Age‐related loss of naïve T cells and dysregulation of T‐cell/B‐cell interactions in human lymph nodes
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Summary: In this study we analysed the effects of age on T and B lymphocytes in human lymph nodes by comparing lymphocyte subsets in paraffin sections from lymph node tissue taken from healthy young and elderly people. We demonstrate that the relative number of CD8+ T cells decreases with age but that the relative number of CD4+ T cells does not. There is also a very pronounced age‐dependent loss of CD45RA+ naïve T cells. The number and size of follicles and the relative number of CD20+ B cells are similar in young and elderly donors. For polymerase chain reaction analysis of the T‐cell receptor (TCR) repertoire the TCR‐γ gene rearrangements were used as a marker of clonality. This is a reliable tool to detect not only clonal TCR‐γδ populations but also TCR‐αβ populations. Young donors with clonal T‐cell expansions in their lymph node tissue do, however, have a higher number of CD20+ B cells, a higher relative size of germinal centres compared to the follicle mantles and a higher number of immunoglobulin M‐expressing cells than young donors without evidence of clonal T‐cell expansions. Corresponding changes are not observed in elderly donors with clonal T‐cell expansions in their lymph node tissue. In summary our findings demonstrate characteristic effects of aging on human lymph node tissue, the most striking feature being the depletion of naïve T cells and the apparent dysregulation of T‐cell/B‐cell interactions in old age.
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Ageing changes can include fewer naive B and T cells.
“These changes can include an involuted thymus235, fewer naive B and T cells236, diminished T cell receptor diversity237, higher susceptibility to T cell apoptosis238 and reduced expression of crucial receptors such as CD28 on cytotoxic CD8+ T cells239.”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [236]
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Homing and cellular traffic in lymph nodes
von Andrian, U. H., & Mempel, T. R. (2003) · Nature reviews. Immunology · doi:10.1038/nri1222 · Cited by 1,271 · see citing works
Age-related changes in lymphocyte development and function
Linton, P. J., & Dorshkind, K. A. (2004) · Nature Immunology · doi:10.1038/ni1033 · Cited by 1,180 · see citing works
Gavazzi, G., & Krause, K.-H. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(02)00437-1 · Cited by 990 · see citing works
Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging
Fagnoni, F. F., Vescovini, R., Passeri, G., Bologna, G., Pedrazzoni, M., Lavagetto, G., Casti, A., Franceschi, C., Passeri, M., & Sansoni, P. (2000) · Blood · doi:10.1182/blood.v95.9.2860.009k35_2860_2868 · Cited by 519 · see citing works
Saurwein-Teissl, M., Lung, T. L., Marx, F., Gschösser, C., Asch, E., Blasko, I., Parson, W., Böck, G., Schönitzer, D., Trannoy, E., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5893 · Cited by 499 · see citing works
Self-citationNK and NK/T cells in human senescence
Solana, R., & Mariani, E. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00495-8 · Cited by 279 · see citing works
A simplified method of detection of clonal rearrangements of the T-cell receptor-gamma chain gene.
McCarthy, K., Sloane, J. P., Kabarowski, J. H. S., Matutes, E., & Wiedemann, L. M. (1992) · PubMed · Cited by 260 · see citing works
Cossarizza, A., Ortolani, C., Paganelli, R., Barbieri, D., Monti, D., Sansoni, P., Fagiolo, U., Castellani, G., Bersani, F., Londei, M., et al. (1996) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(95)01691-0 · Cited by 253 · see citing works
Thymic aging and T‐cell regeneration
Mackall, C. L., & Gress, R. E. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01030.x · Cited by 236 · see citing works
The aging of the immune system
Grubeck-Loebenstein, B., & Wick, G. (2002) · Advances in immunology · doi:10.1016/s0065-2776(02)80017-7 · Cited by 235 · see citing works
Self-citationImmunosenescence and germinal center reaction
Zheng, B. Q., Han, S., Takahashi, Y., & Kelsoe, G. H. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01028.x · Cited by 229 · see citing works
Changes in the B-cell repertoire with age
Weksler, M. E. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00497-1 · Cited by 213 · see citing works
The Effect of Age on the B-Cell Repertoire
Weksler, M. E., & Szabo, P. (2000) · Journal of Clinical Immunology · doi:10.1023/a:1006659401385 · Cited by 205 · see citing works
Yang, X., Štědra, J., & Cerny, J. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.3.959 · Cited by 182 · see citing works
Callard, R. E., Basten, A., & Waters, L. K. (1977) · Cellular Immunology · doi:10.1016/0008-8749(77)90003-x · Cited by 143 · see citing works
T cells and aging (update February 1999)
Pawelec, G. (1999) · Frontiers in bioscience · doi:10.2741/pawelec · Cited by 138 · see citing works
Diagnostic role of tests for T cell receptor (TCR) genes
Hodges, E., Krishna, M. T., Pickard, C., & Smith, J. L. (2002) · Journal of Clinical Pathology · doi:10.1136/jcp.56.1.1 · Cited by 126 · see citing works
T lymphocyte subpopulations and activation markers correlate with severity of Alzheimer's disease.
Shalit, F., Sredni, B., Brodie, C., Kott, E., & Huberman, M. (1995) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1995.1078 · Cited by 97 · see citing works
Crucian, B. E., Dunne, P. B., Friedman, H. P., Ragsdale, R., Pross, S. H., & Widen, R. H. (1995) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.2.2.249-252.1995 · Cited by 86 · see citing works
Schindowski, K., Fröhlich, L. O., Maurer, K., Müller, W. E., & Eckert, A. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00396-7 · Cited by 75 · see citing works
Kirschmann, D. A., & Murasko, D. M. (1992) · Cellular Immunology · doi:10.1016/0008-8749(92)90083-2 · Cited by 67 · see citing works
Age-dependent changes in B lymphocyte development in man and mouse
Ghia, P., Melchers, F., & Rolink, A. G. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00095-9 · Cited by 60 · see citing works
Grubeck‐Loebenstein, B., Berger, P., Saurwein-Teissl, M., Zisterer, K., & Wick, G. (1998) · Nature Medicine · doi:10.1038/nm0898-870b · Cited by 59 · see citing works
Self-citationDysregulation of the humoral immune response in old mice
Zhao, K., Wang, Y., Gueret, R., & Weksler, M. E. (1995) · International Immunology · doi:10.1093/intimm/7.6.929 · Cited by 54 · see citing works
Weinberg, D. S., Ault, K. A., Gurley, M., & Pinkus, G. S. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.5.1486 · Cited by 35 · see citing works
Is immune senescence reversible?
Beverley, P. C. L., & Grubeck-Loebenstein, B. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00514-9 · Cited by 35 · see citing works
Self-citationBanerjee, M., Sanderson, J. D., Spencer, J., & Dunn‐Walters, D. K. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00106-8 · Cited by 28 · see citing works
Kraft, R., Bachmann, M., Bachmann, K., Buerki, H., Hess, M. W., Cottier, H., & Stoner, R. D. (1987) · PubMed Central · Cited by 23 · see citing works
Age-associated defects in B lymphocyte development
Szabo, P., Shen, S. S., & Weksler, M. E. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00023-6 · Cited by 17 · see citing works
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Chaudhary, N., Weissman, D., & Whitehead, K. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00283-5 · Cited by 1,555 · see citing works
Immunosenescence: emerging challenges for an ageing population
Aw, D., Silva, A. B., & Palmer, D. B. (2007) · Immunology · doi:10.1111/j.1365-2567.2007.02555.x · Cited by 880 · see citing works
The aging of the immune system
Weiskopf, D., Weinberger, B., & Grubeck-Loebenstein, B. (2009) · Transplant International · doi:10.1111/j.1432-2277.2009.00927.x · Cited by 908 · see citing works
Self-citationGruver, A., Hudson, L., & Sempowski, G. (2007) · The Journal of Pathology · doi:10.1002/path.2104 · Cited by 834 · see citing works
Immunosenescence and human vaccine immune responses
Crooke, S. N., Ovsyannikova, I. G., Poland, G. A., & Kennedy, R. B. (2019) · Immunity & Ageing · doi:10.1186/s12979-019-0164-9 · Cited by 530 · see citing works
A Comprehensive Review of mRNA Vaccines
Gote, V., Bolla, P. K., Kommineni, N., Butreddy, A., Nukala, P. K., Palakurthi, S. S., & Khan, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032700 · Cited by 457 · see citing works
B‐cell diversity decreases in old age and is correlated with poor health status
Gibson, K. L., Wu, Y., Barnett, Y., Duggan, O., Vaughan, R., Kondeatis, E., Nilsson, B., Wikby, A., Kipling, D., & Dunn‐Walters, D. K. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2008.00443.x · Cited by 433 · see citing works
Biology of Immune Responses to Vaccines in Elderly Persons
Weinberger, B., Herndler‐Brandstetter, D., Schwanninger, A., Weiskopf, D., & Grubeck‐Loebenstein, B. (2008) · Clinical Infectious Diseases · doi:10.1086/529197 · Cited by 392 · see citing works
Self-citationWertheimer, A. M., Bennett, M. S., Park, B., Uhrlaub, J. L., Martinez, C., Pulko, V., Currier, N. L., Nikolich-Žugich, D., Kaye, J., & Nikolich-Žugich, J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301721 · Cited by 352 · see citing works
A Typical Immune T/B Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?
Balistreri, C. R., Buffa, S., Allegra, A., Pisano, C., Ruvolo, G., Colonna‐Romano, G., Lio, D., Mazzesi, G., Schiavon, S., Greco, E., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/5879281 · Cited by 365 · see citing works
Cytomegalovirus and human immunosenescence
Pawelec, G., Derhovanessian, E., Larbi, A., Strindhall, J., & Wikby, A. (2008) · Reviews in Medical Virology · doi:10.1002/rmv.598 · Cited by 339 · see citing works
Immunosenescence and vaccine failure in the elderly
Grubeck-Loebenstein, B., Della Bella, S., Iorio, A. M., Michel, J.-P., Pawelec, G., & Solana, R. (2009) · Aging Clinical and Experimental Research · doi:10.1007/bf03324904 · Cited by 269 · see citing works
Self-citationImmunosenescence: deficits in adaptive immunity in the elderly
Hakim, F. T., & Gress, R. E. (2007) · Tissue Antigens · doi:10.1111/j.1399-0039.2007.00891.x · Cited by 215 · see citing works
Immunosenescence, aging and successful aging
Wang, Y., Chen, D., Han, Y., Gu, Z., & Sun, C. C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.942796 · Cited by 215 · see citing works
Challenges for vaccination in the elderly
Aspinall, R., Giudice, G. D., Effros, R. B., Grubeck‐Loebenstein, B., & Sambhara, S. R. (2007) · Immunity & Ageing · doi:10.1186/1742-4933-4-9 · Cited by 205 · see citing works
Self-citationMechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection
Tu, W., & Rao, S. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02111 · Cited by 189 · see citing works
Pangrazzi, L., & Weinberger, B. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110887 · Cited by 180 · see citing works
Human telomere biology: pitfalls of moving from the laboratory to epidemiology
Aviv, A., Valdes, A. M., & Spector, T. D. (2006) · International Journal of Epidemiology · doi:10.1093/ije/dyl169 · Cited by 172 · see citing works
Aging Affects Human B Cell Responses
Frasca, D., & Blomberg, B. B. (2011) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9501-7 · Cited by 172 · see citing works
Gain and loss of T cell subsets in old age: age-related reshaping of the T cell repertoire.
Arnold, C. R., Wolf, J., Brunner, S., Herndler-Brandstetter, D., & Grubeck-Loebenstein, B. (2011) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9499-x · Cited by 170 · see citing works
Self-citationDerhovanessian, E., Solana, R., Larbi, A., & Pawelec, G. (2008) · Immunity & Ageing · doi:10.1186/1742-4933-5-11 · Cited by 169 · see citing works
Immunosenescence: Aging and Immune System Decline
Goyani, P., Christodoulou, R. C., & Vassiliou, E. K. (2024) · Vaccines · doi:10.3390/vaccines12121314 · Cited by 177 · see citing works
Age-related decline in immunity: implications for vaccine responsiveness
Kumar, R., & Burns, E. A. (2008) · Expert Review of Vaccines · doi:10.1586/14760584.7.4.467 · Cited by 156 · see citing works
Interdisciplinary Critique of Sipuleucel-T as Immunotherapy in Castration-Resistant Prostate Cancer
Huber, M. L., Haynes, L., Parker, C. C., & Iversen, P. (2012) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djr514 · Cited by 155 · see citing works
The Dynamics of B Cell Aging in Health and Disease
de Mol, J., Kuiper, J., Tsiantoulas, D., & Foks, A. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.733566 · Cited by 155 · see citing works
Novak, P., Schmidt, R., Kontsekova, E., Kovacech, B., Smolek, T., Katina, S., Fialova, L., Prcina, M., Parrak, V., Dal-Bianco, P., et al. (2018) · Alzheimer's Research & Therapy · doi:10.1186/s13195-018-0436-1 · Cited by 147 · see citing works
. Persistent viral infections and immune aging.
Brunner, S., Herndler-Brandstetter, D., Weinberger, B., & Grubeck-Loebenstein, B. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.08.003 · Cited by 143 · see citing works
Self-citationLeukocyte telomere dynamics and human hematopoietic stem cell kinetics during somatic growth
Sidorov, I., Kimura, M., Yashin, A., & Aviv, A. (2009) · Experimental Hematology · doi:10.1016/j.exphem.2008.11.009 · Cited by 135 · see citing works
Weinberger, B., Lazuardi, L., Weiskirchner, I., Keller, M., Neuner, C., Fischer, K.-H., Neuman, B., Würzner, R., & Grubeck‐Loebenstein, B. (2006) · Human Immunology · doi:10.1016/j.humimm.2006.10.019 · Cited by 138 · see citing works
Self-citationFrasca, D., Riley, R. L., & Blomberg, B. B. (2005) · Seminars in Immunology · doi:10.1016/j.smim.2005.05.005 · Cited by 136 · see citing works
Decman, V., Laidlaw, B. J., Doering, T. A., Leng, J., Ertl, H. C. J., Goldstein, D. R., & Wherry, E. J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101098 · Cited by 132 · see citing works
Factors that may impact on immunosenescence: an appraisal
Ongrádi, J., & Kövesdi, V. (2010) · Immunity & Ageing · doi:10.1186/1742-4933-7-7 · Cited by 128 · see citing works
Influenza control in the 21st century: Optimizing protection of older adults
Monto, A. S., Ansaldi, F., Aspinall, R., McElhaney, J. E., Montaño, L. F., Nichol, K. L., Puig‐Barberà, J., Schmitt, J., & Stephenson, I. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.06.032 · Cited by 125 · see citing works
High TNF-α levels in resting B cells negatively correlate with their response
Frasca, D., Diaz, A., Romero, M., Landin, A. M., & Blomberg, B. B. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.004 · Cited by 115 · see citing works
Senda, T., Dogra, P., Granot, T., Furuhashi, K., Snyder, M. E., Carpenter, D. J., Szabo, P. A., Thapa, P., Miron, M., & Farber, D. L. (2019) · Mucosal Immunology · doi:10.1038/s41385-018-0110-8 · Cited by 114 · see citing works
Age-associated alterations in immune function and inflammation
Lewis, E. D., Wu, D., & Meydani, S. N. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110576 · Cited by 111 · see citing works
Influence of ageing on the microarchitecture of the spleen and lymph nodes
Turner, V. M., & Mabbott, N. A. (2017) · Biogerontology · doi:10.1007/s10522-017-9707-7 · Cited by 111 · see citing works
Tran, T. T. T., Cousin, F., Lynch, D. B., Menon, R., Brulc, J. M., Brown, J. R.-M., O’Herlihy, E. A., Buttó, L. F., Power, K., Jeffery, I. B., et al. (2019) · Microbiome · doi:10.1186/s40168-019-0654-1 · Cited by 109 · see citing works
Lymphocyte maintenance during healthy aging requires no substantial alterations in cellular turnover
Westera, L., van Hoeven, V., Drylewicz, J., Spierenburg, G., van Velzen, J. F., de Boer, R. J., Tesselaar, K., & Borghans, J. A. M. (2015) · Aging Cell · doi:10.1111/acel.12311 · Cited by 96 · see citing works
Kuštrimović, N. Z., Rasini, E., Legnaro, M., Bombelli, R., Aleksić, I., Blandini, F., Comi, C., Mauri, M. F., Minafra, B., Riboldazzi, G., et al. (2016) · Scientific Reports · doi:10.1038/srep33738 · Cited by 104 · see citing works
Proteomic analysis of aged microglia: shifts in transcription, bioenergetics, and nutrient response
Flowers, A., Bell‐Temin, H., Jalloh, A., Stevens, S. M., & Bickford, P. C. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0840-7 · Cited by 104 · see citing works
The role of immunity in elderly cancer
Malaguarnera, L., Cristaldi, E., & Malaguarnera, M. (2009) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2009.06.002 · Cited by 101 · see citing works
Elderly patients and inflammatory bowel disease
Nimmons, D. (2016) · World Journal of Gastrointestinal Pharmacology and Therapeutics · doi:10.4292/wjgpt.v7.i1.51 · Cited by 94 · see citing works
Adapting Cancer Immunotherapy Models for the Real World
Klevorn, L. E., & Teague, R. M. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.03.010 · Cited by 87 · see citing works
The impact of aging on memory T cell phenotype and function in the human bone marrow
Herndler‐Brandstetter, D., Landgraf, K., Tzankov, A., Jenewein, B., Brunauer, R., Laschober, G. T., Parson, W., Kloss, F. R., Gassner, R. J., Lepperdinger, G., et al. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0611299 · Cited by 88 · see citing works
Self-citationImmune changes in post-menopausal osteoporosis: the Immunos study
Breuil, V., Ticchioni, M., Testa, J., Roux, C. H., Ferrari, P. P., Breittmayer, J. P., Albert-Sabonnadière, C., Durant, J., Perreti, F. D., Bernard, A., et al. (2009) · Osteoporosis International · doi:10.1007/s00198-009-1018-7 · Cited by 87 · see citing works
Immunological factors linked to geographical variation in vaccine responses
van Dorst, M. M. A. R., Pyuza, J. J., Nkurunungi, G., Kullaya, V. I., Smits, H. H., Hogendoorn, P. C. W., Wammes, L. J., Everts, B., Elliott, A. M., Jochems, S. P., et al. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00941-2 · Cited by 85 · see citing works
Aging affects B‐cell antigen receptor repertoire diversity in primary and secondary lymphoid tissues
Tabibian‐Keissar, H., Hazanov, L., Schiby, G., Rosenthal, N., Rakovsky, A., Michaeli, M., Shahaf, G. L., Pickman, Y., Rosenblatt, K., Melamed, D., et al. (2016) · European Journal of Immunology · doi:10.1002/eji.201545586 · Cited by 84 · see citing works
Burel, J. G., Yu, Q., Arlehamn, C. S. L., Weiskopf, D., Zapardiel‐Gonzalo, J., Taplitz, R., Gilman, R. H., Saito, M., Silva, A. D. D., Vijayanand, P., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601750 · Cited by 83 · see citing works
Suzuki, K., Inoue, S., Kametani, Y., Komori, Y., Chiba, S., Sato, T., Inokuchi, S., & Ogura, S. (2016) · Shock · doi:10.1097/shk.0000000000000619 · Cited by 82 · see citing works
Carpenter, D. J., Granot, T., Matsuoka, N., Senda, T., Kumar, B. V., Thome, J. J. C., Gordon, C. L., Miron, M., Weiner, J. I., Connors, T. J., et al. (2017) · American Journal of Transplantation · doi:10.1111/ajt.14434 · Cited by 77 · see citing works
Nutritional modulation of age-related changes in the immune system and risk of infection
Pae, M., & Wu, D. (2017) · Nutrition Research · doi:10.1016/j.nutres.2017.02.001 · Cited by 77 · see citing works
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Kuštrimović, N. Z., Marino, F., & Cosentino, M. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666181009161048 · Cited by 74 · see citing works
Cakala, M., Kołodziej, P., & Puzianowska‐Kuźnicka, M. (2021) · Cells · doi:10.3390/cells10113148 · Cited by 77 · see citing works
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Linterman, M. A. (2014) · Immunology & Cell Biology · doi:10.1038/icb.2013.77 · Cited by 69 · see citing works
The aging bone marrow and its impact on immune responses in old age
Pritz, T., Weinberger, B., & Grubeck‐Loebenstein, B. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.06.016 · Cited by 71 · see citing works
Self-citationImmunosupportive therapies in aging
Fülöp, T., Larbi, A., Hirokawa, K., Mocchegiani, E., Lesourd, B., Castle, S., Wikby, A., Franceschi, C., & Pawelec, G. (2007) · Clinical Interventions in Aging · doi:10.2147/ciia.2007.2.1.33 · Cited by 71 · see citing works
Structural and functional changes to lymph nodes in ageing mice
Turner, V. M., & Mabbott, N. A. (2017) · Immunology · doi:10.1111/imm.12727 · Cited by 70 · see citing works
MicroRNAs miR-155 and miR-16 decrease AID and E47 in B cells from elderly individuals
Frasca, D., Diaz, A., Romero, M., Ferracci, F., & Blomberg, B. B. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500520 · Cited by 69 · see citing works
Howard, W. A., Gibson, K. L., & Dunn‐Walters, D. K. (2006) · Rejuvenation Research · doi:10.1089/rej.2006.9.117 · Cited by 68 · see citing works
Mode of action of adjuvants: Implications for vaccine safety and design
Mastelic, B., Ahmed, S., Egan, W. M., Giudice, G. D., Golding, H., Gust, I. D., Neels, P., Reed, S. G., Sheets, R., Siegrist, C., et al. (2010) · Biologicals · doi:10.1016/j.biologicals.2010.06.002 · Cited by 66 · see citing works
Ashfaq, A., Pockaj, B. A., Gray, R. J., Halfdanarson, T. R., & Wasif, N. (2014) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-014-2566-5 · Cited by 66 · see citing works
Durando, P., Icardi, G., & Ansaldi, F. (2010) · Expert Opinion on Biological Therapy · doi:10.1517/14712591003724662 · Cited by 65 · see citing works
The ageing human B cell repertoire: a failure of selection?
Dunn‐Walters, D. K. (2015) · Clinical & Experimental Immunology · doi:10.1111/cei.12700 · Cited by 63 · see citing works
Mucosal adjuvant activity of flagellin in aged mice
Bates, J. T., Honko, A. N., Graff, A. H., Kock, N. D., & Mizel, S. B. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.01.009 · Cited by 63 · see citing works
Immunosenescence and organ transplantation
Heinbokel, T., Elkhal, A., Liu, G., Edtinger, K., & Tullius, S. G. (2013) · Transplantation Reviews · doi:10.1016/j.trre.2013.03.001 · Cited by 63 · see citing works
Zhang, Z., Reynolds, S. R., Stolrow, H. G., Chen, J., Christensen, B. C., & Salas, L. A. (2023) · Aging Cell · doi:10.1111/acel.14071 · Cited by 59 · see citing works
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Tomusiak, A., Floro, A., Tiwari, R., Riley, R. R., Matsui, H., Andrews, N., Kasler, H. G., & Verdin, E. M. (2024) · Communications Biology · doi:10.1038/s42003-024-06609-4 · Cited by 73 · see citing works
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Boyd, S. D., Liu, Y., Wang, C., Martin, V., & Dunn‐Walters, D. K. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.07.007 · Cited by 61 · see citing works
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de Araújo, A. L., Silva, L. C., Fernandes, J. R., & Benard, G. (2013) · Immunotherapy · doi:10.2217/imt.13.77 · Cited by 61 · see citing works
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Dias-Carvalho, A., Sá, S. I., Carvalho, F., Fernandes, E., & Costa, V. M. (2024) · Archives of Toxicology · doi:10.1007/s00204-023-03628-8 · Cited by 60 · see citing works
Grant, R. W., Mariani, R., Vieira‐Potter, V. J., Fleshner, M., Smith, T. P., Keylock, K. T., Lowder, T., McAuley, E., Hu, L., Chapman‐Novakofski, K., et al. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.01.006 · Cited by 60 · see citing works
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Chen, J., Deng, J. C., & Goldstein, D. R. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.09.008 · Cited by 59 · see citing works
Cohen, M., Narbaitz, M., Metrebian, F., Matteo, E. D., Preciado, M. V., & Chabay, P. (2014) · International Journal of Cancer · doi:10.1002/ijc.28942 · Cited by 58 · see citing works
Does senescence affect lymph node number and morphology? A systematic review
Ahmadi, O., McCall, J. L., & Stringer, M. D. (2013) · ANZ Journal of Surgery · doi:10.1111/ans.12067 · Cited by 57 · see citing works
Baldo, V., Baldovin, T., Pellegrini, M., Angiolelli, G., Majori, S., Floreani, A., Busana, M. C., Bertoncello, C., & Trivello, R. (2010) · Journal of Immunology Research · doi:10.1155/2010/517198 · Cited by 55 · see citing works
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Fülöp, T., Larbi, A., Pawelec, G., Cohen, A. A., Provost, G., Khalil, A., Lacombe, G., Rodrigues, S., Desroches, M., Hirokawa, K., et al. (2022) · Vaccines · doi:10.3390/vaccines10040607 · Cited by 56 · see citing works
Rosenberg, C. A., Bovin, N. V., Bram, L. V., Flyvbjerg, E., Erlandsen, M., Vorup‐Jensen, T., & Petersen, E. (2013) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.24480 · Cited by 52 · see citing works
Pangrazzi, L., Naismith, E., Meryk, A., Keller, M., Jenewein, B., Trieb, K., & Grubeck-loebenstein, B. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00715 · Cited by 50 · see citing works
Self-citationAdams, A. A., Sturgill, T. L., Breathnach, C. C., Chambers, T. M., Siger, L., Minke, J. M. H. M., & Horohov, D. W. (2010) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2010.09.006 · Cited by 51 · see citing works
Impact of immunosenescence on transplant outcome
Heinbokel, T., Hock, K., Liu, G., Edtinger, K., Elkhal, A., & Tullius, S. G. (2012) · Transplant International · doi:10.1111/tri.12013 · Cited by 49 · see citing works
The emerging role of T follicular helper (TFH) cells in aging: Influence on the immune frailty
Varricchi, G., Bencivenga, L., Poto, R., Pecoraro, A., Shamji, M. H., & Rengo, G. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101071 · Cited by 52 · see citing works
Peters, T., Weiss, J. M., Sindrilaru, A., Wang, H., Oreshkova, T., Wlaschek, M., Maity, P., Reimann, J., & Scharffetter‐Kochanek, K. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.07.003 · Cited by 49 · see citing works
Landi, A., Broadhurst, D., Vernon, S. D., Tyrrell, D. L., & Houghton, M. (2015) · Cytokine · doi:10.1016/j.cyto.2015.11.018 · Cited by 47 · see citing works
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Csaba, G. (2016) · Acta Microbiologica et Immunologica Hungarica · doi:10.1556/030.63.2016.2.1 · Cited by 49 · see citing works
Contact sensitization in the elderly
Balato, A., Balato, N., Costanzo, L. D., & Ayala, F. (2010) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2010.07.003 · Cited by 48 · see citing works
Frequency and risk factors of low immunoglobulin levels in patients with inflammatory bowel disease
Rai, T., Wu, X., & Shen, B. (2015) · Gastroenterology report · doi:10.1093/gastro/gou082 · Cited by 45 · see citing works
Epidemiology of non-Hodgkin lymphomas in Tyrol/Austria from 1991 to 2000
Mitterlechner, T., Fiegl, M., Mühlböck, H., Oberaigner, W., Dirnhofer, S., & Tzankov, A. (2006) · Journal of Clinical Pathology · doi:10.1136/jcp.2005.026815 · Cited by 45 · see citing works
Self-citationPfister, G., & Savino, W. (2008) · NeuroImmunoModulation · doi:10.1159/000156477 · Cited by 44 · see citing works
Self-citationThe memory B cell response to influenza vaccination is impaired in older persons
Burton, A. R., Guillaume, S. M., Foster, W. S., Wheatley, A. K., Hill, D. L., Carr, E. J., & Linterman, M. A. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111613 · Cited by 44 · see citing works
Brahmakshatriya, V., Kuang, Y., Devarajan, P., Xia, J., Zhang, W., Vong, A. M., & Swain, S. L. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601119 · Cited by 43 · see citing works
Probiotic modulation of dendritic cell function is influenced by ageing
You, J., Dong, H., Mann, E. R., Knight, S. C., & Yaqoob, P. (2013) · Immunobiology · doi:10.1016/j.imbio.2013.08.012 · Cited by 41 · see citing works
Inflammaging in Endemic Areas for Infectious Diseases
Batista, M. A., Calvo-Fortes, F., Silveira‐Nunes, G., Camatta, G. C., Speziali, E., Turroni, S., Teixeira‐Carvalho, A., Martins‐Filho, O. A., Neretti, N., Maioli, T. U., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.579972 · Cited by 41 · see citing works
Immune function in X-linked retinoschisis subjects in an AAV8-RS1 phase I/IIa gene therapy trial
Mishra, A., Vijayasarathy, C., Cukras, C. A., Wiley, H. E., Sen, H. N., Zeng, Y., Wei, L. L., & Sieving, P. A. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.02.013 · Cited by 38 · see citing works
Aging and Systemic Lupus Erythematosus - Immunosenescence and Beyond
van den Hoogen, L. L., Sims, G. P., van Roon, J. A. G., & Fritsch-Stork, R. D. E. (2015) · Current Aging Science · doi:10.2174/1874609808666150727111904 · Cited by 40 · see citing works
Narang, V., Lu, Y., Tan, C. T., Camous, X., Nyunt, M. S. Z., Carré, C., Mok, E. W. H., Wong, G. C. L., Maurer‐Stroh, S., Abel, B., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02465 · Cited by 39 · see citing works
Vaccines against extraintestinal pathogenic Escherichia coli (ExPEC): progress and challenges
Qiu, L., Chirman, D. M., Clark, J. R., Xing, Y., Santos, H. H., Vaughan, E. E., & Maresso, A. W. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2359691 · Cited by 38 · see citing works
Yamada, K., Takizawa, S., Ohgaku, Y., Asami, T., Furuya, K., Yamamoto, K., Takahashi, F., Hamajima, C., Inaba, C., Endo, K., et al. (2019) · Gene · doi:10.1016/j.gene.2019.144191 · Cited by 38 · see citing works
Ageing and Low-Level Chronic Inflammation: The Role of the Biological Clock
Colombini, B., Dinu, M., Murgo, E., Lotti, S., Tarquini, R., Sofi, F., & Mazzoccoli, G. (2022) · Antioxidants · doi:10.3390/antiox11112228 · Cited by 38 · see citing works
Fading Immune Protection in Old Age: Vaccination in the Elderly
Grubeck‐Loebenstein, B. (2009) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2009.10.002 · Cited by 37 · see citing works
Self-citation
- Authors
- Lazuardi, L., Jenewein, B., Wolf, A. M., Pfister, G., Tzankov, A., & Grubeck‐Loebenstein, B.
- Affiliations
- Austrian Academy of Sciences (AT)
- Innsbruck Medical University (AT)
- Corresponding author
- Grubeck‐Loebenstein, Beatrix
- Venue
- Immunology
- Publisher
- Wiley
- Published
- 2004-12-16
- Volume
- 114
- Issue
- 1
- Pages
- 37-43
- ISSN
- 0019-2805 (ISSN-L)
- 1365-2567
- OpenAlex
- W2074259682
- Cited by
- 263
- References
- 29
- Citations by year
- 2026: 11 · 2025: 8 · 2024: 17 · 2023: 23 · 2022: 15 · 2021: 14 · 2020: 13 · 2019: 14 · 2018: 11 · 2017: 14 · 2016: 10 · 2015: 16 · 2014: 10 · 2013: 20 · 2012: 5
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- immunosenescence, aging, naive T cells, CD45RA, CD8+ T cells, CD4+ T cells, T cell-B cell interaction, lymph nodes, TCR gamma gene rearrangement, T cell clonal expansion, germinal center, follicles, B cells, immunoglobulin M
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, B-Lymphocytes, Cell Division, Child, Child, Preschool, Clone Cells, Female, Humans, Immunoglobulin G, Infant, Lymph Nodes, Lymphocyte Cooperation, Lymphocyte Activation, Male, T-Lymphocytes, CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets, CD8-Positive T-Lymphocytes
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