The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Patterns of Known and Novel Small RNAs in Human Cervical Cancer
Abstract
Recent studies suggest that knowledge of differential expression of microRNAs (miRNA) in cancer may have substantial diagnostic and prognostic value. Here, we use a direct sequencing method to characterize the profiles of miRNAs and other small RNA segments for six human cervical carcinoma cell lines and five normal cervical samples. Of 166 miRNAs expressed in normal cervix and cancer cell lines, we observed significant expression variation of six miRNAs between the two groups. To further show the biological relevance of our findings, we examined the expression level of two significantly varying miRNAs in a panel of 29 matched pairs of human cervical cancer and normal cervical samples. Reduced expression of miR-143 and increased expression of miR-21 were reproducibly displayed in cancer samples, suggesting the potential value of these miRNAs as tumor markers. In addition to the known miRNAs, we found a number of novel miRNAs and an additional set of small RNAs that do not meet miRNA criteria. [Cancer Res 2007;67(13):6031–43]
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MicroRNAs: small RNAs with a big role in gene regulation
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MicroRNA Gene Expression Deregulation in Human Breast Cancer
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Cited by
Lee, Y. S., & Dutta, A. (2009) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092222 · Cited by 1,505
miR‐21: a small multi‐faceted RNA
Krichevsky, A. M., & Gabriely, G. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00556.x · Cited by 987
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death
Schickel, R., Boyerinas, B., Park, S.-M., & Peter, M. E. (2008) · Oncogene · doi:10.1038/onc.2008.274 · Cited by 719
Viruses, microRNAs, and Host Interactions
Skalsky, R. L., & Cullen, B. R. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134243 · Cited by 676
Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21
Hatley, M. E., Patrick, D. M., Garcia, M. R., Richardson, J. A., Bassel-Duby, R., van Rooij, E., & Olson, E. N. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.08.013 · Cited by 626
“…lines showed increased miR-21 expression in glioblastoma (Chan et al., 2005; Ciafre et al., 2005), head and neck carcinomas (Tran et al., 2007), ovarian cancer (Iorio et al., 2007), B cell lymphoma (Lawrie et al., 2007), hepatocellular (Meng et al., 2007), and cervical carcinoma (Lui et al., 2007).”
Metadata
- Authors
- Lui, W.-O., Pourmand, N., Patterson, B. K., & Fire, A.
- Venue
- Cancer Research
- Published
- 2007-07-01
- Volume
- 67
- Issue
- 13
- Pages
- 6031-6043
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W4214489112
- Cited by
- 432
- References
- 49
- FWCI
- 10.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lui, W.-O., Pourmand, N., Patterson, B. K., & Fire, A. (2007). Patterns of Known and Novel Small RNAs in Human Cervical Cancer. Cancer Research. https://doi.org/10.1158/0008-5472.can-06-0561
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