Cited by 326Cancer, Lipids, and MetabolismPancreatic and Hepatic Oncology ResearchCancer, Hypoxia, and Metabolism

The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.

Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis

Open access

Carrer, Alessandro, Trefely, Sophie, Zhao, Steven, Campbell, Sydney L., Norgard, Robert J., Schultz, Kollin C., Sidoli, Simone, Parris, Joshua L.D., Affronti, Hayley C., Sivanand, Sharanya, Egolf, Shaun, Sela, Yogev, Trizzino, Marco, Gardini, Alessandro, Garcia, Benjamin A., Snyder, Nathaniel W., Stanger, Ben Z., Wellen, Kathryn E.·2019·Cancer Discovery

DOI 10.1158/2159-8290.cd-18-0567PMC PMC6643997

Published version of a preprint

Open this paper in CoChat — free account

Abstract

Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis, and new strategies for prevention and treatment are urgently needed. We previously reported that histone H4 acetylation is elevated in pancreatic acinar cells harboring Kras mutations prior to the appearance of premalignant lesions. Because acetyl-CoA abundance regulates global histone acetylation, we hypothesized that altered acetyl-CoA metabolism might contribute to metabolic or epigenetic alterations that promote tumorigenesis. We found that acetyl-CoA abundance is elevated in KRAS-mutant acinar cells and that its use in the mevalonate pathway supports acinar-to-ductal metaplasia (ADM). Pancreas-specific loss of the acetyl-CoA–producing enzyme ATP-citrate lyase (ACLY) accordingly suppresses ADM and tumor formation. In PDA cells, growth factors promote AKT–ACLY signaling and histone acetylation, and both cell proliferation and tumor growth can be suppressed by concurrent BET inhibition and statin treatment. Thus, KRAS-driven metabolic alterations promote acinar cell plasticity and tumor development, and targeting acetyl-CoA–dependent processes exerts anticancer effects. Significance: Pancreatic cancer is among the deadliest of human malignancies. We identify a key role for the metabolic enzyme ACLY, which produces acetyl-CoA, in pancreatic carcinogenesis. The data suggest that acetyl-CoA use for histone acetylation and in the mevalonate pathway facilitates cell plasticity and proliferation, suggesting potential to target these pathways. See related commentary by Halbrook et al., p. 326. This article is highlighted in the In This Issue feature, p. 305

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1158/2159-8290.cd-18-0567

Cites

76 of 76 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

SEER Cancer Statistics Review, 1975-2003
Ries, L. A. G., Harkins, D., Krapcho, M. F., Mariotto, A. B., Miller, B., Feuer, E. J., Clegg, L. X., Eisner, M. P., Horner, M., Howlader, N., et al. (2006) · Digital Archive @ GSU · Cited by 11,404
GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses
Tang, Z., Li, C., Kang, B., Gao, G., Li, C., & Zhang, Z. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx247 · Cited by 9,849
Super-enhancers in the control of cell identity and disease
Hnisz, D., Abraham, B. J., Lee, T. I., Lau, A., Saint-André, V., Sigova, A. A., Hoke, H. A., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.09.053 · Cited by 3,662 · cited 2×
“We also tested regulation of H3K27ac at the EGFR super-enhancer (35) using primers spanning the region (Supplementary Figure S6F).”
BackgroundMethod
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
Hingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.023 · Cited by 2,609
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471
ATP-citrate lyase links cellular metabolism to histone acetylation
Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298
Self-citation
EMT and Dissemination Precede Pancreatic Tumor Formation
Rhim, A. D., Mirek, E. T., Aiello, N. M., Maitra, A., Bailey, J. M., McAllister, F., Reichert, M., Beatty, G. L., Rustgi, A. K., Vonderheide, R. H., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.025 · Cited by 2,136
Self-citation
The mystery of membrane organization: composition, regulation and roles of lipid rafts
Sezgin, E., Levental, I., Mayor, S., & Eggeling, C. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.16 · Cited by 2,124
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
Ying, H., Kimmelman, A. C., Lyssiotis, C. A., Hua, S., Chu, G. C., Fletcher-Sananikone, E., Locasale, J. W., Son, J., Zhang, H., Coloff, J. L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.058 · Cited by 2,043
Acetyl-CoA and the regulation of metabolism: mechanisms and consequences
Shi, L., & Tu, B. P. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.02.003 · Cited by 903

Flagged first, then by citations

Show all 76 references

Research works printed but not linked: 1

Mazur, 2015, Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma, Nat Med, 21, 1163, 10.1038/nm.3952 · DOI

Sorted by citations

Items 101–200 of 326

Metabolic Fuel for Epigenetic: Nuclear Production Meets Local Consumption
Boon, R. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.768996 · Cited by 35
PRP19 Enhances Esophageal Squamous Cell Carcinoma Progression by Reprogramming SREBF1-Dependent Fatty Acid Metabolism
Zhang, G., Yu, X., Guo, H., Sun, J., Liu, Z., Zhu, J., Liu, T., Dong, L., Shen, X., & Yin, J. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-2156 · Cited by 30
Comprehensive analysis of bulk and single-cell transcriptomic data reveals a novel signature associated with endoplasmic reticulum stress, lipid metabolism, and liver metastasis in pancreatic cancer
Liu, X., Ren, B., Fang, Y., Ren, J., Wang, X., Gu, M., Zhou, F., Xiao, R., Luo, X., You, L., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05158-y · Cited by 29
Organic Selenium induces ferroptosis in pancreatic cancer cells
Noè, R., Inglese, N., Romani, P., Serafini, T., Paoli, C., Calciolari, B., Fantuz, M., Zamborlin, A., Surdo, N. C., Spada, V., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102962 · Cited by 30
Self-citation
Bridging epigenomics and tumor immunometabolism: molecular mechanisms and therapeutic implications
Xie, X., Liu, W. L., Yuan, Z., Chen, H.-Q., & Mao, W. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02269-y · Cited by 30
Epigenetic Targeting of Mcl-1 Is Synthetically Lethal with Bcl-xL/Bcl-2 Inhibition in Model Systems of Glioblastoma
Shang, E., Nguyen, T. T. T., Shu, C., Westhoff, M., Karpel‐Massler, G., & Siegelin, M. D. (2020) · Cancers · doi:10.3390/cancers12082137 · Cited by 29
Proteomic Identification of Small Extracellular Vesicle Proteins LAMB1 and Histone H4 for Prostate Cancer Diagnosis and Risk Stratification
Pang, B., Wang, Q., Chen, H., Liu, Z., Han, M., Gong, J., Yue, L., Ding, X., Wang, S., Yan, Z., et al. (2024) · Advanced Science · doi:10.1002/advs.202402509 · Cited by 28
Crosstalk between Epigenetics and Metabolic Reprogramming in Metabolic Dysfunction-Associated Steatotic Liver Disease-Induced Hepatocellular Carcinoma: A New Sight
Li, A., Wang, R., Zhao, Y. Q., Zhao, P., & Yang, J. (2024) · Metabolites · doi:10.3390/metabo14060325 · Cited by 29
BCAA metabolism in pancreatic cancer affects lipid balance by regulating fatty acid import into mitochondria
Gotvaldová, K., Špačková, J., Novotný, J., Baslarová, K., Ježek, P., Rossmeislová, L., Gojda, J., & Smolková, K. (2024) · Cancer & Metabolism · doi:10.1186/s40170-024-00335-5 · Cited by 27
Regulatory effects of statins on Akt signaling for prevention of cancers
Hosseini, F. S., Ahmadi, A., Kesharwani, P., Hosseini, H., & Sahebkar, A. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111213 · Cited by 28
HTR1D functions as a key target of HOXA10-AS/miR-340-3p axis to promote the malignant outcome of pancreatic cancer via PI3K-AKT signaling pathway
Wu, W., Li, Q., Zhu, Z., Li, C., Lu, P.-L., Zhou, X., Huang, Y., Liu, Y., Wang, M., & Gong, J. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.70546 · Cited by 28
Intracellular Citrate/acetyl-CoA flux and endoplasmic reticulum acetylation: Connectivity is the answer
Fernandez-Fuente, G., Rigby, M. J., & Puglielli, L. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101653 · Cited by 30
Crosstalk between metabolic remodeling and epigenetic reprogramming: A new perspective on pancreatic cancer
Ren, J., Ren, B., Liu, X., Cui, M., Fang, Y., Wang, X., Zhou, F., Gu, M., Xiao, R., Bai, J., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216649 · Cited by 30
Acetyl-CoA: an interplay between metabolism and epigenetics in cancer
Hao, Y., Yi, Q., XiaoWu, X., WeiBo, C., GuangChen, Z., & XueMin, C. (2022) · Frontiers in Molecular Medicine · doi:10.3389/fmmed.2022.1044585 · Cited by 26
Mitochondria: a new intervention target for tumor invasion and metastasis
Zhou, Q., Cao, T., Li, F., Zhang, M., Li, X., Zhao, H., & Zhou, Y. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00899-4 · Cited by 26
Metabolism and epigenetics: drivers of tumor cell plasticity and treatment outcomes
Gantner, B. N., Palma, F. R., Pandkar, M. R., Sakiyama, M. J., Arango, D., DeNicola, G. M., Gomes, A. P., & Bonini, M. G. (2024) · Trends in cancer · doi:10.1016/j.trecan.2024.08.005 · Cited by 29
Dealing with saturated and unsaturated fatty acid metabolism for anticancer therapy
Dierge, E., & Féron, O. (2019) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000601 · Cited by 25
Intermediary metabolism: An intricate network at the crossroads of cell fate and function
Ferreira, L. M. R., Li, A. M., Serafim, T. L., Sobral, M. C. M., Alpoim, M. C., & Urbano, A. M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165887 · Cited by 27
Mutant KRAS drives metabolic reprogramming and autophagic flux in premalignant pancreatic cells
Suzuki, T., Kishikawa, T., Sato, T., Takeda, N., Sugiura, Y., Seimiya, T., Sekiba, K., Ohno, M., Iwata, T., Ishibashi, R., et al. (2021) · Cancer Gene Therapy · doi:10.1038/s41417-021-00326-4 · Cited by 28
Cholesterol Metabolism in Pancreatic Cancer
Rebelo, A., Kleeff, J. H., & Sunami, Y. (2023) · Cancers · doi:10.3390/cancers15215177 · Cited by 26
Ductal metaplasia in pancreas
Li, S., & Xie, K. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188698 · Cited by 27
Detection, mechanisms, and therapeutic implications of oncometabolites
Cai, Y., Wang, Z., Guo, S., Lin, C., Yao, H., Yang, Q., Wang, Y., Yu, X., He, X., Sun, W., et al. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.08.018 · Cited by 25
Dendritic cells: understanding ontogeny, subsets, functions, and their clinical applications
Li, W., Yu, C., Zhang, X., Gu, Y., He, X., Xu, R., Xu, J. F., Yu, G., & Wu, Y. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00300-8 · Cited by 28
Intracellular metabolic profiling of drug resistant cells by surface enhanced Raman scattering
Liu, F., Wu, T., Tian, A., He, C., Bi, X., Lu, Y., Yang, K., Xia, W., & Ye, J. (2023) · Analytica Chimica Acta · doi:10.1016/j.aca.2023.341809 · Cited by 24
Optimal energy and redox metabolism in the cyanobacterium Synechocystis sp. PCC 6803
Kugler, A., & Stensjö, K. (2023) · npj Systems Biology and Applications · doi:10.1038/s41540-023-00307-3 · Cited by 27
KRASG12D-driven pentose phosphate pathway remodeling imparts a targetable vulnerability synergizing with MRTX1133 for durable remissions in PDAC
Jiang, X., Wang, T., Zhao, B. X., Sun, H., Dong, Y., Ma, Y., Li, Z., Wu, Y., Wang, K., Guan, X., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.101966 · Cited by 26
Role of Protein Kinase CK2 in Aberrant Lipid Metabolism in Cancer
Guerra, B., & Issinger, O. (2020) · Pharmaceuticals · doi:10.3390/ph13100292 · Cited by 25
Connections between metabolism and epigenetic modifications in cancer
Wang, G., & Han, J. J. (2021) · Medical Review · doi:10.1515/mr-2021-0015 · Cited by 27
Mitochondrial fragmentation in liver cancer: Emerging player and promising therapeutic opportunities
Wang, Q., Yu, P., Liu, C., He, X., & Wang, G. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215912 · Cited by 24
Metabolic reprogramming by histone deacetylase inhibition preferentially targets NRF2-activated tumors
Karagiannis, D., Wu, W., Li, A. M., Hayashi, M., Chen, X., Yip, M., Mangipudy, V. S., Xu, X., Rivera, F. J. S., Soto‐Feliciano, Y. M., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113629 · Cited by 26
Specific regulation of epigenome landscape by metabolic enzymes and metabolites
Yu, X., & Li, S. (2024) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.13049 · Cited by 24
Mammalian SIRT6 Represses Invasive Cancer Cell Phenotypes through ATP Citrate Lyase (ACLY)-Dependent Histone Acetylation
Zheng, W., Tasselli, L., Li, T., & Chua, K. F. (2021) · Genes · doi:10.3390/genes12091460 · Cited by 22
Global landscape of 2-hydroxyisobutyrylation in human pancreatic cancer
Lü, Y., Li, X., Zhao, K., Qiu, P., Deng, Z., Yao, W., & Wang, J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1001807 · Cited by 21
Cytoskeletal association of ATP citrate lyase controls the mechanodynamics of macropinocytosis
Puccini, J., Jia, W., Tong, L., & Bar‐Sagi, D. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2213272120 · Cited by 20
SREBP-Dependent Regulation of Lipid Homeostasis Is Required for Progression and Growth of Pancreatic Ductal Adenocarcinoma
Ishida, C. T., Myers, S. L., Shao, W., McGuire, M. R., Liu, C., Kubota, C. S., Ewachiw, T. E., Mukhopadhyay, D., Ke, S., Wang, H., et al. (2024) · Cancer Research Communications · doi:10.1158/2767-9764.crc-24-0120 · Cited by 19
Mechanisms governing lineage plasticity and metabolic reprogramming in cancer
Perez, L. M., Venugopal, S. V., Martin, A. S., Freedland, S. J., Vizio, D. D., & Freeman, M. R. (2024) · Trends in cancer · doi:10.1016/j.trecan.2024.08.001 · Cited by 19
Overcoming therapy resistance in pancreatic cancer: challenges and emerging strategies
du Toit‐Thompson, T., Leck, L. Y. W., Gillson, J., Pavlakis, N., Gill, A. J., Samra, J. S., Mittal, A., & Sahni, S. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115647 · Cited by 20
The biology of pancreatic cancer morphology
McDonald, O. G. (2021) · Pathology · doi:10.1016/j.pathol.2021.09.012 · Cited by 20
Renoprotective effects of empagliflozin in high-fat diet-induced obesity-related glomerulopathy by regulation of gut-kidney axis
Lei, L., Zhu, T., Cui, T.-J., Liu, Y., Hocher, J.-G., Chen, X., Zhang, X.-M., Cai, K., Deng, Z.-Y., Wang, X., et al. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00367.2024 · Cited by 18
Palmitic acid and palmitoylation in cancer: Understanding, insights, and challenges
Song, P., Jiang, Q., Wu, X., Bu, L., Xie, W., Wei, W., Xing, X., & Guo, J. (2025) · The Innovation · doi:10.1016/j.xinn.2025.100918 · Cited by 20
The role of glycometabolic plasticity in cancer
Peng, Y., Yang, H., & Li, S. (2021) · Pathology - Research and Practice · doi:10.1016/j.prp.2021.153595 · Cited by 17
The Metabolism of Coenzyme A and Its Derivatives Plays a Crucial Role in Diseases
Xie, J., Chen, X., Zheng, M., Zhu, J., & Mao, H. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2904143 · Cited by 18
A novel insight into cancer therapy: Lipid metabolism in tumor-associated macrophages
Ren, Y., Wang, M., Yuan, H., Wang, Z., & Yu, L. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112319 · Cited by 17
In vivo CRISPR screening identifies geranylgeranyl diphosphate as a pancreatic cancer tumor growth dependency
Kubota, C. S., Myers, S. L., Seppälä, T. T., Burkhart, R. A., & Espenshade, P. J. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.101964 · Cited by 17
Organotypic Culture of Acinar Cells for the Study of Pancreatic Cancer Initiation
Carrer, A., & Paoli, C. (2020) · Cancers · doi:10.3390/cancers12092606 · Cited by 16
Self-citation
Ubiquitous Aberration in Cholesterol Metabolism across Pancreatic Ductal Adenocarcinoma
Gunda, V., Genaro-Mattos, T. C., Kaushal, J., Chirravuri-Venkata, R., Natarajan, G., Mallya, K., Grandgenett, P. M., Mirnics, K., Batra, S. K., Korade, Ž., et al. (2022) · Metabolites · doi:10.3390/metabo12010047 · Cited by 17
Cancer Cell Line Classification Using Raman Spectroscopy of Cancer-Derived Exosomes and Machine Learning
Villazon, J. I., Cruz, N. D., & Shi, L. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.4c06966 · Cited by 17
Statins and the risk of pancreatic cancer: A systematic review and meta-analysis of 2,797,186 patients
Karbowska, E., Świeczkowski, D., Gąsecka, A., Pruc, M., Safiejko, K., Ładny, J. R., Kopiec, T., Jaguszewski, M. J., Filipiak, K. J., Rafique, Z., et al. (2022) · Cardiology Journal · doi:10.5603/cj.a2022.0014 · Cited by 16
Neutrophil extracellular traps in rheumatoid arthritis: Activating fibroblast-like synoviocytes via ATP citrate lyase
Li, J., Wang, X., Tan, M., Zheng, J., Mao, J., Hao, J., & Shen, H. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113518 · Cited by 16
Decoding the obesity–cancer connection: lessons from preclinical models of pancreatic adenocarcinoma
Ruiz, C. F., Garcia, C. C., Jacox, J. B., Lawres, L., & Muzumdar, M. D. (2023) · Life Science Alliance · doi:10.26508/lsa.202302228 · Cited by 17
Lipid Metabolic Alterations in KRAS Mutant Tumors: Unmasking New Vulnerabilities for Cancer Therapy
Saliakoura, M., & Konstantinidou, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021793 · Cited by 15
Proteomics in pancreatic cancer
Cai, F., Gu, Y., Ling, Y., Yi, G., Zang, S., Su, T., Liu, Y., Li, A., Wang, D., Zhao, W., et al. (2025) · Biomarker Research · doi:10.1186/s40364-025-00805-y · Cited by 19
Regulation of metabolism in pancreatic ductal adenocarcinoma via nanotechnology-enabled strategies
Wang, Z., Wu, B., Nie, G., Wei, J., & Li, Y. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216138 · Cited by 15
PTGES Expression Is Associated with Metabolic and Immune Reprogramming in Pancreatic Ductal Adenocarcinoma
Murthy, D., & Attri, K. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087304 · Cited by 14
Cholesterol metabolism in pancreatic cancer and associated therapeutic strategies
Daya, T., Breytenbach, A., Gu, L., & Kaur, M. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2024.159578 · Cited by 15
Multiple roles of branched-chain amino acid metabolism in tumour progression
Wang, L., Shi, F., Cao, Y., & Xie, L. (2025) · Journal of Biomedical Science · doi:10.1186/s12929-025-01132-y · Cited by 13
Overcoming the limitations of immunotherapy in pancreatic ductal adenocarcinoma: Combining radiotherapy and metabolic targeting therapy
Zhang, H., Xu, W., Zhu, H., Chen, X., & Tsai, H. (2024) · Journal of Cancer · doi:10.7150/jca.92502 · Cited by 13
Advancements in the study of glucose metabolism in relation to tumor progression and treatment
Zhao, M., Chen, Y., & Yang, L. (2024) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2024.08.001 · Cited by 13
The converging roles of microRNAs and lipid metabolism in atherosclerotic cardiovascular disease and cancer
Vladimirov, S. S., Tomasevic, M., Popov, N., Munjas, J., de Gonzalo‐Calvo, D., & Sopić, M. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.06.005 · Cited by 14
Current clinical trials for epigenetic targets and therapeutic inhibitors for pancreatic cancer therapy
Ganji, C., & Farran, B. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.12.013 · Cited by 13
AaTAS1 and AaMFS1 Genes for Biosynthesis or Efflux Transport of Tenuazonic Acid and Pathogenicity of Alternaria alternata
Sun, F., Cao, X., Yu, D., Hu, D., Yan, Z., Fan, Y., Wang, C., & Wu, A. (2022) · Molecular Plant-Microbe Interactions · doi:10.1094/mpmi-12-21-0300-r · Cited by 13
The critical function of metabolic reprogramming in cancer metastasis
Xie, S., Pan, J., Xu, J., Zhu, W., & Qin, L. (2022) · Aging and Cancer · doi:10.1002/aac2.12044 · Cited by 13
Inhibiting glutamine utilization creates a synthetic lethality for suppression of ATP citrate lyase in KRas-driven cancer cells
Hatipoglu, A., Menon, D., Levy, T., Frías, M. A., & Foster, D. A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0276579 · Cited by 13
A Histone Deacetylase Inhibitor Induces Acetyl-CoA Depletion Leading to Lethal Metabolic Stress in RAS-Pathway Activated Cells
Basseville, A., Violet, P.-C., Safari, M., Sourbier, C., Linehan, W. M., Robey, R. W., Levine, M., Sackett, D. L., & Bates, S. E. (2022) · Cancers · doi:10.3390/cancers14112643 · Cited by 12
The small extracellular vesicle‐mediated intercellular transformation of CXCR1Low to CXCR1High tumour cells promotes the progression of head and neck squamous cell carcinoma
Xu, Q., Cheng, A., Li, B., Tian, X., Han, Z., & Feng, Z. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12427 · Cited by 11
Preclinical efficacy of CBR-5884 against epithelial ovarian cancer cells by targeting the serine synthesis pathway
Gong, K., Huang, Y., Zheng, Y., Zhu, Y., Hao, W., & Shi, K. (2024) · Discover Oncology · doi:10.1007/s12672-024-01013-0 · Cited by 12
A feedforward loop between ACLY and MYC supports T-ALL progression in vivo
da Silva-Diz, V., Singh, A., Aleksandrova, M., Kim, O., Thai, C., Lancho, O., Nunes, P. R., Affronti, H. C., de Paz, A. M., Josefowicz, S. Z., et al. (2025) · Blood Neoplasia · doi:10.1016/j.bneo.2025.100069 · Cited by 12
Self-citation
The Mutual Inhibition of FoxO1 and SREBP‐1c Regulated the Progression of Hepatoblastoma by Regulating Fatty Acid Metabolism
Hu, Y., Zai, H., Jiang, W. H., Ou, Z., Yao, Y., & Zhu, Q. (2021) · Mediators of Inflammation · doi:10.1155/2021/5754592 · Cited by 12
Non-Coding and Regulatory RNAs as Epigenetic Remodelers of Fatty Acid Homeostasis in Cancer
Cruz-Gil, S., Fernández, L. P., Sánchez‐Martínez, R., de Cedrón, M. G., & de Molina, A. R. (2020) · Cancers · doi:10.3390/cancers12102890 · Cited by 12
Oxidative phosphorylation at the crossroads of cancer: Metabolic orchestration, stromal collusion, and emerging therapeutic horizons
Chen, K., Wang, W., Shu, H.-Y., Lyu, J., Cui, W., & Fang, H. (2025) · Interdisciplinary medicine · doi:10.1002/inmd.70054 · Cited by 11
Biomarkers for Immunotherapy in Driver-Gene-Negative Advanced NSCLC
Huang, Y., Chau, Y. F., Bai, H., Wu, X., & Duan, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914521 · Cited by 10
ACLY promotes gastric tumorigenesis and accelerates peritoneal metastasis of gastric cancer regulated by HIF-1A
Yan, Z., Liu, K., Xu, P., Chen, Z., Zhang, P., Pei, S., Cheng, Q., Huang, S., Li, B., Lv, J., et al. (2023) · Cell Cycle · doi:10.1080/15384101.2023.2286805 · Cited by 11
Effect of SNORD113-3/ADAR2 on glycolipid metabolism in glioblastoma via A-to-I editing of PHKA2
Cui, Z., Liu, X., Tiange, E., Lin, H., Wang, D., Liu, Y., Ruan, X., Wang, P., Liu, L., & Xue, Y. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00680-9 · Cited by 11
High‐Throughput Single‐Cell Mass Spectrometry Reveals Abnormal Lipid Metabolism in Pancreatic Ductal Adenocarcinoma
Liu, Q., Ge, W., Wang, T., Lan, J., Martínez‐Jarquín, S., Wolfrum, C., Stoffel, M., & Zenobi, R. (2021) · Angewandte Chemie · doi:10.1002/ange.202107223 · Cited by 11
Epigenetic regulation of mRNA mediates the phenotypic plasticity of cancer cells during metastasis and therapeutic resistance (Review)
Zhang, C., Liang, S., Zhang, H., Wang, R., & Qiao, H. (2023) · Oncology Reports · doi:10.3892/or.2023.8687 · Cited by 12
The Crucial Roles of Intermediate Metabolites in Cancer
Huang, S., Wang, Z., & Zhao, L. (2021) · Cancer Management and Research · doi:10.2147/cmar.s321433 · Cited by 11
SOX2 drives esophageal squamous carcinoma by reprogramming lipid metabolism and histone acetylation landscape
Wang, Z., Dai, R., Li, K., Yang, H., Chen, Z., He, J., Shu, L., Zhong, Y., Zhang, Y., Hua, Z., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63591-z · Cited by 10
Plasticity and Tumor Microenvironment in Pancreatic Cancer: Genetic, Metabolic, and Immune Perspectives
Hashimoto, A., & Hashimoto, S. (2024) · Cancers · doi:10.3390/cancers16234094 · Cited by 11
Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis
Nguyen, P. T., Shiue, M., Kuprasertkul, N., Costa‐Pinheiro, P., Izzo, L., Pinheiro, L. V., Affronti, H. C., Gugiu, G. B., Ghaisas, S., Liu, J. Y., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115284 · Cited by 12
Self-citation
Myeloid-Specific Acly Deletion Alters Macrophage Phenotype In Vitro and In Vivo without Affecting Tumor Growth
de Goede, K. E., Verberk, S. G. S., Baardman, J., Harber, K. J., van Kooyk, Y., de Winther, M. P. J., Schetters, S. T. T., & den Bossche, J. V. (2021) · Cancers · doi:10.3390/cancers13123054 · Cited by 10
The Role of Kallikrein 7 in Tumorigenesis
Xiang, F., Wang, Y., Cao, C., Li, Q., Deng, H., Zheng, J., Liu, X., & Tan, X. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210915104537 · Cited by 10
Circulating Fatty Acid Profile as a Biomarker for Immunotherapy in Advanced Non-Small Cell Lung Cancer
Galli, G., Corsetto, P. A., Proto, C., Russo, G. L., Ganzinelli, M., Rulli, E., Legramandi, L., Morelli, D., Ferrara, R., Prelaj, A., et al. (2022) · Clinical Lung Cancer · doi:10.1016/j.cllc.2022.07.010 · Cited by 10
An extensive bioinformatics study on the role of mitochondrial solute carrier family 25 in PC and its mechanism behind affecting immune infiltration and tumor energy metabolism
Zhang, Q., Tang, Y., Sun, S., Xie, Q., Yao, J. J., Wang, X., Qian, J., & Li, Z. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03756-2 · Cited by 10
The KRAS-BCAA-BCAT2 axis in PDAC development
Falcone, M., & Maddocks, O. D. K. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0467-2 · Cited by 11
Statin as a therapeutic agent in gastroenterological cancer
Uemura, N., Hayashi, H., & Baba, H. (2022) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v14.i1.110 · Cited by 11
Epigenetic reprogramming in pancreatic premalignancy and clinical implications
Zhang, W., Jiang, T., & Xie, K. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1024151 · Cited by 9
Microbiota-metabolism-epigenetics-immunity axis in cancer
Ren, B., Fang, Y., Gu, M., You, L., Zhang, T., & Zhao, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1449912 · Cited by 9
GLP-1 signaling in tumor metabolism and immunity: mechanisms and strategies
Luo, Y., Xu, H., Zhao, Y., Yang, B., & Zhang, Y. (2025) · Food & Function · doi:10.1039/d5fo03273c · Cited by 9
Metabolic plasticity in pancreatic ductal adenocarcinoma progression and response to treatment
Ma, J., Bhardwaj, V., Lobie, P. E., & Pandey, V. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02620-x · Cited by 10
OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma
Nguyen, T. T. T., Torrini, C., Shang, E., Shu, C., Mun, J.-Y., Gao, Q., Humala, N., Akman, H. O., Zhang, G., Westhoff, M., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.172565 · Cited by 9
Comparison of Transcriptomic Profiles of MiaPaCa-2 Pancreatic Cancer Cells Treated with Different Statins
Rimpelová, S., Kolář, M., Strnad, H., Ruml, T., Vítek, L., & Gbelcová, H. (2021) · Molecules · doi:10.3390/molecules26123528 · Cited by 8
Clinical significance of pancreatic ductal metaplasia
Jiang, T., Fang, W., & Xie, K. (2022) · The Journal of Pathology · doi:10.1002/path.5883 · Cited by 8
Review of the endocrine organ–like tumor hypothesis of cancer cachexia in pancreatic ductal adenocarcinoma
Yu, Y., Ahmed, A., Lai, H., Cheng, W., Yang, J.-C., Chang, W., Chen, L., Shan, Y., & Ma, W. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1057930 · Cited by 9
Biliary Tract Carcinogenesis Model Based on Bile Metaproteomics
Arteta, A. A., Sánchez‐Jiménez, M. M., Dávila, D. F., Palacios, O. G., & Cardona-Castro, N. M. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01032 · Cited by 8
Cholesterol Activates Cyclic AMP Signaling in Metaplastic Acinar Cells
Grisan, F., Spacci, M., Paoli, C., Costamagna, A., Fantuz, M., Martini, M., Lefkimmiatis, K., & Carrer, A. (2021) · Metabolites · doi:10.3390/metabo11030141 · Cited by 8
Self-citation
Docking Protein p130Cas Regulates Acinar to Ductal Metaplasia During Pancreatic Adenocarcinoma Development and Pancreatitis
Costamagna, A., Natalini, D., Leal, M. D. P. C., Simoni, M., Gozzelino, L., Cappello, P., Novelli, F., Ambrogio, C., Defilippi, P., Turco, E., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.12.242 · Cited by 8
Targeted single‐cell RNA sequencing analysis reveals metabolic reprogramming and the ferroptosis‐resistant state in hematologic malignancies
Shen, X., Dong, P., Kong, J., Sun, N., Wang, F., Sang, L., Xu, Y., Zhang, M., Chen, X., Guo, R., et al. (2023) · Cell Biochemistry and Function · doi:10.1002/cbf.3869 · Cited by 9
Epigenetic roles of lysine-specific demethylase 1 (LSD1) in cancer metabolism
Cheng, B., Xu, X., Fan, B., Ma, T., & Yu, B. (2025) · Drug Discovery Today · doi:10.1016/j.drudis.2025.104397 · Cited by 7
Mitochondria-centric lipid metabolism and inter-organelle crosstalk in pancreatic Cancer: Unveiling novel therapies
Wang, R., Gao, C., Fan, Z., Qin, Q., & Zhan, H. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217965 · Cited by 7
Construction of a Cuproptosis-Related Gene Signature for Predicting Prognosis in Gastric Cancer
Hu, Y., Du, Y., Qiu, Z., Bai, P., Bai, Z., Zhu, C., Wang, J., Liang, T., & Da, M. (2023) · Biochemical Genetics · doi:10.1007/s10528-023-10406-9 · Cited by 7

Authors: Carrer, A., Trefely, S., Zhao, S., Campbell, S. L., Norgard, R. J., Schultz, K. C., Sidoli, S., Parris, J. L. D., Affronti, H. C., Sivanand, S., Egolf, S., Sela, Y., Trizzino, M., Gardini, A., Garcia, B. A., Snyder, N. W., Stanger, B. Z., & Wellen, K. E.
Affiliations: University of Pennsylvania (US)
Drexel University (US)
The Wistar Institute (US)
Corresponding author: Wellen, Kathryn E.
ORCID: Carrer, Alessandro
Trefely, Sophie
Zhao, Steven
Campbell, Sydney L.
Norgard, Robert J.
Schultz, Kollin C.
Sidoli, Simone
Parris, Joshua L.D.
Affronti, Hayley C.
Sivanand, Sharanya
Egolf, Shaun
Trizzino, Marco
Gardini, Alessandro
Garcia, Benjamin A.
Snyder, Nathaniel W.
Stanger, Ben Z.
Wellen, Kathryn E.
Venue: Cancer Discovery
Publisher: American Association for Cancer Research (AACR)
Published: 2019-03-01
Volume: 9
Issue: 3
Pages: 416-435
ISSN: 2159-8274 (ISSN-L)
2159-8290
DOI: 10.1158/2159-8290.cd-18-0567
PMC: PMC6643997
OpenAlex: W2911157836
Cited by: 313
References: 76
Citations by year: 2026: 23 · 2025: 49 · 2024: 62 · 2023: 47 · 2022: 44 · 2021: 42 · 2020: 31 · 2019: 15
FWCI: 10.44
Type: journal article
Language: en
Update notices: correction (2024-09-04)
Open access: green
www.ncbi.nlm.nih.gov
Locations: Cancer Discovery (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Padua Research Archive (University of Padova) (submittedVersion)
Funders: Pancreatic Cancer Action Network (14-20-25-WELL)
NIH (R01CA174761, R01CA228339, R03HD092630, GM110174, AI118891, CA196539, 1F31CA217070-01, F99CA222741, 4K00CA212455-03)
American Diabetes Association (#1-18-PDF-144)
UPenn Baccalaureate Research Education (R25-GM071745)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords: acetyl-CoA metabolism, pancreatic ductal adenocarcinoma, pancreatic carcinogenesis, ATP citrate lyase, histone H4 acetylation, acinar-to-ductal metaplasia, KRAS mutation, mevalonate pathway, Akt signaling, BET inhibition, statins, cellular plasticity, epigenetic regulation, pancreatic acinar cells
MeSH terms: Acetyl Coenzyme A, Acetylation, Animals, Female, Histones, Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Pancreatic Neoplasms, Protein Processing, Post-Translational, Genes, ras, Signal Transduction, Mice, Knockout, Carcinoma, Pancreatic Ductal, Cell Proliferation, Acinar Cells, Carcinogenesis, Heterografts

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks