The impact of interferon-regulatory factors to macrophage differentiation and polarization into M1 and M2

Chistiakov, Dimitry A.; Myasoedova, Veronika A.; Revin, Victor V.; Orekhov, Alexander N.; Bobryshev, Yuri V.

doi:10.1016/j.imbio.2017.10.005

Cited by 313Immune cells in cancerinterferon and immune responsesMacrophage Migration Inhibitory Factor

The impact of interferon-regulatory factors to macrophage differentiation and polarization into M1 and M2

Chistiakov, Dimitry A., Myasoedova, Veronika A., Revin, Victor V., Orekhov, Alexander N., Bobryshev, Yuri V.·2018·Immunobiology

DOI 10.1016/j.imbio.2017.10.005

Open this paper in CoChat — free account

Abstract

The mononuclear phagocytes control the body homeostasis through the involvement in resolving tissue injury and further wound healing. Indeed, local tissue microenvironmental changes can significantly influence the functional behavior of monocytes and macrophages. Such microenvironmental changes for example occur in an atherosclerotic plaque during all progression stages. In response to exogenous stimuli, macrophages show a great phenotypic plasticity and heterogeneity. Exposure of monocytes to inflammatory or anti-inflammatory conditions also induces predominant differentiation to proinflammatory (M1) or anti-inflammatory (M2) macrophage subsets and phenotype switch between macrophage subsets. The phenotype transition is accompanied with great changes in the macrophage transcriptome and regulatory networks. Interferon-regulatory factors (IRFs) play a key role in hematopoietic development of monocytes, their differentiation to macrophages, and regulating macrophage maturation, phenotypic polarization, phenotypic switch, and function. Of 9 IRFs, at least 3 (IRF-1, IRF-5, and IRF-8) are involved in the commitment of proinflammatory M1 whereas IRF-3 and IRF-4 control M2 polarization. The role of IRF-2 is context-dependent. The IRF impact on macrophage phenotype plasticity and heterogeneity is complex and involves activating and repressive function in triggering transcription of target genes.

Integrity signals

Registry

Crossref · 10.1016/j.imbio.2017.10.005

Cites

151 of 151 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

IRF-5 is critically involved in M1-macrophage polarization.
“IRF-5 is critically involved in M1- macrophage polarization (42)”
From mRNA vaccine with unmodified uridine induces robust type I interferon-dependent anti-tumor immunity in a melanoma model (2022) · cites this paper as [42]
M1 macrophages possess phagocytic capacity and the ability to secrete reactive nitrogen and oxygen species and pro-inflammatory cytokines such as IL-6, IL-12, IL-23 and TNF-α, which in turn promote CD8+ T cell and NK cell cytotoxicity.
“which possesses phagocytic capacity, and the ability to secrete reactive nitrogen and oxygen species and pro-inflammatory cytokines such as IL-6, IL-12, IL-23 and TNF-α, which in turn promote CD8+ T cell and NK cell cytotoxicity.”
From mRNA vaccine with unmodified uridine induces robust type I interferon-dependent anti-tumor immunity in a melanoma model (2022) · cites this paper as [42]

1 retracted

RETRACTED: Macrophage phenotypic plasticity in atherosclerosis: The associated features and the peculiarities of the expression of inflammatory genes
Chistiakov, D. A., Bobryshev, Y. V., Nikiforov, N. G., Elizova, N. V., Sobenin, I. A., & Orekhov, A. N. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.03.055 · Cited by 174 · see citing works
Retracted
Macrophage activation and polarization: nomenclature and experimental guidelines
Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337 · see citing works
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,366 · see citing works
Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,244 · see citing works
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
Ishikawa, H., Ma, Z., & Barber, G. N. (2009) · Nature · doi:10.1038/nature08476 · Cited by 2,759 · see citing works
Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression
Martínez, F. O., Gordon, S., Locati, M., & Mantovani, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.7303 · Cited by 2,336 · see citing works
Transcriptional regulation of macrophage polarization: enabling diversity with identity
Lawrence, T., & Natoli, G. (2011) · Nature Reviews Immunology · doi:10.1038/nri3088 · Cited by 2,284 · see citing works
Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance
Wang, N., Liang, H., & Zen, K. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00614 · Cited by 1,997 · see citing works
Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells
Auffray, C., Sieweke, M. H., & Geissmann, F. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132557 · Cited by 1,647 · see citing works
Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques
Tacke, F., Alvarez, D., Kaplan, T. J., Jakubzick, C., Spanbroek, R., Llodra, J., Garin, A., Liu, J., Mack, M., van Rooijen, N., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28549 · Cited by 1,323 · see citing works
Colony-stimulating factors in inflammation and autoimmunity
Hamilton, J. A. (2008) · Nature reviews. Immunology · doi:10.1038/nri2356 · Cited by 1,305 · see citing works
Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata
Świrski, F. K., Libby, P., Aikawa, E. R., Alcaide, P., Luscinskas, F. W., Weissleder, R., & Pittet, M. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29950 · Cited by 1,258 · see citing works
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection
Satoh, T., Takeuchi, O., Vandenbon, A., Yasuda, K., Tanaka, Y., Kumagai, Y., Miyake, T., Matsushita, K., Okazaki, T., Saitoh, T., et al. (2010) · Nature Immunology · doi:10.1038/ni.1920 · Cited by 1,156 · see citing works
Macrophage Phenotype and Function in Different Stages of Atherosclerosis
Tabas, I., & Bornfeldt, K. E. (2016) · Circulation Research · doi:10.1161/circresaha.115.306256 · Cited by 1,121 · see citing works
Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors
Takaoka, A., Yanai, H., Kondo, S., Duncan, G. S., Negishi, H., Mizutani, T., Kano, S., Honda, K., Ohba, Y., Mak, T. W., et al. (2005) · Nature · doi:10.1038/nature03308 · Cited by 1,042 · see citing works
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Miyamoto, M., Fujita, T., Kimura, Y., Maruyama, M., Harada, H., Sudo, Y., Miyata, T., & Taniguchi, T. (1988) · Cell · doi:10.1016/s0092-8674(88)91307-4 · Cited by 977 · see citing works
The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing
De Santa, F., Totaro, M. G., Prosperini, E., Notarbartolo, S., Testa, G., & Natoli, G. (2007) · Cell · doi:10.1016/j.cell.2007.08.019 · Cited by 965 · see citing works
Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes
Harada, H., Fujita, T., Miyamoto, M., Kimura, Y., Maruyama, M., Furia, A., Miyata, T., & Taniguchi, T. (1989) · Cell · doi:10.1016/0092-8674(89)90107-4 · Cited by 957 · see citing works
The role of macrophage phenotype in vascularization of tissue engineering scaffolds
Spiller, K. L., Anfang, R. R., Spiller, K. J., Ng, J., Nakazawa, K. R., Daulton, J. W., & Vunjak-Novakovic, G. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.02.012 · Cited by 948 · see citing works
Distinct macrophage phenotypes contribute to kidney injury and repair
Lee, S., Huen, S., Nishio, H., Nishio, S., Lee, H. K., Choi, B.-S., Ruhrberg, C., & Cantley, L. G. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009060615 · Cited by 906 · see citing works
Monocytes in atherosclerosis: subsets and functions
Woollard, K. J., & Geissmann, F. (2010) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.228 · Cited by 890 · see citing works
A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF- B and enhanced IRF-3/STAT1 activation)
Biswas, S. K. (2005) · Blood · doi:10.1182/blood-2005-01-0428 · Cited by 693 · see citing works
Efficient Clearance of Early Apoptotic Cells by Human Macrophages Requires M2c Polarization and MerTK Induction
Zizzo, G., Hilliard, B. A., Monestier, M., & Cohen, P. L. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200662 · Cited by 650 · see citing works
Immunodeficiency and Chronic Myelogenous Leukemia-like Syndrome in Mice with a Targeted Mutation of the ICSBP Gene
Holtschke, T., Löhler, J., Kanno, Y., Fehr, T., Giese, N., Rosenbauer, F., Lou, J., Knobeloch, K.-P., Gabriele, L., Waring, J. F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81348-3 · Cited by 644 · see citing works
Granulocyte-Macrophage Colony-Stimulating Factor (CSF) and Macrophage CSF-Dependent Macrophage Phenotypes Display Differences in Cytokine Profiles and Transcription Factor Activities: Implications for CSF Blockade in Inflammation
Fleetwood, A. J., Lawrence, T., Hamilton, J. A., & Cook, A. D. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.5245 · Cited by 607 · see citing works
Adhesion mechanisms regulating the migration of monocytes
Imhof, B. A., & Aurrand‐Lions, M. (2004) · Nature reviews. Immunology · doi:10.1038/nri1375 · Cited by 584 · see citing works
Regulation of Macrophage Polarization and Wound Healing
Ferrante, C., & Leibovich, S. (2012) · Advances in wound care · doi:10.1089/wound.2011.0307 · Cited by 578 · see citing works
Interferon Regulatory Factor 6 ( IRF6 ) Gene Variants and the Risk of Isolated Cleft Lip or Palate
Zucchero, T. M., Cooper, M. E., Maher, B. S., Daack‐Hirsch, S., Nepomuceno, B., Ribeiro, L. A., Caprau, D., Christensen, K., Suzuki, Y. A., Machida, J., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032909 · Cited by 575 · see citing works
The enhanceosome and transcriptional synergy.
Carey, M. (1998) · Cell · doi:10.1016/s0092-8674(00)80893-4 · Cited by 553 · see citing works
Defining GM-CSF– and Macrophage-CSF–Dependent Macrophage Responses by In Vitro Models
Lacey, D. C., Achuthan, A. A., Fleetwood, A. J., Dinh, H., Roiniotis, J., Scholz, G. M., Chang, M. W., Beckman, S. K., Cook, A. D., & Hamilton, J. A. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103426 · Cited by 529 · see citing works
Polarization profiles of human M-CSF-generated macrophages and comparison of M1-markers in classically activated macrophages from GM-CSF and M-CSF origin
Jaguin, M., Houlbert, N., Fardel, O., & Lecureur, V. (2013) · Cellular Immunology · doi:10.1016/j.cellimm.2013.01.010 · Cited by 520 · see citing works
Macrophage plasticity in experimental atherosclerosis
Khallou-Laschet, J., Varthaman, A., Fornasa, G., Compain, C., Gaston, A.-T., Clement, M., Dussiot, M., Levillain, O., Graff-Dubois, S., Nicoletti, A., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008852 · Cited by 517 · see citing works
Macrophage‐mediated cholesterol handling in atherosclerosis
Chistiakov, D. A., Bobryshev, Y. V., & Orekhov, A. N. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12689 · Cited by 513 · see citing works
Epigenetic regulation of the alternatively activated macrophage phenotype
Ishii, M., Wen, H., Corsa, C. A. S., Liu, T., Coelho, A. L., Allen, R., Carson, W. F., Cavassani, K. A., Li, X., Lukacs, N. W., et al. (2009) · Blood · doi:10.1182/blood-2009-04-217620 · Cited by 496 · see citing works
The growing family of interferon regulatory factors
Nguyen, H., Hiscott, J., & Pitha, P. M. (1997) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(97)00019-1 · Cited by 480 · see citing works
Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.
Eisenbeis, C. F., Singh, H., & Storb, U. (1995) · Genes & Development · doi:10.1101/gad.9.11.1377 · Cited by 447 · see citing works
Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization
Xu, H., Zhu, J., Smith, S. M., Foldi, J., Zhao, B., Chung, A. Y., Outtz, H. H., Kitajewski, J., Shi, C., Weber, S., et al. (2012) · Nature Immunology · doi:10.1038/ni.2304 · Cited by 437 · see citing works
The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling
Schoenemeyer, A., Barnes, B. J., Mancl, M. E., Latz, E., Goutagny, N., Pitha, P. M., Fitzgerald, K. A., & Golenbock, D. T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412584200 · Cited by 411 · see citing works
Structure of IRF-1 with bound DNA reveals determinants of interferon regulation
Escalante, C. R., Yie, J., Thanos, D., & Aggarwal, A. K. (1998) · Nature · doi:10.1038/34224 · Cited by 397 · see citing works
Blood monocytes: distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of T‐cell responses
Geissmann, F., Auffray, C., Palframan, R. T., Wirrig, C., Ciocca, A., Campisi, L., Narni-Mancinelli, É., & Lauvau, G. S. (2008) · Immunology and Cell Biology · doi:10.1038/icb.2008.19 · Cited by 385 · see citing works
The Mechanism of Transcriptional Synergy of an In Vitro Assembled Interferon-β Enhanceosome
Kim, T. K., & Maniatis, T. (1997) · Molecular Cell · doi:10.1016/s1097-2765(00)80013-1 · Cited by 340 · see citing works
IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype
Masuda, T., Tsuda, M., Yoshinaga, R., Tozaki-Saitoh, H., Ozato, K., Tamura, T., & Inoue, K. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.02.014 · Cited by 338 · see citing works
The atherosusceptible endothelium: endothelial phenotypes in complex haemodynamic shear stress regions in vivo
Davies, P. F., Civelek, M., Fang, Y. H., & Fleming, I. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt101 · Cited by 327 · see citing works
Essential Role of Interferon Regulatory Factor 3 in Direct Activation of RANTES Chemokine Transcription
Lin, R., Heylbroeck, C., Génin, P., Pitha, P., & Hiscott, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.959 · Cited by 325 · see citing works
Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch
Richardson, R. J., Dixon, J., Malhotra, S., Hardman, M. J., Knowles, L., Boot-Handford, R., Shore, P., Whitmarsh, A. J., & Dixon, M. J. (2006) · Nature Genetics · doi:10.1038/ng1894 · Cited by 325 · see citing works
Structural and Functional Analysis of Interferon Regulatory Factor 3: Localization of the Transactivation and Autoinhibitory Domains
Lin, R., Mamane, Y., & Hiscott, J. B. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2465 · Cited by 321 · see citing works
Endoplasmic Reticulum Stress Controls M2 Macrophage Differentiation and Foam Cell Formation
Oh, J., Riek, A. E., Weng, S., Petty, M., Kim, D., Colonna, M., Cella, M., & Bernal‐Mizrachi, C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.338673 · Cited by 313 · see citing works
Evidence for licensing of IFN-γ-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program
Negishi, H., Fujita, Y., Yanai, H., Sakaguchi, S., Ouyang, X., Shinohara, M., Takayanagi, H., Ohba, Y., Taniguchi, T., & Honda, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607181103 · Cited by 310 · see citing works
Regulation of immunity and oncogenesis by the IRF transcription factor family
Savitsky, D., Tamura, T., Yanai, H., & Taniguchi, T. (2010) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-009-0804-6 · Cited by 298 · see citing works
In Vivo Silencing of the Transcription Factor IRF5 Reprograms the Macrophage Phenotype and Improves Infarct Healing
Courties, G., Heidt, T., Sebas, M., Iwamoto, Y., Jeon, D., Truelove, J. J., Tricot, B., Wojtkiewicz, G. R., Dutta, P., Sager, H. B., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.11.023 · Cited by 278 · see citing works
Current Concept and Update of the Macrophage Plasticity Concept: Intracellular Mechanisms of Reprogramming and M3 Macrophage “Switch” Phenotype
Malyshev, I. Y., & Malyshev, Y. (2015) · BioMed Research International · doi:10.1155/2015/341308 · Cited by 276 · see citing works
Macrophage Subpopulations Are Essential for Infarct Repair With and Without Stem Cell Therapy
Ben-Mordechai, T., Holbová, R., Landa‐Rouben, N., Harel-Adar, T., Feinberg, M. S., Elrahman, I. A., Blum, G., Epstein, F. H., Silman, Z., Cohen, S., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.07.057 · Cited by 266 · see citing works
Integrated Regulation of Toll-like Receptor Responses by Notch and Interferon-γ Pathways
Hu, X., Chung, A. Y., Wu, I., Foldi, J., Chen, J., Ji, J. D., Tateya, T., Kang, Y. J., Han, J., Gessler, M., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.08.016 · Cited by 263 · see citing works
The IRF family of transcription factors: Inception, impact and implications in oncogenesis
Yanai, H., Negishi, H., & Taniguchi, T. (2012) · OncoImmunology · doi:10.4161/onci.22475 · Cited by 261 · see citing works
Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation
Kurotaki, D., Osato, N., Nishiyama, A., Yamamoto, M., Ban, T., Sato, H., Nakabayashi, J., Umehara, M., Miyake, N., Matsumoto, N., et al. (2013) · Blood · doi:10.1182/blood-2012-06-437863 · Cited by 252 · see citing works
Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1.
Brass, A. L., Kehrli, E., Eisenbeis, C. F., Storb, U., & Singh, H. (1996) · Genes & Development · doi:10.1101/gad.10.18.2335 · Cited by 242 · see citing works
Crystal structure of an IRF‐DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences
Fujii, Y., Shimizu, T., Kusumoto, M., Kyogoku, Y., Taniguchi, T., & Hakoshima, T. (1999) · The EMBO Journal · doi:10.1093/emboj/18.18.5028 · Cited by 223 · see citing works
Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation
Qin, B. Y., Liu, C., Lam, S. S., Srinath, H., Delston, R. B., Correia, J. J., Derynck, R., & Lin, K. F. (2003) · Nature Structural & Molecular Biology · doi:10.1038/nsb1002 · Cited by 214 · see citing works
Triggering of the Human Interleukin-6 Gene by Interferon-γ and Tumor Necrosis Factor-α in Monocytic Cells Involves Cooperation between Interferon Regulatory Factor-1, NFκB, and Sp1 Transcription Factors
Sancéau, J., Kaisho, T., Hirano, T., & Wietzerbin, J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27920 · Cited by 211 · see citing works
Minimally modified low density lipoprotein is biologically active in vivo in mice.
Liao, F., Berliner, J. A., Mehrabian, M., Navab, M., Demer, L. L., Lusis, A. J., & Fogelman, A. M. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115261 · Cited by 210 · see citing works
Assembly requirements of PU.1–Pip (IRF‐4) activator complexes: inhibiting function in vivo using fused dimers
Brass, A. L., Zhu, A. Q., & Singh, H. (1999) · The EMBO Journal · doi:10.1093/emboj/18.4.977 · Cited by 207 · see citing works
Cutting Edge: Autoantigen Ro52 Is an Interferon Inducible E3 Ligase That Ubiquitinates IRF-8 and Enhances Cytokine Expression in Macrophages
Kong, H. J., Anderson, D. E., Lee, C. H., Jang, M. K., Tamura, T., Tailor, P. B., Cho, H. K., Cheong, J., Xiong, H., Morse, H. C., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.26 · Cited by 207 · see citing works
Macrophage Phenotypes and Their Modulation in Atherosclerosis
Paoli, F. D., Staels, B., & Chinetti, G. (2014) · Circulation Journal · doi:10.1253/circj.cj-14-0621 · Cited by 207 · see citing works
Heme Oxygenase-1 expression in M-CSF-polarized M2 macrophages contributes to LPS-induced IL-10 release
Sierra‐Filardi, E., Vega, M. A., Sánchez‐Mateos, P., Corbí, A. L., & Puig‐Kröger, A. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.05.020 · Cited by 204 · see citing works
Differential Regulation of Interleukin (IL)-12 p35 and p40 Gene Expression and Interferon (IFN)-γ–primed IL-12 Production by IFN Regulatory Factor 1
Liu, J., Cao, S., Herman, L. M., & Ma, X. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030026 · Cited by 186 · see citing works
Differentiation factors and cytokines in the atherosclerotic plaque micro-environment as a trigger for macrophage polarisation
Wolfs, I. M. J., Donners, M. M. P. C., & de Winther, M. P. J. (2011) · Thrombosis and Haemostasis · doi:10.1160/th11-05-0320 · Cited by 182 · see citing works
Interferon Regulatory Factor 3 Is Regulated by a Dual Phosphorylation-dependent Switch
Panne, D., McWhirter, S. M., Maniatis, T., & Harrison, S. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703019200 · Cited by 178 · see citing works
IFN-γ Represses IL-4 Expression via IRF-1 and IRF-2
Elser, B., Lohoff, M. D., Kock, S., Giaisi, M., Kirchhoff, S., Krammer, P. H., & Li‐Weber, M. (2002) · Immunity · doi:10.1016/s1074-7613(02)00471-5 · Cited by 172 · see citing works
Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway
Tarassishin, L., Suh, H.-S., & Lee, S. C. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-187 · Cited by 169 · see citing works
Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family.
Bovolenta, C., Driggers, P. H., Marks, M. S., Medin, J. A., Politis, A. D., Vogel, S. N., Levy, D. E., Sakaguchi, K., Appella, E., & Coligan, J. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.5046 · Cited by 167 · see citing works
The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongationPreprint
Chen, S., Ma, J., Wu, F., Xiong, L.-J., Ma, H., Xu, W., Lyu, R., Li, X., Villén, J., Gygi, S. P., et al. (2012) · Genes & Development · doi:10.1101/gad.186056.111 · Cited by 165 · see citing works
Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization
Günthner, R., & Anders, H. (2013) · Mediators of Inflammation · doi:10.1155/2013/731023 · Cited by 164 · see citing works
Identification of the interferon regulatory factor 5 gene (IRF-5) as a direct target for p53
Mori, T., Anazawa, Y., Iiizumi, M., Fukuda, S., Nakamura, Y., & Arakawa, H. (2002) · Oncogene · doi:10.1038/sj.onc.1205459 · Cited by 164 · see citing works
Macrophage-mediated injury and repair after ischemic kidney injury
Huen, S. C., & Cantley, L. G. (2014) · Pediatric Nephrology · doi:10.1007/s00467-013-2726-y · Cited by 163 · see citing works
Phosphorylation Events Modulate the Ability of Interferon Consensus Sequence Binding Protein to Interact with Interferon Regulatory Factors and to Bind DNA
Sharf, R., Meraro, D., Azriel, A., Thornton, A. M., Ozato, K., Petricoin, E. F., Larner, A. C., Schaper, F., Hauser, H., & Levi, B.-Z. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.15.9785 · Cited by 162 · see citing works
Crucial Role of Interferon Consensus Sequence Binding Protein, but neither of Interferon Regulatory Factor 1 nor of Nitric Oxide Synthesis for Protection Against Murine Listeriosis
Fehr, T., Schoedon, G., Odermatt, B., Holtschke, T., Schneemann, M., Bachmann, M. F., Mak, T. W., Horak, I., & Zinkernagel, R. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.5.921 · Cited by 162 · see citing works
Dynamic Evolution of Immune System Regulators: The History of the Interferon Regulatory Factor Family
Nehyba, J., Hrdličková, R., & Bose, H. R. (2009) · Molecular Biology and Evolution · doi:10.1093/molbev/msp167 · Cited by 153 · see citing works
Protein-Protein and DNA-Protein Interactions Affect the Activity of Lymphoid-Specific IFN Regulatory Factors
Meraro, D., Hashmueli, S., Koren, B., Azriel, A., Oumard, A., Kirchhoff, S., Hauser, H., Nagulapalli, S., Atchison, M. L., & Levi, B.-Z. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.12.6468 · Cited by 147 · see citing works
IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors
Becker, A. M., Michael, D. G., Satpathy, A. T., Sciammas, R., Singh, H., & Bhattacharya, D. (2012) · Blood · doi:10.1182/blood-2011-06-364976 · Cited by 144 · see citing works
Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3
Zhang, M., Tian, Y., Wang, R., Gao, D., Zhang, Y., Diao, F., Chen, D., Zhai, Z., & Shu, H. (2008) · Cell Research · doi:10.1038/cr.2008.277 · Cited by 144 · see citing works
Chronic exposure to TGFβ1 regulates myeloid cell inflammatory response in an IRF7-dependent manner
Cohen, M., Matcovitch, O., David, E., Barnett‐Itzhaki, Z., Keren‐Shaul, H., Blecher‐Gonen, R., Jaitin, D. A., Sica, A., Amit, I., & Schwartz, M. (2014) · The EMBO Journal · doi:10.15252/embj.201489293 · Cited by 142 · see citing works
Interferon regulatory factor 4 negatively regulates the production of proinflammatory cytokines by macrophages in response to LPS
Honma, K., Udono, H., Kohno, T., Yamamoto, K., Ogawa, A., Takemori, T., Kumatori, A., Suzuki, S., Matsuyama, T., & Yui, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504226102 · Cited by 140 · see citing works
Regulation of myelopoiesis by the transcription factor IRF8
Tamura, T., Kurotaki, D., & Koizumi, S.-I. (2015) · International Journal of Hematology · doi:10.1007/s12185-015-1761-9 · Cited by 139 · see citing works
Interferon Regulatory Factor (Irf)-1 and Irf-2 Regulate Interferon γ–Dependent Cyclooxygenase 2 Expression
Blanco, J. C. G., Contursi, C., Salkowski, C. A., DeWitt, D. L., Ozato, K., & Vogel, S. N. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.12.2131 · Cited by 137 · see citing works
IFN Regulatory Factor 4 Regulates the Expression of a Subset of Th2 Cytokines
Ahyi, A.-N. N., Chang, H.-C., Dent, A. L., Nutt, S. L., & Kaplan, M. H. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803302 · Cited by 137 · see citing works
Crystal Structure of IRF-3 in Complex with CBP
Qin, B. Y., Liu, C., Srinath, H., Lam, S. S., Correia, J. J., Derynck, R., & Lin, K. F. (2005) · Structure · doi:10.1016/j.str.2005.06.011 · Cited by 131 · see citing works
Autoamplification of Notch Signaling in Macrophages by TLR-Induced and RBP-J–Dependent Induction of Jagged1
Foldi, J., Chung, A. Y., Xu, H., Zhu, J., Outtz, H. H., Kitajewski, J., Li, Y., Hu, X., & Ivashkiv, L. B. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001544 · Cited by 129 · see citing works
Functional Regulation of MyD88-Activated Interferon Regulatory Factor 5 by K63-Linked Polyubiquitination
Balkhi, M. Y., Fitzgerald, K. A., & Pitha, P. M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00662-08 · Cited by 128 · see citing works
A dual cis -regulatory code links IRF8 to constitutive and inducible gene expression in macrophagesPreprint
Mancino, A., Termanini, A., Barozzi, I., Ghisletti, S., Ostuni, R., Prosperini, E., Ozato, K., & Natoli, G. (2015) · Genes & Development · doi:10.1101/gad.257592.114 · Cited by 127 · see citing works
GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-α converting enzyme (TACE)
Hiasa, M., Abe, M., Nakano, A., Oda, A., Amou, H., Kido, S., Takeuchi, K., Kagawa, K., Yata, K., Hashimoto, T., et al. (2009) · Blood · doi:10.1182/blood-2009-04-215020 · Cited by 125 · see citing works
Interferon regulatory factor 7 participates in the M 1‐like microglial polarization switch
Tanaka, T., Murakami, K., Bandô, Y., & Yoshida, S. (2014) · Glia · doi:10.1002/glia.22770 · Cited by 122 · see citing works
IRF8 regulates myeloid and B lymphoid lineage diversification
Wang, H., & Morse, H. C. (2008) · Immunologic Research · doi:10.1007/s12026-008-8055-8 · Cited by 121 · see citing works
Interleukin-4 induced interferon regulatory factor (Irf) 4 participates in the regulation of alternative macrophage priming
Chartouni, C. E., Schwarzfischer, L., & Rehli, M. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.05.031 · Cited by 119 · see citing works
PU.1 and Multiple IFN Regulatory Factor Proteins Synergize to Mediate Transcriptional Activation of the Human IL-1β Gene
Marecki, S., Riendeau, C. J., Liang, M. D., & Fenton, M. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.11.6829 · Cited by 111 · see citing works
The Transcription Factor Interferon Regulatory Factor 1 Is Expressed after Cerebral Ischemia and Contributes to Ischemic Brain Injury
Iadecola, C., Salkowski, C. A., Zhang, F., Aber, T., Nagayama, M., Vogel, S. N., & Ross, M. E. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.4.719 · Cited by 111 · see citing works
Synergistic Activation of Interleukin-12 p35 Gene Transcription by Interferon Regulatory Factor-1 and Interferon Consensus Sequence-binding Protein
Liu, J., Guan, X., Tamura, T., Ozato, K., & Ma, X. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406565200 · Cited by 110 · see citing works
PIAS3 induces SUMO‐1 modification and transcriptional repression of IRF‐1
Nakagawa, K., & Yokosawa, H. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03486-5 · Cited by 109 · see citing works
Suppression of PLCβ2 by Endotoxin Plays a Role in the Adenosine A2A Receptor-Mediated Switch of Macrophages from an Inflammatory to an Angiogenic Phenotype
Grinberg, S., Haskó, G., Wu, D., & Leibovich, S. J. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090290 · Cited by 105 · see citing works
Antagonistic regulation of macrophage phenotype by M-CSF and GM-CSF: Implication in atherosclerosis
Brochériou, I., Maouche, S., Durand, H., Braunersreuther, V., Naour, G. L., Gratchev, A. N., Koskas, F., Mach, F., Kzhyshkowska, J. G., & Ninio, E. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.11.023 · Cited by 104 · see citing works
Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells
López‐Peláez, M., Lamont, D. J., Peggie, M. W., Shpiro, N., Gray, N. S., & Cohen, P. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418399111 · Cited by 100 · see citing works
Functional Domain Analysis of Interferon Consensus Sequence Binding Protein (ICSBP) and Its Association with Interferon Regulatory Factors
Sharf, R., Azriel, A., Lejbkowicz, F., Winograd, S. S., Ehrlich, R., & Levi, B.-Z. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.13063 · Cited by 100 · see citing works
Effects of IRF1 and IFN-β interaction on the M1 polarization of macrophages and its antitumor function
XIE, C., Liu, C., Wu, B., Yan, L., Ma, T., Xiong, H.-Y., Wang, Q., Li, Z., Ma, C., & Tu, Z. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2583 · Cited by 100 · see citing works
IKKβ is an IRF5 kinase that instigates inflammation
Ren, J., Chen, X., & Chen, Z. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418516111 · Cited by 99 · see citing works
Changes in transcriptome of macrophages in atherosclerosis
Chistiakov, D. A., Bobryshev, Y. V., & Orekhov, A. N. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12591 · Cited by 98 · see citing works
Functional domains of interferon regulatory factor I (IRF-1)
Schaper, F., KIRCHHOFF, S., Posern, G., Köster, M., Oumard, A., Sharf, R., Levi, B.-Z., & Häuser, H. (1998) · Biochemical Journal · doi:10.1042/bj3350147 · Cited by 94 · see citing works
Ex Vivo and In Vitro Effect of Serum Amyloid A in the Induction of Macrophage M2 Markers and Efferocytosis of Apoptotic Neutrophils
Sun, L., Zhou, H., Zhu, Z., Qian, Y., Wang, L., Liang, Q., & Ye, R. D. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402164 · Cited by 90 · see citing works
Monocyte Differentiation to Macrophage Requires Interferon Regulatory Factor 7
Lu, R., & Pitha, P. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100421200 · Cited by 89 · see citing works
Differential Expression and Distinct Functions of IFN Regulatory Factor 4 and IFN Consensus Sequence Binding Protein in Macrophages
Marecki, S., Atchison, M. L., & Fenton, M. J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.5.2713 · Cited by 87 · see citing works
IRF‐8/ICSBP and IRF‐1 cooperatively stimulate mouse IL‐12 promoter activity in macrophages
Masumi, A., Tamaoki, S., Wang, I., Ozato, K., & Komuro, K. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03556-1 · Cited by 87 · see citing works
Involvement of the IκB Kinase (IKK)-Related Kinases Tank-Binding Kinase 1/IKKi and Cullin-Based Ubiquitin Ligases in IFN Regulatory Factor-3 Degradation
Bibeau-Poirier, A., Gravel, S., Clément, J.-F., Rolland, S., Rodier, G., Coulombe, P., Hiscott, J. B., Grandvaux, N., Meloche, S., & Servant, M. J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.5059 · Cited by 87 · see citing works
IRF8 directs stress-induced autophagy in macrophages and promotes clearance of Listeria monocytogenes
Gupta, M., Shin, D.-M., Ramakrishna, L., Goussetis, D. J., Platanias, L. C., Xiong, H., Morse, H. C., & Ozato, K. (2015) · Nature Communications · doi:10.1038/ncomms7379 · Cited by 86 · see citing works
Cytokine regulation of granulocyte-macrophage colony stimulating factor and macrophage colony-stimulating factor production in human arterial smooth muscle cells
Filonzi, E. L., Zoellner, H. F., Stanton, H., & Hamilton, J. A. (1993) · Atherosclerosis · doi:10.1016/0021-9150(93)90026-q · Cited by 84 · see citing works
Essential control of early B-cell development by Mef2 transcription factors
Herglotz, J., Unrau, L., Hauschildt, F., Fischer, M., Kriebitzsch, N., Alawi, M., Indenbirken, D., Spohn, M., Müller, U., Ziegler, M., et al. (2015) · Blood · doi:10.1182/blood-2015-04-643270 · Cited by 82 · see citing works
A role for casein kinase II phosphorylation in the regulation of IRF-1 transcriptional activity
Lin, R., Lin, R., Hiscott, J. B., Hiscott, J. B., & Hiscott, J. B. (1999) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006850009017 · Cited by 77 · see citing works
KAP1/TRIM28: an inhibitor of IRF5 function in inflammatory macrophages.
Eames, H. L., Saliba, D. G., Krausgruber, T., Lanfrancotti, A., Ryzhakov, G., & Udalova, I. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.07.026 · Cited by 77 · see citing works
Activation of Interferon Regulatory Factor 5 by Site Specific Phosphorylation
Foreman, H.-C. C., Scoy, S. V., Cheng, T., & Reich, N. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033098 · Cited by 76 · see citing works
PU.1/Interferon Regulatory Factor Interactions; Mechanisms of Transcriptional Regulation
Marecki, S., & Fenton, M. J. (2000) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:33:2:127 · Cited by 74 · see citing works
Identification of IFN Regulatory Factor-1 Binding Site in IL-12 p40 Gene Promoter
Maruyama, S., Sumita, K., Shen, H., Kanoh, M., Xu, X., Sato, M., Matsumoto, M., Shinomiya, H., & Asano, Y. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.2.997 · Cited by 72 · see citing works
Expression of the Immune Regulator Tripartite-Motif 21 Is Controlled by IFN Regulatory Factors
Sjöstrand, M., Ambrosi, A., Brauner, S., Sullivan, J. M., Malin, S., Kuchroo, V. K., Espinosa, A., & Wahren‐Herlenius, M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202341 · Cited by 69 · see citing works
Molecular control of monocyte development
Terry, R. L., & Miller, S. D. (2014) · Cellular Immunology · doi:10.1016/j.cellimm.2014.02.008 · Cited by 69 · see citing works
Regulation of Lipopolysaccharide Sensitivity by IFN Regulatory Factor-2
Cuesta, N., Salkowski, C. A., Thomas, K. E., & Vogel, S. N. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.11.5739 · Cited by 68 · see citing works
IRF-1 Promotes Inflammation Early after Ischemic Acute Kidney Injury
Wang, Y., John, R., Chen, J., Richardson, J. A., Shelton, J. M., Bennett, M., Zhou, X. J., Nagami, G. T., Zhang, Y., Wu, Q., et al. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008080843 · Cited by 67 · see citing works
Neddylation and deneddylation in cardiac biology.
Kandala, S., Kim, I., & Su, H. (2014) · PubMed · Cited by 65 · see citing works
Smooth Muscle Cells Express Granulocyte-Macrophage Colony-Stimulating Factor in the Undiseased and Atherosclerotic Human Coronary Artery
Plenz, G. A. M., Koenig, C., Severs, N. J., & Robenek, H. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.2489 · Cited by 64 · see citing works
Macrophage Heterogeneity and Plasticity: Impact of Macrophage Biomarkers on Atherosclerosis
Rojas, J., Salazar, J. J., Martínez, M. S., Palmar, J., Bautista, J., Chávez-Castillo, M., Gómez, A., & Bermúdez, V. (2015) · Scientifica · doi:10.1155/2015/851252 · Cited by 63 · see citing works
Transcriptional regulation of lipopolysaccharide (LPS)-induced Toll-like receptor (TLR) expression in murine macrophages: role of interferon regulatory factors 1 (IRF-1) and 2 (IRF-2)
Nhu, Q. M., Cuesta, N., & Vogel, S. N. (2006) · Journal of Endotoxin Research · doi:10.1179/096805106x118834 · Cited by 59 · see citing works
PU.1, Interferon Regulatory Factor (IRF) 2, and the Interferon Consensus Sequence-binding Protein (ICSBP/IRF8) Cooperate to Activate NF1 Transcription in Differentiating Myeloid Cells
Huang, W., Horvath, E., & Eklund, E. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607760200 · Cited by 58 · see citing works
Multiple Ets Factors and Interferon Regulatory Factor-4 Modulate CD68 Expression in a Cell Type-specific Manner
O’Reilly, D., Quinn, C. M., El‐Shanawany, T., Gordon, S., & Greaves, D. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212150200 · Cited by 55 · see citing works
Bipartite Nuclear Localization Signal Controls Nuclear Import and DNA-Binding Activity of IFN Regulatory Factor 3
Zhu, M., Fang, T., Li, S., Meng, K., & Guo, D. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500232 · Cited by 52 · see citing works
The Small Ubiquitin-like Modifier-Deconjugating Enzyme Sentrin-Specific Peptidase 1 Switches IFN Regulatory Factor 8 from a Repressor to an Activator during Macrophage Activation
Chang, T.-H., Xu, S., Tailor, P. B., Kanno, T., & Ozato, K. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201104 · Cited by 51 · see citing works
IRF8 is a transcriptional determinant for microglial motility
Masuda, T., Nishimoto, N., Tomiyama, D., Matsuda, T., Tozaki‐Saitoh, H., Tamura, T., Kohsaka, S., Tsuda, M., & Inoue, K. (2014) · Purinergic Signalling · doi:10.1007/s11302-014-9413-8 · Cited by 50 · see citing works
Partner-regulated interaction of IFN regulatory factor 8 with chromatin visualized in live macrophages
Laricchia‐Robbio, L., Tamura, T., Karpova, T., Sprague, B. L., McNally, J. G., & Ozato, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504014102 · Cited by 47 · see citing works
Activation and Function of Interferon Regulatory Factor 5
Ryzhakov, G., Eames, H. L., & Udalova, I. A. (2014) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2014.0023 · Cited by 43 · see citing works
IKKα negatively regulates IRF-5 function in a MyD88–TRAF6 pathway
Balkhi, M. Y., Fitzgerald, K. A., & Pitha, P. M. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.09.021 · Cited by 42 · see citing works
Defective Inflammatory Monocyte Development in IRF8-Deficient Mice Abrogates Migration to the West Nile Virus-Infected Brain
Terry, R. L., Deffrasnes, C., Getts, D. R., Minten, C., van Vreden, C., Ashhurst, T. M., Getts, M. T., Xie, R. D. V., Campbell, I. L., & King, N. J. C. (2015) · Journal of Innate Immunity · doi:10.1159/000365972 · Cited by 40 · see citing works
Interferon regulatory factor 8 protects against cerebral ischaemic‐reperfusion injury
Xiang, M., Wang, L., Guo, S., Lu, Y., Lei, H. C., Jiang, D., Zhang, Y., Liu, Y., Zhou, Y., Zhang, X., et al. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12682 · Cited by 39 · see citing works
Interferon regulatory factor-2 is protective against hepatic ischemia-reperfusion injury
Klune, J. R., Dhupar, R., Kimura, S., Ueki, S., Cardinal, J. S., Nakao, A., Nace, G., Evankovich, J. W., Murase, N., Tsung, A., et al. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00050.2012 · Cited by 38 · see citing works
Role of Mdm2 acid domain interactions in recognition and ubiquitination of the transcription factor IRF-2
Pettersson, S., Kelleher, M., Pion, E., Wallace, M., & Ball, K. L. (2008) · Biochemical Journal · doi:10.1042/bj20082087 · Cited by 37 · see citing works
Phosphoinositide Protein Kinase PDPK1 Is a Crucial Cell Signaling Mediator in Multiple Myeloma
Chinen, Y., Kuroda, J., Shimura, Y., Nagoshi, H., Kiyota, M., Yamamoto‐Sugitani, M., Mizutani, S., Sakamoto, N., Ri, M., Kawata, E., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-1420 · Cited by 36 · see citing works
IκB Kinase ε Targets Interferon Regulatory Factor 1 in Activated T Lymphocytes
Sgarbanti, M., Marsili, G., Remoli, A. L., Stellacci, E., Mai, A., Rotili, D., Perrotti, E., Acchioni, C., Orsatti, R., Iraci, N., et al. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01161-13 · Cited by 35 · see citing works
IFN Regulatory Factor-2 Regulates Macrophage Apoptosis through a STAT1/3- and Caspase-1-Dependent Mechanism
Cuesta, N., Nhu, Q. M., Zudaire, E., Polumuri, S. K., Cuttitta, F. F., & Vogel, S. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.6.3602 · Cited by 34 · see citing works
Regulation of IRF2 transcriptional activity by its sumoylation
Han, K.-J., Jiang, L., & Shu, H. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.05.103 · Cited by 33 · see citing works
Glucocorticoid Inhibits Oxidized LDL-Induced Macrophage Growth by Suppressing the Expression of Granulocyte/Macrophage Colony-Stimulating Factor
Sakai, M., Biwa, T., Matsumura, T., Takemura, T., Matsuda, H., Anami, Y., Sasahara, T., Kobori, S., & Shichiri, M. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.7.1726 · Cited by 32 · see citing works
Interferon regulatory factor-1 immunoreactivity in neurons and inflammatory cells following ischemic stroke in rodents and humans
Alexander, M., Forster, C. L., Sugimoto, K., Clark, H. B., Vogel, S. N., Ross, M. E., & Iadecola, C. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0658-x · Cited by 31 · see citing works
Interplay between repressing and activating domains defines the transcriptional activity of IRF-1
Kirchhoff, S., Oumard, A., Nourbakhsh, M., Levi, B.-Z., & Häuser, H. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2000.01750.x · Cited by 31 · see citing works
Human arterial smooth muscle cells synthesize granulocyte colony- stimulating factor in response to interleukin-1 alpha and tumor necrosis factor-alpha
Zoellner, H. F., Filonzi, E. L., Stanton, H., Layton, J., & Hamilton, J. (1992) · Blood · doi:10.1182/blood.v80.11.2805.2805 · Cited by 30 · see citing works
Identification of the secretory leukocyte protease inhibitor (SLPI) as a target of IRF-1 regulation
Nguyen, H., Teskey, L., Lin, R., & Hiscott, J. B. (1999) · Oncogene · doi:10.1038/sj.onc.1202924 · Cited by 24 · see citing works
In vivo formation of IRF-1 homodimers
Kirchhoff, S., Schaper, F., Oumard, A., & Häuser, H. (1998) · Biochimie · doi:10.1016/s0300-9084(99)80019-4 · Cited by 20 · see citing works
Ubc9-mediated sumoylation leads to transcriptional repression of IRF-1
Kim, E., Park, J. S., & Um, S. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.10.092 · Cited by 19 · see citing works
RHS 6 coordinately regulates the Th2 cytokine genes by recruiting GATA 3, SATB1, and IRF 4
Hwang, S. S., Jang, S. W., Lee, K., Kim, H. S., & Lee, G. R. (2016) · Allergy · doi:10.1111/all.13078 · Cited by 18 · see citing works
α-Lipoic acid (α-LA) inhibits the transcriptional activity of interferon regulatory factor 1 (IRF-1) via SUMOylation
Sun, T., Gao, F., Lin, X., Yu, R., Zhao, Y. B., Luan, J., Li, H., & Song, M. (2014) · Toxicology in Vitro · doi:10.1016/j.tiv.2014.06.003 · Cited by 17 · see citing works

Flagged first, then by citations

Sorted by citations

Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers
Zhang, F., Parayath, N. N., Ene, C., Stephan, S. B., Koehne, A. L., Coon, M. E., Holland, E. C., & Stephan, M. T. (2019) · Nature Communications · doi:10.1038/s41467-019-11911-5 · Cited by 526 · see citing works
Macrophage plasticity: signaling pathways, tissue repair, and regeneration
Yan, L., Wang, J., Cai, X., Liou, Y., Shen, H., Hao, J., Huang, C., Luo, G., & He, W. (2024) · MedComm · doi:10.1002/mco2.658 · Cited by 396 · see citing works
M1 and M2 macrophage polarization and potentially therapeutic naturally occurring compounds
Wang, Y., Smith, W. W., Hao, D., He, B., & Kong, L. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.02.050 · Cited by 330 · see citing works
Alternatively activated macrophages; a double-edged sword in allergic asthma
Abdelaziz, M. H., Abdelwahab, S. F., Wan, J., Cai, W., Wang, H., Cheng, J., Kesavan, D. K., Vasudevan, A., Sadek, A., Su, Z., et al. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02251-w · Cited by 283 · see citing works
Macrophage Polarization in the Development and Progression of Ovarian Cancers: An Overview
Cheng, H., Wang, Z., Fu, L., & Xu, T. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00421 · Cited by 265 · see citing works
“In addition, interferon regulatory factor (IRF)-1, IRF-5, and IRF-8 are correlated with polarization to the M1 phenotype, while IRF3 and IRF-4 polarize cells to the M2 phenotype (48).”
Background
Macrophage Polarization in Leishmaniasis: Broadening Horizons
Tomiotto‐Pellissier, F., Bortoleti, B. T. D. S., Assolini, J. P., Gonçalves, M. D., Carloto, A. C. M., Miranda-Sapla, M. M., Costa, I. C., Bordignon, J., & Pavanelli, W. R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02529 · Cited by 225 · see citing works
“IRF4 and IRF5 are involved in the polarization of M1 and M2 macrophages, but the role of IRFs in M2 polarization is not completely clear (44).”
Background
The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review
Zeng, J., Bao, T., Yang, K., Zhu, X., Wang, S., Xiang, W., Ge, A., Zeng, L., & Ge, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1047550 · Cited by 175 · see citing works
Type I interferon signaling, regulation and gene stimulation in chronic virus infection
Lukhele, S., Boukhaled, G. M., & Brooks, D. G. (2019) · Seminars in Immunology · doi:10.1016/j.smim.2019.05.001 · Cited by 166 · see citing works
“In addition, unlike IRFs 1, 5 and 8, which are associated with polarization towards M1 macrophage phenotype, IRF4 is involved in skewing towards the anti-inflammatory M2 phenotype (80).”
Background
Targeting of TAMs: can we be more clever than cancer cells?
Kzhyshkowska, J., Shen, J., & Larionova, I. (2024) · Cellular & Molecular Immunology · doi:10.1038/s41423-024-01232-z · Cited by 166 · see citing works
“IRF3 promotes M-CSF-mediated differentiation of monocytes toward M2-type macrophages; inhibits the expression of proin ﬂ ammatory genes (IL-1 α , IL-1 β , TNF α , IL-6, IL-8, and CXCL1); and stimulates the expression of protumoral IL-10 and IFN-β [292, 295].”
Kupffer Cells
Slevin, E., Baiocchi, L., Wu, N., Ekser, B., Sato, K., Lin, E. P.-Y., Ceci, L., Chen, L., Ramos‐Lorenzo, S., Xu, W., et al. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2020.08.014 · Cited by 164 · see citing works
TLR-3 Stimulation Skews M2 Macrophages to M1 Through IFN-αβ Signaling and Restricts Tumor Progression
Vidyarthi, A., Khan, N., Agnihotri, T., Negi, S., Das, D. K., Aqdas, M., Chatterjee, D., Colegio, O. R., Tewari, M. K., & Agrewala, J. N. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01650 · Cited by 157 · see citing works
Targeting interferon-γ in hyperinflammation: opportunities and challenges
Benedetti, F. D., Prencipe, G., Bracaglia, C., Marasco, E., & Grom, A. A. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00694-z · Cited by 155 · see citing works
BMSC-derived exosomes promote tendon-bone healing after anterior cruciate ligament reconstruction by regulating M1/M2 macrophage polarization in rats
Li, Z., Li, Q., Tong, K., Zhu, J., Zhang, H., Chen, B., & Chen, L. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02975-0 · Cited by 156 · see citing works
“This process is called macrophage polarization [52].”
Macrophages with regulatory functions, a possible new therapeutic perspective in autoimmune diseases
Benedetto, P. D., Ruscitti, P., Vadasz, Z., Toubi, E., & Giacomelli, R. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.102369 · Cited by 139 · see citing works
Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages
Larionova, I., Kazakova, E., Patysheva, M. R., & Kzhyshkowska, J. G. (2020) · Cancers · doi:10.3390/cancers12061411 · Cited by 124 · see citing works
“IRF3 promotes M-CSF-mediated differentiation of monocytes toward M2 type macrophages [25].”
Background
Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases
Koh, Y., Yang, G., Lai, C., Weerawatanakorn, M., & Pan, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082208 · Cited by 127 · see citing works
“Nine IRFs have been identified, with three of them (IRF-1, IRF-5, and IRF-8) being normally associated with the polarization mechanism of M1 macrophages, while IRF-3 and -4 are more often found to be involved in M2 polarization [57].”
Background
Long noncoding RNA NEAT1 modulates immune cell functions and is suppressed in early onset myocardial infarction patients
Gast, M., Rauch, B. H., Haghikia, A., Nakagawa, S., Haas, J., Stroux, A., Schmidt, D., Schumann, P. A., Weiß, S., Jensen, L., et al. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz085 · Cited by 122 · see citing works
Epigenetic regulation of macrophage polarization in wound healing
Chen, C., Liu, T., Tang, Y., Luo, G., Liang, G., & He, W. (2023) · Burns & Trauma · doi:10.1093/burnst/tkac057 · Cited by 123 · see citing works
Hepatitis B virus-induced modulation of liver macrophage function promotes hepatocyte infection
Faure‐Dupuy, S., Delphin, M., Aillot, L., Dimier, L., Lebossé, F., Fresquet, J., Parent, R., Matter, M. S., Rivoire, M. L., Bendriss‐Vermare, N., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.06.032 · Cited by 102 · see citing works
Inhibition of glutamine synthetase in monocytes from patients with acute-on-chronic liver failure resuscitates their antibacterial and inflammatory capacity
Korf, H., Plessis, J. D. D., van Pelt, J., Groote, S. D., Cassiman, D., Verbeke, L., Ghesquière, B., Fendt, S., Bird, M., Talebi, A., et al. (2018) · Gut · doi:10.1136/gutjnl-2018-316888 · Cited by 89 · see citing works
Liver macrophages and inflammation in physiology and physiopathology of non‐alcoholic fatty liver disease
Thibaut, R., Gage, M., Pineda‐Torra, I., Chabrier, G., Venteclef, N., & Alzaïd, F. (2021) · FEBS Journal · doi:10.1111/febs.15877 · Cited by 95 · see citing works
Multifunctional Integrated Nanozymes Facilitate Spinal Cord Regeneration by Remodeling the Extrinsic Neural Environment
Xiong, T., Yang, K., Zhao, T., Zhao, H., Gao, X., You, Z., Fan, C., Kang, X., Yang, W., Zhuang, Y., et al. (2023) · Advanced Science · doi:10.1002/advs.202205997 · Cited by 90 · see citing works
Activation of Kupffer cells in NAFLD and NASH: mechanisms and therapeutic interventions
Xu, G.-X., Song, W., Yu, C., Zhao, S., Yang, W., Feng, Y.-H., Pan, C., Kun-xing, Y., & Ma, Y. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1199519 · Cited by 93 · see citing works
“A growing body of literature shows that IRFs can also influence the phenotype and polarization of both KCs and macrophages (Chistiakov et al., 2018).”
Background
Anti-Inflammatory Activity of Extracts and Pure Compounds Derived from Plants via Modulation of Signaling Pathways, Especially PI3K/AKT in Macrophages
Merecz-Sadowska, A., Sitarek, P., Śliwiński, T., & Zajdel, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249605 · Cited by 90 · see citing works
“In monocyte-derived macrophages, stimulation of IRF-5 expression is induced by granulocyte-macrophage colony-stimulating factor (GM-CSF) [128].”
Background
Macrophages: Subtypes, Distribution, Polarization, Immunomodulatory Functions, and Therapeutics
Peng, M., Li, N., Wang, H., Li, Y., Liu, H., Luo, Y., Lang, B., Zhang, W., Li, S., Tian, L., et al. (2025) · MedComm · doi:10.1002/mco2.70304 · Cited by 95 · see citing works
“IRFs play a crucial role in hematopoietic development, differentiation into macrophages, and regulation of macrophage maturation, phenotype polarization, phenotype switching, and function [104].”
Effects of Environmental pH on Macrophage Polarization and Osteoimmunomodulation
Wu, H. P., Yin, Y., Hu, X., Peng, C., Liu, Y., Li, Q., Huang, W., & Huang, Q. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b01181 · Cited by 85 · see citing works
Glutathione Induced Immune-Stimulatory Activity by Promoting M1-Like Macrophages Polarization via Potential ROS Scavenging Capacity
Kwon, D. H., Lee, H., Park, C., Hong, S. H., Hong, S. H., Kim, G., Cha, H., Kim, S., Kim, H., Hwang, H., et al. (2019) · Antioxidants · doi:10.3390/antiox8090413 · Cited by 87 · see citing works
“The phenotype transition is involved alteration of the macrophage transcriptome and regulatory networks [33].”
Background
Airway hyperresponsiveness development and the toxicity of PM2.5
Lu, X., Li, R., & Yan, X. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-12051-w · Cited by 83 · see citing works
Recent advances in nanomedicines for regulation of macrophages in wound healing
Joorabloo, A., & Liu, T. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01616-1 · Cited by 82 · see citing works
Macrophage Polarization: An Important Candidate Regulator for Lung Diseases
Deng, L., Jian, Z., Xu, T., Li, F., Deng, H., Zhou, Y., Lai, S., Xu, Z., & Zhu, L. (2023) · Molecules · doi:10.3390/molecules28052379 · Cited by 81 · see citing works
The Macrophage Response Is Driven by Mesenchymal Stem Cell-Mediated Metabolic Reprogramming
Luque-Campos, N., Bustamante-Barrientos, F. A., Pradenas, C., García, C., Araya, M. J., Bohaud, C., Contreras-López, R., Elizondo-Vega, R., Djouad, F., Luz-Crawford, P., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.624746 · Cited by 82 · see citing works
“Also, MSCs enhance interferon-regulatory factor-4 (IRF-4) expression levels (100), which participate in M2 macrophage polarization by inducing Arg1, mannose receptor, Ym1, and FIZZ1 expression (102).”
Background
mRNA vaccine with unmodified uridine induces robust type I interferon-dependent anti-tumor immunity in a melanoma model
Sittplangkoon, C., Alameh, M.-G., Weissman, D., Lin, P. J. C., Tam, Y. K., Prompetchara, E., & Palaga, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.983000 · Cited by 79 · see citing works
“IRF-5 is critically involved in M1- macrophage polarization (42), which possesses phagocytic capacity, and the ability to secrete reactive nitrogen and oxygen species and pro-inflammatory cytokines such as IL-6, IL-12, IL-23 and TNF-a, which in turn promote CD8 T cell and NK cell cytotoxicity.”
Background
Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1
Gao, J., Ao, Y.-Q., Zhang, L.-X., Deng, J., Wang, S., Wang, H., Jiang, J.-H., & Ding, J. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02505-z · Cited by 78 · see citing works
“Previous studies had identified IRF4 as an important mediator of M2 polarization of macrophages [21], suggesting that ELF4 could elicit M2 polarization of macrophages via activation of IRF4.”
Result
Macrophage polarization: an effective approach to targeted therapy of inflammatory bowel disease
Du, Y., Rong, L., Cong, Y., Shen, L., Zhang, N., & Wang, B. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1901079 · Cited by 78 · see citing works
“However, under certain circumstances, emodin can inhibit the activation of STAT6 and IRF4 signals while suppressing the polarization of M1 macrophages, thereby reducing the response of macrophages to M1 and M2 stimuli [197].”
BackgroundInfluential
The Role of Tissue-Resident Macrophages in the Development and Treatment of Inflammatory Bowel Disease
Ma, S., Zhang, J., Liu, H., Li, S., & Wang, Q. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.896591 · Cited by 78 · see citing works
Tumor-Associated Macrophages as Major Immunosuppressive Cells in the Tumor Microenvironment
Ghebremedhin, A., Athavale, D., Zhang, Y.-T. Y., Yao, X., Balch, C., & Song, S. (2024) · Cancers · doi:10.3390/cancers16193410 · Cited by 73 · see citing works
“Moreover, the involvement of interferon regulatory factors (IRFs) is notable, with IRF-1, IRF-5, and IRF-8 favoring M1-like polarization, while IRF-3 and IRF-4 promote the M2-like phenotype [28].”
Background
High Molecular Weight Hyaluronan Suppresses Macrophage M1 Polarization and Enhances IL-10 Production in PM2.5-Induced Lung Inflammation
Shi, Q., Zhao, L., Xu, C., Zhang, L., & Zhao, H. (2019) · Molecules · doi:10.3390/molecules24091766 · Cited by 68 · see citing works
“On the contrary, M2 macrophages are stimulated by various factors—such as macrophage colony stimulating factor (M-CSF), interleukin 4 (IL-4), IL-13, and transforming growth factor-β (TGF-β)—and participate in the resolution of inflammation and tissue repair partially through the production of anti-inflammatory factors…”
Background
SIRT1/2 orchestrate acquisition of DNA methylation and loss of histone H3 activating marks to prevent premature activation of inflammatory genes in macrophages
Li, T., García-Gómez, A., Morante-Palacios, O., Ciudad, L., Özkaramehmet, S., Dijck, E. V., Rodríguez‐Ubreva, J., Vaquero, A., & Ballestar, E. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1127 · Cited by 69 · see citing works
Trophoblast-secreted soluble-PD-L1 modulates macrophage polarization and function
Zhang, Y., Aldo, P. B., You, Y., Ding, J., Kaislasuo, J., Petersen, J. F., Løkkegaard, E., Peng, G., Paidas, M. J., Simpson, S., et al. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.1a0420-012rr · Cited by 67 · see citing works
GRaNIE and GRaNPA: inference and evaluation of enhancer‐mediated gene regulatory networks
Kamal, A., Arnold, C., Claringbould, A., Moussa, R., Servaas, N. H., Kholmatov, M. M., Daga, N., Nogina, D., Müller‐Dott, S., Reyes‐Palomares, A., et al. (2023) · Molecular Systems Biology · doi:10.15252/msb.202311627 · Cited by 63 · see citing works
“IRF8 is a known pro-inflammatory interferon response factor, associated with the pro-inflammatory (M1) polarisation of macrophages (Chistiakov et al , 2018), which we confirmed in our data using gene set enrichment analysis (GSEA) of the IRF8 regulon (Appendix Fig S18).”
Result
The Caspase Inhibitor Z-VAD-FMK Alleviates Endotoxic Shock via Inducing Macrophages Necroptosis and Promoting MDSCs-Mediated Inhibition of Macrophages Activation
Li, X., Yao, X., Zhu, Y., Zhang, H., Wang, H., Ma, Q., Yan, F., Yang, Y., Zhang, J., Shi, H., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01824 · Cited by 58 · see citing works
Intravesical BCG in patients with non-muscle invasive bladder cancer induces trained immunity and decreases respiratory infections
van Puffelen, J. H., Novakovic, B., van Emst, L., Kooper, D., Zuiverloon, T. C. M., Oldenhof, U. T. H., Witjes, J. A., Galesloot, T. E., Vrieling, A., Aben, K. K. H., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-005518 · Cited by 56 · see citing works
“Open access”
miR‐130b‐3p regulates M1 macrophage polarization via targeting IRF1
Guo, Q., Zhu, X., Wei, R., Zhao, L., Zhang, Z., Yin, X., Zhang, Y., Chu, C., Wang, B., & Li, X. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29987 · Cited by 54 · see citing works
“Among these transcription factors, IRF1 has been found to play significant roles in macrophage polarization (Chistiakov et al., 2018; Gunthner & Anders, 2013).”
Background
Pathophysiology of Atherosclerotic Plaque Development-Contemporary Experience and New Directions in Research
Kowara, M., & Cudnoch‐Jędrzejewska, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073513 · Cited by 54 · see citing works
“The M1/M2 macrophage balance within the plaque depends also on transcription factors such as interferon-regulatory factors (IRF)—IRF3 promotes macrophage polarization towards the M2 phenotype (by phosphoinositide kinase 3 (PI3K)/ protein kinase B (Akt) signaling), whereas M5 induces macrophage polarization towards the…”
Background
Omega-3 Lipid Mediators: Modulation of the M1/M2 Macrophage Phenotype and Its Protective Role in Chronic Liver Diseases
Videla, L. A., Valenzuela, R., del Campo, A., & Zúñiga‐Hernández, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115528 · Cited by 51 · see citing works
“…in the transformation of KCs expressing the proinﬂammatory phenotype M1 towards the pro-resolving or immune-modulating phenotype M2, which regulates late repair processes, resolution of inﬂammation and induction of immune tolerance, necessary steps at the beginning of tissue regeneration [9,10].”
Background
Nanoceutical Adjuvants as Wound Healing Material: Precepts and Prospects
Banerjee, K., Madhyastha, R., Nakajima, Y., Maruyama, M., & Madhyastha, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094748 · Cited by 52 · see citing works
“TLRs team up with immunoglobulin G (IgG) complexes to stimulate the macrophage cells to produce immunosuppressive IL-10 and TGF-β1 [59].”
BackgroundInfluential
Differential DNA Methylation of Networked Signaling, Transcriptional, Innate and Adaptive Immunity, and Osteoclastogenesis Genes and Pathways in Gout
Wang, Z., Zhao, Y., Phipps‐Green, A. J., Liu‐Bryan, R., Čeponis, A., Boyle, D. L., Wang, J., Merriman, T. R., Wang, W., & Terkeltaub, R. A. (2019) · Arthritis & Rheumatology · doi:10.1002/art.41173 · Cited by 49 · see citing works
“Examples of hypomethylated TF motifs included the circadian clock regulators CLOCK and ARNT (for aryl hydrocarbon nuclear receptor) and genes encoding STAT2 and multiple components of AP1 (for activator protein 1), IRF1 (for interferon regulatory transcription factor 1) (34), and NFATC2 and NFATC3.”
Background
Adoptive transfer of Trichinella spiralis-activated macrophages can ameliorate both Th1- and Th2-activated inflammation in murine models
Kang, S. A., Park, M.-K., Park, S. K., Choi, J. H., Lee, D. I., Song, S. M., & Yu, H. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-43057-1 · Cited by 50 · see citing works
The Role of Macrophage/B-Cell Interactions in the Pathophysiology of B-Cell Lymphomas
Pham, L. V., Pogue, E., & Ford, R. J. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00147 · Cited by 47 · see citing works
“Am J Clin Pathol (2004) 122(5):794–801.”
BackgroundInfluential
GPP (Composition of Ganoderma lucidum Poly-saccharides and Polyporus umbellatus Poly-saccharides) Enhances Innate Immune Function in Mice
Huang, Q., Li, L., Chen, H., Liu, Q., & Wang, Z. (2019) · Nutrients · doi:10.3390/nu11071480 · Cited by 46 · see citing works
“There are mainly two subtypes, namely classical polarization (M1 type) or alternating polarization (M2 type) [36,37].”
Background
Alpha-1 Antitrypsin Attenuates M1 Microglia-Mediated Neuroinflammation in Retinal Degeneration
Zhou, T., Huang, Z., Zhu, X., Sun, X., Liu, Y., Cheng, B., Li, M., Liu, Y., He, C., & Liu, X. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01202 · Cited by 45 · see citing works
“IRF8 could induce the expressions of a large panel of M1-related genes, such as IFN-β, IL-12, iNOS, and so on (40, 41), whereas IRF4 functions as a negative regulator of TLRs signaling, associated with the polarization to M2 state (41, 42).”
Background
Unraveling the Role of Astrocytes in Subthalamic Nucleus Deep Brain Stimulation in a Parkinson’s Disease Rat Model
Campos, A. C. P., Kikuchi, D. S., Paschoa, A. F. N., Kuroki, M. A., Fonoff, E. T., Hamani, C., Pagano, R. L., & Hernandes, M. S. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00784-3 · Cited by 45 · see citing works
Viperin Deficiency Promotes Polarization of Macrophages and Secretion of M1 and M2 Cytokines
Eom, J., Yoo, J., Kim, J. J., Lee, J.-B., Choi, W., Park, C. G., & Seo, J.-Y. (2018) · Immune Network · doi:10.4110/in.2018.18.e32 · Cited by 44 · see citing works
Excess fatty acids induce pancreatic acinar cell pyroptosis through macrophage M1 polarization
Xia, W., Lu, Z., Chen, W., Zhou, J., & Zhao, Y. F. (2022) · BMC Gastroenterology · doi:10.1186/s12876-022-02146-8 · Cited by 44 · see citing works
Porphyromonas gingivalis inhibits M2 activation of macrophages by suppressing α‐ketoglutarate production in mice
Yu, S., Ding, L., Liang, D., & Luo, L. (2018) · Molecular Oral Microbiology · doi:10.1111/omi.12241 · Cited by 45 · see citing works
Leukadherin-1-Mediated Activation of CD11b Inhibits LPS-Induced Pro-inflammatory Response in Macrophages and Protects Mice Against Endotoxic Shock by Blocking LPS-TLR4 Interaction
Yao, X., Dong, G., Zhu, Y., Yan, F., Zhang, H., Ma, Q., Fu, X., Li, X., Zhang, Q., Zhang, J., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00215 · Cited by 44 · see citing works
Contrasting effects of Western vs Mediterranean diets on monocyte inflammatory gene expression and social behavior in a primate model
Johnson, C. S. C., Shively, C. A., Michalson, K. T., Lea, A. J., DeBo, R. J., Howard, T. D., Hawkins, G. A., Appt, S. E., Liu, Y., McCall, C. E., et al. (2021) · eLife · doi:10.7554/elife.68293 · Cited by 46 · see citing works
“…the genes encoding for seven of these 35 transcription factors, including IRF3, IRF8, MEF2C, and SP1, which drive monocyte fate and polarization in response to extracellular signals (Chistiakov et al., 2018; Günthner and Anders, 2013; Schüler et al., 2008; Scott et al., 1994; Zhang et al., 1994).”
Influential
NOX4 promotes mucosal barrier injury in inflammatory bowel disease by mediating macrophages M1 polarization through ROS
Han, C., Sheng, Y., Wang, J., Zhou, X., Li, W., Zhang, C., Guo, L., & Yang, Y. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108361 · Cited by 44 · see citing works
Alveolar macrophages: Achilles’ heel of SARS-CoV-2 infection
Wang, Z., Li, S., & Huang, B. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01106-8 · Cited by 47 · see citing works
The increased ratio of Mg2+/Ca2+ from degrading magnesium alloys directs macrophage fate for functionalized growth of endothelial cells
Hou, Y., Witte, F., Li, J., & Guan, S. (2022) · Smart Materials in Medicine · doi:10.1016/j.smaim.2022.01.001 · Cited by 43 · see citing works
Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases
de Sousa, J. R., Vasconcelos, P. F. D. C., & Quaresma, J. A. S. (2019) · Infection and Drug Resistance · doi:10.2147/idr.s208576 · Cited by 43 · see citing works
“85, 86 It is noteworthy that transcriptome analysis has enabled elucidation of mechanisms underlying the modulation of IL-4 intracellular signaling by the induction of zinc finger TFs, Egr2, and c-Myc expression.”
Background
SerpinB2 inhibits migration and promotes a resolution phase signature in large peritoneal macrophages
Schroder, W. A., Hirata, T. D. C., Le, T. T., Gardner, J., Boyle, G. M., Ellis, J. J., Nakayama, E., Pathirana, D., Nakaya, H. I., & Suhrbier, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-48741-w · Cited by 43 · see citing works
Transcriptional control of metabolism by interferon regulatory factors
Ahmad, Z., Kahloan, W., & Rosen, E. D. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-00990-0 · Cited by 42 · see citing works
“IRF3, in general, drives the expression of pro-inflammatory genes and thus pushes macrophages towards an M1-like phenotype 80,81 .”
Interferon-Responsive Genes Are Targeted during the Establishment of Human Cytomegalovirus Latency
Elder, E., Krishna, B. A., Williamson, J. C., Lim, E. Y., Poole, E. L., Sedikides, G. X., Wills, M. R., O’Connor, C. M., Lehner, P. J., & Sinclair, J. H. (2019) · mBio · doi:10.1128/mbio.02574-19 · Cited by 42 · see citing works
“the polarization of the monocyte (71, 72) or perhaps to avoid the antiviral activities of”
Background
Berberine regulates PADI4-related macrophage function to prevent lung cancer
Gu, W., Zhang, M., Gao, F., Niu, Y., Sun, L., Xia, H., Li, W., Zhang, Y., Guo, Z., & Du, G. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108965 · Cited by 41 · see citing works
Aryl hydrocarbon receptor activation drives polymorphonuclear myeloid-derived suppressor cell response and efficiently attenuates experimental Sjogren’s syndrome
Wei, Y., Peng, N., Deng, C., Zhao, F., Tian, J., Tang, Y., Yu, S., Chen, Y., Xue, Y., Xiao, F., et al. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-022-00943-5 · Cited by 41 · see citing works
“IRF4, a member of the interferon regulatory family of transcription factors, was found to be essential for maintaining the differentiation and homeostasis of various immune cell subsets, including dendritic cells and macrophages [16, 17].”
Background
Heme protects intestinal mucosal barrier in DSS‐induced colitis through regulating macrophage polarization in both HO‐1‐dependent and HO‐1‐independent way
Wu, Y., Wu, B., Zhang, Z., Lu, H., Fan, C., Qi, Q., Gao, Y., Li, H., Feng, C., Zuo, J., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202000313rr · Cited by 42 · see citing works
Transplantation-Induced Ischemia-Reperfusion Injury Modulates Antigen Presentation by Donor Renal CD11c+F4/80+ Macrophages through IL-1R8 Regulation
Aiello, S., Podestà, M. A., Ordonez, P. Y. R., Pezzuto, F., Azzollini, N., Solini, S., Carrara, C., Todeschini, M., Casiraghi, F., Noris, M., et al. (2020) · Journal of the American Society of Nephrology · doi:10.1681/asn.2019080778 · Cited by 40 · see citing works
Regulation of Hepatic Inflammation via Macrophage Cell Death
Li, Z., & Weinman, S. A. (2018) · Seminars in Liver Disease · doi:10.1055/s-0038-1670674 · Cited by 41 · see citing works
Increased Adipose Tissue Expression of Interferon Regulatory Factor (IRF)-5 in Obesity: Association with Metabolic Inflammation
Sindhu, S. T. A. K., Thomas, R., Kochumon, S., Wilson, A., Abu‐Farha, M., Bennakhi, A., Al‐Mulla, F., & Ahmad, R. (2019) · Cells · doi:10.3390/cells8111418 · Cited by 40 · see citing works
The role of natural products targeting macrophage polarization in sepsis-induced lung injury
Li, Y., Ai, S., Li, Y., Ye, W., Li, R., Xu, X., & Liu, Q. (2025) · Chinese Medicine · doi:10.1186/s13020-025-01067-4 · Cited by 40 · see citing works
The kinetics of cellular and humoral immune responses of common carp to presporogonic development of the myxozoan Sphaerospora molnari
Korytář, T., Wiegertjes, G. F., Zusková, E., Tomanová, A., Lisnerová, M., Patra, S., Sieranski, V., Šíma, R., Born‐Torrijos, A., Wentzel, A. S., et al. (2019) · Parasites & Vectors · doi:10.1186/s13071-019-3462-3 · Cited by 39 · see citing works
IFN Regulatory Factor 1 Mediates Macrophage Pyroptosis Induced by Oxidized Low-Density Lipoprotein in Patients with Acute Coronary Syndrome
Guo, M., Yan, R., Yao, H., Duan, L., Sun, M., Xue, Z., & Jia, Y. (2019) · Mediators of Inflammation · doi:10.1155/2019/2917128 · Cited by 39 · see citing works
Macrophages in Bone Homeostasis
Kong, L., Wang, Y., Smith, W. W., & Hao, D. (2019) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x14666190214163815 · Cited by 38 · see citing works
Core-shell nanotherapeutics with leukocyte membrane camouflage for biomedical applications
Fan, M., & Jiang, M. (2020) · Journal of drug targeting · doi:10.1080/1061186x.2020.1757102 · Cited by 37 · see citing works
“For example, M2 macrophages can be transformed into M1 macrophages following LPS stimulation to promote inflammatory response [34,35].”
RETRACTED: The cross-talk between tumor-associated macrophages and tumor endothelium: Recent advances in macrophage-based cancer immunotherapy
Baradaran, A., Asadzadeh, Z., Hemmat, N., Baghbanzadeh, A., Shadbad, M. A., Khosravi, N., Derakhshani, A., Alemohammad, H., Nour, M. A., Safarpour, H., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112588 · Cited by 37 · see citing works
Retracted
A distinct M2 macrophage infiltrate and transcriptomic profile decisively influence adipocyte differentiation in lipedema
Wolf, S., Rannikko, J. H., Virtakoivu, R., Cinelli, P., Felmerer, G., Burger, A. E., Giovanoli, P., Detmar, M. J., Lindenblatt, N., Hollmén, M., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1004609 · Cited by 36 · see citing works
“On the other hand, typical M1 markers were significantly downregulated: IL1b, IL6, IL23a, IL1R1 (28) and genes that inhibit M2 macrophage polarization showed reduced expression, such as TNFAIP8 (29), TLR4 (30) and IRF-1 (31).”
Background
L-arabinose Attenuates LPS-Induced Intestinal Inflammation and Injury through Reduced M1 Macrophage Polarization
Kang, L., Pang, J., Zhang, X., Liu, Y., Wu, Y., Wang, J., & Han, D. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.09.012 · Cited by 37 · see citing works
The Regulatory Network of Transcription Factors in Macrophage Polarization
Liu, J., Wang, M., & Zhao, Y. X. (2025) · ImmunoTargets and Therapy · doi:10.2147/itt.s494550 · Cited by 37 · see citing works
Human Perifollicular Macrophages Undergo Apoptosis, Express Wnt Ligands, and Switch their Polarization during Catagen
Hardman, J. A., Muneeb, F., Pople, J., Bhogal, R. K., Shahmalak, A., & Paus, R. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.04.026 · Cited by 35 · see citing works
Inorganic material based macrophage regulation for cancer therapy: basic concepts and recent advances
Zhao, R., Cao, J., Yang, X., Zhang, Q., Iqbal, M. Z., Lü, J., & Kong, X. (2021) · Biomaterials Science · doi:10.1039/d1bm00508a · Cited by 35 · see citing works
Use of Nanoformulation to Target Macrophages for Disease Treatment
Liu, X., Xie, X., Jiang, J., Lin, M. J., Zheng, E., Qiu, W., Yeung, I., Zhu, M., Li, Q., Xia, T., et al. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202104487 · Cited by 36 · see citing works
Polysaccharides from Citrus grandis associate with luteolin relieves chronic pharyngitis by anti-inflammatory via suppressing NF-κB pathway and the polarization of M1 macrophages
Chen, X., Lai, Y., Song, X., Wu, J., Wang, L., Zhang, H., Liu, Z., & Wang, Y. (2018) · International Journal of Immunopathology and Pharmacology · doi:10.1177/2058738418780593 · Cited by 35 · see citing works
Docosahexaenoic acid decreased neuroinflammation in rat pups after controlled cortical impact
Schober, M. E., Requena, D. F., Casper, T. C., Velhorst, A. K., Lolofie, A., McFarlane, K. E., Otto, T. E., Terry, C. R., & Gensel, J. C. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.112971 · Cited by 35 · see citing works
“(Chistiakov et al., 2018) Irf8 expression is necessary for microgliogenesis.”
Neoadjuvant therapy alters the immune microenvironment in pancreatic cancer
Zhang, H., Ye, L., Yu, X., Jin, K., & Wu, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.956984 · Cited by 34 · see citing works
“IRF-5 is a transcription factor that has been shown to have tumor suppression functions and plays a central role in regulating TAM polarization (59, 60).”
Background
Interferon-stimulated genes: new platforms and computational approaches
Green, R. R., Ireton, R. C., & Gale, M. (2018) · Mammalian Genome · doi:10.1007/s00335-018-9755-6 · Cited by 34 · see citing works
Harnessing myeloid cells in cancer
Park, S., Pylaeva, E., Bhuria, V., Gambardella, A. R., Schiavoni, G., Mougiakakos, D., Kim, S.-H., & Jabłońska, J. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02249-2 · Cited by 35 · see citing works
Pomalidomide Alters Pancreatic Macrophage Populations to Generate an Immune-Responsive Environment at Precancerous and Cancerous Lesions
Bastea, L. I., Liou, G., Pandey, V., Martinez, A. K. F., Roemeling, C. A. V., Döppler, H. R., Li, Z., Qiu, Y., Edenfield, B. H., Copland, J. A., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-1153 · Cited by 32 · see citing works
“Interferon regulatory factors play key roles in hematopoietic development of monocytes and their differentiation into macrophages, but also in regulating polarization phenotype and phenotype switching (36).”
Background
Contribution of Heptose Metabolites and the cag Pathogenicity Island to the Activation of Monocytes/Macrophages by Helicobacter pylori
Faass, L., Stein, S. C., Hauke, M., Gapp, M., Albanese, M., & Josenhans, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.632154 · Cited by 32 · see citing works
“A trend to differentiation towards a proin ﬂ ammatory M1 macrophage phenotype was also supported by the transcriptome results (see below), which showed an increased expression of M1-related upstream activator and M1-speci ﬁ c transcription factor genes such as STAT1, STAT2, and AP-1 (64) as well as IRF5 (62), while M2…”
Influential
Macrophage reprogramming into a pro-healing phenotype by siRNA delivered with LBL assembled nanocomplexes for wound healing applications
Sharifiaghdam, M., Shaabani, E., Sharifiaghdam, Z., Keersmaecker, H. D., Lucas, B., Lammens, J., Ghanbari, H., Teimoori‐Toolabi, L., Vervaet, C., Beer, T. D., et al. (2021) · Nanoscale · doi:10.1039/d1nr03830c · Cited by 32 · see citing works
The Roles of Monocytes and Macrophages in Behçet’s Disease With Focus on M1 and M2 Polarization
Hirahara, L., Takase‐Minegishi, K., Kirino, Y., Iizuka-Iribe, Y., Soejima, Y., Yoshimi, R., & Nakajima, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.852297 · Cited by 32 · see citing works
“IRF8 is also involved in the formation of M1 macrophages (63).”
Background
NLRP3 Inflammasome in Atherosclerosis: Putting Out the Fire of Inflammation
Shao, B., Xu, H., Zhao, Y.-C., Zheng, X.-R., Wang, F., & Zhao, G.-R. (2022) · Inflammation · doi:10.1007/s10753-022-01725-x · Cited by 32 · see citing works
“Furthermore, the inducing formation of the anti-inflammatory phenotype of macrophages (M2 phenotype) was shown to attenuate inflammatory reaction, which serves as an effective way to alleviate AS [62, 63].”
Background
Interrelationship between alcohol consumption, overnutrition, and pharmacotherapy for liver steatosis: Considerations and proposals
Valenzuela, R., Farías, C., Muñoz, Y., Zúñiga‐Hernández, J., & Videla, L. A. (2025) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112676 · Cited by 33 · see citing works
Macrophage-mediated cancer drug delivery
Wang, H., Liu, Y., Yang, G., & Zhao, C. (2020) · Materials Today Sustainability · doi:10.1016/j.mtsust.2020.100055 · Cited by 31 · see citing works
In vitro inhibition of tumor growth by low-dose iron oxide nanoparticles activating macrophages
Zhang, L., Tan, S., Liu, Y., Xie, H., Luo, B., & Wang, J. (2019) · Journal of Biomaterials Applications · doi:10.1177/0885328218817939 · Cited by 30 · see citing works
Compartmentalized Response of IL-6/STAT3 Signaling in the Colonic Mucosa Mediates Colitis Development
Serrano, C., Galán, S., Rubio, J. F., Candelario‐Martínez, A., Montes-Gómez, A. E., Chánez-Paredes, S. D., Cedillo‐Barrón, L., Michael Schnoor, A., Meraz‐Ríos, M. A., Villegas‐Sepúlveda, N., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801060 · Cited by 29 · see citing works
“For example, IFN-g induces a sequential activation of STAT1 and STAT3 in the same epithelial cell, something similar to the observed during priming of immune cells by IFN-g (43, 44).”
Result
Roquin-1 Regulates Macrophage Immune Response and Participates in Hepatic Ischemia–Reperfusion Injury
Zheng, L., Wei, L., Zhu, D., Li, Z., & Kong, L. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900053 · Cited by 29 · see citing works
“Compared with the WT group, clodronate liposomes, and clodronate liposomes + WT mø groups at 1 h after IR, M1-related markers (IL-1b, IL-6, and TNF-a) and cytokines (IL-6 and TNF-a) in the clodronate liposomes + si-Roquin-1 mø group were significantly elevated; M2 markers (IL-10, IL-13, Arg-1, and PPARg) and cytokines…”
Background
Reduction of gender‐associated M2‐like tumor‐associated macrophages in the tumor microenvironment of patients with pancreatic cancer after neoadjuvant chemoradiotherapy
Matsuki, H., Hiroshima, Y., Miyake, K., Murakami, T., Homma, Y., Matsuyama, R., Morioka, D., Kurotaki, D., Tamura, T., & Endo, I. (2020) · Journal of Hepato-Biliary-Pancreatic Sciences · doi:10.1002/jhbp.883 · Cited by 28 · see citing works
YAP Deficiency Attenuates Pulmonary Injury Following Mechanical Ventilation Through the Regulation of M1/M2 Macrophage Polarization
Luo, Q., Luo, J., & Wang, Y. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s288244 · Cited by 28 · see citing works
Role of amino acid metabolism in tumor immune microenvironment of colorectal cancer
Zhu, M. (2025) · American Journal of Cancer Research · doi:10.62347/zsoo2247 · Cited by 27 · see citing works

Interferon regulatory factor 1: a key transcriptional node orchestrating macrophage polarization: mechanisms and therapeutic potential
Cao, S., Feng, S., Gao, Y., Sun, Z., Bai, S., & Su, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1884705
Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization
Günthner, R., & Anders, H. (2013) · Mediators of Inflammation · doi:10.1155/2013/731023 · Cited by 164 · see citing works
Interferon Regulatory Factors: Role in Transcriptional Regulation of Macrophage Plasticity and Activation
Eames, H. L., & Udalova, I. A. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1311-4_22 · Cited by 1 · see citing works
IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses
Krausgruber, T., Blazek, K. D., Smallie, T., Alzabin, S., Lockstone, H. E., Sahgal, N., Hussell, T., Feldmann, M., & Udalova, I. A. (2011) · Nature Immunology · doi:10.1038/ni.1990 · Cited by 1,296 · see citing works
Monocyte differentiation and macrophage polarization
Orekhov, A. N., Orekhova, V. A., Nikiforov, N. G., Myasoedova, V. A., Grechko, A. V., Romanenko, E. B., Zhang, D., & Chistiakov, D. A. (2019) · Vessel Plus · doi:10.20517/2574-1209.2019.04 · Cited by 137 · see citing works

Authors: Chistiakov, D. A., Myasoedova, V. A., Revin, V. V., Orekhov, A. N., & Bobryshev, Y. V.
Affiliations: Federal Medical Research Centre for Psychiatry and Narcology (RU)
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences (RU)
UNSW Sydney (AU)
Corresponding author: Bobryshev, Yuri V.
ORCID: Chistiakov, Dimitry A.
Myasoedova, Veronika A.
Orekhov, Alexander N.
Bobryshev, Yuri V.
Venue: Immunobiology
Publisher: Elsevier BV
Published: 2018-01
Volume: 223
Issue: 1
Pages: 101-111
ISSN: 0171-2985 (ISSN-L)
DOI: 10.1016/j.imbio.2017.10.005
OpenAlex: W2764291671
Cited by: 311
References: 151
Citations by year: 2026: 15 · 2025: 37 · 2024: 29 · 2023: 41 · 2022: 58 · 2021: 48 · 2020: 27 · 2019: 40 · 2018: 16
FWCI: 2.33
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Immunobiology (publishedVersion)
PubMed (publishedVersion)
Funders: Russian Science Foundation (#14-15-00112)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
Keywords: interferon regulatory factors, macrophage polarization, M1 macrophages, M2 macrophages, macrophage differentiation, monocyte differentiation, macrophage heterogeneity, macrophage plasticity, IRF1, IRF5, IRF8, IRF3, IRF4, IRF2, atherosclerosis, tissue microenvironment, wound healing
MeSH terms: Animals, Cell Differentiation, Gene Expression Regulation, Humans, Macrophages, Cytokines, Th1 Cells, Th2 Cells, Interferon Regulatory Factors, Cell Transdifferentiation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The impact of interferon-regulatory factors to macrophage differentiation and polarization into M1 and M2

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks