The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Oxidative Stress in Pancreatic Beta Cell Regeneration
Open accessAbstract
Pancreatic β cell neogenesis and proliferation during the neonatal period are critical for the generation of sufficient pancreatic β cell mass/reserve and have a profound impact on long‐term protection against type 2 diabetes (T2D). Oxidative stress plays an important role in β cell neogenesis, proliferation, and survival under both physiological and pathophysiological conditions. Pancreatic β cells are extremely susceptible to oxidative stress due to a high endogenous production of reactive oxygen species (ROS) and a low expression of antioxidative enzymes. In this review, we summarize studies describing the critical roles and the mechanisms of how oxidative stress impacts β cell neogenesis and proliferation. In addition, the effects of antioxidant supplements on reduction of oxidative stress and increase of β cell proliferation are discussed. Exploring the roles and the potential therapeutic effects of antioxidants in the process of β cell regeneration would provide novel perspectives to preserve and/or expand pancreatic β cell mass for the treatment of T2D.
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Cites
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“Aerobic cells produce ROS such as superoxide anion (O2·) and H2O2 during oxidative phosphorylation in the mitochondria as by-products [7, 8].”
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The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus
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Inactivation of specific β cell transcription factors in type 2 diabetes
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“Beta cell regeneration (neogenesis and proliferation) during the neonatal period is critical for the generation of sufficient pancreatic β cell mass/reserve and has a profound impact on long-term protection against T2D [1].”
BackgroundVery Slow Turnover of β-Cells in Aged Adult Mice
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Cited by
Mechanisms of Oxidative Stress in Metabolic Syndrome
Masenga, S. K., Kabwe, L. S., Chakulya, M., & Kirabo, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097898 · Cited by 717
Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus
Yaribeygi, H., Sathyapalan, T., Atkin, S. L., & Sahebkar, A. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8609213 · Cited by 685
The Impact of Oxidative Stress in Human Pathology: Focus on Gastrointestinal Disorders
Vona, R., Pallotta, L., Cappelletti, M., Severi, C., & Matarrese, P. (2021) · Antioxidants · doi:10.3390/antiox10020201 · Cited by 431
The Role of Oxidative Stress in Pancreatic β Cell Dysfunction in Diabetes
Eguchi, N., Vaziri, N. D., Dafoe, D. C., & Ichii, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041509 · Cited by 341
Mechanism of Ferroptosis and Its Role in Type 2 Diabetes Mellitus
Sha, W., Hu, F., Xi, Y., Chu, Y., & Bu, S. (2021) · Journal of Diabetes Research · doi:10.1155/2021/9999612 · Cited by 266
Metadata
- Authors
- Wang, J., & Wang, H.
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2017-01
- Volume
- 2017
- Issue
- 1
- Pages
- 1930261-1930261
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- OpenAlex
- W2743305150
- Cited by
- 233
- References
- 14
- FWCI
- 13.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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