Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy
Open accessAbstract
Background: Myocardial metabolic impairment is a major feature in chronic heart failure. As the major coenzyme in fuel oxidation and oxidative phosphorylation and a substrate for enzymes signaling energy stress and oxidative stress response, nicotinamide adenine dinucleotide (NAD + ) is emerging as a metabolic target in a number of diseases including heart failure. Little is known on the mechanisms regulating homeostasis of NAD + in the failing heart. Methods: To explore possible alterations of NAD + homeostasis in the failing heart, we quantified the expression of NAD + biosynthetic enzymes in the human failing heart and in the heart of a mouse model of dilated cardiomyopathy (DCM) triggered by Serum Response Factor transcription factor depletion in the heart (SRF HKO ) or of cardiac hypertrophy triggered by transverse aorta constriction. We studied the impact of NAD + precursor supplementation on cardiac function in both mouse models. Results: We observed a 30% loss in levels of NAD + in the murine failing heart of both DCM and transverse aorta constriction mice that was accompanied by a decrease in expression of the nicotinamide phosphoribosyltransferase enzyme that recycles the nicotinamide precursor, whereas the nicotinamide riboside kinase 2 (NMRK2) that phosphorylates the nicotinamide riboside precursor is increased, to a higher level in the DCM (40-fold) than in transverse aorta constriction (4-fold). This shift was also observed in human failing heart biopsies in comparison with nonfailing controls. We show that the Nmrk2 gene is an AMP-activated protein kinase and peroxisome proliferator-activated receptor α responsive gene that is activated by energy stress and NAD + depletion in isolated rat cardiomyocytes. Nicotinamide riboside efficiently rescues NAD + synthesis in response to FK866-mediated inhibition of nicotinamide phosphoribosyltransferase and stimulates glycolysis in cardiomyocytes. Accordingly, we show that nicotinamide riboside supplementation in food attenuates the development of heart failure in mice, more robustly in DCM, and partially after transverse aorta constriction, by stabilizing myocardial NAD + levels in the failing heart. Nicotinamide riboside treatment also robustly increases the myocardial levels of 3 metabolites, nicotinic acid adenine dinucleotide, methylnicotinamide, and N1-methyl-4-pyridone-5-carboxamide, that can be used as validation biomarkers for the treatment. Conclusions: The data show that nicotinamide riboside, the most energy-efficient among NAD precursors, could be useful for treatment of heart failure, notably in the context of DCM, a disease with few therapeutic options.
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NR and NMN have beneficial pharmacological activities in acute renal failure, inflammation, cardio- and vasoprotection, telomere lengthening, and lifespan extension.
“In addition, they have demonstrated beneficial pharmacological activities in acute renal failure [28], anti-inflammatory [29–31], cardio and vasoprotective actions [32–35], telomere lengthening [36, 37•], extend lifespan and promote health in various organisms, from yeasts to mammals [10, 14, 15, 38].”
From NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health (2023) · cites this paper as [35]
The Results section reports that NR preserved cardiac function in mice with dilated cardiomyopathy. It also reports no difference in vascular reactivity between NR-fed and control mice, so this paper does not support a vasoprotective effect. The other listed activities are attached to different citations in the citing sentence. (LLM, conf=0.90)
Experimental — accuracy not yet measuredNR (450 mg/kg body weight for 45 days) stabilized myocardial NAD+ levels, increased glycolysis and citrate and acetyl-coenzyme A metabolism, attenuating heart failure development in a mouse model with dilated cardiomyopathy.
“NR (450 mg/kg body weight for 45 days) stabilized myocardial NAD+ levels, increased glycolysis, and citrate and acetyl-coenzyme A metabolism, attenuating the development of heart failure in a mouse model with dilated cardiomyopathy [35].”
From NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health (2023) · cites this paper as [35]
The Results sections on the SRFHKO heart and cardiac NAD+ metabolome report that dietary NR preserved myocardial NAD+ and attenuated heart-failure development in mice with dilated cardiomyopathy. The reported dose was 400 mg/kg/day from day 5 to day 50, not 450 mg/kg. NR improved cardiac citrate synthase and ATP-citrate lyase activity, but the reported increase in glycolysis was measured in cultured cardiomyocytes, not in the treated mice. Page numbers were not available in our copy. (LLM, conf=0.90)
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- Authors
- Diguet, N., Trammell, S. A. J., Tannous, C., Deloux, R., Piquereau, J., Mougenot, N., Gouge, A., Gressette, M., Manoury, B., Blanc, J., Breton, M., Decaux, J.-F., Lavery, G. G., Baczkó, I., Zoll, J., Garnier, A., Li, Z., Brenner, C., & Mericskay, M.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- University of Iowa (US)
- Université Paris-Sud (FR)
- Inserm (FR)
- Sorbonne Université (FR)
- University of Birmingham (GB)
- University of Szeged (HU)
- Hôpital Lariboisière (FR)
- Corresponding author
- Tannous, Cynthia
- Deloux, Robin
- ORCID
- Venue
- Circulation
- Published
- 2018-05-22
- Volume
- 137
- Issue
- 21
- Pages
- 2256-2273
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC6954688
- OpenAlex
- W2775095764
- Cited by
- 358
- References
- 50
- Citations by year
- 2026: 28 · 2025: 42 · 2024: 49 · 2023: 47 · 2022: 57 · 2021: 47 · 2020: 49 · 2019: 24 · 2018: 12 · 2017: 1 · 2016: 1
- FWCI
- 14.21
- Type
- journal article
- Language
- en
- Update notices
- correction (2018-05-22)
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- SZTE Publicatio Repozitórium (University of Szeged) (acceptedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- Wellcome Trust (104612/Z/14/Z)
- Agence Nationale de la Recherche (ANR-08-GENO-0038, ANR-17-CE17-0015)
- Institut National de la Santé et de la Recherche Médicale
- Université de Strasbourg
- Centre National de la Recherche Scientifique
- Université Pierre et Marie Curie
- Université Paris-Saclay
- Szegedi Tudományegyetem
- Roy J. and Lucille A. Carver College of Medicine, University of Iowa
- National Institute of General Medical Sciences (T32GM008629)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- nicotinamide riboside, NAD+ homeostasis, dilated cardiomyopathy, heart failure, NAD biosynthesis, visfatin, AMPK, PPARα, myocardial energy metabolism, glycolysis, transverse aortic constriction, cardiac hypertrophy, cardiomyocytes, NAD+ precursor supplementation, chronic heart failure
- MeSH terms
- Acrylamides, Animals, Cardiomyopathy, Dilated, Disease Models, Animal, Heart Failure, Mice, Transgenic, NAD, Niacinamide, Piperidines, Pyridinium Compounds, Cytokines, Phosphotransferases (Alcohol Group Acceptor), Citric Acid, Dietary Supplements, Gene Expression Profiling, Serum Response Factor, Myocytes, Cardiac, PPAR alpha, Mice, Rats, Nicotinamide Phosphoribosyltransferase, AMP-Activated Protein Kinases, Metabolome
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