Cited by 306Extracellular vesicles in diseaseCellular transport and secretionNanoparticle-Based Drug Delivery

The DOI matches its Crossref record; 147 of the 148 references it cites were found in a registry or an index.

Internalization of Exosomes through Receptor-Mediated Endocytosis

Gonda, Amber, Kabagwira, Janviere, Senthil, Girish N., Wall, Nathan R.·2019·Molecular Cancer Research

Open this paper in CoChat — free account

Abstract

The tumor microenvironment is replete with factors secreted and internalized by surrounding cells. Exosomes are nano-sized, protein-embedded, membrane-bound vesicles that are released in greater quantities from cancer than normal cells and taken up by a variety of cell types. These vesicles contain proteins and genetic material from the cell of origin and in the case of tumor-derived exosomes, oncoproteins and oncogenes. With increasing understanding of the role exosomes play in basic biology, a more clear view of the potential exosomes are seen to have in cancer therapeutics emerges. However, certain essential aspects of exosome function, such as the uptake mechanisms, are still unknown. Various methods of cell–exosome interaction have been proposed, but this review focuses on the protein–protein interactions that facilitate receptor-mediated endocytosis, a broadly used mechanism by a variety of cells.

Integrity signals

Registry

Crossref · 10.1158/1541-7786.mcr-18-0891

Cites

147 of 147 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

RETRACTED: Toward tailored exosomes: The exosomal tetraspanin web contributes to target cell selection
Rana, S., Yue, S., Stadel, D., & Zöller, M. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.06.018 · Cited by 688
Retracted
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834
Extracellular vesicles: Exosomes, microvesicles, and friends
Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099
Molecular Biology of the Cell
Alberts, B., Johnson, A., Lewis, J. H., Morgan, D. O., RAFF, M. C., Roberts, K. J., & Walter, P. (2017) · W.W. Norton eBooks · doi:10.1201/9781315735368 · Cited by 7,937
Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766
Molecular Cell Biology
Lodish, H. F. (1986) · Cited by 5,650
Tumour exosome integrins determine organotropic metastasis
Hoshino, A., Costa-Silva, B., Shen, T.-L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., et al. (2015) · Nature · doi:10.1038/nature15756 · Cited by 5,101
Regulated portals of entry into the cell
Conner, S. D., & Schmid, S. L. (2003) · Nature · doi:10.1038/nature01451 · Cited by 3,959
Extracellular vesicles: biology and emerging therapeutic opportunities
EL Andaloussi, S., Mäger, I., Breakefield, X. O., & Wood, M. J. A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3978 · Cited by 3,571
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., et al. (2015) · Nature · doi:10.1038/nature14581 · Cited by 2,880
Routes and mechanisms of extracellular vesicle uptake
Mulcahy, L. A., Pink, R. C., & Carter, D. R. F. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24641 · Cited by 2,832
Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
Costa-Silva, B., Aiello, N. M., Ocean, A. J., Singh, S., Zhang, H., Thakur, B. K., Becker, A., Hoshino, A., Mark, M. T., Molina, H., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3169 · Cited by 2,692
Double-stranded DNA in exosomes: a novel biomarker in cancer detection
Thakur, B. K., Zhang, H., Becker, A., Matei, I. R., Huang, Y., Costa‐Silva, B., Zheng, Y., Hoshino, A., Brazier, H., Xiang, J., et al. (2014) · Cell Research · doi:10.1038/cr.2014.44 · Cited by 1,629
Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells
Parolini, I., Federici, C., Raggi, C., Lugini, L., Palleschi, S., Milito, A. D., Coscia, C., Iessi, E., Logozzi, M., Molinari, A., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.041152 · Cited by 1,614
Heparan Sulfate ProteoglycansPreprint
Sarrazin, S., Lamanna, W. C., & Esko, J. D. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004952 · Cited by 1,605
Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles
Théry, C., Boussac, M., Véron, P., Ricciardi‐Castagnoli, P., Raposo, G., Garin, J., & Amigorena, S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7309 · Cited by 1,564
Activated Platelets Release Two Types of Membrane Vesicles: Microvesicles by Surface Shedding and Exosomes Derived From Exocytosis of Multivesicular Bodies and -Granules
Heijnen, H. F. G., Schiel, A. E., Fijnheer, R., Geuze, H. J., & Sixma, J. J. (1999) · Blood · doi:10.1182/blood.v94.11.3791 · Cited by 1,488
Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes.
Montecalvo, A., Larregina, A. T., Shufesky, W. J., Beer Stolz, D., Sullivan, M. L. G., Karlsson, J. M., Baty, C. J., Gibson, G. A., Erdos, G., Wang, Z., et al. (2012) · Blood · doi:10.1182/blood-2011-02-338004 · Cited by 1,429
The LDL Receptor
Goldstein, J. L., & Brown, M. S. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.179564 · Cited by 1,344
Identification of Tim4 as a phosphatidylserine receptor
Miyanishi, M., Tada, K., Koike, M., Uchiyama, Y., Kitamura, T., & Nagata, S. (2007) · Nature · doi:10.1038/nature06307 · Cited by 1,180
Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells
Morelli, A. E., Larregina, A. T., Shufesky, W. J., Sullivan, M. L. G., Stolz, D. B., Papworth, G. D., Zahorchak, A. F., Logar, A., Wang, Z., Watkins, S. C., et al. (2004) · Blood · doi:10.1182/blood-2004-03-0824 · Cited by 1,075
Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors
Jang, S. C., Kim, O. Y., Yoon, C. M., Choi, D., Roh, T., Park, J., Nilsson, J. A., Lötvall, J. O., Kim, Y., & Gho, Y. S. (2013) · ACS Nano · doi:10.1021/nn402232g · Cited by 1,037
Cellular Internalization of Exosomes Occurs Through Phagocytosis
Feng, D., Zhao, W.-L., Ye, Y.-Y., Bai, X., Liu, R.-Q., Chang, L.-F., Zhou, Q., & Sui, S. (2010) · Traffic · doi:10.1111/j.1600-0854.2010.01041.x · Cited by 1,035
Tissue-factor–bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation
Conde, I. D., Shrimpton, C. N., Thiagarajan, P., & López, J. A. (2005) · Blood · doi:10.1182/blood-2004-03-1095 · Cited by 1,030
Lipids in exosomes: current knowledge and the way forward
Skotland, T., Sandvig, K., & Llorente, A. (2017) · Progress in Lipid Research · doi:10.1016/j.plipres.2017.03.001 · Cited by 1,030
Microvesicles: mediators of extracellular communication during cancer progression
Muralidharan-Chari, V., Clancy, J. W., Sedgwick, A., & D’Souza‐Schorey, C. (2010) · Journal of Cell Science · doi:10.1242/jcs.064386 · Cited by 986
Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity
Christianson, H. C., Svensson, K. J., van Kuppevelt, T. H., Li, J.-P., & Belting, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304266110 · Cited by 903
Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication
Frühbeis, C., Fröhlich, D., Kuo, W. P., Amphornrat, J., Thilemann, S., Saab, A. S., Kirchhoff, F., Möbius, W., Goebbels, S., Nave, K.-A., et al. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001604 · Cited by 902
Phagocytosis: An Immunobiologic Process
Gordon, S. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.026 · Cited by 902
Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies
Record, M., Carayon, K., Poirot, M., & Silvente‐Poirot, S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.10.004 · Cited by 893
Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis
Fitzner, D., Schnaars, M., van Rossum, D., Krishnamoorthy, G., Dibaj, P., Bakhti, M., Regen, T., Hanisch, U.-K., & Simons, M. (2011) · Journal of Cell Science · doi:10.1242/jcs.074088 · Cited by 866
Exosome-delivered microRNAs modulate the inflammatory response to endotoxin
Alexander, M., Hu, R., Runtsch, M. C., Kagele, D. A., Mosbruger, T. L., Tolmachova, T., Seabra, M. C., Round, J. L., Ward, D. M., & O’Connell, R. M. (2015) · Nature Communications · doi:10.1038/ncomms8321 · Cited by 769
Sorting it out: Regulation of exosome loading
Villarroya‐Beltri, C., Baixauli, F., Gutiérrez‐Vázquez, C., Sánchez‐Madrid, F., & Mittelbrunn, M. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2014.04.009 · Cited by 766
Exosome uptake through clathrin-mediated endocytosis and macropinocytosis and mediating miR-21 delivery
Tian, T., Zhu, Y.-L., Zhou, Y.-Y., Liang, G.-F., Wang, Y.-Y., Hu, F.-H., & Xiao, Z.-D. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.588046 · Cited by 726
Cell Surface Tetraspanin Tspan8 Contributes to Molecular Pathways of Exosome-Induced Endothelial Cell Activation
Nazarenko, I. A., Rana, S., Baumann, A., McAlear, J., Hellwig, A., Trendelenburg, M. F., Lochnit, G., Preissner, K. T., & Zöller, M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2470 · Cited by 718
Macropinocytosis: an endocytic pathway for internalising large gulps
Lim, J. P., & Gleeson, P. A. (2011) · Immunology and Cell Biology · doi:10.1038/icb.2011.20 · Cited by 705
Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E
Mahley, R. W., & Ji, Z.-S. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33334-4 · Cited by 693
Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR
Al-Nedawi, K. N. I., Meehan, B., Kerbel, R. S., ALLISON, A. C., & Rak, J. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804543106 · Cited by 691
Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1
Svensson, K. J., Christianson, H. C., Wittrup, A., Bourseau-Guilmain, E., Lindqvist, E., Svensson, L. M., Mörgelin, M., & Belting, M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.445403 · Cited by 690
TIM-1 and TIM-4 Glycoproteins Bind Phosphatidylserine and Mediate Uptake of Apoptotic Cells
Kobayashi, N., Karisola, P., Peña‐Cruz, V., Dorfman, D. M., Jinushi, M., Umetsu, S. E., Butte, M. J., Nagumo, H., Chernova, I., Zhu, B., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.11.011 · Cited by 669
Interaction and uptake of exosomes by ovarian cancer cells
Escrevente, C., Keller, S., Altevogt, P., & Costa, J. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-108 · Cited by 666
Molecular cell biology 3.0
Walker, J. (1997) · Biochemical Education · doi:10.1016/s0307-4412(97)88293-3 · Cited by 664
TCR Activation of Human T Cells Induces the Production of Exosomes Bearing the TCR/CD3/ζ Complex
Blanchard, N., Lankar, D., Faure, F., Regnault, A., Dumont, C., Raposo, G., & Hivroz, C. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3235 · Cited by 660
Molecular Biology of the Cell
Schiessel, H. (2013) · doi:10.1201/b16269-3 · Cited by 643
Protein Corona of Nanoparticles: Distinct Proteins Regulate the Cellular Uptake
Ritz, S., Schöttler, S., Kotman, N., Baier, G., Musyanovych, A., Kuharev, J., Landfester, K., Schild, H., Jahn, O., Tenzer, S., et al. (2015) · Biomacromolecules · doi:10.1021/acs.biomac.5b00108 · Cited by 635
Emerging Roles of Exosomes in Normal and Pathological Conditions: New Insights for Diagnosis and Therapeutic Applications
Toro, J. D., Herschlik, L., Waldner, C., & Mongini, C. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00203 · Cited by 632
TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity
Freeman, G. J., Casasnovas, J. M., Umetsu, D. T., & DeKruyff, R. H. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2010.00903.x · Cited by 630
Exosomes and their roles in immune regulation and cancer
Greening, D. W., Gopal, S. K., Xu, R., Simpson, R. J., & Chen, W. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.02.009 · Cited by 627
MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells
Okoye, I., Coomes, S. M., Pelly, V. S., Czieso, S., Papayannopoulos, V., Tolmachova, T., Seabra, M. C., & Wilson, M. S. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.019 · Cited by 619
Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells
Saari, H., Lázaro-Ibáñez, E., Viitala, T., Vuorimaa-Laukkanen, E., Siljander, P., & Yliperttula, M. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.09.031 · Cited by 613
Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia
Yuyama, K., Sun, H., Mitsutake, S., & Igarashi, Y. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.324616 · Cited by 612
Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain
Yuan, D., Zhao, Y., Banks, W. A., Bullock, K. M., Haney, M., Batrakova, E., & Kabanov, A. V. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.07.011 · Cited by 607
Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor inhibiting HIF-1
Umezu, T., Tadokoro, H., Azuma, K., Yoshizawa, S., Ohyashiki, K., & Ohyashiki, J. H. (2014) · Blood · doi:10.1182/blood-2014-05-576116 · Cited by 600
Lipid rafts and membrane dynamics
Rajendran, L., & Simons, K. (2005) · Journal of Cell Science · doi:10.1242/jcs.01681 · Cited by 590
Exosomes and tumor-mediated immune suppression
Whiteside, T. L. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81136 · Cited by 583
Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes
Park, J. E., Tan, H. S., Datta, A., Lai, R. C., Zhang, H., Meng, W., Lim, S. K., & Sze, S. K. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900381-mcp200 · Cited by 582
Cellular uptake of extracellular vesicles is mediated by clathrin-independent endocytosis and macropinocytosis
Verdera, H. C., Gitz-Francois, J. J., Schiffelers, R. M., & Vader, P. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.09.019 · Cited by 580
Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells
Safaei, R., Larson, B. J., Cheng, T., Gibson, M. A., Otani, S., Naerdemann, W., & Howell, S. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0102 · Cited by 563
Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry
Clayton, A., Court, J., Navabi, H., Adams, M., Mason, M. D., Hobot, J. A., Newman, G. R., & Jasani, B. (2001) · Journal of Immunological Methods · doi:10.1016/s0022-1759(00)00321-5 · Cited by 555
Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells
van Balkom, B. W. M., de Jong, O. G., Smits, M., Brummelman, J., den Ouden, K., de Bree, P., van Eijndhoven, M. A. J., Pegtel, D. M., Stoorvogel, W., Würdinger, T., et al. (2013) · Blood · doi:10.1182/blood-2013-02-478925 · Cited by 516
Proteomic Analysis of Exosomes from Mutant KRAS Colon Cancer Cells Identifies Intercellular Transfer of Mutant KRAS
Beckler, M. D., Higginbotham, J. N., Franklin, J. L., Ham, A. L., Halvey, P. J., Imasuen, I., Whitwell, C. A., Li, M., Liebler, D. C., & Coffey, R. J. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.022806 · Cited by 514
Two Distinct Populations of Exosomes Are Released from LIM1863 Colon Carcinoma Cell-derived Organoids
Tauro, B. J., Greening, D. W., Mathias, R. A., Mathivanan, S., Ji, H. L., & Simpson, R. J. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.021303 · Cited by 457
Display of GPI‐anchored anti‐EGFR nanobodies on extracellular vesicles promotes tumour cell targeting
Kooijmans, S. A. A., Gomez‐Aleza, C., Roffler, S. R., van Solinge, W. W., Vader, P., & Schiffelers, R. M. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.31053 · Cited by 447
Activated T cells recruit exosomes secreted by dendritic cells via LFA-1
Hoen, E. N. M. N., Buschow, S. I., Anderton, S. M., Stoorvogel, W., & Wauben, M. H. M. (2008) · Blood · doi:10.1182/blood-2008-08-174094 · Cited by 436
Heparan sulfate proteoglycan as a cell-surface endocytosis receptor
Christianson, H. C., & Belting, M. (2014) · Matrix Biology · doi:10.1016/j.matbio.2013.10.004 · Cited by 429
Exosome removal as a therapeutic adjuvant in cancer
Marleau, A. M., Chen, C.-S., Joyce, J. A., & Tullis, R. H. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-134 · Cited by 419
Exosome-mediated transfer of miR-10b promotes cell invasion in breast cancer
Singh, R., Pochampally, R. R., Watabe, K., Lü, Z., & Mo, Y. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-256 · Cited by 408
CD169 mediates the capture of exosomes in spleen and lymph node
Saunderson, S. C., Dunn, A. C., Crocker, P. R., & McLellan, A. D. (2013) · Blood · doi:10.1182/blood-2013-03-489732 · Cited by 396
Immune modulation of T-cell and NK (natural killer) cell activities by TEXs (tumour-derived exosomes)
Whiteside, T. L. (2013) · Biochemical Society Transactions · doi:10.1042/bst20120265 · Cited by 391
Efficient production and enhanced tumor delivery of engineered extracellular vesicles
Watson, D. C., Bayik, D., Srivatsan, A., Bergamaschi, C., Valentin, A., Niu, G., Bear, J., Monninger, M., Sun, M., Morales-Kastresana, A., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.07.003 · Cited by 385
Exosomes Derived from Epstein-Barr Virus-Infected Cells Are Internalized via Caveola-Dependent Endocytosis and Promote Phenotypic Modulation in Target Cells
Nanbo, A., Kawanishi, E., Yoshida, R., & Yoshiyama, H. (2013) · Journal of Virology · doi:10.1128/jvi.01310-13 · Cited by 374
Endocytosis of Gene Delivery Vectors: From Clathrin-dependent to Lipid Raft-mediated Endocytosis
El‐Sayed, A., & Harashima, H. (2013) · Molecular Therapy · doi:10.1038/mt.2013.54 · Cited by 354
Fibroblast-Derived Exosomes Contribute to Chemoresistance through Priming Cancer Stem Cells in Colorectal Cancer
Hu, Y., Yan, C., Mu, L., Huang, K., Li, X., Tao, D., Wu, Y., & Qin, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125625 · Cited by 352
Tumor cell-derived exosomes: A message in a bottle
Kharaziha, P., Ceder, S., Li, Q., & Panaretakis, T. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.03.006 · Cited by 347
Exosomes secreted by cortical neurons upon glutamatergic synapse activation specifically interact with neurons
Chivet, M., Javalet, C., Laulagnier, K., Blot, B., Hemming, F. J., & Sadoul, R. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24722 · Cited by 340
Heparanase activates the syndecan-syntenin-ALIX exosome pathway
Roucourt, B., Meeussen, S., Bao, J., Zimmermann, P., & David, G. (2015) · Cell Research · doi:10.1038/cr.2015.29 · Cited by 339
Adhesion and signaling by B cell‐derived exosomes: the role of integrins
Clayton, A., Turkes, A., Dewitt, S., Steadman, R., Mason, M. D., & Hallett, M. B. (2004) · The FASEB Journal · doi:10.1096/fj.03-1094fje · Cited by 339
Plasma-Derived Exosomal Survivin, a Plausible Biomarker for Early Detection of Prostate Cancer
Khan, S., Jutzy, J. M. S., Valenzuela, M. M. A., Turay, D., Aspe, J. R., Ashok, A., Mirshahidi, S., Mercola, D., Lilly, M. B., & Wall, N. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046737 · Cited by 331
Self-citation
Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrin-independent carriers
Lakshminarayan, R., Wunder, C., Becken, U., Howes, M. T., Benzing, C., Arumugam, S., Sales, S., Ariotti, N., Chambon, V., Lamaze, C., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb2970 · Cited by 321
Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions
Purushothaman, A., Bandari, S., Liu, J., Mobley, J. A., Brown, E. E., & Sanderson, R. D. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.686295 · Cited by 318
Characterization and proteomic analysis of ovarian cancer-derived exosomes
Liang, B., Peng, P., Chen, S., Li, L., Zhang, M., Cao, D., Yang, J., Li, H., Gui, T., Li, X., et al. (2013) · Journal of Proteomics · doi:10.1016/j.jprot.2012.12.029 · Cited by 315
Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes
Nakase, I., & Futaki, S. (2015) · Scientific Reports · doi:10.1038/srep10112 · Cited by 297
Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages
Barrès, C., Blanc, L., Bette‐Bobillo, P., André, S., Mamoun, R. Z., Gabius, H., & Vidal, M. (2009) · Blood · doi:10.1182/blood-2009-07-231449 · Cited by 295
Reticulocyte maturation and exosome release: transferrin receptor containing exosomes shows multiple plasma membrane functions.
Johnstone, R., Bianchini, A., & Teng, K. (1989) · Blood · doi:10.1182/blood.v74.5.1844.1844 · Cited by 289
Galectin expression in cancer diagnosis and prognosis: A systematic review
Thijssen, V. L., Heusschen, R., Caers, J., & Griffioen, A. W. (2015) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2015.03.003 · Cited by 281
CD8+ Dendritic Cells Use LFA-1 to Capture MHC-Peptide Complexes from Exosomes In Vivo
Segura, É., Guérin, C. L., Hogg, N., Amigorena, S., & Théry, C. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.3.1489 · Cited by 278
Heparan sulfate proteoglycan as a plasma membrane carrier
Belting, M. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00031-8 · Cited by 273
Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes
Nakase, I., Kobayashi, N. B., Takatani‐Nakase, T., & Yoshida, T. (2015) · Scientific Reports · doi:10.1038/srep10300 · Cited by 271
Extracellular Vesicles Exploit Viral Entry Routes for Cargo Delivery
van Dongen, H. M., Masoumi, N., Witwer, K. W., & Pegtel, D. M. (2016) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00063-15 · Cited by 271
Exosomes released by EBV-infected nasopharyngeal carcinoma cells convey the viral Latent Membrane Protein 1 and the immunomodulatory protein galectin 9
Keryer, C., Pioche‐Durieu, C., Villemant, C., Souquère, S., Nishi, N., Hirashima, M., Middeldorp, J. M., & Busson, P. (2006) · BMC Cancer · doi:10.1186/1471-2407-6-283 · Cited by 270
Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
He, M., Qin, H., Poon, T. C. W., Sze, S. C., Ding, X., Co, N. N., Ngai, S. M., Chan, T., & Wong, N. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv081 · Cited by 266
Survivin is released from cancer cells via exosomes
Khan, S., Jutzy, J. M. S., Aspe, J. R., McGregor, D. W., Neidigh, J. W., & Wall, N. R. (2010) · APOPTOSIS · doi:10.1007/s10495-010-0534-4 · Cited by 264
Self-citation
Mature dendritic cells pulsed with exosomes stimulate efficient cytotoxic T‐lymphocyte responses and antitumour immunity
Hao, S., Bai, O., Li, F., Yuan, J., Laferté, S., & Xiang, J. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02483.x · Cited by 253
Exosomes as a Nanodelivery System: a Key to the Future of Neuromedicine?
Aryani, A., & Denecke, B. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-9054-5 · Cited by 242
Role of Phosphatidylserine-Derived Negative Surface Charges in the Recognition and Uptake of Intravenously Injected B16BL6-Derived Exosomes by Macrophages
Matsumoto, A., Takahashi, Y., Nishikawa, M., Sano, K., Morishita, M., Charoenviriyakul, C., Saji, H., & Takakura, Y. (2016) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2016.07.022 · Cited by 236
Local clustering of transferrin receptors promotes clathrin-coated pit initiation
Liu, A. P., Aguet, F., Danuser, G. M., & Schmid, S. L. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201008117 · Cited by 230
Detachment of Breast Tumor Cells Induces Rapid Secretion of Exosomes Which Subsequently Mediate Cellular Adhesion and Spreading
Koumangoye, R. B., Sakwe, A. M., Goodwin, J. S., Patel, T., & Ochieng, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024234 · Cited by 227
Ovarian cancer cell invasiveness is associated with discordant exosomal sequestration of Let-7 miRNA and miR-200
Kobayashi, M., Salomón, C., Tapia, J., Illanes, S. E., Mitchell, M. D., & Rice, G. E. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-4 · Cited by 225
EGFR and NF-κB: partners in cancer
Shostak, K., & Chariot, A. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.04.001 · Cited by 222
Functional exosome-mimic for delivery of siRNA to cancer: in vitro and in vivo evaluation
Yang, Z., Xie, J., Zhu, J., Chen, K., Chiang, C., Wang, X., Wang, X., Kuang, T., Chen, F., Chen, Z., et al. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.10.008 · Cited by 219
Tumor-exosomes and leukocyte activation: an ambivalent crosstalk
Zech, D., Rana, S., Büchler, M. W., & Zöller, M. (2012) · Cell Communication and Signaling · doi:10.1186/1478-811x-10-37 · Cited by 217
Early diagnostic value of survivin and its alternative splice variants in breast cancer
Khan, S., Bennit, H. R. F., Turay, D., Perez, M. N., Mirshahidi, S., Yuan, Y., & Wall, N. R. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-176 · Cited by 216
Self-citation
Characterization of Uptake and Internalization of Exosomes by Bladder Cancer Cells
Franzen, C. A., Simms, P. E., Huis, A. V., Foreman, K. E., Kuo, P. C., & Gupta, G. N. (2014) · BioMed Research International · doi:10.1155/2014/619829 · Cited by 213
Exosomes in development, metastasis and drug resistance of breast cancer
Yu, D., Wu, Y., Shen, H., Lv, M., Chen, W., Zhang, X., Zhong, S., Tang, J., & Zhao, J. (2015) · Cancer Science · doi:10.1111/cas.12715 · Cited by 208
Heparin blocks transfer of extracellular vesicles between donor and recipient cells
Atai, N. A., Balaj, L., van Veen, H. A., Breakefield, X. O., Jarzyna, P. A., Noorden, C. J. F. V., Skog, J., & Maguire, C. A. (2013) · Journal of Neuro-Oncology · doi:10.1007/s11060-013-1235-y · Cited by 205
Phosphatidylserine receptors: Enhancers of enveloped virus entry and infection
Møller-Tank, S., & Maury, W. J. (2014) · Virology · doi:10.1016/j.virol.2014.09.009 · Cited by 192
TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway
Calzolari, A., Raggi, C., Deaglio, S., Sposi, N. M., Stafsnes, M., Fecchi, K., Parolini, I., Malavasi, F., Peschle, C., Sargiacomo, M., et al. (2006) · Journal of Cell Science · doi:10.1242/jcs.03228 · Cited by 190
Discovery of Double-Stranded Genomic DNA in Circulating ExosomesPreprint
Kalluri, R., & LeBleu, V. S. (2016) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2016.81.030932 · Cited by 185
Improvement of neuronal cell survival by astrocyte‐derived exosomes under hypoxic and ischemic conditions depends on prion protein
Guitart, K., Loers, G., Buck, F., Bork, U., Schachner, M., & KLEENE, R. B. (2016) · Glia · doi:10.1002/glia.22963 · Cited by 184
T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice
Rodriguez‐Manzanet, R., Sanjuán, M. A. F., Wu, H. Y., Quintana, F. J., Xiao, S., Anderson, A. C., Weiner, H. L., Green, D. R., & Kuchroo, V. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910359107 · Cited by 182
The Evolving Field of Human Papillomavirus Receptor Research: a Review of Binding and Entry
Raff, A. B., Woodham, A. W., Raff, L. M., Skeate, J. G., Yan, L., Silva, D. M. D., Schelhaas, M., & Kast, W. M. (2013) · Journal of Virology · doi:10.1128/jvi.00330-13 · Cited by 181
Proteomics of MUC1‐containing lipid rafts from plasma membranes and exosomes of human breast carcinoma cells MCF‐7
Staubach, S., Razawi, H., & Hanisch, F. (2009) · PROTEOMICS · doi:10.1002/pmic.200800793 · Cited by 175
Sensing of latent EBV infection through exosomal transfer of 5′pppRNA
Baglio, S. R., van Eijndhoven, M. A. J., Koppers‐Lalic, D., Berenguer, J., Lougheed, S. M., Gibbs, S., Léveillé, N., Rinkel, R. N. P. M., Hopmans, E. S., Swaminathan, S., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1518130113 · Cited by 161
Cell-specific uptake of mantle cell lymphoma-derived exosomes by malignant and non-malignant B-lymphocytes
Hazan‐Halevy, I., Rosenblum, D., Weinstein, S., Bairey, O., Raanani, P., & Peer, D. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.04.026 · Cited by 152
Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel
Kharaziha, P., Chioureas, D., Rutishauser, D., Baltatzis, G., Lennartsson, L., Fonseca, P., Azimi, A., Hultenby, K. R., Zubarev, R. A., Ullén, A., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3226 · Cited by 149
Glycan profiling analysis using evanescent-field fluorescence-assisted lectin array: Importance of sugar recognition for cellular uptake of exosomes from mesenchymal stem cells
Shimoda, A., Tahara, Y., Sawada, S., Sasaki, Y., & Akiyoshi, K. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.07.126 · Cited by 142
Intercellular communication by exosomes in placenta: A possible role in cell fusion?
Record, M. (2014) · Placenta · doi:10.1016/j.placenta.2014.02.009 · Cited by 140
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Pienimaeki‐Roemer, A., Kuhlmann, K., Böttcher, A., Konovalova, T., Black, A., Orsó, E., Liebisch, G., Ahrens, M., Eisenacher, M., Meyer, H. E., et al. (2014) · Transfusion · doi:10.1111/trf.12874 · Cited by 128
Curcumin Modulates Pancreatic Adenocarcinoma Cell-Derived Exosomal Function
Osterman, C. J. D., Lynch, J. C., Leaf, P., Gonda, A., Bennit, H. R. F., Griffiths, D., & Wall, N. R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132845 · Cited by 126
Self-citation
Glycolipids and Lectins in Endocytic Uptake Processes
Johannes, L., Wunder, C., & Shafaq‐Zadah, M. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.10.027 · Cited by 121
Endocytosis and Cancer: an ‘Insider’ Network with Dangerous Liaisons
Lanzetti, L., & Di Fiore, P. P. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00816.x · Cited by 119
DENDRITIC CELL-DERIVED EXOSOMES CONTAINING MILK FAT GLOBULE EPIDERMAL GROWTH FACTOR-FACTOR VIII ATTENUATE PROINFLAMMATORY RESPONSES IN SEPSIS
Miksa, M., Wu, R., Dong, W., Das, P., Yang, D., & Wang, P. (2006) · Shock · doi:10.1097/01.shk.0000209533.22941.d0 · Cited by 111
Delivery of Therapeutic Proteins via Extracellular Vesicles: Review and Potential Treatments for Parkinson’s Disease, Glioma, and Schwannoma
Hall, J. S., Prabhakar, S., Balaj, L., Lai, C. P., Cerione, R. A., & Breakefield, X. O. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0309-0 · Cited by 110
Galectin-3 regulates MUC1 and EGFR cellular distribution and EGFR downstream pathways in pancreatic cancer cells
Merlin, J., Stechly, L., de Beauce, S., Monté, D., Leteurtre, E., SEUNINGEN, I. V., Huet, G., & Pigny, P. (2011) · Oncogene · doi:10.1038/onc.2010.631 · Cited by 105
Active Uptake of Dendritic Cell-Derived Exovesicles by Epithelial Cells Induces the Release of Inflammatory Mediators through a TNF-α-Mediated Pathway
Obregon, C., Rothen‐Rutishauser, B., Gerber, P. A., Gehr, P., & Nicod, L. P. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080716 · Cited by 104
Nanoparticle Targeting and Cholesterol Flux Through Scavenger Receptor Type B-1 Inhibits Cellular Exosome Uptake
Plebanek, M. P., Mutharasan, R. K., Volpert, O. V., Matov, A., Gatlin, J. C., & Thaxton, C. S. (2015) · Scientific Reports · doi:10.1038/srep15724 · Cited by 94
Integrins and heparan sulfate proteoglycans on hepatic stellate cells (HSC) are novel receptors for HSC‐derived exosomes
Chen, L., & Brigstock, D. R. (2016) · FEBS Letters · doi:10.1002/1873-3468.12448 · Cited by 91
Vectorization of biomacromolecules into cells using extracellular vesicles with enhanced internalization induced by macropinocytosis
Nakase, I., Noguchi, K., Fujii, I., & Futaki, S. (2016) · Scientific Reports · doi:10.1038/srep34937 · Cited by 90
Exosomes Secreted from Human Cancer Cell Lines Contain Inhibitors of Apoptosis (IAP)
Valenzuela, M. M. A., Bennit, H. R. F., Gonda, A., Osterman, C. J. D., Hibma, A., Khan, S., & Wall, N. R. (2015) · Cancer Microenvironment · doi:10.1007/s12307-015-0167-9 · Cited by 74
Self-citation
Tumor-derived exosomes
Atay, S., & Godwin, A. (2014) · Communicative & Integrative Biology · doi:10.4161/cib.28231 · Cited by 74
Magnetic nanoparticle-based isolation of endocytic vesicles reveals a role of the heat shock protein GRP75 in macromolecular delivery
Wittrup, A., Zhang, S., Svensson, K. J., Kucharzewska, P., Johansson, M. C., Mörgelin, M., & Belting, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002622107 · Cited by 71
Co‐opting biology to deliver drugs
Yousefpour, P., & Chilkoti, A. (2014) · Biotechnology and Bioengineering · doi:10.1002/bit.25307 · Cited by 71
Role of TIM-4 in exosome-dependent entry of HIV-1 into human immune cells
Sims, B., Farrow, A. L., Williams, S. D., Bansal, A., Krendelchtchikov, A., Gu, L., & Matthews, Q. L. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s132762 · Cited by 70
Limited Transferrin Receptor Clustering Allows Rapid Diffusion of Canine Parvovirus into Clathrin Endocytic Structures
Cureton, D. K., Harbison, C. E., Cocucci, E., Parrish, C. R., & Kirchhausen, T. L. (2012) · Journal of Virology · doi:10.1128/jvi.07194-11 · Cited by 65
ScFv Antibody-induced Translocation of Cell-surface Heparan Sulfate Proteoglycan to Endocytic Vesicles
Wittrup, A., Zhang, S., ten Dam, G. B., Kuppevelt, T. H. V., Bengtson, P., Johansson, M. C., Welch, J. E., Mörgelin, M., & Belting, M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.036129 · Cited by 61
Outsmart tumor exosomes to steal the cancer initiating cell its niche
Thuma, F., & Zöller, M. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2014.02.011 · Cited by 59
Capture of cell-derived microvesicles (exosomes and apoptotic bodies) by human plasmacytoid dendritic cells
Bastos-Amador, P., Pérez‐Cabezas, B., Izquierdo‐Useros, N., Puertas, M. C., Martínez‐Picado, J., Pujol‐Borrell, R., Naranjo‐Gómez, M., & Borràs, F. E. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0111054 · Cited by 54
Proteomics Profiling of Exosomes from Primary Mouse Osteoblasts under Proliferation versus Mineralization Conditions and Characterization of Their Uptake into Prostate Cancer Cells
Bilen, M. A., Pan, T., Lee, Y.-C., Lin, S.-C., Yu, G., Pan, J., Hawke, D. H., Pan, B.-F., Vykoukal, J. V., Gray, K., et al. (2017) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6b00981 · Cited by 49
Exosome and microvesicle mediated phene transfer in mammalian cells
Christianson, H. C., Svensson, K. J., & Belting, M. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2014.04.007 · Cited by 47
Maturation-dependent apoptotic cell death of oligodendrocytes in myelin-deficient rats
Grinspan, J. B., Coulalaglou, M., Beesley, J., Carpio, D. F., & Scherer, S. S. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19981201)54:5 · Cited by 33
Heparan Sulfate Proteoglycans Promote Telomerase Internalization and MHC Class II Presentation on Dendritic Cells
Galaine, J., Kellermann, G., Guillaume, Y. C., Boidot, R., Picard, E., Loyon, R., Queiroz, L., Boullerot, L., Beziaud, L., Jary, M., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502633 · Cited by 25
Effect of space length of mannose ligand on uptake of mannosylated liposome in RAW 264.7 cells:In vitroandin vivostudies
Jeong, H.-S., Na, K. S., Hwang, H., Oh, P.-S., Kim, D. H., Lim, S. T., Sohn, M.-H., & Jeong, H.-J. (2014) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35112 · Cited by 21
Pancreatic cancer exosomes prime the liver for metastasis
Ray, K. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.93 · Cited by 20
FRET Based Quantification and Screening Technology Platform for the Interactions of Leukocyte Function-Associated Antigen-1 (LFA-1) with InterCellular Adhesion Molecule-1 (ICAM-1)
Chakraborty, S., Núñez-Jurado, D., Hu, S.-Y., Domingo, M. P., Pardo, J., Karmenyan, A., Gálvez, E. M., & Chiou, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102572 · Cited by 19
MUC1 Membrane Trafficking: Protocols for Assessing Biosynthetic Delivery, Endocytosis, Recycling, and Release Through Exosomes
Hanisch, F., Kinlough, C. L., Staubach, S., & Hughey, R. P. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-513-8_7 · Cited by 15
Preferences for uptake of carbohydrate-coated liposomes by C-type lectin receptors as antigen-uptake receptors
Kawauchi, Y., Kuroda, Y., & Kojima, N. (2012) · Glycoconjugate Journal · doi:10.1007/s10719-012-9406-1 · Cited by 15
Numb3 is an endocytosis adaptor for the inflammatory marker P-selectin
Schlüter, T., Knauth, P., Wald, S., Boland, S., & Bohnensack, R. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.12.166 · Cited by 9

Research works printed but not linked: 1

Jia, 2016, Exosomes, microvesicles, and head and neck cancers., Int J Clin Exp Med, 9, 15040

Sorted by citations

M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages
Gunassekaran, G. R., Vadevoo, S. M. P., Baek, M., & Lee, B.-H. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121137 · Cited by 490
A review of the regulatory mechanisms of extracellular vesicles-mediated intercellular communication
Liu, Y., & Wang, C. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01103-6 · Cited by 425
Cancer associated-fibroblast-derived exosomes in cancer progression
Li, C., Teixeira, A. F., Zhu, H., & ten Dijke, P. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01463-y · Cited by 352
Exosomes in Angiogenesis and Anti-angiogenic Therapy in Cancers
Olejarz, W., Kubiak-Tomaszewska, G., Chrzanowska, A., & Lorenc, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165840 · Cited by 299
Exosomes: a review of biologic function, diagnostic and targeted therapy applications, and clinical trials
Chen, Y., Luh, F., Ho, Y., & Yen, Y. (2024) · Journal of Biomedical Science · doi:10.1186/s12929-024-01055-0 · Cited by 280

See all 306

Authors: Gonda, A., Kabagwira, J., Senthil, G. N., & Wall, N. R.
Affiliations: Loma Linda University (US)
ORCID: Gonda, Amber
Wall, Nathan R.
Venue: Molecular Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2019-02-01
Volume: 17
Issue: 2
Pages: 337-347
ISSN: 1541-7786 (ISSN-L)
1557-3125
DOI: 10.1158/1541-7786.mcr-18-0891
OpenAlex: W2903083130
Cited by: 296
References: 148
Citations by year: 2026: 24 · 2025: 39 · 2024: 43 · 2023: 50 · 2022: 41 · 2021: 59 · 2020: 26 · 2019: 13
FWCI: 2.40
Type: journal article
Language: en
Open access: closed
Locations: Molecular Cancer Research (publishedVersion)
PubMed (publishedVersion)
Funders: Loma Linda University (LLU) (GCAT2016-2018)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: exosomes, receptor-mediated endocytosis, exosome uptake, tumor microenvironment, tumor-derived exosomes, oncoprotein, oncogenes, protein-protein interaction, cancer therapeutics, extracellular vesicles
MeSH terms: Endocytosis, Humans, Cell Line, Tumor, Exosomes, Tumor Microenvironment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Internalization of Exosomes through Receptor-Mediated Endocytosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks