New Treatment Strategies of Depression: Based on Mechanisms Related to Neuroplasticity
Open accessAbstract
Major depressive disorder is a severe and complex mental disorder. Impaired neurotransmission and disrupted signalling pathways may influence neuroplasticity, which is involved in the brain dysfunction in depression. Traditional neurobiological theories of depression, such as monoamine hypothesis, cannot fully explain the whole picture of depressive disorders. In this review, we discussed new treatment directions of depression, including modulation of glutamatergic system and noninvasive brain stimulation. Dysfunction of glutamatergic neurotransmission plays an important role in the pathophysiology of depression. Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has rapid and lasting antidepressive effects in previous studies. In addition to ketamine, other glutamatergic modulators, such as sarcosine, also show potential antidepressant effect in animal models or clinical trials. Noninvasive brain stimulation is another new treatment strategy beyond pharmacotherapy. Growing evidence has demonstrated that superficial brain stimulations, such as transcranial magnetic stimulation, transcranial direct current stimulation, cranial electrotherapy stimulation, and magnetic seizure therapy, can improve depressive symptoms. The antidepressive effect of these brain stimulations may be through modulating neuroplasticity. In conclusion, drugs that modulate neurotransmission via NMDA receptor and noninvasive brain stimulation may provide new directions of treatment for depression. Furthermore, exploring the underlying mechanisms will help in developing novel therapies for depression in the future.
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Restoration of neuroplasticity is fundamental for antidepressant effects.
“Furthermore, studies suggest that restoration of neuroplasticity is fundamental for antidepressant effects [190,191].”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [191]
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P2X7 Receptor Signaling in Stress and Depression
Ribeiro, D. E., Roncalho, A. L., Glaser, T., Ulrich, H., Wegener, G., & Joca, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112778 · Cited by 129 · see citing works
- Authors
- Huang, Y.-J., Lane, H.-Y., & Lin, C.-H.
- Affiliations
- China Medical University Hospital (TW)
- Asia University (TW)
- Chang Gung University (TW)
- Corresponding author
- Lin, Chieh-Hsin
- Venue
- Neural Plasticity
- Publisher
- Wiley
- Published
- 2017
- Volume
- 2017
- Pages
- 1-11
- ISSN
- 1687-5443 (ISSN-L)
- 2090-5904
- PMC
- PMC5405587
- OpenAlex
- W2605978316
- Cited by
- 74
- References
- 122
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 10 · 2023: 7 · 2022: 7 · 2021: 7 · 2020: 10 · 2019: 11 · 2018: 11 · 2017: 4
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Neural Plasticity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- China Medical University Hospital (DMR-105-073)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Keywords
- major depressive disorder, neuroplasticity, glutamatergic neurotransmission, NMDA receptor, ketamine, sarcosine, non-invasive brain stimulation, transcranial magnetic stimulation, transcranial direct current stimulation, cranial electrotherapy stimulation, magnetic seizure therapy, antidepressant mechanism, monoamine hypothesis
- MeSH terms
- Animals, Antidepressive Agents, Brain, Clinical Trials as Topic, Major Depressive Disorder, Disease Models, Animal, Electroconvulsive Therapy, Humans, Ketamine, Synaptic Transmission, Neuronal Plasticity, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Treatment Outcome, Receptors, Metabotropic Glutamate, Transcranial Magnetic Stimulation, Drug Partial Agonism, Transcranial Direct Current Stimulation
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