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Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis
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Abstract
Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis, and new strategies for prevention and treatment are urgently needed. We previously reported that histone H4 acetylation is elevated in pancreatic acinar cells harboring Kras mutations prior to the appearance of premalignant lesions. Because acetyl-CoA abundance regulates global histone acetylation, we hypothesized that altered acetyl-CoA metabolism might contribute to metabolic or epigenetic alterations that promote tumorigenesis. We found that acetyl-CoA abundance is elevated in KRAS-mutant acinar cells and that its use in the mevalonate pathway supports acinar-to-ductal metaplasia (ADM). Pancreas-specific loss of the acetyl-CoA–producing enzyme ATP-citrate lyase (ACLY) accordingly suppresses ADM and tumor formation. In PDA cells, growth factors promote AKT–ACLY signaling and histone acetylation, and both cell proliferation and tumor growth can be suppressed by concurrent BET inhibition and statin treatment. Thus, KRAS-driven metabolic alterations promote acinar cell plasticity and tumor development, and targeting acetyl-CoA–dependent processes exerts anticancer effects. Significance: Pancreatic cancer is among the deadliest of human malignancies. We identify a key role for the metabolic enzyme ACLY, which produces acetyl-CoA, in pancreatic carcinogenesis. The data suggest that acetyl-CoA use for histone acetylation and in the mevalonate pathway facilitates cell plasticity and proliferation, suggesting potential to target these pathways. See related commentary by Halbrook et al., p. 326. This article is highlighted in the In This Issue feature, p. 305
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“Oncogenic KRas increases the levels of acetyl coenzyme A (CoA) and reactive oxygen species (ROS) before the development of ADM, and inhibiting these phenotypes blocks ADM (19, 20).”
From Metabolic reprogramming and cancer progression (2020) · cites this paper as [20]
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SEER Cancer Statistics Review, 1975-2003
Ries, L. A. G., Harkins, D., Krapcho, M. F., Mariotto, A. B., Miller, B., Feuer, E. J., Clegg, L. X., Eisner, M. P., Horner, M., Howlader, N., et al. (2006) · Digital Archive @ GSU · Cited by 11,404
GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses
Tang, Z., Li, C., Kang, B., Gao, G., Li, C., & Zhang, Z. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx247 · Cited by 9,849
Super-enhancers in the control of cell identity and disease
Hnisz, D., Abraham, B. J., Lee, T. I., Lau, A., Saint-André, V., Sigova, A. A., Hoke, H. A., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.09.053 · Cited by 3,662 · cited 2×
“We also tested regulation of H3K27ac at the EGFR super-enhancer (35) using primers spanning the region (Supplementary Figure S6F).”
BackgroundMethodHingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.023 · Cited by 2,609
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471
ATP-citrate lyase links cellular metabolism to histone acetylation
Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298
Self-citationEMT and Dissemination Precede Pancreatic Tumor Formation
Rhim, A. D., Mirek, E. T., Aiello, N. M., Maitra, A., Bailey, J. M., McAllister, F., Reichert, M., Beatty, G. L., Rustgi, A. K., Vonderheide, R. H., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.025 · Cited by 2,136
Self-citationThe mystery of membrane organization: composition, regulation and roles of lipid rafts
Sezgin, E., Levental, I., Mayor, S., & Eggeling, C. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.16 · Cited by 2,124
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
Ying, H., Kimmelman, A. C., Lyssiotis, C. A., Hua, S., Chu, G. C., Fletcher-Sananikone, E., Locasale, J. W., Son, J., Zhang, H., Coloff, J. L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.058 · Cited by 2,043
Acetyl-CoA and the regulation of metabolism: mechanisms and consequences
Shi, L., & Tu, B. P. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.02.003 · Cited by 903
Hedgehog signalling in cancer formation and maintenance
di Magliano, M. P., & Hebrok, M. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1229 · Cited by 830
Schug, Z. T., Peck, B., Jones, D. T., Zhang, Q., Grosskurth, S., Alam, I. S., Goodwin, L. M., Smethurst, E., Mason, S., Blyth, K., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.12.002 · Cited by 820
Acetate is a bioenergetic substrate for human glioblastoma and brain metastases
Mashimo, T., Pichumani, K., Vemireddy, V., Hatanpaa, K. J., Singh, D. K., Sirasanagandla, S., Nannepaga, S., Piccirillo, S. G., Kovacs, Z., Foong, C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.025 · Cited by 760
Li, J., Byrne, K. T., Yan, F., Yamazoe, T., Chen, Z., Baslan, T., Richman, L. P., Lin, J., Sun, Y. H., Rech, A. J., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.06.006 · Cited by 746
Self-citationThe interplay between cell signalling and the mevalonate pathway in cancer
Mullen, P., Yu, R., Longo, J., Archer, M. C., & Penn, L. Z. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.76 · Cited by 714
Comerford, S. A., Huang, Z., Du, X., Wang, Y., Cai, L., Witkiewicz, A. K., Walters, H., Tantawy, M. N., Fu, A., Manning, H. C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.020 · Cited by 681
Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis
Miyamoto, Y., Maitra, A., Ghosh, B., Zechner, U., Argani, P., Iacobuzio-Donahue, C. A., Sriuranpong, V., Iso, T., Meszoely, I. M., Wolfe, M. S., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00140-5 · Cited by 643
Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras -driven cancers
Mayers, J. R., Torrence, M. E., Danai, L. V., Papagiannakopoulos, T., Davidson, S. M., Bauer, M. R., Lau, A. N., Ji, B. W., Dixit, P. D., Hosios, A. M., et al. (2016) · Science · doi:10.1126/science.aaf5171 · Cited by 582
Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation
Lee, J. V., Carrer, A., Shah, S., Snyder, N. W., Wei, S., Venneti, S., Worth, A. J., Yuan, Z.-F., Lim, H.-W., Liu, S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.004 · Cited by 563
Self-citationQuantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids
Neinast, M. D., Jang, C., Hui, S. T., Murashige, D., Chu, Q., Morscher, R. J., Li, X., Zhan, L., White, E., Anthony, T. G., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.10.013 · Cited by 522
McDonald, O. G., Li, X., Saunders, T., Tryggvadottir, R., Mentch, S. J., Warmoes, M. O., Word, A. E., Carrer, A., Salz, T. H., Natsume, S., et al. (2017) · Nature Genetics · doi:10.1038/ng.3753 · Cited by 494
Self-citationWeakly supervised learning of biomedical information extraction from curated data
Jain, S., Kashyap, R., Kuo, T.-T., Bhargava, S., Lin, G., & Hsu, C. (2016) · BMC Bioinformatics · doi:10.1186/s12859-015-0844-1 · Cited by 454
BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression
Zhu, H., Bengsch, F., Svoronos, N., Rutkowski, M. R., Bitler, B. G., Allegrezza, M. J., Yokoyama, Y., Kossenkov, A. V., Bradner, J. E., Conejo-Garcia, J. R., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.032 · Cited by 437
Mazur, P. K., Herner, A., Mello, S. S., Wirth, M., Hausmann, S., Rivera, F. J. S., Lofgren, S., Kuschma, T., Hahn, S. A., Vangala, D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3952 · Cited by 413
Guillaumond, F., Leca, J., Olivares, O., Lavaut, M.-N., Vidal, N., Berthezène, P., Dusetti, N. J., Loncle, C., Calvo, E., Turrini, O., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219555110 · Cited by 413
Hruban, R., Adsay, N., Albores-saavedra, J., Anver, M., Biankin, A., Boivin, G. P., Furth, E., Furukawa, T., Klein, A., Klimstra, D., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2168 · Cited by 411
Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer
Halbrook, C. J., & Lyssiotis, C. A. (2017) · Cancer Cell · doi:10.1016/j.ccell.2016.12.006 · Cited by 403
Acinar cell plasticity and development of pancreatic ductal adenocarcinoma
Störz, P. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.12 · Cited by 401
ATP-citrate lyase controls a glucose-to-acetate metabolic switch
Zhao, S., Torres, A., Henry, R. A., Trefely, S., Wallace, M., Lee, J. V., Carrer, A., Sengupta, A., Campbell, S. L., Kuo, Y.-M., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.069 · Cited by 394
Self-citationSpatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation
Sivanand, S., Viney, I. A., & Wellen, K. E. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2017.11.004 · Cited by 374
Self-citationOncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation
Tape, C. J., Ling, S., Dimitriadi, M., McMahon, K. M., Worboys, J. D., Leong, H. S., Norrie, I. C., Miller, C. J., Poulogiannis, G., Lauffenburger, D. A., et al. (2016) · Cell · doi:10.1016/j.cell.2016.03.029 · Cited by 369
Eser, S., Reiff, N., Messer, M., Seidler, B., Gottschalk, K., Dobler, M., Hieber, M., Arbeiter, A., Klein, S., Kong, B., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.01.023 · Cited by 360
Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis
Wang, B., Rong, X., Palladino, E. N. D., Wang, J., Fogelman, A. M., Martı́n, M. G., Alrefai, W. A., Ford, D. A., & Tontonoz, P. (2018) · Cell stem cell · doi:10.1016/j.stem.2017.12.017 · Cited by 316
Bailey, J. M., Alsina, J., Rasheed, Z. A., McAllister, F. M., Fu, Y., Plentz, R. R., Zhang, H., Pasricha, P. J., Bardeesy, N. M., Matsui, W. H., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.09.050 · Cited by 315
Hedgehog/Ras interactions regulate early stages of pancreatic cancerPreprint
di Magliano, M. P., Sekine, S., Ermilov, A. N., Ferris, J., Dlugosz, A. A., & Hebrok, M. (2006) · Genes & Development · doi:10.1101/gad.1470806 · Cited by 302
Pten constrains centroacinar cell expansion and malignant transformation in the pancreas
Stanger, B. Z., Stiles, B. L., Lauwers, G. Y., Bardeesy, N. M., Mendoza, M. J., Wang, Y., Greenwood, A. L., Cheng, K., McLaughlin, M. M., Brown, D., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.07.015 · Cited by 301
Self-citationLiou, G.-Y., Döppler, H., DelGiorno, K. E., Zhang, L., Leitges, M., Crawford, H. C., Murphy, M. P., & Storz, P. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.029 · Cited by 270
The Genotype-Tissue Expression (GTEx) project
Lonsdale, J., Thomas, J., Salvatore, M., Phillips, R., Lo, E., Shad, S., Hasz, R., Walters, G., Garcia, F., Young, N., et al. (2013) · Nature Genetics · doi:10.1038/ng.2653 · Cited by 263
The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery
Xia, Y., Xie, Y., Yu, Z., Xiao, H., Jiang, G., Zhou, X., Yang, Y., Li, X., Zhao, M., Li, L., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.070 · Cited by 259
Targeting tumor cell metabolism with statins
Clendening, J. W., & Penn, L. Z. (2012) · Oncogene · doi:10.1038/onc.2012.6 · Cited by 247
Ying, H., Elpek, K. G., Vinjamoori, A., Zimmerman, S. M., Chu, G. C., Yan, H., Fletcher-Sananikone, E., Zhang, H., Liu, Y., Wang, W., et al. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0031 · Cited by 223
BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models
Kagoya, Y., Nakatsugawa, M., Yamashita, Y., Ochi, T., Guo, T., Anczurowski, M., Saso, K., Butler, M. O., Arrowsmith, C. H., & Hirano, N. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86437 · Cited by 218
Hedgehog Signaling Is Required for Effective Regeneration of Exocrine Pancreas
Fendrich, V., Esni, F., Garay, M. V. R., Feldmann, G., Habbe, N., Jensen, J. N., Dor, Y., Stoffers, D., Jensen, J., Leach, S. D., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.011 · Cited by 191
von Figura, G., Fukuda, A., Roy, N., Liku, M. E., Morris IV, J. P., Kim, G. E., Russ, H. A., Firpo, M. A., Mulvihill, S. J., Dawson, D. W., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb2916 · Cited by 190
Impact of a High-fat Diet on Tissue Acyl-CoA and Histone Acetylation Levels
Carrer, A., Parris, J. L. D., Trefely, S., Henry, R. A., Montgomery, D. C., Torres, A., Viola, J. M., Kuo, Y., Blair, I. A., Meier, J. L., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.750620 · Cited by 162
Self-citationRoy, N., Malik, S., Villanueva, K. E., Urano, A., Lu, X., Von Figura, G., Seeley, E. S., Dawson, D. W., Collisson, E. A., & Hebrok, M. (2015) · Genes & Development · doi:10.1101/gad.256628.114 · Cited by 155
Stromal cues regulate the pancreatic cancer epigenome and metabolome
Sherman, M. H., Yu, R. T., Tseng, T. W., Sousa, C. M., Liu, S., Truitt, M. L., He, N., Ding, N., Liddle, C., Atkins, A. R., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620164114 · Cited by 147
Houbracken, I., Waele, E. D., Lardon, J., Ling, Z., Heimberg, H., Rooman, I., & Bouwens, L. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.050 · Cited by 143
Garcia, P. L., Miller, A. L., Kreitzburg, K. M., Gamblin, T. L., Christein, J. D., Heslin, M. J., Arnoletti, J. P., Richardson, J. H., Chen, D., Hanna, C. A., et al. (2015) · Oncogene · doi:10.1038/onc.2015.126 · Cited by 141
PI3K Regulation of RAC1 Is Required for KRAS-Induced Pancreatic Tumorigenesis in Mice
Wu, C.-Y. C., Carpenter, E. S., Takeuchi, K. K., Halbrook, C. J., Peverley, L. V., Bien, H., Hall, J. C., DelGiorno, K. E., Pal, D., Song, Y., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.08.032 · Cited by 135
Baer, R., Cintas, C., Dufresne, M., Cassant-Sourdy, S., Schönhuber, N., Planque, L., Lulka, H., Couderc, B., Bousquet, C., Garmy-Susini, B., et al. (2014) · Genes & Development · doi:10.1101/gad.249409.114 · Cited by 129
Identification and Manipulation of Biliary Metaplasia in Pancreatic Tumors
DelGiorno, K. E., Hall, J. C., Takeuchi, K. K., Pan, F. C., Halbrook, C., Washington, M., Olive, K., Spence, J., Sipos, B., Wright, C., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.053 · Cited by 122
Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca 2+ –NFAT signalingPreprint
Lee, J. V., Berry, C. T., Kim, K., Sen, P., Kim, T., Carrer, A., Trefely, S., Zhao, S., Fernandez, S., Barney, L. E., et al. (2018) · Genes & Development · doi:10.1101/gad.311027.117 · Cited by 121
Self-citationMetabolism and epigenetics: a link cancer cells exploit
Carrer, A., & Wellen, K. E. (2014) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.11.012 · Cited by 110
Self-citationYuan, Z., Lin, S., Molden, R. C., Cao, X.-J., Bhanu, N. V., Wang, X., Sidoli, S., Liu, S., & Garcia, B. A. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.046011 · Cited by 108
Self-citationChen, N., Singh, G., König, A. O., Liou, G., Störz, P., Zhang, J., Regul, L., Nagarajan, S., Kühnemuth, B., Johnsen, S. A., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.01.033 · Cited by 102
FluxFix: automatic isotopologue normalization for metabolic tracer analysis
Trefely, S., Ashwell, P., & Snyder, N. W. (2016) · BMC Bioinformatics · doi:10.1186/s12859-016-1360-7 · Cited by 102
Self-citationFrey, A. J., Feldman, D. R., Trefely, S., Worth, A. J., Basu, S. S., & Snyder, N. W. (2016) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-9448-5 · Cited by 85
Self-citationSukhanova, A. L., Gorin, A. A., Serebriiskii, I. G., Gabitova, L., Zheng, H., Restifo, D., Egleston, B. L., Cunningham, D., Bagnyukova, T., Liu, H., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0031 · Cited by 77
Dangi-Garimella, S. Y., Sahai, V., Ebine, K., Kumar, K., & Munshi, H. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064566 · Cited by 75
Mohammed, A., Li, Q., Janakiram, N. B., Lightfoot, S. A., Steele, V. E., & Rao, C. V. (2012) · International Journal of Cancer · doi:10.1002/ijc.27456 · Cited by 75
Sahar, S., Masubuchi, S., Eckel‐Mahan, K. L., Vollmer, S., Galla, L., Ceglia, N., Masri, S., Barth, T. K., Grimaldi, B., Oluyemi, O. I., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.537191 · Cited by 74
Carrer, A., Moimas, S., Zacchigna, S., Pattarini, L., Zentilin, L., Ruozi, G., Mano, M., Sinigaglia, M., Maione, F., Serini, G., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0762 · Cited by 62
Self-citationChen, M., Tsan, Y., Liou, J., Lee, Y., Wu, M., Chiu, H., Wang, H., & Chen, P. (2015) · International Journal of Cancer · doi:10.1002/ijc.29813 · Cited by 59
Gong, J., Sachdev, E., Robbins, L., Lin, E. M., Hendifar, A. E., & Mita, M. M. (2017) · Oncology Letters · doi:10.3892/ol.2017.5572 · Cited by 56
Cilia loss sensitizes cells to transformation by activating the mevalonate pathway
Deng, Y.-Z., Cai, Z., Shi, S., Jiang, H., Shang, Y., Ma, N., Wang, J. J., Guan, D., Chen, T.-W., Rong, Y., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170399 · Cited by 56
Liao, J., Chung, Y. T., Yang, A. L., Zhang, M., Li, H., Zhang, W., Yan, L. W., & Yang, G. (2012) · Molecular Carcinogenesis · doi:10.1002/mc.21916 · Cited by 52
Statin use and pancreatic cancer risk in two prospective cohort studies
Hamada, T., Khalaf, N. I., Yuan, C., Babić, A., Morales‐Oyarvide, V., Qian, Z. R., Nowak, J. A., Ng, K., Kraft, P. L., Rubinson, D. A., et al. (2018) · Journal of Gastroenterology · doi:10.1007/s00535-018-1430-x · Cited by 45
Pancreatic Cancer: “A Riddle Wrapped in a Mystery inside an Enigma”
Borazanci, E. H., Dang, C. V., Robey, R. W., Bates, S. E., Chabot, J. A., & Hoff, D. D. V. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2070 · Cited by 42
Fendrich, V., Sparn, M. B., Lauth, M., Knoop, R. F., Plaßmeier, L., Bartsch, D. K., & Waldmann, J. (2013) · Pancreatology · doi:10.1016/j.pan.2013.08.002 · Cited by 38
H4K12 and H3K18 Acetylation Associates With Poor Prognosis in Pancreatic Cancer
Juliano, C., Izetti, P., Pereira, M. P., dos Santos, A. P., Bravosi, C. P., Abujamra, A. L., Ashton‐Prolla, P., Osvaldt, A. B., & Edelweiss, M. I. A. (2015) · Applied immunohistochemistry & molecular morphology · doi:10.1097/pai.0000000000000194 · Cited by 38
Hamada, T., Khalaf, N. I., Yuan, C., Morales‐Oyarvide, V., Babić, A., Nowak, J. A., Qian, Z. R., Ng, K., Rubinson, D. A., Kraft, P. L., et al. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.02.022 · Cited by 27
Bang, U. C., Watanabe, T., & Bendtsen, F. (2018) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000001060 · Cited by 26
The secret origins and surprising fates of pancreas tumors
Bailey, J. M., DelGiorno, K. E., & Crawford, H. C. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu056 · Cited by 17
Pro‑metastatic signaling of the trans fatty acid elaidic acid is associated with lipid rafts
Kishi, S., Fujiwara‐Tani, R., Luo, Y., Kawahara, I., Goto, K., Fujii, K., Ohmori, H., Nakashima, C., Sasaki, T., & Kuniyasu, H. (2018) · Oncology Letters · doi:10.3892/ol.2018.7817 · Cited by 17
Lubeseder–Martellato, C., Alexandrow, K., Hidalgo‐Sastre, A., Heid, I., Boos, S. L., von Briel, T., Schmid, R. M., & Siveke, J. T. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.12.013 · Cited by 15
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- Mazur, 2015, Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma, Nat Med, 21, 1163, 10.1038/nm.3952 · DOI
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Metadata
- Authors
- Carrer, A., Trefely, S., Zhao, S., Campbell, S. L., Norgard, R. J., Schultz, K. C., Sidoli, S., Parris, J. L. D., Affronti, H. C., Sivanand, S., Egolf, S., Sela, Y., Trizzino, M., Gardini, A., Garcia, B. A., Snyder, N. W., Stanger, B. Z., & Wellen, K. E.
- Affiliations
- University of Pennsylvania (US)
- Drexel University (US)
- The Wistar Institute (US)
- Corresponding author
- Wellen, Kathryn E.
- ORCID
- Venue
- Cancer Discovery
- Published
- 2019-03-01
- Volume
- 9
- Issue
- 3
- Pages
- 416-435
- ISSN
- 2159-8274 (ISSN-L)
- 2159-8290
- PMC
- PMC6643997
- OpenAlex
- W2911157836
- Cited by
- 313
- References
- 76
- Citations by year
- 2026: 23 · 2025: 49 · 2024: 62 · 2023: 47 · 2022: 44 · 2021: 42 · 2020: 31 · 2019: 15
- FWCI
- 10.44
- Type
- journal article
- Language
- en
- Update notices
- correction (2024-09-04)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Discovery (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Pancreatic Cancer Action Network (14-20-25-WELL)
- NIH (R01CA174761, R01CA228339, R03HD092630, GM110174, AI118891, CA196539, 1F31CA217070-01, F99CA222741, 4K00CA212455-03)
- American Diabetes Association (#1-18-PDF-144)
- UPenn Baccalaureate Research Education (R25-GM071745)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- acetyl-CoA metabolism, pancreatic ductal adenocarcinoma, pancreatic carcinogenesis, ATP citrate lyase, histone H4 acetylation, acinar-to-ductal metaplasia, KRAS mutation, mevalonate pathway, Akt signaling, BET inhibition, statins, cellular plasticity, epigenetic regulation, pancreatic acinar cells
- MeSH terms
- Acetyl Coenzyme A, Acetylation, Animals, Female, Histones, Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Pancreatic Neoplasms, Protein Processing, Post-Translational, Genes, ras, Signal Transduction, Mice, Knockout, Carcinoma, Pancreatic Ductal, Cell Proliferation, Acinar Cells, Carcinogenesis, Heterografts
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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