Resistance exercise with older fallers: its impact on intermuscular adipose tissue
Open accessAbstract
OBJECTIVE: Greater skeletal muscle fat infiltration occurs with age and contributes to numerous negative health outcomes. The primary purpose was to determine whether intermuscular adipose tissue (IMAT) can be influenced by an exercise intervention and if a greater reduction in IMAT occurs with eccentric versus traditional resistance training. METHODS: Seventy-seven older adults (age 75.5 ± 6.8) with multiple comorbidities and a history of falling completed a three-month exercise intervention paired with either eccentric or traditional resistance training. MRI of the mid-thigh was examined at three time points to determine changes in muscle composition after intervention. RESULTS: No differences in IMAT were observed over time, and there were no differences in IMAT response between intervention groups. Participants in the traditional group lost a significant amount of lean tissue (P = 0.007) in the nine months after intervention, while participants in the eccentric group did not (P = 0.32). When IMAT levels were partitioned into high and low IMAT groups, there were differential IMAT responses to intervention with the high group lowering thigh IMAT. CONCLUSIONS: There is no decrease in thigh IMAT after a three-month exercise intervention in older adults at risk for falling and no benefit to eccentric training over traditional resistance training for reducing IMAT in these individuals.
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A decrease in muscle fat infiltration was shown in some but not all previous studies of RT alone in nonobese persons.
“A decrease in muscle fat infiltration was shown in some (42,43) but not all (44) previous studies of RT alone in nonobese persons.”
From Effects of resistance training with and without caloric restriction on physical function and mobility in overweight and obese older adults: a randomized controlled trial (2015) · cites this paper as [44]
The Results report no significant overall change in intermuscular adipose tissue in either training group, supporting the citation’s “not all” point. But the Methods describe a multicomponent program that included aerobic, flexibility, and balance exercise alongside resistance training—not RT alone—and the cited passages do not establish that the participants were nonobese. (LLM, conf=0.90)
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- Authors
- Jacobs, J. L., Marcus, R. L., Morrell, G., & LaStayo, P.
- Affiliations
- University of Utah (US)
- Corresponding author
- LaStayo, Paul
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2014
- Volume
- 2014
- Pages
- 1-7
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- PMC
- PMC3996328
- OpenAlex
- W2064273648
- Cited by
- 34
- References
- 36
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 1
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institute on Aging (R01AG031255)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- intermuscular adipose tissue, resistance training, eccentric training, older adults, fallers, sarcopenia, lean tissue loss, muscle composition, exercise intervention, fall risk
- MeSH terms
- Accidental Falls, Adipose Tissue, Aged, Aged, 80 and over, Female, Humans, Male, Risk Factors, Exercise, Muscle, Skeletal
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