Cited by 306Extracellular vesicles in diseaseCellular transport and secretionNanoparticle-Based Drug Delivery

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Internalization of Exosomes through Receptor-Mediated Endocytosis

Gonda, Amber, Kabagwira, Janviere, Senthil, Girish N., Wall, Nathan R.·2019·Molecular Cancer Research

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Abstract

The tumor microenvironment is replete with factors secreted and internalized by surrounding cells. Exosomes are nano-sized, protein-embedded, membrane-bound vesicles that are released in greater quantities from cancer than normal cells and taken up by a variety of cell types. These vesicles contain proteins and genetic material from the cell of origin and in the case of tumor-derived exosomes, oncoproteins and oncogenes. With increasing understanding of the role exosomes play in basic biology, a more clear view of the potential exosomes are seen to have in cancer therapeutics emerges. However, certain essential aspects of exosome function, such as the uptake mechanisms, are still unknown. Various methods of cell–exosome interaction have been proposed, but this review focuses on the protein–protein interactions that facilitate receptor-mediated endocytosis, a broadly used mechanism by a variety of cells.

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Authors: Gonda, A., Kabagwira, J., Senthil, G. N., & Wall, N. R.
Affiliations: Loma Linda University (US)
ORCID: Gonda, Amber
Wall, Nathan R.
Venue: Molecular Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2019-02-01
Volume: 17
Issue: 2
Pages: 337-347
ISSN: 1541-7786 (ISSN-L)
1557-3125
DOI: 10.1158/1541-7786.mcr-18-0891
OpenAlex: W2903083130
Cited by: 296
References: 148
Citations by year: 2026: 24 · 2025: 39 · 2024: 43 · 2023: 50 · 2022: 41 · 2021: 59 · 2020: 26 · 2019: 13
FWCI: 2.40
Type: journal article
Language: en
Open access: closed
Locations: Molecular Cancer Research (publishedVersion)
PubMed (publishedVersion)
Funders: Loma Linda University (LLU) (GCAT2016-2018)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: exosomes, receptor-mediated endocytosis, exosome uptake, tumor microenvironment, tumor-derived exosomes, oncoprotein, oncogenes, protein-protein interaction, cancer therapeutics, extracellular vesicles
MeSH terms: Endocytosis, Humans, Cell Line, Tumor, Exosomes, Tumor Microenvironment

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Internalization of Exosomes through Receptor-Mediated Endocytosis

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