance is associated with elevated serum pigment epithelium–derived factor (PEDF) levels in morbidly obese patients
Gattu, A. K., Birkenfeld, A. L., Jornayvaz, F. R., Dziura, J. D., Li, F., Crawford, S. E., Chu, X., Still, C. D., Gerhard, G. S., Chung, C., et al. (2012) · Acta Diabetologica · doi:10.1007/s00592-012-0397-y · Cited by 31
Proteomics and Systems Biology in Exercise and Sport Sciences Research
Hittel, D. S., Hathout, Y., & Hoffman, E. P. (2007) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e31802d744a · Cited by 25
Necrotizing myopathy induced by overexpression of interferon-? in transgenic mice
Shelton, G. D., Calcutt, N. A., Garrett, R. S., Gu, D., Sarvetnick, N., Campana, W. M., & Powell, H. C. (1999) · Muscle & Nerve · doi:10.1002/(sici)1097-4598(199902)22:2 · Cited by 24
Myocytes Respond to both Interleukin-4 and Interferon-γ: Cytokine Responsiveness with the Potential to Influence the Severity and Course of Experimental Myasthenia Gravis
Stegall, T., & Krolick, K. A. (2000) · Clinical Immunology · doi:10.1006/clim.1999.4822 · Cited by 22
Effects of 3T3 adipocytes on interleukin-6 expression and insulin signaling in L6 skeletal muscle cells
Seyoum, B., Fite, A., & Abou‐Samra, A. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.05.073 · Cited by 20
Plasma cytokine response, lipid peroxidation and NF-κB activation in skeletal muscle following maximum progressive swimming
Cleto, L. S., Oleto, A. F., Sousa, L. P., Barreto, T. O., Cruz, J. S., Penaforte, C. L., de Magalhães, J. C., Sousa-Franco, J., Pinto, K. M., Campi‐Azevedo, A. C., et al. (2011) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2011007500050 · Cited by 20
Brown adipocyte progenitor population is modified in obese and diabetic skeletal muscle
Russell, A. P., Crisan, M., Léger, B., Corselli, M., McAinch, A. J., O’Brien, P. E., Cameron‐Smith, D., Péault, B., Casteilla, L., & Giacobino, J.-P. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.85 · Cited by 18
Secretome Analysis of Skeletal Myogenesis Using SILAC and Shotgun Proteomics
Chan, C. Y. X., McDermott, J. C., & Siu, K. W. M. (2011) · International Journal of Proteomics · doi:10.1155/2011/329467 · Cited by 15

Research works printed but not linked: 27

10.1042/0300-5127:0290072 · DOI
2012, PLoS ONE, 7
2011, American Journal of Physiology, 301, E1013
2012, PLoS ONE, 7
1996, American Journal of Physiology, 271, E601
2006, Exercise immunology review, 12, 6
2012, Journal of Sports Medicine and Physical Fitness, 52, 448
2012, Endocrine, 43, 579
2012, Nature, 488, 9
2013, PLOS ONE, 8
1994, Advances in Immunology, 55, 97
2012, American Journal of Physiology, 302, R667
2012, Diabetologia, 55, article s598
2012, PLoS ONE, 7
2012, PLOS ONE, 7
2012, Inflammation, 36, 226
10.1210/jc.87.5.2084 · DOI
2003, American Journal of Physiology, 285, E527
2012, Molecular & Cellular Proteomics, 11, M111
2009, General Physiology and Biophysics, 28, 179
10.2337/db07-1438 · DOI · Paper page
1999, Journal of Physiology, 515, 287, 10.1111/j.1469-7793.1999.287ad.x · DOI · Paper page
10.1113/jphysiol.2007.139618 · DOI · Paper page
2004, Diabetologia, 47, 1029
10.2337/db05-1404 · DOI · Paper page
2012, PLOS ONE, 7
2012, Acta Diabetologica, 49, 161

Sorted by citations

Muscle–Organ Crosstalk: The Emerging Roles of Myokines
Severinsen, M. C. K., & Pedersen, B. K. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa016 · Cited by 1,226
“The role of myokines has previously been reviewed (7, 11-37), identifying more than 650 myokines (38).”
Background
Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis
Kalinkovich, A., & Livshits, G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.008 · Cited by 882
Sedentary Behavior and Cardiovascular Morbidity and Mortality: A Science Advisory From the American Heart Association
Young, D. R., Hivert, M.-F., Alhassan, S., Camhi, S. M., Ferguson, J. F., Katzmarzyk, P. T., Lewis, C. E., Owen, N., Perry, C. K., Siddique, J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000440 · Cited by 791
Physical activity and muscle-brain crosstalk
Pedersen, B. K. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0174-x · Cited by 772
Skeletal muscle: A review of molecular structure and function, in health and disease
Mukund, K., & Subramaniam, S. (2019) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1462 · Cited by 805

See all 296

Authors: Raschke, S., & Eckel, J.
Affiliations: Deutsches Diabetes-Zentrum e.V. (DE)
Corresponding author: Eckel, Jürgen
ORCID: Raschke, Silja
Eckel, Jürgen
Venue: Mediators of Inflammation
Publisher: Wiley
Published: 2013
Volume: 2013
Pages: 1-16
ISSN: 0962-9351 (ISSN-L)
1466-1861
DOI: 10.1155/2013/320724
PMC: PMC3686148
OpenAlex: W2116932335
Cited by: 296
References: 179
Citations by year: 2026: 12 · 2025: 11 · 2024: 16 · 2023: 17 · 2022: 26 · 2021: 21 · 2020: 24 · 2019: 18 · 2018: 30 · 2017: 30 · 2016: 37 · 2015: 28 · 2014: 22 · 2013: 3
FWCI: 4.98
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (unspecified)
Locations: Mediators of Inflammation (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Bundesministerium für Bildung und Forschung
Bundesministerium für Gesundheit
Ministerium für Wissenschaft und Forschung des Landes Nordrhein-Westfalen
Topics: Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: myokines, adipokines, skeletal muscle contraction, interleukin-6, irisin, brain-derived neurotrophic factor, ANGPTL4, FGF21, myonectin, MCP-1, IL-15, obesity, inflammation, physical activity, autocrine signaling, adipocytes
MeSH terms: Angiopoietin-Like Protein 4, Adipose Tissue, Animals, Endocrine System, Fibroblast Growth Factors, Gene Expression Regulation, Humans, Inflammation, RNA, Messenger, Exercise, Interleukin-6, Muscle, Skeletal, Chemokine CCL2, Brain-Derived Neurotrophic Factor, Interleukin-15, Leptin, Follistatin-Related Proteins, Angiopoietins, Adipokines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Adipo-myokines: two sides of the same coin–mediators of inflammation and mediators of exercise

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks