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Cited by 283

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Association of Insulin Resistance and Elevated Androgen Levels with Polycystic Ovarian Syndrome (PCOS): A Review of Literature

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Xu, Yalan, Qiao, Jie·2022·Journal of Healthcare Engineering
DOI 10.1155/2022/9240569
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Abstract

The polycystic ovary syndrome (PCOS) is the disease featured by elevated levels of androgens, ovulatory dysfunction, and morphological abnormalities. At reproductive stage of women, the rate of PCOS occurrence is measured as 6–10% and the prevalence rate may be double. There are different pathophysiological factors involved in PCOS, and they play a major role in various abnormalities in individual patient. It is clear that there is noteworthy elevation of androgen in PCOS, causing substantial misery and infertility problems. The overexposure of androgen is directly linked with insulin resistance and hyperinsulinaemia. It has been reported previously that PCOS is related to cardiac metabolic miseries and potently increases the risk of heart diseases. Endometrial cancer is also a serious concern which is reported with exceedingly high incidence in women with PCOS. However, the overexposure of androgen has direct and specific influence on the development of insulin resistance. Although many factors are involved, resistance to the insulin and enhanced level of androgen are considered the major causes of PCOS. In the present review, we have focused on the pathophysiology and major revolutions of insulin resistance and excessive levels of androgen in females with PCOS.

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Cited by

Metadata

Authors
Xu, Y., & Qiao, J.
Venue
Journal of Healthcare Engineering
Publisher
Wiley
Published
2022-03-21
Volume
2022
Pages
1-13
ISSN
  • 2040-2295 (ISSN-L)
  • 2040-2309
DOI
10.1155/2022/9240569
OpenAlex
W4226435784
Cited by
283
References
23
FWCI
41.62
Type
journal article
Language
en
Open access
hybrid
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)
Funders
  • National Natural Science Foundation of China (81730038, 2019-I2M-5-001)
  • CAMS Innovation Fund for Medical Sciences (81730038, 2019-I2M-5-001)

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