Exosomes as bio-inspired nanocarriers for RNA delivery: preparation and applications

Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease

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Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

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The biology <b>,</b> function <b>,</b> and biomedical applications of exosomes

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Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles

Santos, A. G., da Rocha, G. O., & de Andrade, J. B. (2019) · Scientific Reports · doi:10.1038/s41598-018-37186-2 · Cited by 8,495 · see citing works

Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids

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Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

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mRNA vaccines — a new era in vaccinology

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Lipid nanoparticles for mRNA delivery

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Membrane vesicles as conveyors of immune responses

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Extracellular vesicles: biology and emerging therapeutic opportunities

EL Andaloussi, S., Mäger, I., Breakefield, X. O., & Wood, M. J. A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3978 · Cited by 3,254 · see citing works

Exosomes

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Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

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Exosomes – vesicular carriers for intercellular communication

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Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes

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Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

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Identification and proteomic profiling of exosomes in human urine

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Exosomes: biogenesis, biologic function and clinical potential

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Extracellular vesicles as a next-generation drug delivery platform

Herrmann, I. K., Wood, M. J. A., & Fuhrmann, G. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00931-2 · Cited by 1,951 · see citing works

Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

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Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

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A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

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Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

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Exosomal-like vesicles are present in human blood plasma

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Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

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Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication

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Exosomal MicroRNA: A Diagnostic Marker for Lung Cancer

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Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes.

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Exosomes with Immune Modulatory Features Are Present in Human Breast Milk

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Engineering exosomes as refined biological nanoplatforms for drug delivery

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Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury

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Exfoliation of membrane ecto-enzymes in the form of micro-vesicles

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Malignant effusions and immunogenic tumour-derived exosomes

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Bovine milk-derived exosomes for drug delivery

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In vitro and ex vivo strategies for intracellular delivery

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ExoCarta: A compendium of exosomal proteins and RNA

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Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery

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Exosomes Mediate the Cytoprotective Action of Mesenchymal Stromal Cells on Hypoxia-Induced Pulmonary Hypertension

Lee, C., Mitsialis, S. A., Aslam, M., Vitali, S. H., Vergadi, E., Konstantinou, G., Sdrimas, K., Fernandez‐Gonzalez, A., & Kourembanas, S. (2012) · Circulation · doi:10.1161/circulationaha.112.114173 · Cited by 784 · see citing works

Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression

Doeppner, T. R., Herz, J., Görgens, A., Schlechter, J., Ludwig, A., Radtke, S., de Miroschedji, K., Horn, P. A., Giebel, B., & Hermann, D. M. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0078 · Cited by 773 · see citing works

Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth

Katakowski, M., Buller, B., Zheng, X., Lü, Y., Rogers, T., Osobamiro, O. O., Shu, W., Jiang, F., & Chopp, M. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.02.019 · Cited by 748 · see citing works

Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment

Kojima, R., Bojar, D., Rizzi, G., Hamri, G. C.-E., El-Baba, M. D., Saxena, P., Ausländer, S., Tan, K. R., & Fussenegger, M. (2018) · Nature Communications · doi:10.1038/s41467-018-03733-8 · Cited by 748 · see citing works

Engineering hybrid exosomes by membrane fusion with liposomes

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Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

Yang, Z., Shi, J., Xie, J., Wang, Y., Sun, J., Liu, T., Zhao, Y., Zhao, X., Wang, X., Ma, Y., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0485-1 · Cited by 744 · see citing works

microRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma

Kefas, B. A., Godlewski, J. A., Comeau, L., Li, Y., Abounader, R., Hawkinson, M. P., Lee, J., Fine, H. A., Chiocca, E. A., Lawler, S. E., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6639 · Cited by 742 · see citing works

Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions

Hoen, E. N. M. N., Buermans, H. P. J., Waasdorp, M., Stoorvogel, W., Wauben, M. H. M., & Hoen, P. A. C. ’. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks658 · Cited by 741 · see citing works

Exosomes from human saliva as a source of microRNA biomarkers

Michael, A., Bajracharya, S., Yuen, P. S. T., Zhou, H., Star, R., Illei, G. G., & Alevizos, I. (2009) · Oral Diseases · doi:10.1111/j.1601-0825.2009.01604.x · Cited by 725 · see citing works

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

Wahlgren, J., Karlson, T. D. L., Brisslert, M., Sani, F. V., Telemo, E., Sunnerhagen, P., & Valadi, H. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks463 · Cited by 716 · see citing works

Targeting of the Bmi-1 Oncogene/Stem Cell Renewal Factor by MicroRNA-128 Inhibits Glioma Proliferation and Self-Renewal

Godlewski, J. A., Nowicki, M. O., Bronisz, A., Williams, S. P., Otsuki, A., Nuovo, G. J., Ray‐Chaudhury, A., Newton, H. B., Chiocca, E. A., & Lawler, S. E. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2629 · Cited by 702 · see citing works

Production and characterization of clinical grade exosomes derived from dendritic cells

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Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma

Lou, G., Song, X., Yang, F., Wu, S., Wang, J., Chen, Z., & Liu, Y. (2015) · Journal of Hematology & Oncology · doi:10.1186/s13045-015-0220-7 · Cited by 700 · see citing works

Efficient RNA drug delivery using red blood cell extracellular vesicles

Usman, W. M., Pham, T. C., Kwok, Y. Y., Vu, L. T., Ma, V., Peng, B., Chan, Y. S., Wei, L., Chin, S. M., Azad, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04791-8 · Cited by 663 · see citing works

Comparative analysis of exosome isolation methods using culture supernatant for optimum yield, purity and downstream applications

Patel, G. K., Khan, M. A., Zubair, H., Srivastava, S. K., Khushman, M. M., Singh, S., & Singh, A. P. (2019) · Scientific Reports · doi:10.1038/s41598-019-41800-2 · Cited by 645 · see citing works

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins

Subra, C., Grand, D., Laulagnier, K., Stella, A., Lambeau, G. J., Paillasse, M. R., de Médina, P., Monsarrat, B., Perret, B., Silvente‐Poirot, S., et al. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m003657 · Cited by 635 · see citing works

Exosome–Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs

Lin, Y., Wu, J., Gu, W., Huang, Y., Tong, Z., Huang, L., & Tan, J. (2018) · Advanced Science · doi:10.1002/advs.201700611 · Cited by 625 · see citing works

Exosome lipidomics unravels lipid sorting at the level of multivesicular bodies

Subra, C., Laulagnier, K., Perret, B., & Record, M. (2006) · Biochimie · doi:10.1016/j.biochi.2006.10.014 · Cited by 623 · see citing works

Prospects and challenges of extracellular vesicle-based drug delivery system: considering cell source

Meng, W., He, C., Hao, Y., Wang, L., Li, L., & Zhu, G. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1748758 · Cited by 618 · see citing works

Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases

Lou, G., Chen, Z., Zheng, M., & Liu, Y. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.63 · Cited by 605 · see citing works

Exosome-mediated delivery of siRNA in vitro and in vivo

Andaloussi, S. E., Lee, Y., Lakhal‐Littleton, S., Li, J., Seow, Y., Gardiner, C., Alvarez‐Erviti, L., Sargent, I. L., & Wood, M. J. A. (2012) · Nature Protocols · doi:10.1038/nprot.2012.131 · Cited by 602 · see citing works

Recent advancements in the use of exosomes as drug delivery systems

Bunggulawa, E. J., Wang, W., Yin, T., Wang, N., Durkan, C., Wang, Y., & Wang, G. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0403-9 · Cited by 600 · see citing works

Opportunities and Challenges in the Delivery of mRNA-Based Vaccines

Wadhwa, A., Aljabbari, A., Lokras, A., Foged, C., & Thakur, A. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12020102 · Cited by 584 · see citing works

Exosomes for targeted siRNA delivery across biological barriers

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Milk-derived exosomes for oral delivery of paclitaxel

Agrawal, A. K., Aqil, F., Jeyabalan, J., Spencer, W. A., Beck, J., Gachuki, B. W., Alhakeem, S. S., Oben, K. Z., Munagala, R., Bondada, S., et al. (2017) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.03.001 · Cited by 544 · see citing works

Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell–derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity

Munoz, J. L., Bliss, S. A., Greco, S. J., Ramkissoon, S. H., Ligon, K. L., & Rameshwar, P. (2013) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2013.60 · Cited by 520 · see citing works

The Polyethyleneglycol Dilemma: Advantage and Disadvantage of PEGylation of Liposomes for Systemic Genes and Nucleic Acids Delivery to Tumors

Hatakeyama, H., Akita, H., & Harashima, H. (2013) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b13-00059 · Cited by 500 · see citing works

Exosomes are natural carriers of exogenous siRNA to human cells in vitro

Shtam, T. A., Kovalev, R. A., Varfolomeeva, E. Y., Makarov, E. M., Kil, Y. V., & Filatov, M. V. (2013) · Cell Communication and Signaling · doi:10.1186/1478-811x-11-88 · Cited by 499 · see citing works

Exosomes as Potent Cell-Free Peptide-Based Vaccine. I. Dendritic Cell-Derived Exosomes Transfer Functional MHC Class I/Peptide Complexes to Dendritic Cells

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Field-Free Isolation of Exosomes from Extracellular Vesicles by Microfluidic Viscoelastic Flows

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Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection

Yu, B., Kim, H. W., Gong, M., Wang, J., Millard, R. W., Wang, Y., Ashraf, M., & Xu, M. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.12.043 · Cited by 473 · see citing works

Pancreatic cancer-targeting exosomes for enhancing immunotherapy and reprogramming tumor microenvironment

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Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells

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Challenges in Exosome Isolation and Analysis in Health and Disease

Ludwig, N., Whiteside, T. L., & Reichert, T. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194684 · Cited by 430 · see citing works

Packaging of prions into exosomes is associated with a novel pathway of PrP processing

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Liposomes and Extracellular Vesicles as Drug Delivery Systems: A Comparison of Composition, Pharmacokinetics, and Functionalization

van der Koog, L., Gandek, T. B., & Nagelkerke, A. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202100639 · Cited by 420 · see citing works

Design strategies and application progress of therapeutic exosomes

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Manufacturing Exosomes: A Promising Therapeutic Platform

Colao, I. L., Corteling, R. L., Bracewell, D. G., & Wall, I. B. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.01.006 · Cited by 414 · see citing works

Exosomal cargo-loading and synthetic exosome-mimics as potential therapeutic tools

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Exosome-based tumor antigens–adjuvant co-delivery utilizing genetically engineered tumor cell-derived exosomes with immunostimulatory CpG DNA

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A review of nanocarriers for the delivery of small interfering RNA

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Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung

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Cardiac progenitor-derived exosomes protect ischemic myocardium from acute ischemia/reperfusion injury

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Artificial exosomes for translational nanomedicine

Li, Y., Wu, J., Liu, J., Xu, W., Qiu, X., Huang, S. Q., Hu, X.-B., & Xiang, D. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00986-2 · Cited by 337 · see citing works

Tumor cell-derived exosomes: A message in a bottle

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Transfer of extracellular vesicles during immune cell‐cell interactions

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Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia

Masyuk, A. I., Huang, B. Q., Ward, C. J., Gradilone, S. A., Bañales, J. M., Masyuk, T. V., Radtke, B. N., Splinter, P. L., & LaRusso, N. F. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00093.2010 · Cited by 286 · see citing works

Exosomes Increase the Therapeutic Index of Doxorubicin in Breast and Ovarian Cancer Mouse Models

Hadla, M., Palazzolo, S., Corona, G., Caligiuri, I., Canzonieri, V., Toffoli, G., & Rizzolio, F. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0154 · Cited by 285 · see citing works

Cationic liposome-mediated delivery of siRNAs in adult mice

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