miR-195 and miR-483-5p Identified as Predictors of Poor Prognosis in Adrenocortical Cancer

Soon, Patsy Siok Hwa; Tacon, Lyndal J.; Gill, Anthony J.; Bambach, Christopher P.; Sywak, Mark S.; Campbell, Peter R.; Yeh, Michael W.; Wong, Steven G.; Clifton-Bligh, Roderick J.; Robinson, Bruce G.; Sidhu, Stan B.

doi:10.1158/1078-0432.ccr-09-1587

Cited by 262Adrenal and Paraganglionic TumorsMicroRNA in disease regulationCancer-related molecular mechanisms research

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

miR-195 and miR-483-5p Identified as Predictors of Poor Prognosis in Adrenocortical Cancer

Soon, Patsy Siok Hwa, Tacon, Lyndal J., Gill, Anthony J., Bambach, Christopher P., Sywak, Mark S., Campbell, Peter R., Yeh, Michael W., Wong, Steven G., Clifton-Bligh, Roderick J., Robinson, Bruce G., Sidhu, Stan B.·2009·Clinical Cancer Research

DOI 10.1158/1078-0432.ccr-09-1587

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Abstract

PURPOSE: Adrenocortical adenomas are common, whereas adrenocortical carcinomas are rare. Discriminating between benign and malignant adrenocortical tumors using conventional histology can be difficult. In addition, adrenocortical carcinomas generally have poor prognosis and limited treatment options. MicroRNAs are short noncoding RNAs that are involved in regulation of gene transcription. EXPERIMENTAL DESIGN: To identify microRNAs involved in the pathogenesis of adrenocortical tumors, expression profiling of microRNAs was done on a cohort of 22 adrenocortical carcinomas, 27 adrenocortical adenomas, and 6 normal adrenal cortices. RESULTS: Twenty-three microRNAs were found to be significantly differentially expressed between adrenocortical carcinomas and adrenocortical adenomas. miR-335 and miR-195 were significantly downregulated in adrenocortical carcinomas compared with adrenocortical adenomas. This result was further validated in an external cohort of six adrenocortical carcinomas and four adrenocortical adenomas. Using Kaplan-Meier analysis, downregulation of miR-195 and upregulation of miR-483-5p in adrenocortical carcinomas were significantly associated with poorer disease-specific survival. CONCLUSIONS: These findings indicate that deregulation of microRNAs is a recurring event in human adrenocortical carcinomas and that aberrant expression of miR-195 and miR-483-5p identifies a subset of poorer prognosis adrenocortical carcinomas. (Clin Cancer Res 2009;15(24):7684-92).

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miR-483 is significantly upregulated in ACC (diagnostic sensitivity 80%, specificity 100%), and miR-195 and miR-335 are downregulated in ACC.
“the study identified a significant upregulation of miR-483 (diagnostic sensitivity of 80% and specificity of 100%) and downregulation of miR-195 and miR-335 in ACC (198).”
From Adrenocortical carcinoma (2014) · cites this paper as [198]
A study of 55 adrenal samples determined an miRNA expression signature unique to ACC, with 14 upregulated and 9 downregulated miRNAs.
“A recent study of 55 adrenal samples (6 normal tissues, 22 ACAs, and 27 ACCs) similarly determined an miRNA expression signature unique to ACC (198). The investigation identified 14 upregulated miRNAs and 9 downregulated miRNAs unique to ACC.”
From Adrenocortical carcinoma (2014) · cites this paper as [198]
miR-483 is located in an intron of IGF2.
“Moreover, miR-483 is located in an intron of IGF2.”
From Adrenocortical carcinoma (2014) · cites this paper as [198]

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Authors: Soon, P. S. H., Tacon, L. J., Gill, A. J., Bambach, C. P., Sywak, M. S., Campbell, P. R., Yeh, M. W., Wong, S. G., Clifton-Bligh, R. J., Robinson, B. G., & Sidhu, S. B.
Affiliations: The University of Sydney (AU)
ORCID: Soon, Patsy Siok Hwa
Gill, Anthony J.
Yeh, Michael W.
Clifton-Bligh, Roderick J.
Venue: Clinical Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2009-12-14
Volume: 15
Issue: 24
Pages: 7684-7692
ISSN: 1078-0432 (ISSN-L)
1557-3265
DOI: 10.1158/1078-0432.ccr-09-1587
OpenAlex: W2101164480
Cited by: 262
References: 35
Citations by year: 2026: 5 · 2025: 7 · 2024: 8 · 2023: 9 · 2022: 6 · 2021: 17 · 2020: 12 · 2019: 13 · 2018: 16 · 2017: 28 · 2016: 18 · 2015: 29 · 2014: 28 · 2013: 25 · 2012: 13
FWCI: 13.70
Type: journal article
Language: en
Open access: closed
Locations: Clinical Cancer Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords: adrenocortical carcinoma, adrenal adenoma, microRNA, miR-195, miR-483-5p, miR-335, prognosis, disease-specific survival, miRNA expression profiling, microRNA downregulation

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miR-195 and miR-483-5p Identified as Predictors of Poor Prognosis in Adrenocortical Cancer

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