The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.
Current Concept and Update of the Macrophage Plasticity Concept: Intracellular Mechanisms of Reprogramming and M3 Macrophage “Switch” Phenotype
Open accessAbstract
Macrophages play a key role in immunity. In this review, we consider the traditional notion of macrophage plasticity, data that do not fit into existing concepts, and a hypothesis for existence of a new switch macrophage phenotype. Depending on the microenvironment, macrophages can reprogram their phenotype toward the proinflammatory M1 phenotype or toward the anti-inflammatory M2 phenotype. Macrophage reprogramming involves well-coordinated changes in activities of signalling and posttranslational mechanisms. Macrophage reprogramming is provided by JNK-, PI3K/Akt-, Notch-, JAK/STAT-, TGF-β-, TLR/NF-κ B-, and hypoxia-dependent pathways. Posttranscriptional regulation is based on micro-mRNA. We have hypothesized that, in addition to the M1 and M2 phenotypes, an M3 switch phenotype exists. This switch phenotype responds to proinflammatory stimuli with reprogramming towards the anti-inflammatory M2 phenotype or, contrarily, it responds to anti-inflammatory stimuli with reprogramming towards the proinflammatory M1 phenotype. We have found signs of such a switch phenotype in lung diseases. Understanding the mechanisms of macrophage reprogramming will assist in the selection of new therapeutic targets for correction of impaired immunity.
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Cites
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BackgroundCancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
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Cited by
Chen, X., Tang, J., Shuai, W., Meng, J., Feng, J., & Han, Z. (2020) · Inflammation Research · doi:10.1007/s00011-020-01378-2 · Cited by 423
Chistiakov, D. A., Myasoedova, V. A., Revin, V. V., Orekhov, A. N., & Bobryshev, Y. V. (2018) · Immunobiology · doi:10.1016/j.imbio.2017.10.005 · Cited by 311
Aging and cancer: The role of macrophages and neutrophils
Jackaman, C., Tomay, F., Duong, L., Abdol Razak, N. B., Pixley, F. J., Metharom, P., & Nelson, D. J. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.03.008 · Cited by 251
Hacking the host: exploitation of macrophage polarization by intracellular bacterial pathogens
Thiriot, J. D., Martinez-Martinez, Y. B., Endsley, J. J., & Torres, A. G. (2020) · Pathogens and Disease · doi:10.1093/femspd/ftaa009 · Cited by 103
Matrix stiffness regulates macrophage polarisation via the Piezo1‐YAP signalling axis
Mei, F., Guo, Y., Wang, Y., Zhou, Y., Heng, B. C., Xie, M., Huang, X., Zhang, S., Ding, S., Liu, F., et al. (2024) · Cell Proliferation · doi:10.1111/cpr.13640 · Cited by 118
“32 Previous studies have addressed the effects of substrate stiffness on macrophage function.”
Background
Metadata
- Authors
- Malyshev, I., & Malyshev, Y.
- Venue
- BioMed Research International
- Publisher
- Hindawi Limited
- Published
- 2015
- Volume
- 2015
- Pages
- 1-22
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- OpenAlex
- W1592393293
- Cited by
- 276
- References
- 128
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Malyshev, I., & Malyshev, Y. (2015). Current Concept and Update of the Macrophage Plasticity Concept: Intracellular Mechanisms of Reprogramming and M3 Macrophage “Switch” Phenotype. BioMed Research International. https://doi.org/10.1155/2015/341308
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