The DOI matches its Crossref record; 147 of the 148 references it cites were found in a registry or an index.
Internalization of Exosomes through Receptor-Mediated Endocytosis
Abstract
The tumor microenvironment is replete with factors secreted and internalized by surrounding cells. Exosomes are nano-sized, protein-embedded, membrane-bound vesicles that are released in greater quantities from cancer than normal cells and taken up by a variety of cell types. These vesicles contain proteins and genetic material from the cell of origin and in the case of tumor-derived exosomes, oncoproteins and oncogenes. With increasing understanding of the role exosomes play in basic biology, a more clear view of the potential exosomes are seen to have in cancer therapeutics emerges. However, certain essential aspects of exosome function, such as the uptake mechanisms, are still unknown. Various methods of cell–exosome interaction have been proposed, but this review focuses on the protein–protein interactions that facilitate receptor-mediated endocytosis, a broadly used mechanism by a variety of cells.
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“Internalization of exosomes at target cells may occur predominantly by endocytosis, membrane fusion, or receptor-mediated uptake [129].”
From Exosome for mRNA delivery: Strategies and therapeutic applications (2024) · cites this paper as [129]
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1 retracted
Rana, S., Yue, S., Stadel, D., & Zöller, M. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.06.018 · Cited by 688
RetractedValadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834
Extracellular vesicles: Exosomes, microvesicles, and friends
Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099
Alberts, B., Johnson, A., Lewis, J. H., Morgan, D. O., RAFF, M. C., Roberts, K. J., & Walter, P. (2017) · W.W. Norton eBooks · doi:10.1201/9781315735368 · Cited by 7,937
Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766
Lodish, H. F. (1986) · Cited by 5,650
Tumour exosome integrins determine organotropic metastasis
Hoshino, A., Costa-Silva, B., Shen, T.-L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., et al. (2015) · Nature · doi:10.1038/nature15756 · Cited by 5,101
Regulated portals of entry into the cell
Conner, S. D., & Schmid, S. L. (2003) · Nature · doi:10.1038/nature01451 · Cited by 3,959
Extracellular vesicles: biology and emerging therapeutic opportunities
EL Andaloussi, S., Mäger, I., Breakefield, X. O., & Wood, M. J. A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3978 · Cited by 3,571
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., et al. (2015) · Nature · doi:10.1038/nature14581 · Cited by 2,880
Research works printed but not linked: 1
- Jia, 2016, Exosomes, microvesicles, and head and neck cancers., Int J Clin Exp Med, 9, 15040
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Items 301–306 of 306
Qadeer, A., Wajid, A., Ullah, H., Ali, S., Alzahrani, F. M., Alzahrani, K. J., Alsharif, K. F., Khan, M. Z., & Abuderman, A. (2026) · Acta Tropica · doi:10.1016/j.actatropica.2026.108162
Lee, J. M., Kim, K. T., Lee, C., & Hwang, H. S. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18060668
Xu, Y., Xia, Q., Li, J., Ding, H., & Zhang, L.-H. (2026) · Soft Matter · doi:10.1039/d6sm00356g
Farahani, M. S., Shamsara, M., Moazzeni, S. M., Khalili, S., Johnson, B., Darzi, L., Shoae, M., Ghavami, M., Razi, A., Hosseini-Beheshti, E., et al. (2026) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-026-13976-x
Luo, J.-R., Chai, Z., Li, C., Shi, J., Zhu, Y.-J., & Zhang, F. (2026) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2026.115210
Vafadar, A., Shaghaghian, D., Charami, H., Hadinia, F., Didehdar, D., Movahedpour, A., & Ehtiati, S. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06205-z
Metadata
- Authors
- Gonda, A., Kabagwira, J., Senthil, G. N., & Wall, N. R.
- Affiliations
- Loma Linda University (US)
- Venue
- Molecular Cancer Research
- Published
- 2019-02-01
- Volume
- 17
- Issue
- 2
- Pages
- 337-347
- ISSN
- 1541-7786 (ISSN-L)
- 1557-3125
- OpenAlex
- W2903083130
- Cited by
- 296
- References
- 148
- Citations by year
- 2026: 24 · 2025: 39 · 2024: 43 · 2023: 50 · 2022: 41 · 2021: 59 · 2020: 26 · 2019: 13
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Loma Linda University (LLU) (GCAT2016-2018)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- exosomes, receptor-mediated endocytosis, exosome uptake, tumor microenvironment, tumor-derived exosomes, oncoprotein, oncogenes, protein-protein interaction, cancer therapeutics, extracellular vesicles
- MeSH terms
- Endocytosis, Humans, Cell Line, Tumor, Exosomes, Tumor Microenvironment
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