The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Extracellular Vesicles: Evolving Factors in Stem Cell Biology
Open accessAbstract
Stem cells are proposed to continuously secrete trophic factors that potentially serve as mediators of autocrine and paracrine activities, associated with reprogramming of the tumor microenvironment, tissue regeneration, and repair. Hitherto, significant efforts have been made to understand the level of underlying paracrine activities influenced by stem cell secreted trophic factors, as little is known about these interactions. Recent findings, however, elucidate this role by reporting the effects of stem cell derived extracellular vesicles (EVs) that mimic the phenotypes of the cells from which they originate. Exchange of genetic information utilizing persistent bidirectional communication mediated by stem cell‐EVs could regulate stemness, self‐renewal, and differentiation in stem cells and their subpopulations. This review therefore discusses stem cell‐EVs as evolving communication factors in stem cell biology, focusing on how they regulate cell fates by inducing persistent and prolonged genetic reprogramming of resident cells in a paracrine fashion. In addition, we address the role of stem cell‐secreted vesicles in shaping the tumor microenvironment and immunomodulation and in their ability to stimulate endogenous repair processes during tissue damage. Collectively, these functions ensure an enormous potential for future therapies.
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B lymphocytes secrete antigen-presenting vesicles.
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Mesenchymal stem cells as trophic mediators
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Nanotubular Highways for Intercellular Organelle Transport
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Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration
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“More direct effectors of the stem cell phenotype such as WNT [43, 44], 𝛽 -catenin [45], and Hedgehog [46] have also been identified on stem cell-EVs together with several other components that may be considered potential factors in stem cell biology (Table 1).”
Human saliva, plasma and breast milk exosomes contain RNA: Uptake by macrophages
Lässer, C., Seyed Alikhani, V., Ekström, K., Eldh, M., Torregrosa Paredes, P., Bossios, A., Sjöstrand, M., Gabrielsson, S., Lötvall, J., & Valadi, H. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-9 · Cited by 899
Self-citationTan, C. Y., Lai, R. C., Wong, W., Dan, Y. Y., Lim, S.-K., & Ho, H. K. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt465 · Cited by 548
Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo
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Transfer of MicroRNAs by Embryonic Stem Cell Microvesicles
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Cited by
Mesenchymal Stem Cell-Derived Extracellular Vesicles: Challenges in Clinical Applications
Gowen, A., Shahjin, F., Chand, S., Odegaard, K. E., & Yelamanchili, S. V. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00149 · Cited by 334
Liu, D., Kou, X., Chen, C., Liu, S., Liu, Y., Yu, W., Yu, T., Yang, R., Wang, R., Zhou, Y., et al. (2018) · Cell Research · doi:10.1038/s41422-018-0070-2 · Cited by 298
Extracellular microvesicles/exosomes: discovery, disbelief, acceptance, and the future?
Ratajczak, M. Z., & Ratajczak, J. (2020) · Leukemia · doi:10.1038/s41375-020-01041-z · Cited by 294
Stem Cell-Derived Extracellular Vesicles and Immune-Modulation
Burrello, J., Monticone, S., Gai, C., Gomez, Y., Kholia, S., & Camussi, G. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00083 · Cited by 266
Self-citationExosomes Derived from Human Induced Pluripotent Stem Cells Ameliorate the Aging of Skin Fibroblasts
Oh, M., Lee, J., Kim, Y. J., Rhee, W. J., & Park, J. H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061715 · Cited by 257
Metadata
- Authors
- Nawaz, M., Fatima, F., Vallabhaneni, K. C., Penfornis, P., Valadi, H., Ekström, K., Kholia, S., Whitt, J. D., Fernandes, J. D., Pochampally, R., Squire, J. A., & Camussi, G.
- Venue
- Stem Cells International
- Publisher
- Wiley
- Published
- 2015-11-16
- Volume
- 2016
- Issue
- 1
- Pages
- 1073140-1073140
- ISSN
- 1687-966X (ISSN-L)
- 1687-9678
- OpenAlex
- W1615093431
- Cited by
- 227
- References
- 13
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- gold
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- Nawaz, M., Fatima, F., Vallabhaneni, K. C., Penfornis, P., Valadi, H., Ekström, K., Kholia, S., Whitt, J. D., Fernandes, J. D., Pochampally, R., Squire, J. A., & Camussi, G. (2016). Extracellular Vesicles: Evolving Factors in Stem Cell Biology. Stem Cells International. https://doi.org/10.1155/2016/1073140
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
