The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Local Overexpression of V1a-Vasopressin Receptor Enhances Regeneration in Tumor Necrosis Factor-Induced Muscle Atrophy
Open accessAbstract
Skeletal muscle atrophy occurs during disuse and aging, or as a consequence of chronic diseases such as cancer and diabetes. It is characterized by progressive loss of muscle tissue due to hypotrophic changes, degeneration, and an inability of the regeneration machinery to replace damaged myofibers. Tumor necrosis factor (TNF) is a proinflammatory cytokine known to mediate muscle atrophy in many chronic diseases and to inhibit skeletal muscle regeneration. In this study, we investigated the role of Arg-vasopressin-(AVP-)dependent pathways in muscles in which atrophy was induced by local overexpression of TNF. AVP is a potent myogenesis-promoting factor and is able to enhance skeletal muscle regeneration by stimulating Ca 2+/calmodulin-dependent kinase and calcineurin signaling. We performed morphological and molecular analyses and demonstrated that local over-expression of the AVP receptor V1a enhances regeneration of atrophic muscle. By upregulating the regeneration/differentiation markers, modulating the inflammatory response, and attenuating fibrogenesis, the stimulation of AVP-dependent pathways creates a favourable environment for efficient and sustained muscle regeneration and repair even in the presence of elevated levels of TNF. This study highlights a novel in vivo role for AVP-dependent pathways, which may represent an interesting strategy to counteract muscle decline in aging or in muscular pathologies.
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Cites
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Cited by
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The interplay of ROS and the PI3K/Akt pathway in autophagy regulation
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A comprehensive review of metabolic and genomic aspects of PAH-degradation
Sakshi, & Haritash, A. K. (2020) · Archives of Microbiology · doi:10.1007/s00203-020-01929-5 · Cited by 273
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Metadata
- Authors
- Costa, A., Toschi, A., Murfuni, I., Pelosi, L., Sica, G., Adamo, S., & Scicchitano, B. M.
- Venue
- BioMed Research International
- Publisher
- Hindawi Limited
- Published
- 2014
- Volume
- 2014
- Pages
- 1-14
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- OpenAlex
- W2041597162
- Cited by
- 247
- References
- 10
- FWCI
- 8.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Costa, A., Toschi, A., Murfuni, I., Pelosi, L., Sica, G., Adamo, S., & Scicchitano, B. M. (2014). Local Overexpression of V1a-Vasopressin Receptor Enhances Regeneration in Tumor Necrosis Factor-Induced Muscle Atrophy. BioMed Research International. https://doi.org/10.1155/2014/235426
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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